{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T03:45:55Z","timestamp":1786419955253,"version":"build-2736575974"},"reference-count":117,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.joca.2023.05.010","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T17:00:34Z","timestamp":1684861234000},"page":"1425-1436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Tick tock, the cartilage clock"],"prefix":"10.1016","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7384-5253","authenticated-orcid":false,"given":"Natalie","family":"Rogers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing-Jun","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2023.05.010_bib1","unstructured":"Network. GBoDC. Global Burden of Disease Study 2019 (GBD 2019) results. Institute for Health Metrics and Evaluation (IHME)2019 [updated 2019. Available from: \u3008https:\/\/vizhub.healthdata.org\/gbd-results\/\u3009."},{"issue":"12","key":"10.1016\/j.joca.2023.05.010_bib2","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.joca.2012.07.010","article-title":"Osteoarthritis year 2012 in review: biology","volume":"20","author":"van der Kraan","year":"2012","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib3","doi-asserted-by":"crossref","first-page":"R5","DOI":"10.1186\/ar4133","article-title":"MMP13 is a critical target gene during the progression of osteoarthritis","volume":"15","author":"Wang","year":"2013","journal-title":"Arthritis Res Ther"},{"issue":"12","key":"10.1016\/j.joca.2023.05.010_bib4","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1002\/jcb.23298","article-title":"ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis","volume":"112","author":"Verma","year":"2011","journal-title":"J Cell Biochem"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/ard.53.1.8","article-title":"Release of cartilage oligomeric matrix protein (COMP) into joint fluid after knee injury and in osteoarthritis","volume":"53","author":"Lohmander","year":"1994","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2023.05.010_bib6","doi-asserted-by":"crossref","first-page":"D713","DOI":"10.2741\/Homandberg","article-title":"Potential regulation of cartilage metabolism in osteoarthritis by fibronectin fragments","volume":"4","author":"Homandberg","year":"1999","journal-title":"Front Biosci"},{"issue":"2","key":"10.1016\/j.joca.2023.05.010_bib7","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.joca.2009.09.003","article-title":"Contrast Enhanced Computed Tomography can predict the glycosaminoglycan content and biomechanical properties of articular cartilage","volume":"18","author":"Bansal","year":"2010","journal-title":"Osteoarthr Cartil"},{"issue":"suppl_4","key":"10.1016\/j.joca.2023.05.010_bib8","doi-asserted-by":"crossref","first-page":"iv43","DOI":"10.1093\/rheumatology\/kex419","article-title":"Osteoarthritis: the genesis of pain","volume":"57","author":"Fu","year":"2017","journal-title":"Rheumatology."},{"issue":"4","key":"10.1016\/j.joca.2023.05.010_bib9","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.jocd.2010.07.004","article-title":"Low bone mineral density in rotating-shift workers","volume":"13","author":"Quevedo","year":"2010","journal-title":"J Clin Densitom"},{"issue":"4","key":"10.1016\/j.joca.2023.05.010_bib10","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00198-008-0729-5","article-title":"Nightshift work and fracture risk: the Nurses\u2019 Health Study","volume":"20","author":"Feskanich","year":"2009","journal-title":"Osteoporosis Int"},{"issue":"2","key":"10.1016\/j.joca.2023.05.010_bib11","doi-asserted-by":"crossref","first-page":"152","DOI":"10.5271\/sjweh.3861","article-title":"Shift work and the risk of knee osteoarthritis among Chinese workers: a retrospective cohort study","volume":"46","author":"Zhou","year":"2020","journal-title":"Scand J Work Environ Health"},{"issue":"5","key":"10.1016\/j.joca.2023.05.010_bib12","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1159\/000320673","article-title":"Systemic and cellular reflections on ageing and the circadian oscillator: a mini-review","volume":"57","author":"Brown","year":"2011","journal-title":"Gerontology."},{"issue":"9","key":"10.1016\/j.joca.2023.05.010_bib13","doi-asserted-by":"crossref","first-page":"2334","DOI":"10.1002\/art.38035","article-title":"The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis","volume":"65","author":"Gossan","year":"2013","journal-title":"Arthritis Rheum"},{"issue":"12","key":"10.1016\/j.joca.2023.05.010_bib14","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1136\/ard.61.12.1075","article-title":"Rhythmic variations in pain, stiffness, and manual dexterity in hand osteoarthritis","volume":"61","author":"Bellamy","year":"2002","journal-title":"Ann Rheum Dis"},{"issue":"10","key":"10.1016\/j.joca.2023.05.010_bib15","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.joca.2009.03.021","article-title":"Daily pain variations among patients with hand, hip, and knee osteoarthritis","volume":"17","author":"Allen","year":"2009","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.archger.2015.03.009","article-title":"Diurnal variation on balance control in patients with symptomatic knee osteoarthritis","volume":"61","author":"Zhang","year":"2015","journal-title":"Arch Gerontol Geriatr"},{"issue":"4","key":"10.1016\/j.joca.2023.05.010_bib17","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.gaitpost.2014.01.002","article-title":"Impaired postural balance in the morning in patients with knee osteoarthritis","volume":"39","author":"S\u00f8rensen","year":"2014","journal-title":"Gait Posture"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib18","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/clpt.1985.15","article-title":"Timing optimizes sustained-release indomethacin treatment of osteoarthritis","volume":"37","author":"Levi","year":"1985","journal-title":"Clin Pharmacol Ther"},{"issue":"7","key":"10.1016\/j.joca.2023.05.010_bib19","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1136\/ard.49.7.536","article-title":"Influence of cyclic loading on the nutrition of articular cartilage","volume":"49","author":"O'Hara","year":"1990","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib20","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1002\/(SICI)1522-2594(200001)43:1<126::AID-MRM15>3.0.CO;2-#","article-title":"Diurnal variation in the femoral articular cartilage of the knee in young adult humans","volume":"43","author":"Waterton","year":"2000","journal-title":"Mag Reson Med"},{"issue":"3","key":"10.1016\/j.joca.2023.05.010_bib21","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jbiomech.2012.09.013","article-title":"Diurnal variations in articular cartilage thickness and strain in the human knee","volume":"46","author":"Coleman","year":"2013","journal-title":"J Biomech"},{"issue":"7","key":"10.1016\/j.joca.2023.05.010_bib22","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.acthis.2014.07.001","article-title":"Clock gene expression in different synovial cells of patients with rheumatoid arthritis and osteoarthritis","volume":"116","author":"Becker","year":"2014","journal-title":"Acta Histochem"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib23","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1172\/JCI82755","article-title":"The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity","volume":"126","author":"Dudek","year":"2016","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1016\/j.joca.2023.05.010_bib24","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.joca.2020.04.004","article-title":"Suppression of circadian clock protein cryptochrome 2 promotes osteoarthritis","volume":"28","author":"Bekki","year":"2020","journal-title":"Osteoarthr Cartil"},{"issue":"6","key":"10.1016\/j.joca.2023.05.010_bib25","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.joca.2016.11.007","article-title":"Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-\u03b2 signaling in chondrocytes","volume":"25","author":"Akagi","year":"2017","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2023.05.010_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119036","article-title":"Clock knockdown attenuated reactive oxygen species-mediated senescence of chondrocytes through restoring autophagic flux","volume":"269","author":"Zhong","year":"2021","journal-title":"Life Sci"},{"key":"10.1016\/j.joca.2023.05.010_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109692","article-title":"Cartilage-specific deficiency of clock gene Bmal1 accelerated articular cartilage degeneration in osteoarthritis by up-regulation of mTORC1 signaling","volume":"115","author":"Qian","year":"2023","journal-title":"Int Immunopharmacol"},{"issue":"3","key":"10.1016\/j.joca.2023.05.010_bib28","doi-asserted-by":"crossref","DOI":"10.1186\/ar3852","article-title":"Disruption of rhythms of molecular clocks in primary synovial fibroblasts of patients with osteoarthritis and rheumatoid arthritis, role of IL-1 beta\/TNF","volume":"14","author":"Haas","year":"2012","journal-title":"Arthritis Res Ther"},{"issue":"57","key":"10.1016\/j.joca.2023.05.010_bib29","doi-asserted-by":"crossref","first-page":"97633","DOI":"10.18632\/oncotarget.19276","article-title":"Role of melatonin combined with exercise as a switch-like regulator for circadian behavior in advanced osteoarthritic knee","volume":"8","author":"Hong","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.joca.2023.05.010_bib30","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/annrheumdis-2017-212603","article-title":"Stratification of knee osteoarthritis: two major patient subgroups identified by genome-wide expression analysis of articular cartilage","volume":"77","author":"Soul","year":"2018","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"10.1016\/j.joca.2023.05.010_bib31","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1016\/j.joca.2018.07.012","article-title":"Identification of transcription factors responsible for dysregulated networks in human osteoarthritis cartilage by global gene expression analysis","volume":"26","author":"Fisch","year":"2018","journal-title":"Osteoarthr Cartil"},{"issue":"3","key":"10.1016\/j.joca.2023.05.010_bib32","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/gene.20102","article-title":"Progressive arthropathy in mice with a targeted disruption of the Mop3\/Bmal-1 locus","volume":"41","author":"Bunger","year":"2005","journal-title":"Genesis"},{"issue":"6","key":"10.1016\/j.joca.2023.05.010_bib33","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.joca.2019.01.012","article-title":"Clock mutant promotes osteoarthritis by inhibiting the acetylation of NF\u03baB","volume":"27","author":"Yuan","year":"2019","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2023.05.010_bib34","article-title":"The clock transcription factor BMAL1 is a key regulator of extracellular matrix homeostasis and cell fate in the intervertebral disc","author":"Dudek","year":"2023","journal-title":"BioRxiv"},{"issue":"9","key":"10.1016\/j.joca.2023.05.010_bib35","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/jcp.24946","article-title":"Environmental disruption of circadian rhythm predisposes mice to osteoarthritis-like changes in knee joint","volume":"230","author":"Kc","year":"2015","journal-title":"J Cell Physiol"},{"issue":"6","key":"10.1016\/j.joca.2023.05.010_bib36","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1038\/ki.1996.258","article-title":"Aldosterone and potassium homeostasis","volume":"49","author":"Rabinowitz","year":"1996","journal-title":"Kidney Int"},{"issue":"11","key":"10.1016\/j.joca.2023.05.010_bib37","doi-asserted-by":"crossref","first-page":"R670","DOI":"10.1016\/S0960-9822(06)00350-2","article-title":"Circadian clocks","volume":"7","author":"Hastings","year":"1997","journal-title":"Curr Biol"},{"key":"10.1016\/j.joca.2023.05.010_bib38","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1749-6632.1984.tb23452.x","article-title":"Circadian timing","volume":"423","author":"Aschoff","year":"1984","journal-title":"Ann N Y Acad Sci"},{"issue":"6901","key":"10.1016\/j.joca.2023.05.010_bib39","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1038\/nature00965","article-title":"Coordination of circadian timing in mammals","volume":"418","author":"Reppert","year":"2002","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.joca.2023.05.010_bib40","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/j.celrep.2015.10.043","article-title":"Cycling transcriptional networks optimize energy utilization on a genome scale","volume":"13","author":"Wang","year":"2015","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.901460102","article-title":"A retinohypothalamic projection in the rat","volume":"146","author":"Moore","year":"1972","journal-title":"J Comp Neurol"},{"issue":"10","key":"10.1016\/j.joca.2023.05.010_bib42","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.cub.2012.03.038","article-title":"Social jetlag and obesity","volume":"22","author":"Roenneberg","year":"2012","journal-title":"Curr Biol"},{"issue":"4","key":"10.1016\/j.joca.2023.05.010_bib43","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1152\/physiol.00012.2011","article-title":"Circadian rhythms, aging, and life span in mammals","volume":"26","author":"Froy","year":"2011","journal-title":"Physiology"},{"key":"10.1016\/j.joca.2023.05.010_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.111163","article-title":"A matter of time: circadian clocks in osteoarthritis and the potential of chronotherapy","volume":"143","author":"Dernie","year":"2021","journal-title":"Exp Gerontol"},{"issue":"16","key":"10.1016\/j.joca.2023.05.010_bib45","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1093\/eurheartj\/ehaa215","article-title":"Investigators ftHP. Chronotherapy of hypertension, asleep ambulatory blood pressure, and glaucoma","volume":"41","author":"Hermida","year":"2020","journal-title":"Eur Heart J"},{"issue":"7","key":"10.1016\/j.joca.2023.05.010_bib46","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2020.01.050","article-title":"Circadian rhythms in the pathogenesis and treatment of fatty liver disease","volume":"158","author":"Saran","year":"2020","journal-title":"Gastroenterology"},{"issue":"6524","key":"10.1016\/j.joca.2023.05.010_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/science.abb0738","article-title":"Clocks, cancer, and chronochemotherapy","volume":"371","author":"Sancar","year":"2021","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.joca.2023.05.010_bib48","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1073\/pnas.68.9.2112","article-title":"Clock mutants of Drosophila melanogaster","volume":"68","author":"Konopka","year":"1971","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib49","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev.physiol.63.1.647","article-title":"Molecular analysis of mammalian circadian rhythms","volume":"63","author":"SMR","year":"2001","journal-title":"Annu Rev Physiol"},{"issue":"12","key":"10.1016\/j.joca.2023.05.010_bib50","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nrm1766","article-title":"Circadian clocks\u2014the fall and rise of physiology","volume":"6","author":"Roenneberg","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"10","key":"10.1016\/j.joca.2023.05.010_bib51","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/nrg2430","article-title":"The genetics of mammalian circadian order and disorder: implications for physiology and disease","volume":"9","author":"Takahashi","year":"2008","journal-title":"Nat Rev Genet"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib52","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev-physiol-021909-135821","article-title":"The mammalian circadian timing system: organization and coordination of central and peripheral clocks","volume":"72","author":"Dibner","year":"2010","journal-title":"Annu Rev Physiol"},{"issue":"3","key":"10.1016\/j.joca.2023.05.010_bib53","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nrg.2016.150","article-title":"Transcriptional architecture of the mammalian circadian clock","volume":"18","author":"Takahashi","year":"2017","journal-title":"Nat Rev Genet"},{"issue":"6381","key":"10.1016\/j.joca.2023.05.010_bib54","doi-asserted-by":"crossref","DOI":"10.1126\/science.aao0318","article-title":"Diurnal transcriptome atlas of a primate across major neural and peripheral tissues","volume":"359","author":"Mure","year":"2018","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.joca.2023.05.010_bib55","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.tips.2013.09.002","article-title":"How to fix a broken clock","volume":"34","author":"Schroeder","year":"2013","journal-title":"Trends Pharmacol Sci"},{"issue":"12","key":"10.1016\/j.joca.2023.05.010_bib56","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1101\/gr.195404.115","article-title":"Ribosome profiling reveals the rhythmic liver translatome and circadian clock regulation by upstream open reading frames","volume":"25","author":"Janich","year":"2015","journal-title":"Genome Res"},{"issue":"Suppl 3","key":"10.1016\/j.joca.2023.05.010_bib57","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1186\/ar561","article-title":"Tissue engineering: chondrocytes and cartilage","volume":"4","author":"Hardingham","year":"2002","journal-title":"Arthritis Res"},{"key":"10.1016\/j.joca.2023.05.010_bib58","series-title":"Biology of Cartilage Cells","first-page":"329","author":"Howell","year":"1979"},{"key":"10.1016\/j.joca.2023.05.010_bib59","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1002\/bdrc.21042","article-title":"Towards regeneration of articular cartilage","author":"Iwamoto","year":"2013","journal-title":"Birth Defects Research Part C"},{"key":"10.1016\/j.joca.2023.05.010_bib60","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/ar2592","article-title":"Cartilage homeostasis in health and rheumatic diseases","volume":"11","author":"Goldring","year":"2009","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"10.1016\/j.joca.2023.05.010_bib61","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1177\/0748730416662748","article-title":"Circadian clocks in articular cartilage and bone: a compass in the sea of matrices","volume":"31","author":"Yang","year":"2016","journal-title":"J Biol Rhythms"},{"issue":"2","key":"10.1016\/j.joca.2023.05.010_bib62","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1152\/jappl.1963.18.2.393","article-title":"Nature of \"imperfect\" elasticity of articular cartilage","volume":"18","author":"Elmore","year":"1963","journal-title":"J Appl Physiol"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib63","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0736-0266(00)00004-8","article-title":"The effect of dynamic compression on the response of articular cartilage to insulin-like growth factor-I","volume":"19","author":"Bonassar","year":"2001","journal-title":"J Orthop Res"},{"key":"10.1016\/j.joca.2023.05.010_bib64","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1146\/annurev.bioeng.2.1.691","article-title":"Cartilage tissue remodeling in response to mechanical forces","volume":"2","author":"Grodzinsky","year":"2000","journal-title":"Annu Rev Biomed Eng"},{"issue":"4","key":"10.1016\/j.joca.2023.05.010_bib65","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1111\/j.1469-7580.2006.00546.x","article-title":"The effects of exercise on human articular cartilage","volume":"208","author":"Eckstein","year":"2006","journal-title":"J Anat"},{"issue":"5","key":"10.1016\/j.joca.2023.05.010_bib66","first-page":"409","article-title":"Cell kinetics of growth cartilage in the rat tibia. II. Measurements during ageing","volume":"5","author":"Walker","year":"1972","journal-title":"Cell Tissue Kinet"},{"issue":"11","key":"10.1016\/j.joca.2023.05.010_bib67","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1016\/j.joca.2015.02.020","article-title":"Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NF\u043aB-dependent pathway","volume":"23","author":"Guo","year":"2015","journal-title":"Osteoarthr Cartil"},{"issue":"4","key":"10.1016\/j.joca.2023.05.010_bib68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008729","article-title":"Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator","volume":"16","author":"Yang","year":"2020","journal-title":"PLoS Genet"},{"key":"10.1016\/j.joca.2023.05.010_bib69","article-title":"Mechanical loading and hyperosmolarity as a daily resetting cue for skeletal circadian clocks","author":"Dudek","year":"2021","journal-title":"BioRxiv"},{"issue":"8","key":"10.1016\/j.joca.2023.05.010_bib70","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.7150\/thno.70893","article-title":"Development of human cartilage circadian rhythm in a stem cell-chondrogenesis model","volume":"12","author":"Naven","year":"2022","journal-title":"Theranostics"},{"issue":"21","key":"10.1016\/j.joca.2023.05.010_bib71","doi-asserted-by":"crossref","first-page":"eabj8892","DOI":"10.1126\/sciadv.abj8892","article-title":"Synthetic gene circuits for preventing disruption of the circadian clock due to interleukin-1 induced inflammation","volume":"8","author":"Pferdehirt","year":"2022","journal-title":"Sci Adv"},{"issue":"3","key":"10.1016\/j.joca.2023.05.010_bib72","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3109\/s10165-006-0469-3","article-title":"Identification of clock as a mechanosensitive gene by large-scale DNA microarray analysis: downregulation in osteoarthritic cartilage","volume":"16","author":"Kanbe","year":"2006","journal-title":"Mod Rheumatol"},{"issue":"11","key":"10.1016\/j.joca.2023.05.010_bib73","doi-asserted-by":"crossref","first-page":"3513","DOI":"10.1002\/art.22170","article-title":"Functional characterization of an orphan nuclear receptor, Rev-ErbA\u03b1, in chondrocytes and its potential role in osteoarthritis","volume":"54","author":"Chaturvedi","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.joca.2023.05.010_bib74","doi-asserted-by":"crossref","first-page":"574","DOI":"10.3109\/07420528.2016.1158183","article-title":"The chondrocyte-intrinsic circadian clock is disrupted in human osteoarthritis","volume":"33","author":"Snelling","year":"2016","journal-title":"Chronobiol Int"},{"issue":"8","key":"10.1016\/j.joca.2023.05.010_bib75","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1210\/en.2015-2042","article-title":"Clock gene Bmal1 modulates human cartilage gene expression by crosstalk with Sirt1","volume":"157","author":"Yang","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.joca.2023.05.010_bib76","doi-asserted-by":"crossref","first-page":"S193","DOI":"10.1016\/j.joca.2019.02.297","article-title":"In silico validation of a cartilage specific circadian clock: mutation of BMAL1 increased MMP expression","volume":"27","author":"Khurana","year":"2019","journal-title":"Osteoarthr Cartil"},{"issue":"43","key":"10.1016\/j.joca.2023.05.010_bib77","doi-asserted-by":"crossref","first-page":"36081","DOI":"10.1074\/jbc.M112.408963","article-title":"Clock genes influence gene expression in growth plate and endochondral ossification in mice","volume":"287","author":"Takarada","year":"2012","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib78","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41556-019-0441-z","article-title":"Circadian control of the secretory pathway maintains collagen homeostasis","volume":"22","author":"Chang","year":"2020","journal-title":"Nat Cell Biol"},{"issue":"3","key":"10.1016\/j.joca.2023.05.010_bib79","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1136\/annrheumdis-2016-209428","article-title":"The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration","volume":"76","author":"Dudek","year":"2017","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"10.1016\/j.joca.2023.05.010_bib80","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1359\/jbmr.080209","article-title":"ALK1 opposes ALK5\/Smad3 signaling and expression of extracellular matrix components in human chondrocytes","volume":"23","author":"Finnson","year":"2008","journal-title":"J Bone Miner Res"},{"issue":"12","key":"10.1016\/j.joca.2023.05.010_bib81","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/j.joca.2009.06.008","article-title":"TGF-beta signaling in chondrocyte terminal differentiation and osteoarthritis: modulation and integration of signaling pathways through receptor-Smads","volume":"17","author":"van der Kraan","year":"2009","journal-title":"Osteoarthr Cartil"},{"issue":"6","key":"10.1016\/j.joca.2023.05.010_bib82","first-page":"394","article-title":"Regulation and role of TGF\u03b2 signaling pathway in aging and osteoarthritis joints","volume":"5","author":"Baug\u00e9","year":"2014","journal-title":"Aging Dis"},{"issue":"2","key":"10.1016\/j.joca.2023.05.010_bib83","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/path.2578","article-title":"Transcription factor Nfat1 deficiency causes osteoarthritis through dysfunction of adult articular chondrocytes","volume":"219","author":"Wang","year":"2009","journal-title":"J Pathol"},{"issue":"8","key":"10.1016\/j.joca.2023.05.010_bib84","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1002\/jbmr.397","article-title":"Nfat1 regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone methylation","volume":"26","author":"Rodova","year":"2011","journal-title":"J Bone Miner Res"},{"issue":"49","key":"10.1016\/j.joca.2023.05.010_bib85","doi-asserted-by":"crossref","first-page":"19914","DOI":"10.1073\/pnas.1320036110","article-title":"NFATc1 and NFATc2 repress spontaneous osteoarthritis","volume":"110","author":"Greenblatt","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"10.1016\/j.joca.2023.05.010_bib86","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/jb\/mvt068","article-title":"Different circadian expression of major matrix-related genes in various types of cartilage: modulation by light-dark conditions","volume":"154","author":"Honda","year":"2013","journal-title":"J Biochem"},{"issue":"9","key":"10.1016\/j.joca.2023.05.010_bib87","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s11926-017-0679-z","article-title":"Wnt\/\u03b2-catenin signaling in osteoarthritis and in other forms of arthritis","volume":"19","author":"Zhou","year":"2017","journal-title":"Curr Rheumatol Rep"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib88","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s00774-021-01271-w","article-title":"Disruption of the mouse Bmal1 locus promotes heterotopic ossification with aging via TGF-beta\/BMP signaling","volume":"40","author":"Liang","year":"2022","journal-title":"J Bone Miner Metab"},{"issue":"5","key":"10.1016\/j.joca.2023.05.010_bib89","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.joca.2021.02.008","article-title":"Circadian time series proteomics reveals daily dynamics in cartilage physiology","volume":"29","author":"Dudek","year":"2021","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.joca.2023.05.010_bib90","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.matbio.2014.08.007","article-title":"Integrins and chondrocyte-matrix interactions in articular cartilage","volume":"39","author":"Loeser","year":"2014","journal-title":"Matrix Biol"},{"issue":"50","key":"10.1016\/j.joca.2023.05.010_bib91","doi-asserted-by":"crossref","first-page":"39027","DOI":"10.1074\/jbc.M006700200","article-title":"Effect of collagen turnover on the accumulation of advanced glycation end products","volume":"275","author":"Verzijl","year":"2000","journal-title":"J Biol Chem"},{"issue":"3","key":"10.1016\/j.joca.2023.05.010_bib92","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s00586-013-2767-8","article-title":"Biochemical composition and turnover of the extracellular matrix of the normal and degenerate intervertebral disc","volume":"23","author":"Sivan","year":"2014","journal-title":"Eur Spine J"},{"key":"10.1016\/j.joca.2023.05.010_bib93","doi-asserted-by":"crossref","DOI":"10.1530\/JOE-19-0256","article-title":"Timing metabolism in cartilage and bone: links between circadian clocks and tissue homeostasis","author":"Gon\u00e7alves","year":"2019","journal-title":"J Endocrinol"},{"issue":"6","key":"10.1016\/j.joca.2023.05.010_bib94","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1210\/endo-113-6-2035","article-title":"Meal timing as a Zeitgeber for skeletal deoxyribonucleic acid and collagen synthesis rhythms","volume":"113","author":"Russell","year":"1983","journal-title":"Endocrinology"},{"issue":"7\u20138","key":"10.1016\/j.joca.2023.05.010_bib95","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.matbio.2012.11.008","article-title":"Towards definition of an ECM parts list: an advance on GO categories","volume":"31","author":"Naba","year":"2012","journal-title":"Matrix Biol"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib96","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015848","article-title":"Circadian rhythm and cartilage extracellular matrix genes in osseointegration: a genome-wide screening of implant failure by vitamin D deficiency","volume":"6","author":"Mengatto","year":"2011","journal-title":"PLoS One"},{"issue":"33","key":"10.1016\/j.joca.2023.05.010_bib97","doi-asserted-by":"crossref","first-page":"23632","DOI":"10.1074\/jbc.M512362200","article-title":"Up-regulation of per mRNA expression by parathyroid hormone through a protein kinase A-CREB-dependent mechanism in chondrocytes","volume":"281","author":"Hinoi","year":"2006","journal-title":"J Biol Chem"},{"issue":"6002","key":"10.1016\/j.joca.2023.05.010_bib98","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1126\/science.1195262","article-title":"Temperature as a universal resetting cue for mammalian circadian oscillators","volume":"330","author":"Buhr","year":"2010","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib99","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cmet.2016.09.014","article-title":"Rhythmic oxygen levels reset circadian clocks through HIF1\u03b1","volume":"25","author":"Adamovich","year":"2017","journal-title":"Cell Metab"},{"issue":"8","key":"10.1016\/j.joca.2023.05.010_bib100","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.joca.2009.03.002","article-title":"Aging and osteoarthritis: the role of chondrocyte senescence and aging changes in the cartilage matrix","volume":"17","author":"Loeser","year":"2009","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib101","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.berh.2009.08.006","article-title":"Why is osteoarthritis an age-related disease?","volume":"24","author":"Shane Anderson","year":"2010","journal-title":"Best Pract Res Clin Rheumatol"},{"issue":"3\u20134","key":"10.1016\/j.joca.2023.05.010_bib102","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.bbrc.2011.11.037","article-title":"Extracellular low pH affects circadian rhythm expression in human primary fibroblasts","volume":"416","author":"Lee","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"issue":"S1","key":"10.1016\/j.joca.2023.05.010_bib103","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/dom.12521","article-title":"The molecular clock as a metabolic rheostat","volume":"17","author":"Perelis","year":"2015","journal-title":"Diabetes Obes Metab"},{"issue":"7","key":"10.1016\/j.joca.2023.05.010_bib104","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1172\/JCI41192","article-title":"Adrenal glucocorticoids have a key role in circadian resynchronization in a mouse model of jet lag","volume":"120","author":"Kiessling","year":"2010","journal-title":"J Clin Investig"},{"issue":"17","key":"10.1016\/j.joca.2023.05.010_bib105","doi-asserted-by":"crossref","first-page":"7218","DOI":"10.1073\/pnas.1008882108","article-title":"Serum factors in older individuals change cellular clock properties","volume":"108","author":"Pagani","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"8","key":"10.1016\/j.joca.2023.05.010_bib106","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1002\/art.21977","article-title":"Diurnal variation of serum and urine biomarkers in patients with radiographic knee osteoarthritis","volume":"54","author":"Kong","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"5","key":"10.1016\/j.joca.2023.05.010_bib107","first-page":"252","article-title":"\u201cFeeding time\u201d for the brain: a matter of clocks","volume":"100","author":"Feillet","year":"2006","journal-title":"J Physiol"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib108","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s42003-021-02239-2","article-title":"Timed daily exercise remodels circadian rhythms in mice","volume":"4","author":"Hughes","year":"2021","journal-title":"Commun Biol"},{"key":"10.1016\/j.joca.2023.05.010_bib109","first-page":"305","article-title":"Chapter 18 - Feedback actions of locomotor activity to the circadian clock","volume":"199","author":"Hughes","year":"2012"},{"issue":"9","key":"10.1016\/j.joca.2023.05.010_bib110","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1249\/MSS.0b013e318255cf4c","article-title":"Scheduled exercise phase shifts the circadian clock in skeletal muscle","volume":"44","author":"Wolff","year":"2012","journal-title":"Med Sci Sports Exerc"},{"issue":"7396","key":"10.1016\/j.joca.2023.05.010_bib111","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature11030","article-title":"Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists","volume":"485","author":"Solt","year":"2012","journal-title":"Nature"},{"issue":"21","key":"10.1016\/j.joca.2023.05.010_bib112","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1242\/jcs.035048","article-title":"Ligand modulation of REV-ERB\u03b1 function resets the peripheral circadian clock in a phasic manner","volume":"121","author":"Meng","year":"2008","journal-title":"J Cell Sci"},{"issue":"6098","key":"10.1016\/j.joca.2023.05.010_bib113","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1126\/science.1223710","article-title":"Identification of small molecule activators of cryptochrome","volume":"337","author":"Hirota","year":"2012","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.joca.2023.05.010_bib114","doi-asserted-by":"crossref","DOI":"10.1152\/ajpgi.00130.2022","article-title":"The biological clock enhancer nobiletin ameliorates steatosis in genetically obese mice by restoring aberrant hepatic circadian rhythm","volume":"323","author":"Larion","year":"2022","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"10.1016\/j.joca.2023.05.010_bib115","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41413-022-00187-z","article-title":"Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration","volume":"10","author":"Wang","year":"2022","journal-title":"Bone Res"},{"issue":"3","key":"10.1016\/j.joca.2023.05.010_bib116","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s11096-013-9749-0","article-title":"Timing is important in medication administration: a timely review of chronotherapy research","volume":"35","author":"Kaur","year":"2013","journal-title":"Int J Clin Pharm"},{"issue":"45","key":"10.1016\/j.joca.2023.05.010_bib117","doi-asserted-by":"crossref","first-page":"16219","DOI":"10.1073\/pnas.1408886111","article-title":"A circadian gene expression atlas in mammals: Implications for biology and medicine","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc Natl Acad Sci"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458423008002?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458423008002?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T03:59:52Z","timestamp":1761019192000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458423008002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":117,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S1063458423008002"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2023.05.010","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tick tock, the cartilage clock","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2023.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}