{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:53:06Z","timestamp":1790664786785,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,11]],"date-time":"2021-02-11T00:00:00Z","timestamp":1613001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.joca.2020.11.009","type":"journal-article","created":{"date-parts":[[2021,1,30]],"date-time":"2021-01-30T07:12:38Z","timestamp":1611990758000},"page":"491-501","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Effectiveness, safety, and cost\u2013utility of a knee brace in medial knee osteoarthritis: the ERGONOMIE randomized controlled trial"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-8369","authenticated-orcid":false,"given":"M.","family":"Gueugnon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Fournel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.-L.","family":"Soilly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Baulot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bussi\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Casillas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Cherasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Conrozier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Loeuille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.-F.","family":"Maillefert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Mazalovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Timsit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Wendling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ramon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Binquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Morisset","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Ornetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10182","key":"10.1016\/j.joca.2020.11.009_bib1","first-page":"1745","volume":"393","author":"Hunter","year":"2019","journal-title":"Osteoarthritis. The Lancet."},{"issue":"5","key":"10.1016\/j.joca.2020.11.009_bib2","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1002\/art.10293","article-title":"High prevalence of lateral knee osteoarthritis in Beijing Chinese compared with Framingham Caucasian subjects","volume":"46","author":"Felson","year":"2002","journal-title":"Arthritis Rheum"},{"issue":"9","key":"10.1016\/j.joca.2020.11.009_bib3","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.joca.2009.04.005","article-title":"Prevalence of radiographic knee osteoarthritis and its association with knee pain in the elderly of Japanese population-based cohorts: the ROAD study","volume":"17","author":"Muraki","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"issue":"11","key":"10.1016\/j.joca.2020.11.009_bib4","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis","volume":"27","author":"Bannuru","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2020.11.009_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2012-202745","article-title":"EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis","author":"Fernandes","year":"2013","journal-title":"Ann Rheum Dis. Published online"},{"issue":"2","key":"10.1016\/j.joca.2020.11.009_bib6","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/art.41142","article-title":"American College of rheumatology\/arthritis foundation guideline for the management of osteoarthritis of the hand, hip, and knee","volume":"72","author":"Kolasinski","year":"2019","journal-title":"Arthritis and Rheumatology"},{"key":"10.1016\/j.joca.2020.11.009_bib7","article-title":"Braces and orthoses for treating osteoarthritis of the knee","volume":"3","author":"Duivenvoorden","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"10.1016\/j.joca.2020.11.009_bib8","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.joca.2014.11.018","article-title":"Biomechanical effects of valgus knee bracing: a systematic review and meta-analysis","volume":"23","author":"Moyer","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.joca.2020.11.009_bib9","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.rehab.2016.10.005","article-title":"Orthoses for osteoarthritis: a narrative review","volume":"60","author":"Beaudreuil","year":"2017","journal-title":"Annals of Physical and Rehabilitation Medicine"},{"key":"10.1016\/j.joca.2020.11.009_bib10","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.b421","article-title":"ARTIST (osteoarthritis intervention standardized) study of standardised consultation versus usual care for patients with osteoarthritis of the knee in primary care in France: pragmatic randomised controlled trial","volume":"338","author":"Ravaud","year":"2009","journal-title":"BMJ (Clinical research ed)"},{"key":"10.1016\/j.joca.2020.11.009_bib11","series-title":"Valgus bracing for knee osteoarthritis: a meta-analysis of randomized trials","author":"Moyer","year":"2015"},{"issue":"8","key":"10.1016\/j.joca.2020.11.009_bib12","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.joca.2006.02.004","article-title":"Brace treatment for osteoarthritis of the knee: a prospective randomized multi-centre trial","volume":"14","author":"Brouwer","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2020.11.009_bib13","doi-asserted-by":"crossref","first-page":"S173","DOI":"10.1016\/j.joca.2017.02.299","article-title":"The clinical effect of unloader one\u00ae knee brace on patients with osteoarthritis of the knee. A randomized placebo controlled trial","volume":"25","author":"Hjartarson","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1016\/j.joca.2020.11.009_bib14","doi-asserted-by":"crossref","first-page":"539","DOI":"10.2106\/00004623-199904000-00012","article-title":"The effect of bracing on varus gonarthrosis","volume":"81","author":"Kirkley","year":"1999","journal-title":"JBJS"},{"issue":"6","key":"10.1016\/j.joca.2020.11.009_bib15","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1177\/1941738118763913","article-title":"Effectiveness of valgus offloading knee braces in the treatment of medial compartment knee osteoarthritis: a systematic review","volume":"10","author":"Gohal","year":"2018","journal-title":"Sport Health"},{"issue":"3","key":"10.1016\/j.joca.2020.11.009_bib16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.semarthrit.2013.07.003","article-title":"Health economics in the field of osteoarthritis: an expert's consensus paper from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)","volume":"43","author":"Hiligsmann","year":"2013","journal-title":"Semin Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.joca.2020.11.009_bib17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.semarthrit.2014.06.005","article-title":"A\u00a0reference case for economic evaluations in osteoarthritis: an expert consensus article from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO)","volume":"44","author":"Hiligsmann","year":"2014","journal-title":"Semin Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.joca.2020.11.009_bib18","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteo-arthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann Rheum Dis"},{"issue":"7495","key":"10.1016\/j.joca.2020.11.009_bib19","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1136\/bmj.330.7495.843","article-title":"Treatment allocation by minimisation","volume":"330","author":"Altman","year":"2005","journal-title":"BMJ"},{"issue":"3","key":"10.1016\/j.joca.2020.11.009_bib20","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.knee.2014.02.015","article-title":"Biomechanical effectiveness of a distraction\u2013rotation knee brace in medial knee osteoarthritis: preliminary results","volume":"21","author":"Laroche","year":"2014","journal-title":"Knee"},{"issue":"3","key":"10.1016\/j.joca.2020.11.009_bib21","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.rehab.2015.03.004","article-title":"Clinical effectiveness and safety of a distraction\u2013rotation knee brace for medial knee osteoarthritis","volume":"58","author":"Ornetti","year":"2015","journal-title":"Annals of Physical and Rehabilitation Medicine"},{"issue":"1","key":"10.1016\/j.joca.2020.11.009_bib22","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jclinepi.2004.04.011","article-title":"OAKHQOL: a new instrument to measure quality of life in knee and hip osteoarthritis","volume":"58","author":"Rat","year":"2005","journal-title":"J\u00a0Clin Epidemiol"},{"key":"10.1016\/j.joca.2020.11.009_bib23","doi-asserted-by":"crossref","DOI":"10.2519\/jospt.1998.28.2.88","article-title":"Knee injury and osteoarthritis outcome score (KOOS) \u2014 development of a self-administered outcome measure","author":"Roos","year":"1998","journal-title":"Journal of Orthopaedic and Sports Physical Therapy"},{"issue":"1","key":"10.1016\/j.joca.2020.11.009_bib24","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0168-8510(96)00822-6","article-title":"EuroQol: the current state of play","volume":"37","author":"Brooks","year":"1996","journal-title":"Health Pol"},{"key":"10.1016\/j.joca.2020.11.009_bib25","series-title":"Methods for the Economic Evaluation of Health Care Programmes","author":"Drummond","year":"2015"},{"key":"10.1016\/j.joca.2020.11.009_bib26","series-title":"Choices in Methods for Medico-Economic Evaluation. A Methodological Guide","year":"2012"},{"key":"10.1016\/j.joca.2020.11.009_bib27","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.a2390","article-title":"Improving the reporting of pragmatic trials: an extension of the CONSORT statement","volume":"337","author":"Zwarenstein","year":"2008","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.joca.2020.11.009_bib28","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.jbspin.2006.01.027","article-title":"Development and testing of a specific quality-of-life questionnaire for knee and hip osteoarthritis: OAKHQOL (OsteoArthritis of Knee Hip Quality of Life)","volume":"73","author":"Rat","year":"2006","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.joca.2020.11.009_bib29","article-title":"Evaluation of clinically relevant changes in patient reported outcomes in knee and hip osteoarthritis: the minimal clinically important improvement","author":"Tubach","year":"2005","journal-title":"Ann Rheum Dis. Published online"},{"key":"10.1016\/j.joca.2020.11.009_bib30","doi-asserted-by":"crossref","DOI":"10.1136\/ard.2007.079798","article-title":"Minimal clinically important improvement\/difference (MCII\/MCID) and patient acceptable symptom state (PASS): what do these concepts mean?","volume":"66","author":"Kvien","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2020.11.009_bib31","first-page":"599","article-title":"Clinically relevant change and patient acceptable quality of life after total hip or knee replacement surgery for osteoarthritis","author":"Rat","year":"2006","journal-title":"Annals of the Rheumatic Diseases"},{"issue":"4","key":"10.1016\/j.joca.2020.11.009_bib32","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1017\/S0266462300008461","article-title":"Utilities and quality-adjusted life years","volume":"5","author":"Torrance","year":"1989","journal-title":"Int J Technol Assess Health Care"},{"issue":"11","key":"10.1016\/j.joca.2020.11.009_bib33","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1002\/acr.21747","article-title":"Minimum clinically important improvement and patient acceptable symptom state in pain and function in rheumatoid arthritis, ankylosing spondylitis, chronic back pain, hand osteoarthritis, and hip and knee osteoarthritis: results from a prospective multina","volume":"64","author":"Tubach","year":"2012","journal-title":"Arthritis Care Res"},{"issue":"1","key":"10.1016\/j.joca.2020.11.009_bib34","first-page":"135","article-title":"Withdrawals in a therapeutic trial","volume":"23","author":"Schwartz","year":"1967","journal-title":"Biometrics"},{"key":"10.1016\/j.joca.2020.11.009_bib35","series-title":"Assessment Principles Established by the Medical Device and Health Technology Evaluation Committee (CNEDiMTS) to Determine the Reimbursement Eligibility of Medical Devices for Individual Use","year":"2019"},{"issue":"11","key":"10.1016\/j.joca.2020.11.009_bib36","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s40273-018-0695-5","article-title":"Cost effectiveness of intra-articular hyaluronic acid and disease-modifying drugs in knee osteoarthritis","volume":"36","author":"Salmon","year":"2018","journal-title":"Pharmacoeconomics"},{"issue":"3","key":"10.1016\/j.joca.2020.11.009_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173683","article-title":"Intra articular hyaluronic acid in the management of knee osteoarthritis: pharmaco-economic study from the perspective of the national health insurance system","volume":"12","author":"Thomas","year":"2017","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.joca.2020.11.009_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-28782-3","article-title":"Effect of unloading brace\u00a0treatment on pain and function in patients with symptomatic knee osteoarthritis: the ROTOR randomized clinical trial","volume":"8","author":"Thoumie","year":"2018","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.joca.2020.11.009_bib39","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1136\/annrheumdis-2011-200728","article-title":"Realignment treatment for medial tibiofemoral osteoarthritis: randomised trial","volume":"71","author":"Hunter","year":"2012","journal-title":"Ann Rheum Dis"},{"issue":"4","key":"10.1016\/j.joca.2020.11.009_bib40","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/art.22110","article-title":"Feeling good rather than feeling better matters more to patients","volume":"55","author":"Tubach","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.joca.2020.11.009_bib41","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.joca.2014.01.003","article-title":"OARSI guidelines for the non-surgical management of knee osteoarthritis","volume":"22","author":"McAlindon","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2020.11.009_bib42","first-page":"6","article-title":"Efficacy of unloader bracing in reducing symptoms of knee osteoarthritis","author":"Ostrander","year":"2016","journal-title":"The American Journal of Orthopedics. Published online"},{"issue":"1","key":"10.1016\/j.joca.2020.11.009_bib43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/acr.20014","article-title":"Total hip or knee replacement for osteoarthritis: mid- and long-term quality of life","volume":"62","author":"Rat","year":"2010","journal-title":"Arthritis Care Res"},{"issue":"6","key":"10.1016\/j.joca.2020.11.009_bib44","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1007\/s11999-013-2814-0","article-title":"Unloader knee braces for osteoarthritis: do patients actually wear them?","volume":"471","author":"Squyer","year":"2013","journal-title":"Clin Orthop Relat Res"},{"issue":"3","key":"10.1016\/j.joca.2020.11.009_bib45","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1111\/1756-185X.12796","article-title":"Effectiveness of knee bracing in osteoarthritis: pragmatic trial in a multidisciplinary clinic","volume":"19","author":"Yu","year":"2016","journal-title":"International Journal of Rheumatic Diseases"},{"issue":"4","key":"10.1016\/j.joca.2020.11.009_bib46","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3109\/10582452.2014.937550","article-title":"Annual cost of patients with\u00a0osteoarthritis of the hip and knee in France","volume":"22","author":"Bertin","year":"2014","journal-title":"J\u00a0Muscoskel Pain"},{"issue":"4","key":"10.1016\/j.joca.2020.11.009_bib47","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/S1297-319X(03)00043-5","article-title":"Prospective randomized study comparing the medicoeconomic benefits of Hylan GF-20 vs. conventional treatment in knee osteoarthritis","volume":"70","author":"Kahan","year":"2003","journal-title":"Joint Bone Spine"},{"issue":"8","key":"10.1016\/j.joca.2020.11.009_bib48","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1001\/jama.290.8.1062","article-title":"Methodological differences in clinical trials evaluating nonpharmacological and pharmacological treatments of hip and knee osteoarthritis","volume":"290","author":"Boutron","year":"2003","journal-title":"J\u00a0Am Med Assoc"},{"issue":"12","key":"10.1016\/j.joca.2020.11.009_bib49","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1136\/ard.2008.092015","article-title":"The placebo effect and its determinants in osteoarthritis: meta-analysis of randomised controlled trials","volume":"67","author":"Zhang","year":"2008","journal-title":"Ann Rheum Dis"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345842100011X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345842100011X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:55:03Z","timestamp":1761018903000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S106345842100011X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S106345842100011X"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2020.11.009","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effectiveness, safety, and cost\u2013utility of a knee brace in medial knee osteoarthritis: the ERGONOMIE randomized controlled trial","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2020.11.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}