{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T01:46:43Z","timestamp":1793238403109,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.joca.2022.08.019","type":"journal-article","created":{"date-parts":[[2022,9,17]],"date-time":"2022-09-17T18:55:47Z","timestamp":1663440947000},"page":"1583-1592","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Knee osteoarthritis phenotypes based on synovial fluid immune cells correlate with clinical outcome trajectories"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9572-8613","authenticated-orcid":false,"given":"M.","family":"Trajerova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8969-4197","authenticated-orcid":false,"given":"E.","family":"Kriegova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5509-7562","authenticated-orcid":false,"given":"Z.","family":"Mikulkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3067-7867","authenticated-orcid":false,"given":"J.","family":"Savara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7219-1008","authenticated-orcid":false,"given":"M.","family":"Kudelka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7424-8653","authenticated-orcid":false,"given":"J.","family":"Gallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9991","key":"10.1016\/j.joca.2022.08.019_bib1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0140-6736(14)60802-3","article-title":"Osteoarthritis","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.joca.2022.08.019_bib2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1080\/00325481.2020.1730669","article-title":"Osteoarthritis and inflammation: a serious disease with overlapping phenotypic patterns","volume":"132","author":"Berenbaum","year":"2020","journal-title":"Postgrad Med"},{"issue":"2","key":"10.1016\/j.joca.2022.08.019_bib3","doi-asserted-by":"crossref","DOI":"10.1186\/ar3779","article-title":"Clinical features of symptomatic patellofemoral joint osteoarthritis","volume":"14","author":"Peat","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1016\/j.joca.2022.08.019_bib4","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1007\/s11999-014-3973-3","article-title":"Patients with knee osteoarthritis have a phenotype with higher bone mass, higher fat mass, and lower lean body mass","volume":"473","author":"Karlsson","year":"2015","journal-title":"Clin Orthop Relat Res"},{"issue":"8","key":"10.1016\/j.joca.2022.08.019_bib5","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1016\/j.joca.2019.04.007","article-title":"Characterization of synovial fluid metabolomic phenotypes of cartilage morphological changes associated with osteoarthritis","volume":"27","author":"Carlson","year":"2019","journal-title":"Osteoarthr Cartil"},{"issue":"3","key":"10.1016\/j.joca.2022.08.019_bib6","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/pm\/pnaa398","article-title":"Determination of pain phenotypes in knee osteoarthritis using latent profile analysis","volume":"22","author":"Kittelson","year":"2021","journal-title":"Pain Med"},{"issue":"9","key":"10.1016\/j.joca.2022.08.019_bib7","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1093\/rheumatology\/kev100","article-title":"Distinct subtypes of knee osteoarthritis: data from the osteoarthritis initiative","volume":"54","author":"Waarsing","year":"2015","journal-title":"Rheumatology"},{"issue":"9","key":"10.1016\/j.joca.2022.08.019_bib8","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.joca.2018.04.016","article-title":"Gender-related differences observed among immune cells in synovial fluid in knee osteoarthritis","volume":"26","author":"Kriegova","year":"2018","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2022.08.019_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00111","article-title":"Macrophage: a potential target on cartilage regeneration","volume":"11","author":"Fernandes","year":"2020","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.joca.2022.08.019_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-018-1798-2","article-title":"Synovial fluid monocyte\/macrophage subsets and their correlation to patient-reported outcomes in osteoarthritic patients: a cohort study","volume":"21","author":"G\u00f3mez-Aristiz\u00e1bal","year":"2019","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1016\/j.joca.2022.08.019_bib11","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/art.41486","article-title":"Synergistic roles of macrophages and neutrophils in osteoarthritis progression","volume":"73","author":"Hsueh","year":"2021","journal-title":"Arthritis Rheumatol"},{"issue":"5","key":"10.1016\/j.joca.2022.08.019_bib12","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.joca.2020.01.007","article-title":"Macrophages regulate the progression of osteoarthritis","volume":"28","author":"Zhang","year":"2020","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2022.08.019_bib13","first-page":"356","article-title":"T\u00a0cells in osteoarthritis: alterations and beyond","volume":"8","author":"Yu-Sheng","year":"2017","journal-title":"Front Immunol"},{"issue":"10","key":"10.1016\/j.joca.2022.08.019_bib14","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1016\/j.joca.2017.06.007","article-title":"CD56+\/CD16\u2212 Natural Killer cells expressing the inflammatory protease granzyme A are enriched in synovial fluid from patients with osteoarthritis","volume":"25","author":"Jaime","year":"2017","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"10.1016\/j.joca.2022.08.019_bib15","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-019-1923-x","article-title":"Synovial fluid biomarkers associated with osteoarthritis severity reflect macrophage and neutrophil related inflammation","volume":"21","author":"Haraden","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2022.08.019_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.763702","article-title":"Monocytes, macrophages, and their potential niches in synovial joints \u2013 therapeutic targets in post-traumatic osteoarthritis?","volume":"12","author":"Haubruck","year":"2021","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.joca.2022.08.019_bib17","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/art.1780290816","article-title":"Development of criteria for the classification and reporting of osteoarthritis. Classification of osteoarthritis of the knee. Diagnostic and Therapeutic Criteria Committee of the American Rheumatism Association","volume":"29","author":"Altman","year":"1986","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"10.1016\/j.joca.2022.08.019_bib18","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1136\/ard.2009.113100","article-title":"EULAR evidence-based recommendations for the diagnosis of knee osteoarthritis","volume":"69","author":"Zhang","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2022.08.019_bib19","series-title":"International Computing and Combinatorics Conference","first-page":"645","article-title":"Graph construction based on local representativeness","author":"Ochodkova","year":"2017"},{"key":"10.1016\/j.joca.2022.08.019_bib20","doi-asserted-by":"crossref","DOI":"10.1088\/1742-5468\/2008\/10\/P10008","article-title":"Fast unfolding of communities in large networks","author":"Blondel","year":"2008","journal-title":"J\u00a0Stat Mech"},{"key":"10.1016\/j.joca.2022.08.019_bib21","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1016\/j.jmb.2018.05.037","article-title":"Patient similarity networks for precision medicine","volume":"430","author":"Pai","year":"2018","journal-title":"J\u00a0Mol Biol"},{"issue":"7","key":"10.1016\/j.joca.2022.08.019_bib22","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/cyto.a.22625","article-title":"FlowSOM: using self-organizing maps for visualization and interpretation of cytometry data","volume":"87","author":"Van Gassen","year":"2015","journal-title":"Cytometry A"},{"issue":"5","key":"10.1016\/j.joca.2022.08.019_bib23","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/cyto.a.22837","article-title":"flowClean: Automated identification and removal of fluorescence anomalies in flow cytometry data","volume":"89","author":"Fletez-Brant","year":"2016","journal-title":"Cytometry A"},{"issue":"3","key":"10.1016\/j.joca.2022.08.019_bib24","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.clim.2012.12.011","article-title":"Immunopathogenesis of osteoarthritis","volume":"146","author":"Haseeb","year":"2013","journal-title":"Clin Immunol"},{"issue":"140","key":"10.1016\/j.joca.2022.08.019_bib25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.actbio.2021.12.006","article-title":"The immune microenvironment in cartilage injury and repair","volume":"1","author":"Li","year":"2022","journal-title":"Acta Biomater"},{"key":"10.1016\/j.joca.2022.08.019_bib26","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.20575.1","article-title":"Recent advances in understanding the phenotypes of osteoarthritis","volume":"8","author":"Mobasheri","year":"2019","journal-title":"F1000Research"},{"issue":"6","key":"10.1016\/j.joca.2022.08.019_bib27","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.arth.2020.01.056","article-title":"Gender differences in contribution of smoking, low physical activity, and high BMI to increased risk of early reoperation after TKA","volume":"35","author":"Gallo","year":"2020","journal-title":"J\u00a0Arthroplasty"},{"key":"10.1016\/j.joca.2022.08.019_bib28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jbi.2018.06.001","article-title":"Patient similarity for precision medicine: a systematic review","volume":"83","author":"Parimbelli","year":"2018","journal-title":"J\u00a0Biomed Inform"},{"issue":"9","key":"10.1016\/j.joca.2022.08.019_bib29","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.joca.2016.04.010","article-title":"Direct in vivo evidence of activated macrophages in human osteoarthritis","volume":"24","author":"Kraus","year":"2016","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"10.1016\/j.joca.2022.08.019_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0176048","article-title":"T140 blocks the SDF-1\/CXCR4 signaling pathway and prevents cartilage degeneration in an osteoarthritis disease model","volume":"12","author":"Wang","year":"2017","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.joca.2022.08.019_bib31","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/jor.23671","article-title":"Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis","volume":"36","author":"Sambamurthy","year":"2018","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.joca.2022.08.019_bib32","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.cytogfr.2020.05.007","article-title":"The pathogenic importance of CCL21 and CCR7 in rheumatoid arthritis","volume":"55","author":"Van Raemdonck","year":"2020","journal-title":"Cytokine Growth Factor Rev"},{"issue":"7","key":"10.1016\/j.joca.2022.08.019_bib33","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1007\/s00018-019-03235-w","article-title":"CCL21\/CCR7 signaling in macrophages promotes joint inflammation and Th17-mediated osteoclast formation in rheumatoid arthritis","volume":"77","author":"Van Raemdonck","year":"2020","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"10.1016\/j.joca.2022.08.019_bib34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1189\/jlb.1A0314-170R","article-title":"The chemotaxis of M1 and M2 macrophages is regulated by different chemokines","volume":"97","author":"Xuan","year":"2015","journal-title":"J\u00a0Leukoc Biol"},{"issue":"2","key":"10.1016\/j.joca.2022.08.019_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117454","article-title":"The HIV-1 Gp120\/CXCR4 Axis promotes CCR7 ligand-dependent CD4 T cell migration: CCR7 homo- and CCR7\/CXCR4 hetero-oligomer formation as a possible mechanism for up-regulation of functional CCR7","volume":"10","author":"Hayasaka","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2022.08.019_bib36","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3389\/fimmu.2015.00571","article-title":"The interplay between monocytes\/macrophages and CD4+ T cell subsets in rheumatoid arthritis","volume":"6","author":"Roberts","year":"2015","journal-title":"Front Immunol"},{"issue":"10","key":"10.1016\/j.joca.2022.08.019_bib37","doi-asserted-by":"crossref","first-page":"19951","DOI":"10.3390\/ijms141019951","article-title":"CD8+ T cell-induced expression of tissue inhibitor of metalloproteinses-1 exacerbated osteoarthritis","volume":"14","author":"Hsieh","year":"2013","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.joca.2022.08.019_bib38","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3899\/jrheum.151068","article-title":"Inflammatory cells in patients with endstage knee osteoarthritis: a comparison between the synovium and the infrapatellar fat pad","volume":"43","author":"Klein-Wieringa","year":"2016","journal-title":"J\u00a0Rheumatol"},{"issue":"3","key":"10.1016\/j.joca.2022.08.019_bib39","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.molmed.2007.01.003","article-title":"Natural regulatory T cells: mechanisms of suppression","volume":"13","author":"Miyara","year":"2007","journal-title":"Trends Mol Med"},{"issue":"3","key":"10.1016\/j.joca.2022.08.019_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2021.100193","article-title":"Regulatory T cells provide chondroprotection through increased TIMP1, IL-10 and IL-4, but cannot mitigate the catabolic effects of IL-1\u03b2 and IL-6 in a tri-culture model of osteoarthritis","volume":"3","author":"Keller","year":"2021","journal-title":"Osteoarthr Cartil Open"},{"issue":"3","key":"10.1016\/j.joca.2022.08.019_bib41","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/art.23264","article-title":"Mediation of the proinflammatory cytokine response in rheumatoid arthritis and spondylarthritis by interactions between fibroblast-like synoviocytes and natural killer cells","volume":"58","author":"Chan","year":"2008","journal-title":"Arthritis Rheumatol"},{"issue":"4","key":"10.1016\/j.joca.2022.08.019_bib42","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1084\/jem.180.4.1395","article-title":"Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor","volume":"180","author":"Carson","year":"1994","journal-title":"J\u00a0Exp Med"},{"issue":"12","key":"10.1016\/j.joca.2022.08.019_bib43","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.1002\/art.27751","article-title":"Synovial tissue\u2013infiltrating natural killer cells in osteoarthritis and periprosthetic inflammation","volume":"62","author":"Huss","year":"2010","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2022.08.019_bib44","first-page":"711","article-title":"Neutrophil elastase induces chondrocyte apoptosis and facilitates the occurrence of osteoarthritis via caspase signaling pathway","volume":"12","author":"Wang","year":"2021","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.joca.2022.08.019_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-017-0944-0","article-title":"Prophylactic inhibition of neutrophil elastase prevents the development of chronic neuropathic pain in osteoarthritic mice","volume":"14","author":"Muley","year":"2017","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.joca.2022.08.019_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.748360","article-title":"Single-cell profiles of age-related osteoarthritis uncover underlying heterogeneity associated with disease progression","volume":"8","author":"Liu","year":"2022","journal-title":"Front Mol Biosci"},{"issue":"11","key":"10.1016\/j.joca.2022.08.019_bib47","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.joca.2010.08.003","article-title":"Chemokine profile of synovial fluid from normal, osteoarthritis and rheumatoid arthritis patients: CCL25, CXCL10 and XCL1 recruit human subchondral mesenchymal progenitor cells","volume":"18","author":"Endres","year":"2010","journal-title":"Osteoarthr Cartil"},{"issue":"2","key":"10.1016\/j.joca.2022.08.019_bib48","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00264-020-04571-4","article-title":"Human bone marrow mesenchymal stem cell injection in subchondral lesions of knee osteoarthritis: a prospective randomized study versus contralateral arthroplasty at a mean fifteen year follow-up","volume":"45","author":"Hernigou","year":"2021","journal-title":"Int Orthop"},{"issue":"5","key":"10.1016\/j.joca.2022.08.019_bib49","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.4049\/jimmunol.1601359","article-title":"CXCR3\/CXCL10 axis regulates neutrophil\u2013NK cell cross-talk determining the severity of experimental osteoarthritis","volume":"198","author":"Benigni","year":"2017","journal-title":"J\u00a0Immunol"},{"issue":"1","key":"10.1016\/j.joca.2022.08.019_bib50","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1128\/IAI.00825-07","article-title":"Effects of CXCL10 on dendritic cell and CD4+ T-cell functions during Leishmania amazonensis infection","volume":"76","author":"Vasquez","year":"2008","journal-title":"Infect Immun"},{"issue":"11","key":"10.1016\/j.joca.2022.08.019_bib51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0048727","article-title":"CXCL10 is critical for the generation of protective CD8 T cell response induced by antigen pulsed CpG-ODN activated dendritic cells","volume":"7","author":"Majumder","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.joca.2022.08.019_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep28786","article-title":"CXCL10-Mediates macrophage, but not other innate immune cells-associated inflammation in murine nonalcoholic steatohepatitis","volume":"6","author":"Tomita","year":"2016","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.joca.2022.08.019_bib53","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.yexcr.2010.12.017","article-title":"CXCR3 in T cell function","volume":"317","author":"Groom","year":"2011","journal-title":"Exp Cell Res"},{"issue":"4","key":"10.1016\/j.joca.2022.08.019_bib54","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1172\/JCI1422","article-title":"The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions","volume":"101","author":"Qin","year":"1998","journal-title":"J\u00a0Clin Investig"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458422008561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458422008561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:58:07Z","timestamp":1761019087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458422008561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":54,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S1063458422008561"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2022.08.019","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Knee osteoarthritis phenotypes based on synovial fluid immune cells correlate with clinical outcome trajectories","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2022.08.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Osteoarthritis Research Society International. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}