{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:26:35Z","timestamp":1789874795916,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"Osteoarthritis Research Society International"},{"name":"Innovative Medicines Initiative Joint Undertaking","award":["115770"],"award-info":[{"award-number":["115770"]}]},{"DOI":"10.13039\/100011102","name":"European Union's Seventh Framework","doi-asserted-by":"publisher","award":["FP7\/2007-2013"],"award-info":[{"award-number":["FP7\/2007-2013"]}],"id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013322","name":"EFPIA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.joca.2019.11.007","type":"journal-article","created":{"date-parts":[[2019,12,27]],"date-time":"2019-12-27T11:27:05Z","timestamp":1577446025000},"page":"296-315","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Osteoarthritis year in review 2019: biomarkers (biochemical markers)"],"prefix":"10.1016","volume":"28","author":[{"given":"W.E.","family":"van Spil","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.A.","family":"Szilagyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2019.11.007_bib1","series-title":"Osteoarthritis: a serious disease","year":"2016"},{"issue":"8","key":"10.1016\/j.joca.2019.11.007_bib2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.joca.2006.04.001","article-title":"Classification of osteoarthritis biomarkers: a proposed approach","volume":"14","author":"Bauer","year":"2006","journal-title":"Osteoarthr Cartil"},{"issue":"2","key":"10.1016\/j.joca.2019.11.007_bib3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.joca.2016.12.016","article-title":"Osteoarthritis Year in Review 2016: biomarkers (biochemical markers)","volume":"25","author":"Mobasheri","year":"2017","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2019.11.007_bib4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.clinbiochem.2018.04.022","article-title":"Aggrecanase degradation of type III collagen is associated with clinical knee pain","volume":"58","author":"Bay-Jensen","year":"2018","journal-title":"Clin Biochem"},{"issue":"3","key":"10.1016\/j.joca.2019.11.007_bib5","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.joca.2017.10.016","article-title":"Osteoarthritis biomarkers: year in review","volume":"26","author":"Watt","year":"2018","journal-title":"Osteoarthr Cartil"},{"issue":"3","key":"10.1016\/j.joca.2019.11.007_bib6","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.joca.2018.12.002","article-title":"Bay-Jensen AC. Osteoarthritis year in review 2018: biomarkers (biochemical markers)","volume":"27","author":"Saberi Hosnijeh","year":"2019","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"10.1016\/j.joca.2019.11.007_bib7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan-a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst Rev"},{"issue":"4","key":"10.1016\/j.joca.2019.11.007_bib8","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.joca.2019.01.001","article-title":"Potential diagnostic value of a type X collagen neo-epitope biomarker for knee osteoarthritis","volume":"27","author":"He","year":"2019","journal-title":"Osteoarthr Cartil"},{"issue":"11","key":"10.1016\/j.joca.2019.11.007_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113485","article-title":"A\u00a0novel high sensitivity type II collagen blood-based biomarker, PRO-C2, for assessment of cartilage formation","volume":"19","author":"Luo","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.joca.2019.11.007_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20020447","article-title":"The expression of thrombospondin-4 correlates with disease severity in osteoarthritic knee cartilage","volume":"20","author":"Maly","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.joca.2019.11.007_bib11","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.joca.2018.05.009","article-title":"New insights into the natural course of knee osteoarthritis: early regulation of cytokines and growth factors, with emphasis on sex-dependent angiogenesis and tissue remodeling. A pilot study","volume":"26","author":"Kisand","year":"2018","journal-title":"Osteoarthr Cartil"},{"issue":"7","key":"10.1016\/j.joca.2019.11.007_bib12","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1002\/art.38614","article-title":"Intraarticular sprifermin (recombinant human fibroblast growth factor 18) in knee osteoarthritis: a randomized, double-blind, placebo-controlled trial","volume":"66","author":"Lohmander","year":"2014","journal-title":"Arthr Rheumatol"},{"issue":"10","key":"10.1016\/j.joca.2019.11.007_bib13","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.joca.2017.07.006","article-title":"A\u00a0novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study","volume":"25","author":"Yazici","year":"2017","journal-title":"Osteoarthr Cartil"},{"issue":"5","key":"10.1016\/j.joca.2019.11.007_bib14","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.joca.2018.01.026","article-title":"Colchicine lack of effectiveness in symptom and inflammation modification in knee osteoarthritis (COLKOA): a randomized controlled trial","volume":"26","author":"Leung","year":"2018","journal-title":"Osteoarthr Cartil"},{"issue":"3","key":"10.1016\/j.joca.2019.11.007_bib15","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/annrheumdis-2018-213336","article-title":"Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1 alpha and anti-interleukin-1 beta dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis","volume":"78","author":"Kloppenburg","year":"2019","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"10.1016\/j.joca.2019.11.007_bib16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1177\/1753425919839125","article-title":"The synovial fluid neuropeptide PACAP may act as a protective factor during disease progression of primary knee osteoarthritis and is increased following hyaluronic acid injection","volume":"25","author":"Sun","year":"2019","journal-title":"Innate Immun"},{"issue":"3","key":"10.1016\/j.joca.2019.11.007_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005986","article-title":"An evolutionary learning and network approach to identifying key metabolites for osteoarthritis","volume":"14","author":"Hu","year":"2018","journal-title":"PLoS Comput Biol"},{"issue":"6","key":"10.1016\/j.joca.2019.11.007_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0199618","article-title":"A\u00a0classification modeling approach for determining metabolite signatures in osteoarthritis","volume":"13","author":"Rockel","year":"2018","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.joca.2019.11.007_bib19","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.bbrc.2018.03.117","article-title":"Application of global metabolomic profiling of synovial fluid for osteoarthritis biomarkers","volume":"499","author":"Carlson","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"issue":"5","key":"10.1016\/j.joca.2019.11.007_bib20","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1007\/s10067-019-04428-1","article-title":"Investigation of the relationships between knee osteoarthritis and obesity via untargeted metabolomics analysis","volume":"38","author":"Senol","year":"2019","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.joca.2019.11.007_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s41927-018-0041-8","article-title":"A\u00a0proteomic analysis of serum-derived exosomes in rheumatoid arthritis","volume":"2","author":"Tsuno","year":"2018","journal-title":"BMC Rheumatol"},{"issue":"6","key":"10.1016\/j.joca.2019.11.007_bib22","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/1756-185X.13251","article-title":"Medium- and long-chain acylcarnitines are associated with osteoarthritis severity and arterial stiffness in end-stage osteoarthritis patients: a case-control study","volume":"21","author":"Tootsi","year":"2018","journal-title":"Int J Rheum Dis"},{"issue":"9","key":"10.1016\/j.joca.2019.11.007_bib23","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1194\/jlr.P085118","article-title":"Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis","volume":"59","author":"Valdes","year":"2018","journal-title":"J\u00a0Lipid Res"},{"issue":"4","key":"10.1016\/j.joca.2019.11.007_bib24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1177\/1947603518767998","article-title":"The effects of well-rounded exercise program on systemic biomarkers related to cartilage metabolism","volume":"10","author":"Azukizawa","year":"2018","journal-title":"Cartilage"},{"issue":"3","key":"10.1016\/j.joca.2019.11.007_bib25","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.joca.2018.12.001","article-title":"Serological biomarker profiles of rapidly progressive osteoarthritis in tanezumab-treated patients","volume":"27","author":"Karsdal","year":"2019","journal-title":"Osteoarthr Cartil"},{"issue":"3","key":"10.1016\/j.joca.2019.11.007_bib26","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.bbrc.2018.07.036","article-title":"Identification of antibodies against extracellular matrix proteins in human osteoarthritis","volume":"503","author":"Ruthard","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1016\/j.joca.2019.11.007_bib27","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/rheumatology\/key435","article-title":"Synovial fluid fetuin-A levels in patients affected by osteoarthritis with or without evidence of calcium crystals","volume":"58","author":"Favero","year":"2019","journal-title":"Rheumatology"},{"issue":"6","key":"10.1016\/j.joca.2019.11.007_bib28","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1007\/s00264-018-3761-x","article-title":"Differential expression of adipokines in knee osteoarthritis patients with and without metabolic syndrome","volume":"42","author":"Dong","year":"2018","journal-title":"Int Orthop"},{"issue":"1","key":"10.1016\/j.joca.2019.11.007_bib29","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1089\/gtmb.2018.0184","article-title":"Cartilage oligomeric matrix protein levels in type 2 diabetes associated with primary knee osteoarthritis patients","volume":"23","author":"Arellano Perez Vertti","year":"2019","journal-title":"Genet Test Mol Biomark"},{"issue":"4","key":"10.1016\/j.joca.2019.11.007_bib30","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1055\/s-0043-122223","article-title":"Expression and significance of MMPs in synovial fluid, serum and PBMC culture supernatant stimulated by LPS in osteoarthritis patients with or without diabetes","volume":"127","author":"Luo","year":"2019","journal-title":"Exp Clin Endocrinol Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association"},{"issue":"11","key":"10.1016\/j.joca.2019.11.007_bib31","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1007\/s00296-018-4141-y","article-title":"Serum uric acid level is not associated with osteoarthritis in Korean population: data from the Seventh Korea National Health and Nutrition Examination Survey 2016","volume":"38","author":"Kim","year":"2018","journal-title":"Rheumatol Int"},{"issue":"12","key":"10.1016\/j.joca.2019.11.007_bib32","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/AJP.0000000000000644","article-title":"Clinical pain-related outcomes and inflammatory cytokine response to pain following insomnia improvement in adults with knee osteoarthritis","volume":"34","author":"Heffner","year":"2018","journal-title":"Clin J Pain"},{"issue":"4","key":"10.1016\/j.joca.2019.11.007_bib33","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1002\/cpt.1362","article-title":"The foundation for the national Institutes of Health biomarkers consortium: past accomplishments and new strategic direction","volume":"105","author":"Menetski","year":"2019","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.joca.2019.11.007_bib34","doi-asserted-by":"crossref","first-page":"S272","DOI":"10.1016\/j.joca.2018.02.554","article-title":"The approach consortium: a 2-year, European, cohort study to describe, validate, and predict phenotypes of knee osteoarthritis by use of clinical, imaging, and biochemical markers","volume":"26","author":"van Helvoort","year":"2018","journal-title":"Osteoarthr Cartil"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458419312944?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458419312944?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:52:48Z","timestamp":1761018768000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458419312944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S1063458419312944"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2019.11.007","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Osteoarthritis year in review 2019: biomarkers (biochemical markers)","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2019.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}