{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T03:48:22Z","timestamp":1792900102376,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001509","name":"Royal Society Te Ap\u0101rangi","doi-asserted-by":"publisher","award":["UOA2110"],"award-info":[{"award-number":["UOA2110"]}],"id":[{"id":"10.13039\/501100001509","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009193","name":"Marsden Fund","doi-asserted-by":"publisher","award":["UoA1509"],"award-info":[{"award-number":["UoA1509"]}],"id":[{"id":"10.13039\/501100009193","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.joca.2022.04.006","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T22:19:56Z","timestamp":1655245196000},"page":"1234-1243","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Detection of subtle cartilage and bone tissue degeneration in the equine joint using polarisation-sensitive optical coherence tomography"],"prefix":"10.1016","volume":"30","author":[{"given":"M.","family":"Goodwin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Klufts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2444-6272","authenticated-orcid":false,"given":"J.","family":"Workman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Thambyah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9653-6907","authenticated-orcid":false,"given":"F.","family":"Vanholsbeeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2022.04.006_bib1","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrrheum.2014.44","article-title":"The individual and socioeconomic impact of osteoarthritis","volume":"10","author":"Hunter","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2022.04.006_bib2","first-page":"46","article-title":"Operative treatment of osteoarthritis","volume":"2","author":"Brackett","year":"1915","journal-title":"JBJS"},{"key":"10.1016\/j.joca.2022.04.006_bib3","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1136\/bmj.2.4837.660","article-title":"Composition of articular cartilage in osteoarthritis; changes in collagen\/chondroitin-sulphate ratio","volume":"2","author":"Matthews","year":"1953","journal-title":"Br Med J"},{"key":"10.1016\/j.joca.2022.04.006_bib4","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/art.1780140306","article-title":"Response of joints to impact loading. I. In vitro wear","volume":"14","author":"Radin","year":"1971","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2022.04.006_bib5","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/00003086-198612000-00005","article-title":"Role of subchondral bone in the initiation and progression of cartilage damage","volume":"213","author":"Radin","year":"1986","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.joca.2022.04.006_bib6","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000213866","article-title":"Do subchondral bone changes exacerbate or precede articular cartilage destruction in osteoarthritis of the elderly?","volume":"43","author":"Bailey","year":"1997","journal-title":"Gerontology"},{"key":"10.1016\/j.joca.2022.04.006_bib7","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/j.joca.2007.05.006","article-title":"On how degeneration influences load-bearing in the cartilage\u2013bone system: a microstructural and micromechanical study","volume":"15","author":"Thambyah","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"10","key":"10.1016\/j.joca.2022.04.006_bib8","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1136\/ard.2006.058347","article-title":"Yet more evidence that osteoarthritis is not a cartilage disease","volume":"65","author":"Brandt","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2022.04.006_bib9","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.joca.2016.09.023","article-title":"Osteoarthritis year in review 2016: mechanics","volume":"25","author":"Saxby","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2022.04.006_bib10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nrrheum.2010.197","article-title":"The bone\u2013cartilage unit in osteoarthritis","volume":"7","author":"Lories","year":"2011","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2022.04.006_bib11","first-page":"611","article-title":"Micro-anatomical response of cartilage-on-bone to compression: mechanisms of deformation within and beyond the directly loaded matrix","volume":"209","author":"Thambyah","year":"2006","journal-title":"J\u00a0Anatomy"},{"key":"10.1016\/j.joca.2022.04.006_bib12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.joca.2008.09.005","article-title":"On new bone formation in the pre-osteoarthritic joint","volume":"17","author":"Thambyah","year":"2009","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2022.04.006_bib13","doi-asserted-by":"crossref","first-page":"7747","DOI":"10.1088\/0031-9155\/60\/19\/7747","article-title":"3D human cartilage surface characterization by optical coherence tomography","volume":"60","author":"Brill","year":"2015","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.joca.2022.04.006_bib14","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/jor.22828","article-title":"Three-dimensional imaging and analysis of human cartilage degeneration using optical coherence tomography","volume":"33","author":"Nebelung","year":"2015","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.joca.2022.04.006_bib15","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1364\/BOE.6.002398","article-title":"Optical coherence tomography-based parameterization and quantification of articular cartilage surface integrity","volume":"6","author":"Brill","year":"2015","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.joca.2022.04.006_bib16","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1088\/0022-3727\/38\/15\/012","article-title":"The collagen structure of equine articular cartilage, characterized using polarization-sensitive optical coherence tomography","volume":"38","author":"Ugryumova","year":"2005","journal-title":"J\u00a0Phys D Appl Phys"},{"key":"10.1016\/j.joca.2022.04.006_bib17","doi-asserted-by":"crossref","first-page":"6837","DOI":"10.1088\/0031-9155\/54\/22\/006","article-title":"Quantification of the optical surface reflection and surface roughness of articular cartilage using optical coherence tomography","volume":"54","author":"Saarakkala","year":"2009","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.joca.2022.04.006_bib18","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/jor.22673","article-title":"Morphometric grading of osteoarthritis by optical coherence\u00a0tomography\u2014an ex vivo study","volume":"32","author":"Nebelung","year":"2014","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.joca.2022.04.006_bib19","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jmbbm.2015.11.025","article-title":"Towards optical coherence tomography-based elastographic evaluation of human cartilage","volume":"56","author":"Nebelung","year":"2016","journal-title":"J.\u00a0Mech Behav Biomed Mater"},{"key":"10.1016\/j.joca.2022.04.006_bib20","first-page":"1","article-title":"Changes in viscoelastic properties of articular cartilage in early stage of osteoarthritis, as determined by optical coherence tomography-based strain rate tomography","volume":"20","author":"Nakamura","year":"2019","journal-title":"BMC Muscoskel Disord"},{"key":"10.1016\/j.joca.2022.04.006_bib21","doi-asserted-by":"crossref","first-page":"433","DOI":"10.3109\/03008207.2011.555824","article-title":"Quantification of stiffness change in degenerated articular cartilage using optical coherence tomography-based air-jet indentation","volume":"52","author":"Huang","year":"2011","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.joca.2022.04.006_bib22","doi-asserted-by":"crossref","first-page":"76013","DOI":"10.1117\/1.JBO.21.7.076013","article-title":"Polarization-sensitive optical coherence tomography- based imaging, parameterization, and quantification of human cartilage degeneration","volume":"21","author":"Brill","year":"2016","journal-title":"J\u00a0Biomed Opt"},{"key":"10.1016\/j.joca.2022.04.006_bib23","doi-asserted-by":"crossref","first-page":"36006","DOI":"10.1117\/1.JBO.24.3.036006","article-title":"Slope-based segmentation of articular cartilage using polarization-sensitive optical coherence tomography phase retardation image","volume":"24","author":"Zhou","year":"2019","journal-title":"J\u00a0Biomed Opt"},{"key":"10.1016\/j.joca.2022.04.006_bib24","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1364\/BOE.387242","article-title":"Detecting human articular cartilage degeneration in its early stage with polarization-sensitive optical coherence tomography","volume":"11","author":"Zhou","year":"2020","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.joca.2022.04.006_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-25982-9","article-title":"Quantifying birefringence in the bovine model of early osteoarthritis using polarisation-sensitive optical coherence tomography and mechanical indentation","volume":"8","author":"Goodwin","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.joca.2022.04.006_bib26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1136\/ard.58.4.208","article-title":"Validity of histopathological grading of articular cartilage from osteoarthritic knee joints","volume":"58","author":"Ostergaard","year":"1999","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2022.04.006_bib27","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.tvjl.2013.05.031","article-title":"Arthroscopic optical coherence tomography provides detailed information on articular cartilage lesions in horses","volume":"197","author":"te Moller","year":"2013","journal-title":"Vet J"},{"key":"10.1016\/j.joca.2022.04.006_bib28","article-title":"Towards real time assessment of intramuscular fat content in meat using optical fiber-based optical coherence tomography","volume":"108411","author":"Thampi","year":"2020","journal-title":"Meat Sci"},{"key":"10.1016\/j.joca.2022.04.006_bib29","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1007\/BF00583443","article-title":"Form und bau der gelenkknorpel in ihren beziehungen zur funktion","volume":"2","author":"Benninghoff","year":"1925","journal-title":"Z\u00a0f\u00fcr Zellforsch Mikrosk Anat"},{"key":"10.1016\/j.joca.2022.04.006_bib30","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/nrrheum.2012.130","article-title":"Bone remodelling in osteoarthritis","volume":"8","author":"Burr","year":"2012","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2022.04.006_bib31","doi-asserted-by":"crossref","first-page":"541","DOI":"10.7326\/0003-4819-134-7-200104030-00007","article-title":"The association of bone marrow lesions with pain in knee osteoarthritis","volume":"134","author":"Felson","year":"2001","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.joca.2022.04.006_bib32","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bone.2018.01.012","article-title":"Bone matrix microdamage and vascular changes characterize bone marrow lesions in the subchondral bone of knee osteoarthritis","volume":"108","author":"Muratovic","year":"2018","journal-title":"Bone"},{"key":"10.1016\/j.joca.2022.04.006_bib33","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1093\/rheumatology\/keq286","article-title":"Bone marrow lesions in people with knee osteoarthritis predict progression of disease and joint replacement: a longitudinal study","volume":"49","author":"Tanamas","year":"2010","journal-title":"Rheumatology"},{"key":"10.1016\/j.joca.2022.04.006_bib34","first-page":"706","article-title":"Exercise-induced metacarpophalangeal joint adaptation in the thoroughbred racehorse","volume":"213","author":"Muir","year":"2008","journal-title":"J\u00a0Anat"},{"key":"10.1016\/j.joca.2022.04.006_bib35","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.aanat.2018.10.001","article-title":"Quantitative articular cartilage sub-surface defect assessment using optical coherence tomography: an in-vitro study","volume":"221","author":"Michalik","year":"2019","journal-title":"Ann Anat-Anatomischer Anzeiger"},{"key":"10.1016\/j.joca.2022.04.006_bib36","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1177\/0363546503261736","article-title":"Arthroscopic microscopy of articular cartilage using optical coherence tomography","volume":"32","author":"Chu","year":"2004","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.joca.2022.04.006_bib37","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/art.27378","article-title":"Clinical optical coherence tomography of early articular cartilage degeneration in patients with degenerative meniscal tears","volume":"62","author":"Chu","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2022.04.006_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1751-0147-56-3","article-title":"Application of optical coherence tomography enhances reproducibility of arthroscopic evaluation of equine joints","volume":"56","author":"Niemel\u00e4","year":"2014","journal-title":"Acta Vet Scand"},{"key":"10.1016\/j.joca.2022.04.006_bib39","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1117\/1.1609201","article-title":"Hand-held arthroscopic optical coherence tomography for in vivo high-resolution imaging of articular cartilage","volume":"8","author":"Pan","year":"2003","journal-title":"J\u00a0Biomed Opt"},{"key":"10.1016\/j.joca.2022.04.006_bib40","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/jbio.201500130","article-title":"Imaging of subchondral bone by optical coherence tomography upon optical clearing of articular cartilage","volume":"9","author":"Bykov","year":"2016","journal-title":"J.\u00a0Biophotonics"},{"key":"10.1016\/j.joca.2022.04.006_bib41","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1302\/2046-3758.111.2000132","article-title":"The horse as a model of naturally occurring osteoarthritis","volume":"1","author":"McIlwraith","year":"2012","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.joca.2022.04.006_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0235251","article-title":"An experimentally induced osteoarthritis model in horses performed on both metacarpophalangeal and metatarsophalangeal joints: technical, clinical, imaging, biochemical, macroscopic and microscopic characterization","volume":"15","author":"Bertoni","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2022.04.006_bib43","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.joca.2013.02.653","article-title":"Non-terminal animal model of post-traumatic osteoarthritis induced by acute joint injury","volume":"21","author":"Boyce","year":"2013","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458422007622?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458422007622?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:56:53Z","timestamp":1761019013000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458422007622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":43,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S1063458422007622"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2022.04.006","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Detection of subtle cartilage and bone tissue degeneration in the equine joint using polarisation-sensitive optical coherence tomography","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2022.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Osteoarthritis Research Society International. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}