{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:52:47Z","timestamp":1793047967957,"version":"4.5.0"},"reference-count":109,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","oarsijournal.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.joca.2023.12.005","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T22:05:44Z","timestamp":1703282744000},"page":"355-364","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":80,"title":["Inflammation in osteoarthritis: Our view on its presence and involvement in disease development over the years"],"prefix":"10.1016","volume":"32","author":[{"given":"Martijn H.J.","family":"van den Bosch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjen B.","family":"Blom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M.","family":"van der Kraan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3 Suppl 2","key":"10.1016\/j.joca.2023.12.005_bib1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0049-0172(91)90036-Y","article-title":"Mechanical determinants of osteoarthrosis","volume":"21","author":"Radin","year":"1991","journal-title":"Semin Arthritis Rheum"},{"issue":"Gen Rep","key":"10.1016\/j.joca.2023.12.005_bib2","first-page":"1","article-title":"Discussion on \"the Aetiology and Treatment of Osteo-Arthritis and Rheumatoid Arthritis\"","volume":"17","author":"Garrod","year":"1924","journal-title":"Proc R Soc Med"},{"issue":"6307","key":"10.1016\/j.joca.2023.12.005_bib3","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1136\/bmj.283.6307.1668","article-title":"Arthritis in Saxon and mediaeval skeletons","volume":"283","author":"Rogers","year":"1981","journal-title":"Br Med J"},{"issue":"2","key":"10.1016\/j.joca.2023.12.005_bib4","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/ajpa.1330460214","article-title":"Stress and the etiology of osteoarthritis","volume":"46","author":"Jurman","year":"1977","journal-title":"Am J Phys Anthropol"},{"issue":"7","key":"10.1016\/j.joca.2023.12.005_bib5","first-page":"1434","article-title":"Knee osteoarthritis after anterior cruciate ligament injury: a systematic review","volume":"37","author":"Oiestad","year":"2009","journal-title":"Am J Sports Med"},{"issue":"24","key":"10.1016\/j.joca.2023.12.005_bib6","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1136\/bjsports-2022-105496","article-title":"Risk factors for knee osteoarthritis after traumatic knee injury: a systematic review and meta-analysis of randomised controlled trials and cohort studies for the OPTIKNEE Consensus","volume":"56","author":"Whittaker","year":"2022","journal-title":"Br J Sports Med"},{"issue":"2","key":"10.1016\/j.joca.2023.12.005_bib7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/annrheumdis-2011-201070","article-title":"The role of varus and valgus alignment in the initial development of knee cartilage damage by MRI: the MOST study","volume":"72","author":"Sharma","year":"2013","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"10.1016\/j.joca.2023.12.005_bib8","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1002\/art.30523","article-title":"The association between hip morphology parameters and nineteen-year risk of end-stage osteoarthritis of the hip: a nested case-control study","volume":"63","author":"Nicholls","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"9","key":"10.1016\/j.joca.2023.12.005_bib9","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1007\/s10067-018-4121-3","article-title":"Running does not increase symptoms or structural progression in people with knee osteoarthritis: data from the osteoarthritis initiative","volume":"37","author":"Lo","year":"2018","journal-title":"Clin Rheumatol"},{"issue":"4","key":"10.1016\/j.joca.2023.12.005_bib10","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1136\/ard.2008.106930","article-title":"Association between weight or body mass index and hand osteoarthritis: a systematic review","volume":"69","author":"Yusuf","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"10.1016\/j.joca.2023.12.005_bib11","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1136\/ard.38.5.423","article-title":"Another look at osteoarthritis","volume":"38","author":"Huskisson","year":"1979","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.joca.2023.12.005_bib12","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/art.1780090302","article-title":"Erosive osteoarthritis of the hands","volume":"9","author":"Peter","year":"1966","journal-title":"Arthritis Rheum"},{"issue":"121","key":"10.1016\/j.joca.2023.12.005_bib13","first-page":"191","article-title":"Microscopic comparison of the synovial changes in posttraumatic synovitis and osteoarthritis","author":"Soren","year":"1976","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"10.1016\/j.joca.2023.12.005_bib14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1001\/jama.1975.03250020031020","article-title":"Osteoarthritis beginning with inflammation. Definitions and correlations","volume":"232","author":"Ehrlich","year":"1975","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.joca.2023.12.005_bib15","first-page":"1021","article-title":"The stimulation of collagenase production in rabbit articular chondrocytes by interleukin-1 is increased by collagens","volume":"15","author":"Kandel","year":"1987","journal-title":"Biochem Int"},{"issue":"Suppl 1","key":"10.1016\/j.joca.2023.12.005_bib16","doi-asserted-by":"crossref","first-page":"33","DOI":"10.2165\/00003495-198800351-00008","article-title":"Effects of interleukin-1 and anti-inflammatory drugs on the degradation of human articular cartilage","volume":"35","author":"Shinmei","year":"1988","journal-title":"Drugs"},{"issue":"6 Suppl 2","key":"10.1016\/j.joca.2023.12.005_bib17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/0049-0172(91)90024-T","article-title":"Are cytokines involved in osteoarthritic pathophysiology?","volume":"20","author":"Pelletier","year":"1991","journal-title":"Semin Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.joca.2023.12.005_bib18","first-page":"163","article-title":"Effects of exogenous IL-1 beta, TNF alpha, IL-6, IL-8 and LIF on cytokine production by human articular chondrocytes","volume":"4","author":"Henrotin","year":"1996","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"17","key":"10.1016\/j.joca.2023.12.005_bib19","doi-asserted-by":"crossref","first-page":"9518","DOI":"10.1111\/jcmm.15669","article-title":"The emerging role of fibroblast-like synoviocytes-mediated synovitis in osteoarthritis: An update","volume":"24","author":"Han","year":"2020","journal-title":"J Cell Mol Med"},{"issue":"5","key":"10.1016\/j.joca.2023.12.005_bib20","first-page":"416","article-title":"Basic calcium phosphate crystals up-regulate metalloproteinases but down-regulate tissue inhibitor of metalloproteinase-1 and -2 in human fibroblasts","volume":"9","author":"Bai","year":"2001","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"12","key":"10.1016\/j.joca.2023.12.005_bib21","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1002\/art.11355","volume":"48","author":"Clements","year":"2003","journal-title":"Arthritis Rheum"},{"issue":"3","key":"10.1016\/j.joca.2023.12.005_bib22","first-page":"385","article-title":"Interleukin-1 is not involved in synovial inflammation and cartilage destruction in collagenase-induced osteoarthritis","volume":"25","author":"van Dalen","year":"2017","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"5","key":"10.1016\/j.joca.2023.12.005_bib23","first-page":"361","article-title":"Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis -- results of a 1 year longitudinal arthroscopic study in 422 patients","volume":"13","author":"Ayral","year":"2005","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"5","key":"10.1016\/j.joca.2023.12.005_bib24","first-page":"1140","article-title":"Arthroscopic evaluation of post-traumatic patellofemoral chondropathy","volume":"26","author":"Ayral","year":"1999","journal-title":"J Rheumatol"},{"issue":"10","key":"10.1016\/j.joca.2023.12.005_bib25","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1136\/ard.2011.150243","article-title":"Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study","volume":"70","author":"Roemer","year":"2011","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.joca.2023.12.005_bib26","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/art.39438","article-title":"Brief report: Association of inflammation with development of erosions in patients with hand osteoarthritis: A prospective ultrasonography study","volume":"68","author":"Kortekaas","year":"2016","journal-title":"Arthritis Rheumatol"},{"issue":"10","key":"10.1016\/j.joca.2023.12.005_bib27","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1097\/AJP.0000000000000334","article-title":"Sensitization and serological biomarkers in knee osteoarthritis patients with different degrees of synovitis","volume":"32","author":"Petersen","year":"2016","journal-title":"Clin J Pain"},{"issue":"3","key":"10.1016\/j.joca.2023.12.005_bib28","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/art.39488","article-title":"Association of joint inflammation with pain sensitization in knee osteoarthritis: The multicenter osteoarthritis study","volume":"68","author":"Neogi","year":"2016","journal-title":"Arthritis Rheumatol"},{"issue":"1085","key":"10.1016\/j.joca.2023.12.005_bib29","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20170349","article-title":"Imaging of osteoarthritis-recent research developments and future perspective","volume":"91","author":"Hayashi","year":"2018","journal-title":"Br J Radiol"},{"issue":"3","key":"10.1016\/j.joca.2023.12.005_bib30","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2214\/AJR.21.26170","article-title":"Imaging of synovial inflammation in osteoarthritis, from the AJR special series on inflammation","volume":"218","author":"Thoenen","year":"2022","journal-title":"AJR Am J Roentgenol"},{"issue":"1","key":"10.1016\/j.joca.2023.12.005_bib31","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/art.22337","article-title":"Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3","volume":"56","author":"Blom","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"8","key":"10.1016\/j.joca.2023.12.005_bib32","first-page":"627","article-title":"Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis","volume":"12","author":"Blom","year":"2004","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"5","key":"10.1016\/j.joca.2023.12.005_bib33","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1080\/03008207.2020.1780218","article-title":"Maresin-1 suppresses IL-1beta-induced MMP-13 secretion by activating the PI3K\/AKT pathway and inhibiting the NF-kappaB pathway in synovioblasts of an osteoarthritis rat model with treadmill exercise","volume":"62","author":"Lu","year":"2021","journal-title":"Connect Tissue Res"},{"issue":"8","key":"10.1016\/j.joca.2023.12.005_bib34","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00011-016-0946-x","article-title":"The role of resolvin D1 in the regulation of inflammatory and catabolic mediators in osteoarthritis","volume":"65","author":"Benabdoune","year":"2016","journal-title":"Inflamm Res"},{"issue":"257","key":"10.1016\/j.joca.2023.12.005_bib35","first-page":"384","article-title":"The palaeopathology of bone disease","volume":"210","author":"Wells","year":"1973","journal-title":"Practitioner"},{"issue":"5","key":"10.1016\/j.joca.2023.12.005_bib36","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1007\/BF00367181","article-title":"Paleoradiologic evaluation of the Egyptian royal mummies","volume":"17","author":"Braunstein","year":"1988","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.joca.2023.12.005_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00982","article-title":"Immunobiography and the heterogeneity of immune responses in the elderly: A focus on inflammaging and trained immunity","volume":"8","author":"Franceschi","year":"2017","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.joca.2023.12.005_bib38","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/s41577-020-0285-6","article-title":"Defining trained immunity and its role in health and disease","volume":"20","author":"Netea","year":"2020","journal-title":"Nat Rev Immunol"},{"issue":"Suppl 1","key":"10.1016\/j.joca.2023.12.005_bib39","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"2","key":"10.1016\/j.joca.2023.12.005_bib40","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s12016-021-08899-6","article-title":"Immunology of aging: The birth of inflammaging","volume":"64","author":"Fulop","year":"2023","journal-title":"Clin Rev Allergy Immunol"},{"issue":"6","key":"10.1016\/j.joca.2023.12.005_bib41","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nm.4324","article-title":"Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment","volume":"23","author":"Jeon","year":"2017","journal-title":"Nat Med"},{"issue":"11","key":"10.1016\/j.joca.2023.12.005_bib42","first-page":"1966","article-title":"Aging-related inflammation in osteoarthritis","volume":"23","author":"Greene","year":"2015","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"1","key":"10.1016\/j.joca.2023.12.005_bib43","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1093\/rheumatology\/keac359","article-title":"Activation of circulating monocytes by low-density lipoprotein-a risk factor for osteoarthritis?","volume":"62","author":"Kruisbergen","year":"2022","journal-title":"Rheumatology"},{"issue":"7640","key":"10.1016\/j.joca.2023.12.005_bib44","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nature21363","article-title":"Inflammation, metaflammation and immunometabolic disorders","volume":"542","author":"Hotamisligil","year":"2017","journal-title":"Nature"},{"issue":"9945","key":"10.1016\/j.joca.2023.12.005_bib45","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/S0140-6736(14)60460-8","article-title":"Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013","volume":"384","author":"Ng","year":"2014","journal-title":"Lancet"},{"issue":"8","key":"10.1016\/j.joca.2023.12.005_bib46","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/art.39707","article-title":"Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: A population-based cohort study","volume":"68","author":"Reyes","year":"2016","journal-title":"Arthritis Rheumatol"},{"issue":"6","key":"10.1016\/j.joca.2023.12.005_bib47","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.joca.2023.12.005_bib48","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s00256-020-03550-5","article-title":"Obese and overweight individuals have greater knee synovial inflammation and associated structural and cartilage compositional degeneration: data from the osteoarthritis initiative","volume":"50","author":"Kanthawang","year":"2021","journal-title":"Skeletal Radiol"},{"issue":"9","key":"10.1016\/j.joca.2023.12.005_bib49","first-page":"1278","article-title":"Effusion-synovitis worsening mediates the association between body mass index and Kellgren-Lawrence progression in obese individuals: data from the Osteoarthritis Initiative","volume":"30","author":"Banuls-Mirete","year":"2022","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"35","key":"10.1016\/j.joca.2023.12.005_bib50","doi-asserted-by":"crossref","first-page":"9332","DOI":"10.1073\/pnas.1703856114","article-title":"Knee osteoarthritis has doubled in prevalence since the mid-20th century","volume":"114","author":"Wallace","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7203","key":"10.1016\/j.joca.2023.12.005_bib51","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature07206","article-title":"The role of exercise and PGC1alpha in inflammation and chronic disease","volume":"454","author":"Handschin","year":"2008","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.joca.2023.12.005_bib52","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1023\/B:ABME.0000017538.72511.48","article-title":"Integrin-dependent signal cascades in chondrocyte mechanotransduction","volume":"32","author":"Millward-Sadler","year":"2004","journal-title":"Ann Biomed Eng"},{"issue":"10","key":"10.1016\/j.joca.2023.12.005_bib53","first-page":"991","article-title":"Roles for the interleukin-4 receptor and associated JAK\/STAT proteins in human articular chondrocyte mechanotransduction","volume":"14","author":"Millward-Sadler","year":"2006","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"3S","key":"10.1016\/j.joca.2023.12.005_bib54","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.semarthrit.2019.09.018","article-title":"Mechanoflammation in osteoarthritis pathogenesis","volume":"49","author":"Vincent","year":"2019","journal-title":"Semin Arthritis Rheum"},{"issue":"11","key":"10.1016\/j.joca.2023.12.005_bib55","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/s41584-018-0073-x","article-title":"Modern-day environmental factors in the pathogenesis of osteoarthritis","volume":"14","author":"Berenbaum","year":"2018","journal-title":"Nat Rev Rheumatol"},{"issue":"4","key":"10.1016\/j.joca.2023.12.005_bib56","first-page":"501","article-title":"Fundamentals of OA. An initiative of osteoarthritis and cartilage. Obesity and metabolic factors in OA","volume":"30","author":"Batushansky","year":"2022","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"5","key":"10.1016\/j.joca.2023.12.005_bib57","first-page":"532","article-title":"Identifying effector molecules, cells, and cytokines of innate immunity in OA","volume":"28","author":"van den Bosch","year":"2020","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"10","key":"10.1016\/j.joca.2023.12.005_bib58","first-page":"1303","article-title":"Fundamentals of osteoarthritis: Inflammatory mediators in osteoarthritis","volume":"31","author":"De Roover","year":"2023","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"3","key":"10.1016\/j.joca.2023.12.005_bib59","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.rdc.2008.05.004","article-title":"The symptoms of osteoarthritis and the genesis of pain","volume":"34","author":"Hunter","year":"2008","journal-title":"Rheum Dis Clin N\u00a0Am"},{"issue":"12","key":"10.1016\/j.joca.2023.12.005_bib60","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1093\/rheumatology\/ker283","article-title":"What makes osteoarthritis painful? The evidence for local and central pain processing","volume":"50","author":"Sofat","year":"2011","journal-title":"Rheumatology"},{"issue":"5","key":"10.1016\/j.joca.2023.12.005_bib61","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s11914-018-0477-1","article-title":"Mechanisms of osteoarthritis (OA) pain","volume":"16","author":"O'Neill","year":"2018","journal-title":"Curr Osteoporos Rep"},{"issue":"8","key":"10.1016\/j.joca.2023.12.005_bib62","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1136\/annrheumdis-2020-217363","article-title":"Does cartilage loss cause pain in osteoarthritis and if so, how much?","volume":"79","author":"Bacon","year":"2020","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.joca.2023.12.005_bib63","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cger.2021.11.013","article-title":"The genesis of pain in osteoarthritis: Inflammation as a mediator of osteoarthritis pain","volume":"38","author":"Wood","year":"2022","journal-title":"Clin Geriatr Med"},{"issue":"1","key":"10.1016\/j.joca.2023.12.005_bib64","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-020-02410-w","article-title":"Proinflammatory T cell polarization is already present in patients with early knee osteoarthritis","volume":"23","author":"Rosshirt","year":"2021","journal-title":"Arthritis Res Ther"},{"issue":"8","key":"10.1016\/j.joca.2023.12.005_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9082423","article-title":"T helper cell infiltration in osteoarthritis-related knee pain and disability","volume":"9","author":"Nees","year":"2020","journal-title":"J Clin Med"},{"issue":"10","key":"10.1016\/j.joca.2023.12.005_bib66","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1172\/JCI134091","article-title":"IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis","volume":"130","author":"Faust","year":"2020","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.joca.2023.12.005_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23020890","article-title":"Cytokine profiling and intra-articular injection of autologous platelet-rich plasma in knee osteoarthritis","volume":"23","author":"Riewruja","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"8","key":"10.1016\/j.joca.2023.12.005_bib68","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1111\/joor.12649","article-title":"Th1\/Th17\/Th22 immune response and their association with joint pain, imagenological bone loss, RANKL expression and osteoclast activity in temporomandibular joint osteoarthritis: A preliminary report","volume":"45","author":"Monasterio","year":"2018","journal-title":"J Oral Rehabil"},{"issue":"2","key":"10.1016\/j.joca.2023.12.005_bib69","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/cei.13007","article-title":"Nerve growth factor regulation and production by macrophages in osteoarthritic synovium","volume":"190","author":"Takano","year":"2017","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"10.1016\/j.joca.2023.12.005_bib70","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/papr.12267","article-title":"Intradermal injection with nerve growth factor: a reproducible model to induce experimental allodynia and hyperalgesia","volume":"16","author":"Andresen","year":"2016","journal-title":"Pain Pract"},{"issue":"10","key":"10.1016\/j.joca.2023.12.005_bib71","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1182\/blood-2004-10-4055","article-title":"Endogenous NGF regulates CGRP expression in human monocytes, and affects HLA-DR and CD86 expression and IL-10 production","volume":"106","author":"Bracci-Laudiero","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.joca.2023.12.005_bib72","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev-neuro-072116-031121","article-title":"Nerve growth factor and pain mechanisms","volume":"40","author":"Denk","year":"2017","journal-title":"Annu Rev Neurosci"},{"issue":"1","key":"10.1016\/j.joca.2023.12.005_bib73","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-023-03008-8","article-title":"Machine learning identification of thresholds to discriminate osteoarthritis and rheumatoid arthritis synovial inflammation","volume":"25","author":"Mehta","year":"2023","journal-title":"Arthritis Res Ther"},{"issue":"7","key":"10.1016\/j.joca.2023.12.005_bib74","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.pain.2014.03.018","article-title":"Fasinumab (REGN475), an antibody against nerve growth factor for the treatment of pain: results from a double-blind, placebo-controlled exploratory study in osteoarthritis of the knee","volume":"155","author":"Tiseo","year":"2014","journal-title":"Pain"},{"issue":"10","key":"10.1016\/j.joca.2023.12.005_bib75","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1016\/j.pain.2013.05.051","article-title":"Efficacy, safety, and tolerability of fulranumab, an anti-nerve growth factor antibody, in the treatment of patients with moderate to severe osteoarthritis pain","volume":"154","author":"Sanga","year":"2013","journal-title":"Pain"},{"issue":"Suppl 1","key":"10.1016\/j.joca.2023.12.005_bib76","first-page":"S18","article-title":"Serious joint-related adverse events in randomized controlled trials of anti-nerve growth factor monoclonal antibodies","volume":"23","author":"Hochberg","year":"2015","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"1","key":"10.1016\/j.joca.2023.12.005_bib77","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1097\/BOR.0000000000000354","article-title":"Nerve growth factor blockade for the management of osteoarthritis pain: what can we learn from clinical trials and preclinical models?","volume":"29","author":"Miller","year":"2017","journal-title":"Curr Opin Rheumatol"},{"issue":"11","key":"10.1016\/j.joca.2023.12.005_bib78","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1002\/art.39291","article-title":"Damage-associated molecular patterns generated in osteoarthritis directly excite murine nociceptive neurons through Toll-like receptor 4","volume":"67","author":"Miller","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"10.1016\/j.joca.2023.12.005_bib79","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-020-02295-9","article-title":"The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis","volume":"22","author":"Blom","year":"2020","journal-title":"Arthritis Res Ther"},{"issue":"6","key":"10.1016\/j.joca.2023.12.005_bib80","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.95704","article-title":"An aggrecan fragment drives osteoarthritis pain through toll-like receptor 2","volume":"3","author":"Miller","year":"2018","journal-title":"JCI Insight"},{"issue":"5","key":"10.1016\/j.joca.2023.12.005_bib81","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/art.42056","article-title":"Associations of body mass index with pain and the mediating role of inflammatory biomarkers in people with hand osteoarthritis","volume":"74","author":"Gloersen","year":"2022","journal-title":"Arthritis Rheumatol"},{"issue":"6","key":"10.1016\/j.joca.2023.12.005_bib82","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1002\/art.41199","article-title":"Associations between radiographic and ultrasound-detected features in hand osteoarthritis and local pressure pain thresholds","volume":"72","author":"Steen Pettersen","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2023.12.005_bib83","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X231158618","article-title":"An update on the use of conventional and biological disease-modifying anti-rheumatic drugs in hand osteoarthritis","volume":"15","author":"Tenti","year":"2023","journal-title":"Ther Adv Musculoskelet Dis"},{"issue":"50","key":"10.1016\/j.joca.2023.12.005_bib84","doi-asserted-by":"crossref","first-page":"20602","DOI":"10.1073\/pnas.1209294110","article-title":"CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis","volume":"109","author":"Miller","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"issue":"39","key":"10.1016\/j.joca.2023.12.005_bib85","doi-asserted-by":"crossref","first-page":"8249","DOI":"10.1523\/JNEUROSCI.1787-20.2021","article-title":"Dorsal root ganglia macrophages maintain osteoarthritis pain","volume":"41","author":"Raoof","year":"2021","journal-title":"J Neurosci"},{"issue":"1","key":"10.1016\/j.joca.2023.12.005_bib86","article-title":"Neuroimmune interactions and osteoarthritis pain: focus on macrophages","volume":"6","author":"Geraghty","year":"2021","journal-title":"Pain Rep"},{"issue":"570","key":"10.1016\/j.joca.2023.12.005_bib87","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.aav5183","article-title":"Specificity, versatility, and control of TGF-beta family signaling","volume":"12","author":"Derynck","year":"2019","journal-title":"Sci Signal"},{"issue":"6","key":"10.1016\/j.joca.2023.12.005_bib88","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1242\/dev.121.6.1845","article-title":"Defective haematopoiesis and vasculogenesis in transforming growth factor-beta 1 knock out mice","volume":"121","author":"Dickson","year":"1995","journal-title":"Development"},{"issue":"4","key":"10.1016\/j.joca.2023.12.005_bib89","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/00006534-200109150-00018","article-title":"The transforming growth factor-beta 3 knock-out mouse: an animal model for cleft palate","volume":"108","author":"Koo","year":"2001","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.joca.2023.12.005_bib90","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.matbio.2015.05.006","article-title":"The extracellular matrix and transforming growth factor-beta1: Tale of a strained relationship","volume":"47","author":"Hinz","year":"2015","journal-title":"Matrix Biol"},{"issue":"10","key":"10.1016\/j.joca.2023.12.005_bib91","first-page":"1807","article-title":"Unloading results in rapid loss of TGFbeta signaling in articular cartilage: role of loading-induced TGFbeta signaling in maintenance of articular chondrocyte phenotype?","volume":"24","author":"Madej","year":"2016","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"1","key":"10.1016\/j.joca.2023.12.005_bib92","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.knee.2019.12.007","article-title":"Osteoarthritis-related biomarkers profile in chronic anterior cruciate ligament injured knee","volume":"27","author":"Alonso","year":"2020","journal-title":"Knee"},{"issue":"4","key":"10.1016\/j.joca.2023.12.005_bib93","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1136\/annrheumdis-2016-209757","article-title":"Systemic inhibition of IL-6\/Stat3 signalling protects against experimental osteoarthritis","volume":"76","author":"Latourte","year":"2017","journal-title":"Ann Rheum Dis"},{"issue":"3","key":"10.1016\/j.joca.2023.12.005_bib94","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s42000-022-00381-y","article-title":"Correlation of systemic metabolic inflammation with knee osteoarthritis","volume":"21","author":"Christoforakis","year":"2022","journal-title":"Hormones"},{"issue":"11","key":"10.1016\/j.joca.2023.12.005_bib95","first-page":"1906","article-title":"Interleukin-6 and tumor necrosis factor alpha in synovial fluid are associated with progression of radiographic knee osteoarthritis in subjects with previous meniscectomy","volume":"23","author":"Larsson","year":"2015","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"8","key":"10.1016\/j.joca.2023.12.005_bib96","first-page":"1197","article-title":"TGF-beta dampens IL-6 signaling in articular chondrocytes by decreasing IL-6 receptor expression","volume":"27","author":"Wiegertjes","year":"2019","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"5","key":"10.1016\/j.joca.2023.12.005_bib97","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.joca.2021.01.008","article-title":"Increased IL-6 receptor expression and signaling in ageing cartilage can be explained by loss of TGF-beta-mediated IL-6 receptor suppression.","volume":"29","author":"Wiegertjes","year":"2021","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"10.1016\/j.joca.2023.12.005_bib98","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00441-013-1740-5","article-title":"TGF-ss induces Lysyl hydroxylase 2b in human synovial osteoarthritic fibroblasts through ALK5 signaling","volume":"355","author":"Remst","year":"2014","journal-title":"Cell Tissue Res"},{"issue":"8","key":"10.1016\/j.joca.2023.12.005_bib99","first-page":"1185","article-title":"Controlling joint instability after anterior cruciate ligament transection inhibits transforming growth factor-beta-mediated osteophyte formation","volume":"27","author":"Murata","year":"2019","journal-title":"Osteoarthr\u00a0Cartil"},{"issue":"10","key":"10.1016\/j.joca.2023.12.005_bib100","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1016\/j.cellsig.2013.06.001","article-title":"Transforming growth factor-beta signalling: role and consequences of Smad linker region phosphorylation","volume":"25","author":"Kamato","year":"2013","journal-title":"Cell Signal"},{"issue":"15","key":"10.1016\/j.joca.2023.12.005_bib101","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22158124","article-title":"Osteoarthritis-related inflammation blocks TGF-beta's protective effect on chondrocyte hypertrophy via (de)phosphorylation of the SMAD2\/3 linker region","volume":"22","author":"Thielen","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"7","key":"10.1016\/j.joca.2023.12.005_bib102","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nrrheum.2013.44","article-title":"Biologic agents in osteoarthritis: hopes and disappointments","volume":"9","author":"Chevalier","year":"2013","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2023.12.005_bib103","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.20575.1","article-title":"Recent advances in understanding the phenotypes of osteoarthritis","volume":"8","author":"Mobasheri","year":"2019","journal-title":"F1000Res"},{"issue":"7","key":"10.1016\/j.joca.2023.12.005_bib104","doi-asserted-by":"crossref","first-page":"509","DOI":"10.7326\/M20-0527","article-title":"Effects of interleukin-1beta inhibition on incident hip and knee replacement: exploratory analyses from a randomized, double-blind, placebo-controlled trial","volume":"173","author":"Schieker","year":"2020","journal-title":"Ann Intern Med"},{"issue":"6","key":"10.1016\/j.joca.2023.12.005_bib105","doi-asserted-by":"crossref","first-page":"737","DOI":"10.7326\/M23-0289","article-title":"Association of low-dose colchicine with incidence of knee and hip replacements: exploratory analyses from a randomized, controlled, double-blind trial","volume":"176","author":"Heijman","year":"2023","journal-title":"Ann Intern Med"},{"issue":"1","key":"10.1016\/j.joca.2023.12.005_bib106","article-title":"Identification of clinical phenotypes in knee osteoarthritis: a systematic review of the literature","volume":"17","author":"Dell'Isola","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"issue":"1","key":"10.1016\/j.joca.2023.12.005_bib107","article-title":"Classification of patients with knee osteoarthritis in clinical phenotypes: Data from the osteoarthritis initiative","volume":"13","author":"Dell'Isola","year":"2018","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.joca.2023.12.005_bib108","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/art.40840","article-title":"A phase II trial of lutikizumab, an anti-interleukin-1alpha\/beta dual variable domain immunoglobulin, in knee osteoarthritis patients with synovitis","volume":"71","author":"Fleischmann","year":"2019","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"10.1016\/j.joca.2023.12.005_bib109","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/annrheumdis-2018-213336","article-title":"Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1alpha and anti-interleukin-1beta dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis","volume":"78","author":"Kloppenburg","year":"2019","journal-title":"Ann Rheum Dis"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458423010208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458423010208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T01:49:51Z","timestamp":1722044991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458423010208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":109,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S1063458423010208"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2023.12.005","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inflammation in osteoarthritis: Our view on its presence and involvement in disease development over the years","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2023.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}