{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:17:48Z","timestamp":1791389868481,"version":"4.3.3"},"reference-count":59,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000940","name":"Arthritis Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000940","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001774","name":"The University of Sydney","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.joca.2021.03.023","type":"journal-article","created":{"date-parts":[[2021,7,28]],"date-time":"2021-07-28T11:22:13Z","timestamp":1627471333000},"page":"1448-1461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Pathology-pain relationships in different osteoarthritis animal model phenotypes: it matters what you measure, when you measure, and how you got there"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6393-6055","authenticated-orcid":false,"given":"S.","family":"Zaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.M.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.B.","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.joca.2021.03.023_bib1","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s13075-020-2143-0","article-title":"A consensus-based framework for conducting and reporting osteoarthritis phenotype research","volume":"22","author":"van Spil","year":"2020","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"10.1016\/j.joca.2021.03.023_bib2","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1136\/annrheumdis-2013-204763","article-title":"The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study","volume":"73","author":"Cross","year":"2014","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"10.1016\/j.joca.2021.03.023_bib3","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.joca.2019.06.011","article-title":"OARSI guidelines for the non-surgical management of knee, hip, and polyarticular osteoarthritis","volume":"27","author":"Bannuru","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.joca.2021.03.023_bib4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.joca.2020.01.002","article-title":"Osteoarthritis year in review 2019: epidemiology and therapy","volume":"28","author":"Kloppenburg","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.joca.2021.03.023_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-015-0747-6","article-title":"On the predictive utility of animal models of osteoarthritis","volume":"17","author":"Malfait","year":"2015","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1016\/j.joca.2021.03.023_bib6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pain.2010.07.015","article-title":"The necessity of animal models in pain research","volume":"151","author":"Mogil","year":"2010","journal-title":"Pain"},{"issue":"4","key":"10.1016\/j.joca.2021.03.023_bib7","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.joca.2012.01.017","article-title":"What constitutes an \u201canimal model of osteoarthritis\u201d\u2013the need for consensus?","volume":"20","author":"Little","year":"2012","journal-title":"Osteoarthritis and Cartilage"},{"issue":"2","key":"10.1016\/j.joca.2021.03.023_bib8","doi-asserted-by":"crossref","first-page":"e634","DOI":"10.1097\/PR9.0000000000000634","article-title":"Reconsidering the international association for the study of pain definition of pain","volume":"3","author":"Cohen","year":"2018","journal-title":"Pain Rep"},{"issue":"9","key":"10.1016\/j.joca.2021.03.023_bib9","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1016\/j.joca.2013.06.003","article-title":"A commentary on modelling osteoarthritis pain in small animals","volume":"21","author":"Malfait","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.joca.2021.03.023_bib10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s11926-012-0279-x","article-title":"Mechanisms of chronic pain in osteoarthritis","volume":"14","author":"Schaible","year":"2012","journal-title":"Curr Rheumatol Rep"},{"issue":"6","key":"10.1016\/j.joca.2021.03.023_bib11","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s11914-016-0326-z","article-title":"Emerging targets for the management of osteoarthritis pain","volume":"14","author":"Malfait","year":"2016","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.joca.2021.03.023_bib12","first-page":"iv99","volume":"vol. 57","author":"Miller","year":"2018"},{"issue":"1\u20132","key":"10.1016\/j.joca.2021.03.023_bib13","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pain.2004.08.004","article-title":"Pain related behaviour in two models of osteoarthritis in the rat knee","volume":"112","author":"Fernihough","year":"2004","journal-title":"Pain"},{"issue":"9","key":"10.1016\/j.joca.2021.03.023_bib14","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/j.joca.2013.06.016","article-title":"Pain, motor and gait assessment of murine osteoarthritis in a cruciate ligament transection model","volume":"21","author":"Ruan","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.joca.2021.03.023_bib15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pain.2011.09.007","article-title":"Partial medial meniscectomy produces osteoarthritis pain-related behaviour in female C57BL\/6 mice","volume":"153","author":"Knights","year":"2012","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.joca.2021.03.023_bib16","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.joca.2016.08.007","article-title":"Measuring and realizing the translational significance of preclinical in vivo studies of painful osteoarthritis","volume":"25","author":"Hummel","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"issue":"7","key":"10.1016\/j.joca.2021.03.023_bib17","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.joca.2020.04.009","article-title":"Differential patterns of pathology in and interaction between joint tissues in long-term osteoarthritis with different initiating causes: phenotype matters","volume":"28","author":"Zaki","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.joca.2021.03.023_bib18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J\u00a0Neurosci Methods"},{"key":"10.1016\/j.joca.2021.03.023_bib19","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"10.1016\/j.joca.2021.03.023_bib20","doi-asserted-by":"crossref","first-page":"S419","DOI":"10.1016\/j.joca.2014.02.790","article-title":"Establishing a method for measuring primary knee hyperalgesia in the murine DMM model of osteoarthritis","volume":"22","author":"Miller","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"issue":"1\u20132","key":"10.1016\/j.joca.2021.03.023_bib21","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.pain.2009.06.006","article-title":"Gait abnormalities differentially indicate pain or structural joint damage in monoarticular antigen-induced arthritis","volume":"145","author":"Boettger","year":"2009","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.joca.2021.03.023_bib22","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13075-020-2117-2","article-title":"The relationship between synovial inflammation, structural pathology, and pain in post-traumatic osteoarthritis: differential effect of stem cell and hyaluronan treatment","volume":"22","author":"Shu","year":"2020","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"10.1016\/j.joca.2021.03.023_bib23","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/sj.gene.6364190","article-title":"Real-time RT-PCR normalisation; strategies and considerations","volume":"6","author":"Huggett","year":"2005","journal-title":"Gene Immun"},{"issue":"12","key":"10.1016\/j.joca.2021.03.023_bib24","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1002\/art.38876","article-title":"Depletion of protease-activated receptor 2 but not protease-activated receptor 1 may confer protection against osteoarthritis in mice through extracartilaginous mechanisms","volume":"66","author":"Jackson","year":"2014","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.joca.2021.03.023_bib25","doi-asserted-by":"crossref","first-page":"e1001863","DOI":"10.1371\/journal.pbio.1001863","article-title":"Distinguishing between exploratory and confirmatory preclinical research will improve translation","volume":"12","author":"Kimmelman","year":"2014","journal-title":"PLoS Biol"},{"issue":"4","key":"10.1016\/j.joca.2021.03.023_bib26","article-title":"Focal experimental injury leads to widespread gene expression and histologic changes in equine flexor tendons","volume":"10","author":"Jacobson","year":"2015","journal-title":"PloS One"},{"issue":"8","key":"10.1016\/j.joca.2021.03.023_bib27","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/nrrheum.2013.72","article-title":"Post-traumatic osteoarthritis: from mouse models to clinical trials","volume":"9","author":"Little","year":"2013","journal-title":"Nat Rev Rheumatol"},{"issue":"3","key":"10.1016\/j.joca.2021.03.023_bib28","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/jor.23343","article-title":"Using mouse models to investigate the pathophysiology, treatment, and prevention of post-traumatic osteoarthritis","volume":"35","author":"Blaker","year":"2017","journal-title":"J\u00a0Orthop Res"},{"issue":"5","key":"10.1016\/j.joca.2021.03.023_bib29","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.joca.2020.01.008","article-title":"Microarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis","volume":"28","author":"Miller","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2021.03.023_bib30","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/j.1749-6632.2009.05301.x","article-title":"The role of proinflammatory cytokines in the generation and maintenance of joint pain","volume":"1193","author":"Schaible","year":"2010","journal-title":"Ann N Y Acad Sci"},{"issue":"12","key":"10.1016\/j.joca.2021.03.023_bib31","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1002\/art.34675","article-title":"The role of interleukin-1beta in arthritic pain: main involvement in thermal, but not mechanical, hyperalgesia in rat antigen-induced arthritis","volume":"64","author":"Ebbinghaus","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.joca.2021.03.023_bib32","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.joca.2009.11.013","article-title":"ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization.","volume":"18","author":"Malfait","year":"2010","journal-title":"Osteoarthritis and Cartilage"},{"issue":"50","key":"10.1016\/j.joca.2021.03.023_bib33","doi-asserted-by":"crossref","first-page":"20602","DOI":"10.1073\/pnas.1209294110","article-title":"CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis","volume":"109","author":"Miller","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.1016\/j.joca.2021.03.023_bib34","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/art.39523","article-title":"Nociceptive sensitizers are regulated in damaged joint tissues, including articular cartilage, when osteoarthritic mice display pain behavior","volume":"68","author":"Driscoll","year":"2016","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.joca.2021.03.023_bib35","doi-asserted-by":"crossref","first-page":"e95704","DOI":"10.1172\/jci.insight.95704","article-title":"An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2","volume":"3","author":"Miller","year":"2018","journal-title":"JCI Insight"},{"issue":"1-","key":"10.1016\/j.joca.2021.03.023_bib36","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1002\/art.23870","article-title":"Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system","volume":"58","author":"Inglis","year":"2008","journal-title":"Arthritis Rheum"},{"issue":"6","key":"10.1016\/j.joca.2021.03.023_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar2331","article-title":"Gait analysis in a murine model of collagen-induced arthritis","volume":"9","author":"Vincelette","year":"2007","journal-title":"Arthritis Res Ther"},{"issue":"4","key":"10.1016\/j.joca.2021.03.023_bib38","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1136\/annrheumdis-2013-204191","article-title":"Sensitivity and sensitisation in relation to pain severity in knee osteoarthritis: trait or state?","volume":"74","author":"Neogi","year":"2015","journal-title":"Ann Rheum Dis"},{"issue":"14","key":"10.1016\/j.joca.2021.03.023_bib39","doi-asserted-by":"crossref","first-page":"7723","DOI":"10.1073\/pnas.96.14.7723","article-title":"Transcriptional and posttranslational plasticity and the generation of inflammatory pain","volume":"96","author":"Woolf","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"10.1016\/j.joca.2021.03.023_bib40","first-page":"75","article-title":"Structural correlates of pain in osteoarthritis","volume":"35 Suppl 107","author":"Neogi","year":"2017","journal-title":"Clin Exp Rheumatol"},{"issue":"9","key":"10.1016\/j.joca.2021.03.023_bib41","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.joca.2013.05.017","article-title":"Structural correlates of pain in joints with osteoarthritis","volume":"21","author":"Hunter","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"10.1016\/j.joca.2021.03.023_bib42","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.joca.2019.11.006","article-title":"The innate immune response as a mediator of osteoarthritis pain","volume":"28","author":"Miller","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2021.03.023_bib43","first-page":"iv43","volume":"vol. 57","author":"Fu","year":"2018"},{"issue":"2","key":"10.1016\/j.joca.2021.03.023_bib44","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cyto.2014.06.019","article-title":"Osteoarthritis joint pain: the cytokine connection","volume":"70","author":"Miller","year":"2014","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.joca.2021.03.023_bib45","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/nrn.2016.162","article-title":"Structural plasticity and reorganisation in chronic pain","volume":"18","author":"Kuner","year":"2017","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.joca.2021.03.023_bib46","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fnmol.2017.00349","article-title":"Mechanisms of osteoarthritic pain. Studies in humans and experimental models","volume":"10","author":"Eitner","year":"2017","journal-title":"Front Mol Neurosci"},{"issue":"4","key":"10.1016\/j.joca.2021.03.023_bib47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3390\/ph11040105","article-title":"Evidence for transient receptor potential (TRP) channel contribution to arthritis pain and pathogenesis","volume":"11","author":"Galindo","year":"2018","journal-title":"Pharmaceuticals"},{"issue":"3","key":"10.1016\/j.joca.2021.03.023_bib48","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/art.30150","article-title":"A distinct role for transient receptor potential ankyrin 1, in addition to transient receptor potential vanilloid 1, in tumor necrosis factor alpha-induced inflammatory hyperalgesia and Freund\u2019s complete adjuvant-induced monarthritis","volume":"63","author":"Fernandes","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"9","key":"10.1016\/j.joca.2021.03.023_bib49","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1002\/art.40894","article-title":"Randomized, double-blind, placebo-controlled trial of intraarticular trans-capsaicin for pain associated with osteoarthritis of the knee","volume":"71","author":"Stevens","year":"2019","journal-title":"Arthritis Rheum"},{"issue":"4","key":"10.1016\/j.joca.2021.03.023_bib50","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s00210-014-1078-x","article-title":"TRPV4 as a therapeutic target for joint diseases","volume":"388","author":"McNulty","year":"2015","journal-title":"Naunyn-Schmiedeberg\u2019s Arch Pharmacol"},{"issue":"8","key":"10.1016\/j.joca.2021.03.023_bib51","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.joca.2015.02.778","article-title":"Translational development of an ADAMTS-5 antibody for osteoarthritis disease modification","volume":"23","author":"Larkin","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.joca.2021.03.023_bib52","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.joca.2015.09.005","article-title":"Therapeutic effects of an anti-ADAMTS-5 antibody on joint damage and mechanical allodynia in a murine model of osteoarthritis","volume":"24","author":"Miller","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2021.03.023_bib53","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.matbio.2015.01.014","article-title":"ADAMTS expression and function in central nervous system injury and disorders","volume":"44","author":"Gottschall","year":"2015","journal-title":"Matrix Biol"},{"issue":"3","key":"10.1016\/j.joca.2021.03.023_bib54","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3390\/biom10030403","article-title":"New insights into ADAMTS metalloproteases in the central nervous system","volume":"10","author":"Mohamedi","year":"2020","journal-title":"Biomolecules"},{"issue":"12","key":"10.1016\/j.joca.2021.03.023_bib55","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1016\/j.bbadis.2011.08.009","article-title":"Proteoglycan degradation by the ADAMTS family of proteinases","volume":"1812","author":"Stanton","year":"2011","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"10.1016\/j.joca.2021.03.023_bib56","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1186\/ar2803","article-title":"Lessons from animal models of arthritis over the past decade","volume":"11","author":"van den Berg","year":"2009","journal-title":"Arthritis Res Ther"},{"issue":"1\u20132","key":"10.1016\/j.joca.2021.03.023_bib57","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.pain.2009.06.002","article-title":"Experimental arthritis causes tumor necrosis factor-alpha-dependent infiltration of macrophages into rat dorsal root ganglia which correlates with pain-related behavior","volume":"145","author":"Segond von Banchet","year":"2009","journal-title":"Pain"},{"issue":"9","key":"10.1016\/j.joca.2021.03.023_bib58","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1002\/art.39698","article-title":"Quantification and impact of secondary osteoarthritis in patients with anti-citrullinated protein antibody-positive rheumatoid arthritis","volume":"68","author":"Figueiredo","year":"2016","journal-title":"Arthritis Rheum"},{"issue":"7","key":"10.1016\/j.joca.2021.03.023_bib59","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-035101","volume":"10","author":"van Helvoort","year":"2020","journal-title":"BMJ Open"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458421008499?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458421008499?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:57:53Z","timestamp":1761019073000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458421008499"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":59,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S1063458421008499"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2021.03.023","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathology-pain relationships in different osteoarthritis animal model phenotypes: it matters what you measure, when you measure, and how you got there","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2021.03.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Osteoarthritis Research Society International. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}