{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T20:03:41Z","timestamp":1769976221881,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["201806380153"],"award-info":[{"award-number":["201806380153"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014028","name":"Horizon 2020","doi-asserted-by":"publisher","award":["654248"],"award-info":[{"award-number":["654248"]}],"id":[{"id":"10.13039\/100014028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["120520001"],"award-info":[{"award-number":["120520001"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.joca.2021.07.007","type":"journal-article","created":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T19:18:24Z","timestamp":1626895104000},"page":"1426-1431","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Are changes in meniscus volume and extrusion associated to knee osteoarthritis development? A structural equation model"],"prefix":"10.1016","volume":"29","author":[{"given":"D.","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"van der Voet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.","family":"Waarsing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.H.","family":"Oei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Englund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Bierma-Zeinstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Runhaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2021.07.007_bib1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00003086-197506000-00027","article-title":"The role of the menisci in force transmission across the knee","author":"Walker","year":"1975","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.joca.2021.07.007_bib2","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.joca.2016.08.004","article-title":"The relationship between meniscal pathology and osteoarthritis depends on the type of meniscal damage visible on magnetic resonance images: data from the Osteoarthritis Initiative","volume":"25","author":"Antony","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2021.07.007_bib3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1002\/art.21724","article-title":"The association of meniscal pathologic changes with cartilage loss in symptomatic knee osteoarthritis","volume":"54","author":"Hunter","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2021.07.007_bib4","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.joca.2018.02.907","article-title":"Knee menisci segmentation using convolutional neural networks: data from the Osteoarthritis Initiative","volume":"26","author":"Tack","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2021.07.007_bib5","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.joca.2017.10.012","article-title":"Where does meniscal damage progress most rapidly? An analysis using three-dimensional shape models on data from the Osteoarthritis Initiative","volume":"26","author":"Dube","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2021.07.007_bib6","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.joca.2017.03.014","article-title":"Baseline meniscal extrusion associated with incident knee osteoarthritis after 30 months in overweight and obese women","volume":"25","author":"van der Voet","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2021.07.007_bib7","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1002\/art.37947","article-title":"Meniscus body position, size, and shape in persons with and persons without radiographic knee osteoarthritis: quantitative analyses of knee magnetic resonance images from the osteoarthritis initiative","volume":"65","author":"Wenger","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2021.07.007_bib8","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1007\/s00167-019-05580-6","article-title":"Medial meniscus posterior root tear causes swelling of the medial meniscus and expansion of the extruded meniscus: a comparative analysis between 2D and 3D MRI","volume":"28","author":"Okazaki","year":"2020","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"10.1016\/j.joca.2021.07.007_bib9","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1002\/mrm.22380","article-title":"A\u00a0three-dimensional quantitative method to measure meniscus shape, position, and signal intensity using MR images: a pilot study and preliminary results in knee osteoarthritis","volume":"63","author":"Wirth","year":"2010","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.joca.2021.07.007_bib10","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.amjmed.2015.03.006","article-title":"Prevention of knee osteoarthritis in overweight females: the first preventive randomized controlled trial in osteoarthritis","volume":"128","author":"Runhaar","year":"2015","journal-title":"Am J Med"},{"key":"10.1016\/j.joca.2021.07.007_bib11","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2021.07.007_bib12","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.joca.2016.12.001","article-title":"Factors associated with meniscal body extrusion on knee MRI in overweight and obese women","volume":"25","author":"Zhang","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2021.07.007_bib13","first-page":"2664","article-title":"Substantial superiority of semiflexed (MTP) views in knee osteoarthritis: a comparative radiographic study, without fluoroscopy, of standing extended, semiflexed (MTP), and schuss views","volume":"26","author":"Buckland-Wright","year":"1999","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.joca.2021.07.007_bib14","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteo-arthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2021.07.007_bib15","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1093\/rheumatology\/keu141","article-title":"Malalignment: a possible target for prevention of incident knee osteoarthritis in overweight and obese women","volume":"53","author":"Runhaar","year":"2014","journal-title":"Rheumatology"},{"key":"10.1016\/j.joca.2021.07.007_bib16","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1093\/rheumatology\/keaa522","article-title":"Association between meniscal volume and development of knee osteoarthritis","volume":"60","author":"Xu","year":"2021","journal-title":"Rheumatology"},{"key":"10.1016\/j.joca.2021.07.007_bib17","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1109\/TMI.2011.2168420","article-title":"Automated brain structure segmentation based on atlas registration and appearance models","volume":"31","author":"van der Lijn","year":"2012","journal-title":"IEEE Trans Med Imag"},{"key":"10.1016\/j.joca.2021.07.007_bib18","doi-asserted-by":"crossref","DOI":"10.1118\/1.4810971","article-title":"Tissue segmentation of head and neck CT images for treatment planning: a multiatlas approach combined with intensity modeling","volume":"40","author":"Fortunati","year":"2013","journal-title":"Med Phys"},{"key":"10.1016\/j.joca.2021.07.007_bib19","series-title":"9th International Workshop on Osteoarthritis Imaging (IWOAI)","article-title":"Evaluation of two multi-atlas cartilage segmentation models for knee MRI: data from the osteoarthritis initiative","author":"Hansson","year":"2016"},{"key":"10.1016\/j.joca.2021.07.007_bib20","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.joca.2015.12.003","article-title":"Risk factors for meniscal body extrusion on MRI in subjects free of radiographic knee osteoarthritis: longitudinal data from the Osteoarthritis Initiative","volume":"24","author":"Zhang","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2021.07.007_bib21","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.joca.2011.05.004","article-title":"Evolution of semi-quantitative whole joint assessment of knee OA: MOAKS (MRI Osteoarthritis Knee Score)","volume":"19","author":"Hunter","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2021.07.007_bib22","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1016\/j.joca.2014.06.022","article-title":"How to define subregional osteoarthritis progression using semi-quantitative MRI osteoarthritis knee score (MOAKS)","volume":"22","author":"Runhaar","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2021.07.007_bib23","series-title":"An Introduction to Statistical Learning","author":"Gareth James","year":"2013"},{"key":"10.1016\/j.joca.2021.07.007_bib24","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S1076-6332(03)00671-8","article-title":"Statistical validation of image segmentation quality based on a spatial overlap index","volume":"11","author":"Zou","year":"2004","journal-title":"Acad Radiol"},{"key":"10.1016\/j.joca.2021.07.007_bib25","series-title":"Statistical Analysis with Missing Data","author":"Little","year":"1987"},{"key":"10.1016\/j.joca.2021.07.007_bib26","doi-asserted-by":"crossref","first-page":"101849","DOI":"10.1016\/j.artmed.2020.101849","article-title":"Automatic segmentation of knee menisci - a systematic review","volume":"105","author":"Rahman","year":"2020","journal-title":"Artif Intell Med"},{"key":"10.1016\/j.joca.2021.07.007_bib27","series-title":"2009 IEEE International Symposium on Biomedical Imaging: From Nano to Macro","first-page":"510","article-title":"Automated segmentation of the menisci from MR images","author":"Fripp","year":"2009"},{"key":"10.1016\/j.joca.2021.07.007_bib28","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1037\/1082-989X.1.2.130","article-title":"Power analysis and determination of sample size for covariance structure modeling","volume":"1","author":"MacCallum","year":"1996","journal-title":"Psychol Methods"},{"key":"10.1016\/j.joca.2021.07.007_bib29","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1037\/0033-2909.97.3.562","article-title":"Application of confirmatory factor analysis to the study of self-concept: first-and higher order factor models and their invariance across groups","volume":"97","author":"Marsh","year":"1985","journal-title":"Psychol Bull"},{"key":"10.1016\/j.joca.2021.07.007_bib30","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/1471-2474-15-32","article-title":"Meniscus body position and its change over four years in asymptomatic adults: a cohort study using data from the Osteoarthritis Initiative (OAI)","volume":"15","author":"Bruns","year":"2014","journal-title":"BMC Muscoskel Disord"},{"key":"10.1016\/j.joca.2021.07.007_bib31","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1002\/art.39731","article-title":"Semiquantitative imaging biomarkers of knee osteoarthritis progression: data from the foundation for the national institutes of Health osteoarthritis biomarkers consortium","volume":"68","author":"Collins","year":"2016","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2021.07.007_bib32","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1038\/s41598-020-59573-4","article-title":"Functional MRI mapping of human meniscus functionality and its relation to degeneration","volume":"10","author":"Nebelung","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.joca.2021.07.007_bib33","doi-asserted-by":"crossref","first-page":"3435","DOI":"10.1007\/s00167-020-05953-2","article-title":"Medial meniscus posterior root repair restores the intra-articular volume of the medial meniscus by decreasing posteromedial extrusion at knee flexion","volume":"28","author":"Okazaki","year":"2020","journal-title":"Knee Surg Sports Traumatol Arthrosc"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345842100844X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345842100844X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:57:19Z","timestamp":1761019039000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S106345842100844X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S106345842100844X"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2021.07.007","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Are changes in meniscus volume and extrusion associated to knee osteoarthritis development? A structural equation model","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2021.07.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}