{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T11:28:34Z","timestamp":1782905314244,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100018764","name":"Rheumatic Diseases Research Resource-Based Center, Washington University School of Medicine in St. Louis","doi-asserted-by":"publisher","award":["P30 AR073752"],"award-info":[{"award-number":["P30 AR073752"]}],"id":[{"id":"10.13039\/100018764","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG15768"],"award-info":[{"award-number":["AG15768"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AG46927"],"award-info":[{"award-number":["AG46927"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR072999"],"award-info":[{"award-number":["AR072999"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR073752"],"award-info":[{"award-number":["AR073752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR074992"],"award-info":[{"award-number":["AR074992"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR078949"],"award-info":[{"award-number":["AR078949"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR080902"],"award-info":[{"award-number":["AR080902"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018645","name":"Musculoskeletal Research Center, Washington University in St. Louis","doi-asserted-by":"publisher","award":["P30 AR074992"],"award-info":[{"award-number":["P30 AR074992"]}],"id":[{"id":"10.13039\/100018645","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.joca.2022.10.011","type":"journal-article","created":{"date-parts":[[2022,10,20]],"date-time":"2022-10-20T12:51:45Z","timestamp":1666270305000},"page":"23-25","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Trimming the fat \u2014 is leptin crosstalk the link between obesity and osteoarthritis?"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7348-7348","authenticated-orcid":false,"given":"K.H.","family":"Collins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Guilak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2022.10.011_bib1","doi-asserted-by":"crossref","first-page":"2935","DOI":"10.1002\/art.24854","article-title":"Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis","volume":"60","author":"Griffin","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2022.10.011_bib2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1002\/art.33332","article-title":"Induction of osteoarthritis and metabolic inflammation by a very high-fat diet in mice: effects of short-term exercise","volume":"64","author":"Griffin","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2022.10.011_bib3","doi-asserted-by":"crossref","first-page":"R130","DOI":"10.1186\/ar3068","article-title":"Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice","volume":"12","author":"Griffin","year":"2010","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2022.10.011_bib4","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021096118","article-title":"Adipose tissue is a critical regulator of osteoarthritis","volume":"118","author":"Collins","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joca.2022.10.011_bib5","first-page":"132","article-title":"Impact of age on host responses to diet-induced obesity: development of joint damage and metabolic set points","volume":"9","author":"Collins","year":"2020","journal-title":"J\u00a0Sport Health Sci"},{"key":"10.1016\/j.joca.2022.10.011_bib6","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/art.41147","article-title":"Intergenerational transmission of diet-induced obesity, metabolic imbalance, and osteoarthritis in mice","volume":"72","author":"Harasymowicz","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2022.10.011_bib7","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40608-018-0201-9","article-title":"Association of metabolic markers with self-reported osteoarthritis among middle-aged BMI-defined non-obese individuals: a cross-sectional study","volume":"5","author":"Collins","year":"2018","journal-title":"BMC Obes"},{"key":"10.1016\/j.joca.2022.10.011_bib8","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1302\/2046-3758.74.BJR-2017-0201.R2","article-title":"High-fat\/high-sucrose diet-induced obesity results in joint-specific development of osteoarthritis-like degeneration in a rat model","volume":"7","author":"Collins","year":"2018","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.joca.2022.10.011_bib9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fphys.2018.00112","article-title":"Obesity, metabolic syndrome, and musculoskeletal disease: common inflammatory pathways suggest a central role for loss of muscle integrity","volume":"9","author":"Collins","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.joca.2022.10.011_bib10","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.95997","article-title":"Targeting the gut microbiome to treat the osteoarthritis of obesity","volume":"3","author":"Schott","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.joca.2022.10.011_bib11","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1002\/art.40161","article-title":"Conditional macrophage depletion increases inflammation and does not inhibit the development of osteoarthritis in obese macrophage Fas-induced apoptosis-transgenic mice","volume":"69","author":"Wu","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2022.10.011_bib12","article-title":"Serum and synovial\u00a0fluid lipidomic profiles predict obesity-associated osteoarthritis, synovitis, and wound repair","volume":"7","author":"Wu","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.joca.2022.10.011_bib13","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/art.40056","article-title":"Pro-fibrotic infrapatellar fat pad remodeling without M1-macrophage polarization precedes knee osteoarthritis in diet-induced obese mice","volume":"69","author":"Barboza","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2022.10.011_bib14","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/art.40102","article-title":"Regional differences between perisynovial and infrapatellar adipose tissue depots and their response to class II and class III obesity in patients with osteoarthritis","volume":"69","author":"Harasymowicz","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2022.10.011_bib15","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/jor.23103","article-title":"Response to diet-induced obesity produces time-dependent induction and progression of metabolic osteoarthritis in rat knees","volume":"34","author":"Collins","year":"2016","journal-title":"J\u00a0Orthop Res"},{"key":"10.1016\/j.joca.2022.10.011_bib16","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1002\/art.39561","article-title":"Suppressive effects of insulin on tumor necrosis factor-dependent early osteoarthritic changes associated with obesity and type 2 diabetes mellitus","author":"Hamada","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2022.10.011_bib17","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.joca.2015.03.014","article-title":"Relationship between inflammation, the gut microbiota, and metabolic osteoarthritis development: studies in a rat model","volume":"23","author":"Collins","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2022.10.011_bib18","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.joca.2015.01.015","article-title":"Using diet-induced obesity to understand a metabolic subtype of osteoarthritis in rats","volume":"23","author":"Collins","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2022.10.011_bib19","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1001\/jama.2013.277669","article-title":"Effects of intensive diet and exercise on knee joint loads, inflammation, and clinical outcomes among overweight and obese adults with knee osteoarthritis: the IDEA randomized clinical trial","volume":"310","author":"Messier","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.joca.2022.10.011_bib20","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.pain.2012.02.023","article-title":"Pain coping skills training and lifestyle behavioral weight management in patients with knee osteoarthritis: a randomized controlled study","volume":"153","author":"Somers","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.joca.2022.10.011_bib21","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-94125-4","article-title":"Taxonomic changes in the gut microbiota are associated with cartilage damage independent of adiposity, high fat diet, and joint injury","volume":"11","author":"Collins","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.joca.2022.10.011_bib22","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/art.40241","article-title":"Regional differences between perisynovial and infrapatellar adipose tissue depots and their response to class II and III obesity in patients with osteoarthritis: comment on the article by Harasymowicz et\u00a0al","volume":"70","author":"Macchi","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2022.10.011_bib23","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/gerona\/glv151","article-title":"Effect of aging on adipose tissue inflammation in the knee joints of F344BN rats","volume":"71","author":"Fu","year":"2016","journal-title":"J\u00a0Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.joca.2022.10.011_bib24","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1002\/art.37996","article-title":"Stimulation of fibrotic processes by the infrapatellar fat pad in cultured synoviocytes from patients with osteoarthritis: a possible role for prostaglandin f2alpha","volume":"65","author":"Bastiaansen-Jenniskens","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2022.10.011_bib25","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1136\/annrheumdis-2011-200688","article-title":"Cytokine production by infrapatellar fat pad can be stimulated by interleukin 1 beta and inhibited by peroxisome proliferator activated receptor alpha agonist","volume":"71","author":"Clockaerts","year":"2012","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2022.10.011_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008244","article-title":"Congenital lipodystrophy induces severe osteosclerosis","volume":"15","author":"Zou","year":"2019","journal-title":"PLoS Genet"},{"key":"10.1016\/j.joca.2022.10.011_bib27","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1113\/JP283034","article-title":"Leptin mediates the regulation of muscle mass and strength by adipose tissue","volume":"600","author":"Collins","year":"2022","journal-title":"J\u00a0Physiol"},{"key":"10.1016\/j.joca.2022.10.011_bib28","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1007\/s00296-010-1731-8","article-title":"Increased synovial fluid visfatin is positively linked to cartilage degradation biomarkers in osteoarthritis","volume":"32","author":"Duan","year":"2012","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.joca.2022.10.011_bib29","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1186\/s13075-017-1472-0","article-title":"Resistin upregulates chemokine production by fibroblast-like synoviocytes from patients with rheumatoid arthritis","volume":"19","author":"Sato","year":"2017","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2022.10.011_bib30","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1093\/rheumatology\/key181","article-title":"High in vivo levels of adipsin lead to increased knee tissue degradation in osteoarthritis: data from humans and animal models","volume":"57","author":"Valverde-Franco","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.joca.2022.10.011_bib31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.3109\/03008207.2011.597902","article-title":"The effects of adipokines on cartilage and meniscus catabolism","volume":"52","author":"McNulty","year":"2011","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.joca.2022.10.011_bib32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1186\/s13075-016-1112-0","article-title":"Catabolic and proinflammatory effects of leptin in chondrocytes are regulated by suppressor of cytokine signaling-3","volume":"18","author":"Koskinen-Kolasa","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2022.10.011_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/7385160","article-title":"Leptin induced TLR4 expression via the JAK2-STAT3 pathway in obesity-related osteoarthritis","volume":"2021","author":"Jiang","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"10.1016\/j.joca.2022.10.011_bib34","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1172\/JCI28898","article-title":"TLR4 links innate immunity and fatty acid-induced insulin resistance","volume":"116","author":"Shi","year":"2006","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.joca.2022.10.011_bib35","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.2353\/ajpath.2007.060699","article-title":"Leptin-dependent toll-like receptor expression and responsiveness in preadipocytes and adipocytes","volume":"170","author":"Batra","year":"2007","journal-title":"Am J Pathol"},{"key":"10.1016\/j.joca.2022.10.011_bib36","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fendo.2020.00039","article-title":"Congenital generalized lipoatrophy (Berardinelli-Seip syndrome) type 1: description of novel AGPAT2 homozygous variants showing the highly heterogeneous presentation of the disease","volume":"11","author":"Ceccarini","year":"2020","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.joca.2022.10.011_bib37","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13098-016-0140-x","article-title":"Clinical and laboratory data of a large series of patients with congenital generalized lipodystrophy","volume":"8","author":"Lima","year":"2016","journal-title":"Diabetol Metab Syndrome"},{"key":"10.1016\/j.joca.2022.10.011_bib38","doi-asserted-by":"crossref","first-page":"E1676","DOI":"10.1210\/jc.2014-1878","article-title":"Lipid regulation in lipodystrophy versus the obesity-associated metabolic syndrome: the dissociation of HDL-C and triglycerides","volume":"99","author":"Joseph","year":"2014","journal-title":"J\u00a0Clin Endocrinol Metab"},{"key":"10.1016\/j.joca.2022.10.011_bib39","first-page":"172","article-title":"Leptin, its implication in physical exercise and training: a short review","volume":"5","author":"Bouassida","year":"2006","journal-title":"J\u00a0Sports Sci Med"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458422008925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458422008925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:58:17Z","timestamp":1761019097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458422008925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["S1063458422008925"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2022.10.011","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trimming the fat \u2014 is leptin crosstalk the link between obesity and osteoarthritis?","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2022.10.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Osteoarthritis Research Society International. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}