{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:28:38Z","timestamp":1790422118410,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,2]],"date-time":"2021-04-02T00:00:00Z","timestamp":1617321600000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EC1408L"],"award-info":[{"award-number":["01EC1408L"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2020,4]]},"DOI":"10.1016\/j.joca.2019.11.003","type":"journal-article","created":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T21:20:21Z","timestamp":1575926421000},"page":"475-485","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["Pain and knee damage in male and female mice in the medial meniscal transection-induced osteoarthritis"],"prefix":"10.1016","volume":"28","author":[{"given":"J.","family":"Temp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Labuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Negrete","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Sunkara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Machelska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2019.11.003_bib1","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/S0140-6736(12)61689-4","article-title":"Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Murray","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.joca.2019.11.003_bib2","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/nrd1693","article-title":"Osteoarthritis - an untreatable disease?","volume":"4","author":"Wieland","year":"2005","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.joca.2019.11.003_bib3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.joca.2019.11.003_bib4","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/art.1780380817","article-title":"Incidence of symptomatic hand, hip, and knee osteoarthritis among patients in a health maintenance organization","volume":"38","author":"Oliveria","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2019.11.003_bib5","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.joca.2005.04.014","article-title":"A\u00a0meta-analysis of sex differences prevalence, incidence and severity of osteoarthritis","volume":"13","author":"Srikanth","year":"2005","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.003_bib6","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/j.joca.2011.08.009","article-title":"The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review","volume":"19","author":"Pereira","year":"2011","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.003_bib7","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.joca.2009.08.010","article-title":"Risk factors for onset of osteoarthritis of the knee in older adults: a systematic review and meta-analysis","volume":"18","author":"Blagojevic","year":"2010","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.003_bib8","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/art.22475","article-title":"Prognostic factors of progression of osteoarthritis of the knee: a systematic review of observational studies","volume":"57","author":"Belo","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2019.11.003_bib9","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1471-2474-9-82","article-title":"Gender difference in symptomatic radiographic knee osteoarthritis in the Knee Clinical Assessment--CAS(K): a prospective study in the general population","author":"Lacey","year":"2008","journal-title":"BMC Muscoskelet Disord"},{"key":"10.1016\/j.joca.2019.11.003_bib10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2042-6410-2-12","article-title":"Women with knee osteoarthritis have more pain and poorer function than men, but similar physical activity prior to total knee replacement","author":"Tonelli","year":"2011","journal-title":"Biol Sex Differ"},{"key":"10.1016\/j.joca.2019.11.003_bib11","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/acr.22712","article-title":"Enhanced pain sensitivity among individuals with symptomatic knee osteoarthritis: potential sex differences in central sensitization","volume":"68","author":"Bartley","year":"2016","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.joca.2019.11.003_bib12","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1007\/s11999-011-1921-z","article-title":"Women recover faster than men after standard knee arthroplasty","volume":"469","author":"Liebs","year":"2011","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.joca.2019.11.003_bib13","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.joca.2014.06.030","article-title":"Examining sex differences in knee pain: the multicenter osteoarthritis study","volume":"22","author":"Glass","year":"2014","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.003_bib14","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13293-019-0237-7","article-title":"Sex differences in negative affect and postoperative pain in patients undergoing total knee arthroplasty","author":"Nandi","year":"2019","journal-title":"Biol Sex Differ"},{"key":"10.1016\/j.joca.2019.11.003_bib15","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0304-3959(00)00296-7","article-title":"The relationship of gender to pain, pain behavior, and disability in osteoarthritis patients: the role of catastrophizing","volume":"87","author":"Keefe","year":"2000","journal-title":"Pain"},{"key":"10.1016\/j.joca.2019.11.003_bib16","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1302\/0301-620X.91B3.21771","article-title":"Analysis of the outcome in male and female patients using a unisex total knee replacement system","volume":"91","author":"Dalury","year":"2009","journal-title":"J\u00a0Bone Joint Surg Br"},{"key":"10.1016\/j.joca.2019.11.003_bib17","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.joca.2009.11.013","article-title":"ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization","volume":"18","author":"Malfait","year":"2010","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.003_bib18","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1056\/NEJMoa0800777","article-title":"Incidental meniscal findings on knee MRI in middle-aged and elderly persons","volume":"359","author":"Englund","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.joca.2019.11.003_bib19","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-017247","article-title":"Patient-reported outcome measures for patients with meniscal tears: a systematic review of measurement properties and evaluation with the COSMIN checklist","volume":"7","author":"Abram","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.joca.2019.11.003_bib20","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.joca.2005.03.004","article-title":"Osteoarthritis development in novel experimental mouse models induced by knee joint instability","volume":"13","author":"Kamekura","year":"2005","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.003_bib21","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.joca.2006.05.001","article-title":"Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia","volume":"14","author":"Bove","year":"2006","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.003_bib22","first-page":"18","article-title":"Behavioural and electrophysiological characterisation of experimentally induced osteoarthritis and neuropathy in C57Bl\/6 mice","author":"Harvey","year":"2009","journal-title":"Mol Pain"},{"key":"10.1016\/j.joca.2019.11.003_bib23","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0140-6736(05)71086-2","article-title":"Pathogenesis and management of pain in osteoarthritis","volume":"365","author":"Dieppe","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.joca.2019.11.003_bib24","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrrheum.2013.138","article-title":"Towards a mechanism-based approach to pain management in osteoarthritis","volume":"9","author":"Malfait","year":"2013","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2019.11.003_bib25","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.joca.2015.02.163","article-title":"Pain sensitization in people with knee osteoarthritis: a systematic review and meta-analysis","volume":"23","author":"Fingleton","year":"2015","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.003_bib26","first-page":"441","article-title":"Pain and hyperalgesia in osteoarthritis of the hands","volume":"27","author":"Farrell","year":"2000","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2019.11.003_bib27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3959(01)00300-1","article-title":"And its association with muscle hyperalgesia: an experimental controlled study","volume":"93","author":"Bajaj","year":"2001","journal-title":"Pain"},{"key":"10.1016\/j.joca.2019.11.003_bib28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pain.2004.08.004","article-title":"Pain related behaviour in two models of osteoarthritis in the rat knee","volume":"112","author":"Fernihough","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.joca.2019.11.003_bib29","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fnmol.2017.00349","article-title":"Mechanisms of osteoarthritic pain. Studies in humans and experimental models","volume":"10","author":"Eitner","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.joca.2019.11.003_bib30","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1002\/art.23870","article-title":"Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system","volume":"58","author":"Inglis","year":"2008","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2019.11.003_bib31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pain.2011.09.007","article-title":"Partial medial meniscectomy produces osteoarthritis pain-related behaviour in female C57BL\/6 mice","volume":"153","author":"Knights","year":"2012","journal-title":"Pain"},{"issue":"Suppl 107","key":"10.1016\/j.joca.2019.11.003_bib32","first-page":"37","article-title":"Why we should study pain in animal models of rheumatic diseases","volume":"35","author":"Malfait","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.joca.2019.11.003_bib33","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.joca.2018.09.016","article-title":"Models of osteoarthritis: the good, the bad and the promising","volume":"27","author":"Cope","year":"2019","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.003_bib34","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1053\/joca.2002.0823","article-title":"Induction of osteoarthritis in the rat by surgical tear of the meniscus: inhibition of joint damage by a matrix metalloproteinase inhibitor","volume":"10","author":"Janusz","year":"2002","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.003_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0213734","article-title":"Discerning the spatio-temporal disease patterns of surgically induced OA mouse models","volume":"14","author":"Haase","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2019.11.003_bib36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S1063-4584(05)80323-1","article-title":"Association of pain with radiological changes in different compartments and views of the knee joint","volume":"4","author":"Cicuttini","year":"1996","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.003_bib37","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1136\/ard.57.10.595","article-title":"Radiographic assessment of symptomatic knee osteoarthritis in the community: definitions and normal joint space","volume":"57","author":"Lanyon","year":"1998","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2019.11.003_bib38","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1136\/ard.2006.052548","article-title":"Symptoms and radiographic osteoarthritis: not as discordant as they are made out to be?","volume":"66","author":"Duncan","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2019.11.003_bib39","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.b2844","article-title":"Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies","volume":"339","author":"Neogi","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.joca.2019.11.003_bib40","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1002\/art.30414","article-title":"Greater rates of cartilage loss in painful knees than in pain-free knees after adjustment for radiographic disease stage: data from the osteoarthritis initiative","volume":"63","author":"Eckstein","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2019.11.003_bib41","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1063-4584(97)80002-7","article-title":"The Bristol 'OA500' study: progression of osteoarthritis (OA) over 3 years and the relationship between clinical and radiographic changes at the knee joint","volume":"5","author":"Dieppe","year":"1997","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.003_bib42","first-page":"1513","article-title":"Analysis of the discordance between radiographic changes and knee pain in osteoarthritis of the knee","volume":"27","author":"Hannan","year":"2000","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2019.11.003_bib43","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.joca.2005.11.012","article-title":"High signal in knee osteophytes is not associated with knee pain","volume":"14","author":"Sengupta","year":"2006","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.003_bib44","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/art.34646","article-title":"Discordance between pain and radiographic severity in knee osteoarthritis: findings from quantitative sensory testing of central sensitization","volume":"65","author":"Finan","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2019.11.003_bib45","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1007\/s00167-013-2402-6","article-title":"Correlation of WOMAC and KOOS scores to tibiofemoral cartilage loss on plain radiography and 3 Tesla MRI: data from the osteoarthritis initiative","volume":"22","author":"Illingworth","year":"2014","journal-title":"Knee Surg Sport Traumatol Arthrosc"},{"key":"10.1016\/j.joca.2019.11.003_bib46","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S1063-4584(05)80088-3","article-title":"Induction of osteoarthritis by intra-articular injection of collagenase in mice. Strain and sex related differences","volume":"1","author":"van Osch","year":"1993","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.003_bib47","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1136\/ard.2002.005041","article-title":"Sexual dimorphism in the osteoarthritis of STR\/ort mice may be linked to articular cytokines","volume":"62","author":"Mahr","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2019.11.003_bib48","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.joca.2006.11.005","article-title":"Osteoarthritis severity is sex dependent in a surgical mouse model","volume":"15","author":"Ma","year":"2007","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.003_bib49","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1126\/science.aap7679","article-title":"Measuring and managing bias","volume":"357","author":"Berg","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.joca.2019.11.003_bib50","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrn2606","article-title":"Animal models of pain: progress and challenges","volume":"10","author":"Mogil","year":"2009","journal-title":"Nat Rev Neurosci"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458419312695?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458419312695?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T17:03:53Z","timestamp":1778519033000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458419312695"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":50,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["S1063458419312695"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2019.11.003","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pain and knee damage in male and female mice in the medial meniscal transection-induced osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2019.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}