{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T17:54:57Z","timestamp":1777398897894,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T00:00:00Z","timestamp":1612137600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","oarsijournal.com","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2021,2]]},"DOI":"10.1016\/j.joca.2020.10.008","type":"journal-article","created":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T07:44:45Z","timestamp":1606203885000},"page":"248-256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["NF-\u03baB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6639-5506","authenticated-orcid":false,"given":"I.M.","family":"Berke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2352-9321","authenticated-orcid":false,"given":"B.","family":"Yavuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"McGrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Mbalaviele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Guilak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.L.","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.A.","family":"Setton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.joca.2020.10.008_bib1","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/art.39692","article-title":"Updated projected prevalence of self-reported doctor-diagnosed arthritis and arthritis-attributable Activity limitation among US adults, 2015-2040","volume":"68","author":"Hootman","year":"2016","journal-title":"Arthritis Rheum"},{"issue":"8","key":"10.1016\/j.joca.2020.10.008_bib2","doi-asserted-by":"crossref","first-page":"2178","DOI":"10.1002\/art.11088","article-title":"Impact of type of meniscal tear on radiographic and symptomatic knee osteoarthritis: a sixteen-year followup of meniscectomy with matched controls","volume":"48","author":"Englund","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"10","key":"10.1016\/j.joca.2020.10.008_bib3","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1177\/0363546507307396","article-title":"The long-term consequence of anterior cruciate ligament and meniscus injuries: Osteoarthritis","volume":"35","author":"Lohmander","year":"2007","journal-title":"Am J Sports Med"},{"issue":"6","key":"10.1016\/j.joca.2020.10.008_bib4","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/jor.21359","article-title":"Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention","volume":"29","author":"Anderson","year":"2011","journal-title":"J\u00a0Orthop Res"},{"issue":"2","key":"10.1016\/j.joca.2020.10.008_bib5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/jor.22208","article-title":"Acute and late changes in intraarticular cytokine levels following anterior cruciate ligament injury","volume":"31","author":"Bigoni","year":"2013","journal-title":"J\u00a0Orthop Res"},{"issue":"1","key":"10.1016\/j.joca.2020.10.008_bib6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0968-0160(02)00083-2","article-title":"Intraarticular inflammatory cytokines in acute anterior cruciate ligament injured knee","volume":"10","author":"Irie","year":"2003","journal-title":"Knee"},{"issue":"11","key":"10.1016\/j.joca.2020.10.008_bib7","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.joca.2012.07.021","article-title":"Cartilage and bone markers and inflammatory cytokines are increased in synovial fluid in the acute phase of knee injury (hemarthrosis) - a cross-sectional analysis","volume":"20","author":"Sw\u00e4rd","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"10","key":"10.1016\/j.joca.2020.10.008_bib8","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.joca.2015.05.009","article-title":"Non-invasive mouse models of post-traumatic osteoarthritis","volume":"23","author":"Christiansen","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.joca.2020.10.008_bib9","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/jor.23252","article-title":"Osteophyte formation after ACL rupture in mice is associated with joint restabilization and loss of range of motion","volume":"35","author":"Hsia","year":"2017","journal-title":"J\u00a0Orthop Res"},{"issue":"45223","key":"10.1016\/j.joca.2020.10.008_bib10","first-page":"1","article-title":"Post-traumatic osteoarthritis in mice following mechanical injury to the synovial joint","volume":"7","author":"Rai","year":"2017","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.joca.2020.10.008_bib11","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.joca.2012.04.014","article-title":"Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis","volume":"20","author":"Christiansen","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"12","key":"10.1016\/j.joca.2020.10.008_bib12","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1016\/j.joca.2017.08.016","article-title":"Role of subchondral bone properties and changes in development of load-induced osteoarthritis in mice","volume":"25","author":"Adebayo","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"issue":"41","key":"10.1016\/j.joca.2020.10.008_bib13","doi-asserted-by":"crossref","first-page":"E6199","DOI":"10.1073\/pnas.1608245113","article-title":"Suppression of NF-\u03baB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury","volume":"113","author":"Yan","year":"2016","journal-title":"Proc Natl Acad Sci Unit States Am"},{"issue":"5","key":"10.1016\/j.joca.2020.10.008_bib14","doi-asserted-by":"crossref","first-page":"599","DOI":"10.2174\/138945010791011938","article-title":"NF-\u03baB Signaling: Multiple angles to target OA","volume":"11","author":"B Marcu","year":"2010","journal-title":"Curr Drug Targets"},{"key":"10.1016\/j.joca.2020.10.008_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms13336","article-title":"Biphasic regulation of chondrocytes by Rela through induction of anti-apoptotic and catabolic target genes","volume":"7","author":"Kobayashi","year":"2016","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.joca.2020.10.008_bib16","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.pain.2010.01.001","article-title":"Transgenic inhibition of glial NF-kappa B reduces pain behavior and inflammation after peripheral nerve injury","volume":"148","author":"Fu","year":"2010","journal-title":"Pain"},{"issue":"12","key":"10.1016\/j.joca.2020.10.008_bib17","doi-asserted-by":"crossref","first-page":"3375","DOI":"10.1111\/j.0953-816X.2004.03441.x","article-title":"Spinal NF-kB activation induces COX-2 upregulation and contributes to inflammatory pain hypersensitivity","volume":"19","author":"Lee","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.joca.2020.10.008_bib18","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.isci.2019.08.017","article-title":"Nuclear factor-kappaB gates Nav1.7 channels in DRG neurons via protein-protein interaction","volume":"19","author":"Xie","year":"2019","journal-title":"iScience"},{"issue":"3","key":"10.1016\/j.joca.2020.10.008_bib19","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/art.38279","article-title":"In vivo luminescence imaging of NF-\u03baB activity and serum cytokine levels predict pain sensitivities in a rodent model of osteoarthritis","volume":"66","author":"Bowles","year":"2014","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.joca.2020.10.008_bib20","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1124\/jpet.108.143800","article-title":"A\u00a0novel , highly selective , tight binding I\u03baB kinase-2 ( IKK-2 ) Inhibitor: a tool to correlate IKK-2 activity to the fate and functions of the components of the nuclear factor- \u03baB pathway in arthritis-relevant cells and animal models","volume":"329","author":"Mbalaviele","year":"2009","journal-title":"J\u00a0Pharmacol Exp Therapeut"},{"issue":"1","key":"10.1016\/j.joca.2020.10.008_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-34830-9","article-title":"Intra-articular administration of I\u03baB\u03b1 kinase inhibitor suppresses mouse knee osteoarthritis via downregulation of the NF-\u03baB\/HIF-2\u03b1 axis","volume":"8","author":"Murahashi","year":"2018","journal-title":"Sci Rep"},{"issue":"November 2017","key":"10.1016\/j.joca.2020.10.008_bib22","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.biocel.2017.12.020","article-title":"NF-\u03baB in the crosshairs: rethinking an old riddle","volume":"95","author":"Bennett","year":"2018","journal-title":"Int J Biochem Cell Biol"},{"issue":"1\u20132","key":"10.1016\/j.joca.2020.10.008_bib23","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2016.12.012","article-title":"30 Years of NF-\u03baB: a blossoming of relevance to human pathobiology","volume":"168","author":"Zhang","year":"2017","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.joca.2020.10.008_bib24","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1002\/art.38375","article-title":"Early response of mouse joint tissue to noninvasive knee injury suggests treatment targets","volume":"66","author":"Wu","year":"2014","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2020.10.008_bib25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia evoked by unilateral ligation of the fifth and sixth lumbar nerves in the rat","volume":"53","author":"Chaplan","year":"1994","journal-title":"J\u00a0Neurosci"},{"issue":"6","key":"10.1016\/j.joca.2020.10.008_bib26","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.95704","article-title":"An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2","volume":"3","author":"Miller","year":"2018","journal-title":"JCI insight"},{"issue":"9","key":"10.1016\/j.joca.2020.10.008_bib27","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1002\/art.1780400917","article-title":"Mono-iodoacetate-induced experimental osteoarthritis. A dose-response study of loss of mobility, morphology, and biochemistry","volume":"40","author":"Guingamp","year":"1997","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.joca.2020.10.008_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-39657-6","article-title":"Behavioral compensations and neuronal remodeling in a rodent model of chronic intervertebral disc degeneration","volume":"9","author":"Leimer","year":"2019","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.joca.2020.10.008_bib29","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.joca.2019.11.003","article-title":"Pain and knee damage in male and female mice in the medial meniscal transection-induced osteoarthritis","volume":"28","author":"Temp","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"issue":"8","key":"10.1016\/j.joca.2020.10.008_bib30","doi-asserted-by":"crossref","first-page":"2893","DOI":"10.1172\/JCI83676","article-title":"Induced superficial chondrocyte death reduces catabolic cartilage damage in murine posttraumatic osteoarthritis","volume":"126","author":"Zhang","year":"2016","journal-title":"J\u00a0Clin Invest"},{"issue":"Suppl 3","key":"10.1016\/j.joca.2020.10.008_bib31","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1016\/j.joca.2020.10.008_bib32","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.joca.2009.11.013","article-title":"ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization","volume":"18","author":"Malfait","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.joca.2020.10.008_bib33","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.pbb.2010.11.003","article-title":"Gait analysis and pain response of two rodent models of osteoarthritis","volume":"97","author":"Ferland","year":"2011","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.joca.2020.10.008_bib34","article-title":"Osteoarthritis-related nociceptive behaviour following mechanical joint loading correlates with cartilage damage","author":"Heegde","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.joca.2020.10.008_bib35","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/art.40342","article-title":"Visualization of peripheral neuron sensitization in a surgical mouse model of osteoarthritis by in vivo calcium imaging","volume":"70","author":"Miller","year":"2018","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2020.10.008_bib36","first-page":"1","article-title":"Characterization and comparison of rat monosodium iodoacetate and medial meniscal tear models of osteoarthritic pain","volume":"11","author":"Brederson","year":"2018","journal-title":"J\u00a0Orthop Res"},{"issue":"10","key":"10.1016\/j.joca.2020.10.008_bib37","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1002\/jor.23178","article-title":"Contribution of mechanical unloading to trabecular bone loss following non-invasive knee injury in mice","volume":"34","author":"Anderson","year":"2016","journal-title":"J\u00a0Orthop Res"},{"issue":"9","key":"10.1016\/j.joca.2020.10.008_bib38","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.joca.2013.06.016","article-title":"Pain, motor and gait assessment of murine osteoarthritis in a cruciate ligament transection model","volume":"21","author":"Ruan","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2020.10.008_bib39","first-page":"1","article-title":"Factors affecting the reliability of behavioral assessments for rodent osteoarthritis models","author":"Jacobs","year":"2019","journal-title":"Lab Anim"},{"key":"10.1016\/j.joca.2020.10.008_bib40","first-page":"1","article-title":"Bioluminescence and second harmonic generation imaging reveal dynamic changes in the inflammatory and collagen landscape in early osteoarthritis","volume":"14","author":"Hui Mingalone","year":"2018","journal-title":"Lab Invest"},{"issue":"1","key":"10.1016\/j.joca.2020.10.008_bib41","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.celrep.2016.05.085","article-title":"Neutrophil-derived IL-1\u03b2 impairs the efficacy of NF-\u03baB inhibitors against lung cancer","volume":"16","author":"McLoed","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.joca.2020.10.008_bib42","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.bbi.2015.07.014","article-title":"Nuclear factor-kappa B regulates pain and COMT expression in a rodent model of inflammation","volume":"50","author":"Hartung","year":"2015","journal-title":"Brain Behav Immun"},{"issue":"1","key":"10.1016\/j.joca.2020.10.008_bib43","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.joca.2016.08.010","article-title":"I\u03baB kinase inhibition as a potential treatment of osteoarthritis \u2013 results of a clinical proof-of-concept study","volume":"25","author":"Grothe","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"10.1016\/j.joca.2020.10.008_bib44","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.joca.2020.01.015","article-title":"Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee","volume":"28","author":"Bailey","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.joca.2020.10.008_bib45","doi-asserted-by":"crossref","first-page":"245","DOI":"10.33218\/prnano2(1).181129.1","article-title":"Nanotherapy targeting NF-kB attenuates acute pain after joint injury","volume":"2","author":"Yan","year":"2019","journal-title":"Precis Nanomedicine"},{"issue":"1","key":"10.1016\/j.joca.2020.10.008_bib46","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1517\/17425240802647259","article-title":"Intra-articular drug delivery systems: overcoming the shortcomings of joint disease therapy","volume":"6","author":"Burt","year":"2009","journal-title":"Expet Opin Drug Deliv"},{"issue":"May","key":"10.1016\/j.joca.2020.10.008_bib47","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.jconrel.2018.05.029","article-title":"Intra-articular clearance of labeled dextrans from naive and arthritic rat knee joints","volume":"283","author":"Mwangi","year":"2018","journal-title":"J\u00a0Contr Release"},{"key":"10.1016\/j.joca.2020.10.008_bib48","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.actbio.2019.04.025","article-title":"Endothelin-1 inhibits size dependent lymphatic clearance of PEG-based conjugates after intra-articular injection into the rat knee","volume":"93","author":"Doan","year":"2019","journal-title":"Acta Biomater"},{"key":"10.1016\/j.joca.2020.10.008_bib49","first-page":"1","article-title":"Injectable mechanical pillows for attenuation of load-induced post-traumatic osteoarthritis","author":"Holyoak","year":"2019","journal-title":"Regen Biomater"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458420311808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458420311808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T17:05:26Z","timestamp":1635959126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458420311808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,2]]}},"alternative-id":["S1063458420311808"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2020.10.008","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2021,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NF-\u03baB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2020.10.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}