{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T07:55:52Z","timestamp":1791705352619,"version":"4.3.4"},"reference-count":39,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AR0063643"],"award-info":[{"award-number":["R01-AR0063643"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-AR074492"],"award-info":[{"award-number":["R01-AR074492"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00-EB022634"],"award-info":[{"award-number":["R00-EB022634"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-EB002524"],"award-info":[{"award-number":["R01-EB002524"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.joca.2021.04.014","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T11:41:13Z","timestamp":1620474073000},"page":"1155-1162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["[18F]NaF PET-MRI provides direct in-vivo evidence of the association between bone metabolic activity and adjacent synovitis in knee osteoarthritis: a cross-sectional study"],"prefix":"10.1016","volume":"29","author":[{"given":"J.W.","family":"MacKay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3592-4089","authenticated-orcid":false,"given":"L.","family":"Watkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Kogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.joca.2021.04.014_bib1","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.joca.2010.07.008","article-title":"Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI","volume":"18","author":"Roemer","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"issue":"7","key":"10.1016\/j.joca.2021.04.014_bib2","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.joca.2007.01.020","article-title":"Angiogenesis in the synovium and at the\u00a0osteochondral junction in osteoarthritis","volume":"15","author":"Walsh","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"10","key":"10.1016\/j.joca.2021.04.014_bib3","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1136\/ard.2009.121426","article-title":"Relation of synovitis to knee pain using contrast-enhanced MRIs","volume":"69","author":"Baker","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.joca.2021.04.014_bib4","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/annrheumdis-2014-205894","article-title":"Synovitis in knee osteoarthritis: a precursor of disease?","volume":"75","author":"Atukorala","year":"2016","journal-title":"Ann Rheum Dis"},{"issue":"19","key":"10.1016\/j.joca.2021.04.014_bib5","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1001\/jama.2017.5283","article-title":"Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial","volume":"317","author":"McAlindon","year":"2017","journal-title":"J\u00a0Am Med Assoc"},{"key":"10.1016\/j.joca.2021.04.014_bib6","article-title":"Etanercept in patients with inflammatory hand osteoarthritis (EHOA): a multicentre, randomised, double-blind, placebo-controlled trial","volume":"3","author":"Kloppenburg","year":"2018","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"10.1016\/j.joca.2021.04.014_bib7","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.joca.2004.03.003","article-title":"Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis","volume":"12","author":"Blom","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"issue":"1","key":"10.1016\/j.joca.2021.04.014_bib8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/art.11422","article-title":"Crucial role of synovial lining macrophages in the promotion of transforming growth factor beta-mediated osteophyte formation","volume":"50","author":"van Lent","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"2","key":"10.1016\/j.joca.2021.04.014_bib9","first-page":"365","article-title":"Synovial membrane inflammation and cytokine production in patients with early osteoarthritis","volume":"24","author":"Smith","year":"1997","journal-title":"J\u00a0Rheumatol"},{"issue":"12","key":"10.1016\/j.joca.2021.04.014_bib10","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.2967\/jnumed.110.077933","article-title":"Molecular mechanisms of bone 18F-NaF deposition","volume":"51","author":"Czernin","year":"2010","journal-title":"J\u00a0Nucl Med"},{"issue":"7","key":"10.1016\/j.joca.2021.04.014_bib11","first-page":"1091","article-title":"Assessment of porcine bone metabolism by dynamic [18F]fluoride ion PET: correlation with bone histomorphometry","volume":"42","author":"Piert","year":"2001","journal-title":"J\u00a0Nucl Med"},{"issue":"11","key":"10.1016\/j.joca.2021.04.014_bib12","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrrheum.2012.130","article-title":"Bone remodelling in osteoarthritis","volume":"8","author":"Burr","year":"2012","journal-title":"Nat Rev Rheumatol"},{"issue":"5","key":"10.1016\/j.joca.2021.04.014_bib13","first-page":"633","article-title":"Evaluation of the skeletal kinetics of fluorine-18-fluoride ion with PET","volume":"33","author":"Hawkins","year":"1992","journal-title":"J\u00a0Nucl Med Off Publ Soc Nucl Med"},{"issue":"4","key":"10.1016\/j.joca.2021.04.014_bib14","first-page":"595","article-title":"CT arthrography, MR arthrography, PET, and scintigraphy in osteoarthritis","volume":"47","author":"Omoumi","year":"2009","journal-title":"Radiol Clin"},{"issue":"1","key":"10.1016\/j.joca.2021.04.014_bib15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0001-2998(98)80018-4","article-title":"Orthopedic pathology of the lower extremities: scintigraphic evaluation in the thigh, knee, and leg","volume":"28","author":"Etchebehere","year":"1998","journal-title":"Semin Nucl Med"},{"issue":"8","key":"10.1016\/j.joca.2021.04.014_bib16","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/ard.52.8.557","article-title":"Prediction of the progression of joint space narrowing in osteoarthritis of the knee by bone scintigraphy","volume":"52","author":"Dieppe","year":"1993","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.joca.2021.04.014_bib17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1136\/ard.58.1.20","article-title":"Bone scintigraphy in chronic knee pain: comparison with magnetic resonance imaging","volume":"58","author":"Boegard","year":"1999","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.joca.2021.04.014_bib18","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1002\/mrm.27045","article-title":"Simultaneous bilateral-knee MR imaging","volume":"80","author":"Kogan","year":"2018","journal-title":"Magn Reson Med"},{"issue":"8","key":"10.1016\/j.joca.2021.04.014_bib19","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.joca.2011.05.004","article-title":"Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score)","volume":"19","author":"Hunter","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.joca.2021.04.014_bib20","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/(SICI)1522-2586(199909)10:3<223::AID-JMRI2>3.0.CO;2-S","article-title":"Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols","volume":"10","author":"Tofts","year":"1999","journal-title":"J\u00a0Magn Reson Imag"},{"issue":"5","key":"10.1016\/j.joca.2021.04.014_bib21","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1002\/mrm.21066","article-title":"Experimentally-derived functional form for a population-averaged high-temporal-resolution arterial input function for dynamic contrast-enhanced MRI","volume":"56","author":"Parker","year":"2006","journal-title":"Magn Reson Med"},{"issue":"5","key":"10.1016\/j.joca.2021.04.014_bib22","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/RLI.0000000000000132","article-title":"T1 relaxivities of gadolinium-based magnetic resonance contrast agents in human whole blood at 1.5, 3, and 7 T","volume":"50","author":"Shen","year":"2015","journal-title":"Invest Radiol"},{"issue":"5","key":"10.1016\/j.joca.2021.04.014_bib23","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/mrm.1910050502","article-title":"Optimizing the precision in T1 relaxation estimation using limited flip angles","volume":"5","author":"Wang","year":"1987","journal-title":"Magn Reson\u00a0Med"},{"key":"10.1016\/j.joca.2021.04.014_bib24","doi-asserted-by":"crossref","DOI":"10.1007\/s00330-021-07698-z","article-title":"Dynamic contrast-enhanced MRI of synovitis in knee osteoarthritis: repeatability, discrimination and sensitivity to change in a prospective experimental study","author":"MacKay","year":"2021","journal-title":"Eur Radiol"},{"issue":"1","key":"10.1016\/j.joca.2021.04.014_bib25","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.mri.2006.10.018","article-title":"Improved wrist pannus volume measurement from contrast-enhanced MRI in rheumatoid arthritis using shuffle transform","volume":"25","author":"Xanthopoulos","year":"2007","journal-title":"Magn Reson Imaging"},{"issue":"6","key":"10.1016\/j.joca.2021.04.014_bib26","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.joca.2018.04.001","article-title":"Quantitative imaging of bone\u2013cartilage interactions in ACL-injured patients with PET\u2013MRI","volume":"26","author":"Kogan","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2021.04.014_bib27","series-title":"R: A Language and Environment for Statistical Computing","year":"2019"},{"issue":"1","key":"10.1016\/j.joca.2021.04.014_bib28","first-page":"1","article-title":"Robustlmm: an R package for robust estimation of linear mixed-effects models","volume":"75","author":"Koller","year":"2016","journal-title":"J\u00a0Stat Software"},{"issue":"3","key":"10.1016\/j.joca.2021.04.014_bib29","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.rdc.2008.05.004","article-title":"The symptoms of osteoarthritis\u00a0and the genesis of pain","volume":"34","author":"Hunter","year":"2008","journal-title":"Rheum Dis Clin N Am"},{"issue":"3","key":"10.1016\/j.joca.2021.04.014_bib30","first-page":"142","article-title":"The blood supply of the synovial membrane and intra-articular structures","volume":"2","author":"Davies","year":"1948","journal-title":"Ann R Coll Surg Engl"},{"issue":"5","key":"10.1016\/j.joca.2021.04.014_bib31","first-page":"377","article-title":"Kinetic [18F]-Fluoride of the knee in normal volunteers","volume":"44","author":"Haddock","year":"2019","journal-title":"Clin\u00a0Nucl Med"},{"issue":"1","key":"10.1016\/j.joca.2021.04.014_bib32","first-page":"277","article-title":"Vasculature of the normal and arthritic synovial joint","volume":"16","author":"Haywood","year":"2001","journal-title":"Histol Histopathol"},{"issue":"7","key":"10.1016\/j.joca.2021.04.014_bib33","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.joca.2018.04.003","article-title":"Subchondral bone circulation in osteoarthritis of the human knee","volume":"26","author":"Aaron","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2021.04.014_bib34","doi-asserted-by":"crossref","DOI":"10.1002\/jmri.27146","article-title":"Principal component analysis of simultaneous PET-MRI reveals patterns\u00a0of bone-cartilage interactions in osteoarthritis: PET-MRI\u00a0for bone-cartilage interactions","author":"Tibrewala","year":"2020","journal-title":"J\u00a0Magn Reson Imag"},{"issue":"12","key":"10.1016\/j.joca.2021.04.014_bib35","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1002\/jor.24443","article-title":"[18F]-sodium fluoride PET\/MR imaging for bone\u2013cartilage interactions in hip osteoarthritis: a feasibility study","volume":"37","author":"Tibrewala","year":"2019","journal-title":"J\u00a0Orthop Res"},{"issue":"5","key":"10.1016\/j.joca.2021.04.014_bib36","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.joca.2010.10.029","article-title":"Systematic review of the concurrent and predictive validity of MRI biomarkers in OA","volume":"19","author":"Hunter","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"issue":"6","key":"10.1016\/j.joca.2021.04.014_bib37","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1002\/jmri.25529","article-title":"PET\/MRI of metabolic activity in osteoarthritis: a feasibility study","volume":"45","author":"Kogan","year":"2017","journal-title":"J\u00a0Magn Reson Imag"},{"issue":"11","key":"10.1016\/j.joca.2021.04.014_bib38","first-page":"1655","article-title":"3-D localization of\u00a0non-radioactive strontium in osteoarthritic bone: role in\u00a0the\u00a0dynamic labeling of bone pathological changes","volume":"33","author":"Panahifar","year":"2015","journal-title":"J\u00a0Orthop\u00a0Res"},{"issue":"10","key":"10.1016\/j.joca.2021.04.014_bib39","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1016\/j.joca.2014.06.013","article-title":"Development and reliability of a multi-modality scoring system for evaluation of disease progression in pre-clinical models of osteoarthritis: celecoxib may possess disease-modifying properties","volume":"22","author":"Panahifar","year":"2014","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458421007275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458421007275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T11:56:29Z","timestamp":1778586989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458421007275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":39,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S1063458421007275"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2021.04.014","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"[18F]NaF PET-MRI provides direct in-vivo evidence of the association between bone metabolic activity and adjacent synovitis in knee osteoarthritis: a cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2021.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Osteoarthritis Research Society International. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}