{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:43:27Z","timestamp":1792802607776,"version":"4.5.0"},"reference-count":94,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR077019"],"award-info":[{"award-number":["R01AR077019"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","oarsijournal.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.joca.2024.01.005","type":"journal-article","created":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T20:52:09Z","timestamp":1705697529000},"page":"398-405","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Molecular pathogenesis of OA pain: Past, present, and future"],"prefix":"10.1016","volume":"32","author":[{"given":"Tonia L.","family":"Vincent","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2024.01.005_bib1","first-page":"255","article-title":"Relief of pain in osteo-arthritis of the hip by partial denervation of the hip joint","volume":"7","author":"Obletz","year":"1948","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2024.01.005_bib2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/pgmj.41.474.172","article-title":"The pain in primary osteoarthritis of the knee. Its causes and treatment by osteotomy","volume":"41","author":"Helal","year":"1965","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.joca.2024.01.005_bib3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0049-0172(89)90021-8","article-title":"Pain, synovitis, and articular cartilage changes in osteoarthritis","volume":"18","author":"Brandt","year":"1989","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.01.005_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0049-0172(89)90007-3","article-title":"Pain in osteoarthritis. Introduction and overview","volume":"18","author":"Altman","year":"1989","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.01.005_bib5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1302\/0301-620X.32B1.84","article-title":"The sensitivity and innervation of the articular capsule","volume":"32","author":"Kellgren","year":"1950","journal-title":"J Bone Joint Surg [Br]"},{"key":"10.1016\/j.joca.2024.01.005_bib6","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1177\/03635465980260060601","article-title":"Conscious neurosensory mapping of the internal structures of the human knee without intraarticular anesthesia","volume":"26","author":"Dye","year":"1998","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.joca.2024.01.005_bib7","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1136\/ard.49.8.649","article-title":"Neurogenic influences in arthritis","volume":"49","author":"Kidd","year":"1990","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2024.01.005_bib8","first-page":"177","article-title":"Regional distribution of mast cells and peptide containing nerves in normal and adjuvant arthritic rat synovium","volume":"18","author":"Hukkanen","year":"1991","journal-title":"J Rheumatol"},{"key":"10.1016\/j.joca.2024.01.005_bib9","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/00003086-200007000-00024","article-title":"Distribution of neuropeptides in synovium of the knee with osteoarthritis","author":"Saito","year":"2000","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.joca.2024.01.005_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ejpain.2005.12.011","article-title":"Localization of SP- and CGRP-immunopositive nerve fibers in the hip joint of patients with painful osteoarthritis and of patients with painless failed total hip arthroplasties","volume":"11","author":"Saxler","year":"2007","journal-title":"Eur J Pain"},{"key":"10.1016\/j.joca.2024.01.005_bib11","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S1471-4914(02)02383-3","article-title":"Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets","volume":"8","author":"Samad","year":"2002","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.joca.2024.01.005_bib12","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1152\/jn.1985.54.5.1109","article-title":"Effects of an experimental arthritis on the sensory properties of fine articular afferent units","volume":"54","author":"Schaible","year":"1985","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.joca.2024.01.005_bib13","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/ar2069","article-title":"Arthritis and pain. Neurogenic origin of joint pain","volume":"8","author":"McDougall","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2024.01.005_bib14","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1093\/rheumatology\/kes219","article-title":"A randomized, double-blind, placebo-controlled trial of low-dose oral prednisolone for treating painful hand osteoarthritis","volume":"51","author":"Wenham","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.joca.2024.01.005_bib15","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/S0140-6736(19)32489-4","article-title":"Results of a 6-week treatment with 10 mg prednisolone in patients with hand osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial","volume":"394","author":"Kroon","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.joca.2024.01.005_bib16","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/rheumatology\/15.1.26","article-title":"The suppressing effect of indomethacin on articular cartilage","volume":"15","author":"Watson","year":"1976","journal-title":"Rheumatol Rehabil"},{"key":"10.1016\/j.joca.2024.01.005_bib17","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/anr.1780320420","article-title":"Effects of salicylate on chondrocytes from osteoarthritic and contralateral knees of dogs with unilateral anterior cruciate ligament transection","volume":"32","author":"Slowman-Kovacs","year":"1989","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.01.005_bib18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/art.1780230114","article-title":"Marked suppression by salicylate of the augmented proteoglycan synthesis in osteoarthritic cartilage","volume":"23","author":"Palmoski","year":"1980","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.01.005_bib19","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1002\/art.1780260808","article-title":"In vivo effect of aspirin on canine osteoarthritic cartilage","volume":"26","author":"Palmoski","year":"1983","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.01.005_bib20","first-page":"2013","article-title":"Indomethacin hastens large joint osteoarthritis in humans--how strong is the evidence?","volume":"22","author":"Doherty","year":"1995","journal-title":"J Rheumatol"},{"key":"10.1016\/j.joca.2024.01.005_bib21","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/S0140-6736(89)90651-X","article-title":"Effect of non-steroidal anti-inflammatory drugs on the course of osteoarthritis","volume":"2","author":"Rashad","year":"1989","journal-title":"Lancet"},{"key":"10.1016\/j.joca.2024.01.005_bib22","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1001\/jama.2017.5283","article-title":"Effect of intra-articular triamcinolone vs saline on knee cartilage volume and pain in patients with knee osteoarthritis: a randomized clinical trial","volume":"317","author":"McAlindon","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.joca.2024.01.005_bib23","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/mrm.10389","article-title":"Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in early knee osteoarthritis","volume":"49","author":"Tiderius","year":"2003","journal-title":"Magn Reson Med"},{"key":"10.1016\/j.joca.2024.01.005_bib24","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1136\/ard.48.11.893","article-title":"Osteoarthritis of the knee joint: an eight year prospective study","volume":"48","author":"Massardo","year":"1989","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2024.01.005_bib25","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.joca.2018.12.021","article-title":"Marked and rapid change of bone shape in acutely ACL injured knees - an exploratory analysis of the Kanon trial","volume":"27","author":"Bowes","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib26","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.joca.2015.05.017","article-title":"Bone marrow lesions, subchondral bone cysts and subchondral bone attrition are associated with histological synovitis in patients with end-stage knee osteoarthritis: a cross-sectional study","volume":"23","author":"Yusup","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib27","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/j.joca.2006.05.011","article-title":"MRI of bone marrow edema-like signal in the pathogenesis of subchondral cysts","volume":"14","author":"Carrino","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib28","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3899\/jrheum.130541","article-title":"Synovitis in knee osteoarthritis assessed by contrast-enhanced magnetic resonance imaging (MRI) is associated with radiographic tibiofemoral osteoarthritis and MRI-detected widespread cartilage damage: the MOST study","volume":"41","author":"Guermazi","year":"2014","journal-title":"J Rheumatol"},{"key":"10.1016\/j.joca.2024.01.005_bib29","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/art.24824","article-title":"Cartilage loss occurs in the same subregions as subchondral bone attrition: a within-knee subregion-matched approach from the Multicenter Osteoarthritis Study","volume":"61","author":"Neogi","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.01.005_bib30","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1002\/art.23071","article-title":"Effect of meniscal damage on the development of frequent knee pain, aching, or stiffness","volume":"56","author":"Englund","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.01.005_bib31","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1002\/art.22851","article-title":"Correlation of the development of knee pain with enlarging bone marrow lesions on magnetic resonance imaging","volume":"56","author":"Felson","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.01.005_bib32","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1136\/ard.2008.096834","article-title":"Change in MRI-detected subchondral bone marrow lesions is associated with cartilage loss: the MOST Study. A longitudinal multicentre study of knee osteoarthritis","volume":"68","author":"Roemer","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2024.01.005_bib33","doi-asserted-by":"crossref","first-page":"b2844","DOI":"10.1136\/bmj.b2844","article-title":"Association between radiographic features of knee osteoarthritis and pain: results from two cohort studies","volume":"339","author":"Neogi","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.joca.2024.01.005_bib34","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/art.33434","article-title":"Prevalence of reported knee pain over twelve years in a community-based cohort","volume":"64","author":"Soni","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.01.005_bib35","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1136\/annrheumdis-2013-204191","article-title":"Sensitivity and sensitisation in relation to pain severity in knee osteoarthritis: trait or state?","volume":"74","author":"Neogi","year":"2015","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2024.01.005_bib36","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/art.40752","article-title":"Pain susceptibility phenotypes in those free of knee pain with or at risk of knee osteoarthritis: the multicenter osteoarthritis study","volume":"71","author":"Carlesso","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2024.01.005_bib37","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1053\/eujp.2000.0175","article-title":"Abnormalities of somatosensory perception in patients with painful osteoarthritis normalize following successful treatment","volume":"4","author":"Kosek","year":"2000","journal-title":"Eur J Pain"},{"key":"10.1016\/j.joca.2024.01.005_bib38","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1002\/art.40749","article-title":"Central sensitization in knee osteoarthritis: relating presurgical brainstem neuroimaging and PainDETECT-based patient stratification to arthroplasty outcome","volume":"71","author":"Soni","year":"2019","journal-title":"Arthritis Rheumatol (Hoboken, N.J.)"},{"key":"10.1016\/j.joca.2024.01.005_bib39","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1002\/art.34466","article-title":"Normalization of widespread hyperesthesia and facilitated spatial summation of deep-tissue pain in knee osteoarthritis patients after knee replacement","volume":"64","author":"Graven-Nielsen","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.01.005_bib40","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1002\/art.24837","article-title":"Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients","volume":"61","author":"Gwilym","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.01.005_bib41","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1002\/art.27585","article-title":"Thalamic atrophy associated with painful osteoarthritis of the hip is reversible after arthroplasty: a longitudinal voxel-based morphometric study","volume":"62","author":"Gwilym","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.01.005_bib42","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1016\/j.joca.2021.10.001","article-title":"Can we prevent chronic osteoarthritis pain? A view from the bench","volume":"29","author":"Miller","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib43","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S1063-4584(03)00163-8","article-title":"Weight bearing as a measure of disease progression and efficacy of anti-inflammatory compounds in a model of monosodium iodoacetate-induced osteoarthritis","volume":"11","author":"Bove","year":"2003","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib44","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1292\/jvms.65.1195","article-title":"Sodium iodoacetate-induced experimental osteoarthritis and associated pain model in rats","volume":"65","author":"Kobayashi","year":"2003","journal-title":"J Vet Med Sci"},{"key":"10.1016\/j.joca.2024.01.005_bib45","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.joca.2006.05.001","article-title":"Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia","volume":"14","author":"Bove","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib46","doi-asserted-by":"crossref","first-page":"3110","DOI":"10.1002\/art.23870","article-title":"Regulation of pain sensitivity in experimental osteoarthritis by the endogenous peripheral opioid system","volume":"58","author":"Inglis","year":"2008","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2024.01.005_bib47","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.joca.2009.11.013","article-title":"ADAMTS-5 deficient mice do not develop mechanical allodynia associated with osteoarthritis following medial meniscal destabilization","volume":"18","author":"Malfait","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib48","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pain.2004.08.004","article-title":"Pain related behaviour in two models of osteoarthritis in the rat knee","volume":"112","author":"Fernihough","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.joca.2024.01.005_bib49","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.berh.2018.03.003","article-title":"Osteoarthritis pain: what are we learning from animal models?","volume":"31","author":"Miller","year":"2017","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.joca.2024.01.005_bib50","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1002\/art.41421","article-title":"Does pain at an earlier stage of chondropathy protect female mice from structural progression after surgically induced osteoarthritis","volume":"72","author":"von Loga","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2024.01.005_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.joca.2023.07.012","article-title":"Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury","author":"Bergman","year":"2023","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib52","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/art.40342","article-title":"Visualization of peripheral neuron sensitization in a surgical mouse model of osteoarthritis by in vivo calcium imaging","volume":"70","author":"Miller","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2024.01.005_bib53","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.pain.2010.11.025","article-title":"Local application of the endocannabinoid hydrolysis inhibitor URB597 reduces nociception in spontaneous and chemically induced models of osteoarthritis","volume":"152","author":"Schuelert","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.joca.2024.01.005_bib54","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1002\/art.42353","article-title":"Role of human mesenchymal stem cells and derived extracellular vesicles in reducing sensory neuron hyperexcitability and pain behaviors in murine osteoarthritis","volume":"75","author":"Ai","year":"2023","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2024.01.005_bib55","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1038\/350500a0","article-title":"Requirement for nerve growth factor in the development of myelinated nociceptors in vivo","volume":"350","author":"Ritter","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.joca.2024.01.005_bib56","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.143.3602.105","article-title":"Growth control of nerve cells by a protein factor and its antiserum: discovery of this factor may provide new leads to understanding of some neurogenetic processes","volume":"143","author":"Levi-Montalcini","year":"1964","journal-title":"Science"},{"key":"10.1016\/j.joca.2024.01.005_bib57","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0306-4522(94)90366-2","article-title":"Nerve growth factor contributes to the generation of inflammatory sensory hypersensitivity","volume":"62","author":"Woolf","year":"1994","journal-title":"Neuroscience"},{"key":"10.1016\/j.joca.2024.01.005_bib58","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/nm0895-774","article-title":"The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule","volume":"1","author":"McMahon","year":"1995","journal-title":"Nat Med"},{"key":"10.1016\/j.joca.2024.01.005_bib59","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.pain.2010.03.002","article-title":"Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain","volume":"149","author":"McNamee","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.joca.2024.01.005_bib60","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1136\/annrheumdis-2018-214489","article-title":"Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis","volume":"78","author":"von Loga","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2024.01.005_bib61","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1136\/annrheumdis-2015-208913","article-title":"Nerve growth factor inhibition with tanezumab influences weight-bearing and subsequent cartilage damage in the rat medial meniscal tear model","volume":"76","author":"LaBranche","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2024.01.005_bib62","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1056\/NEJMoa0901510","article-title":"Tanezumab for the treatment of pain from osteoarthritis of the knee","volume":"363","author":"Lane","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.joca.2024.01.005_bib63","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/art.39492","article-title":"When is osteonecrosis not osteonecrosis?: adjudication of reported serious adverse joint events in the tanezumab clinical development program","volume":"68","author":"Hochberg","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2024.01.005_bib64","doi-asserted-by":"crossref","first-page":"975","DOI":"10.2147\/JPR.S191297","article-title":"Pooled analysis of tanezumab efficacy and safety with subgroup analyses of phase III clinical trials in patients with osteoarthritis pain of the knee or hip","volume":"12","author":"Tive","year":"2019","journal-title":"J Pain Res"},{"key":"10.1016\/j.joca.2024.01.005_bib65","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/vr.104590","article-title":"Anti-nerve growth factor monoclonal antibodies for the control of pain in dogs and cats","volume":"184","author":"Enomoto","year":"2019","journal-title":"Vet Rec"},{"key":"10.1016\/j.joca.2024.01.005_bib66","doi-asserted-by":"crossref","DOI":"10.1002\/art.38778","article-title":"Structural associations of symptomatic knee osteoarthritis","author":"Stoppiello","year":"2014","journal-title":"Arthritis & rheumatology (Hoboken, N. J. )"},{"key":"10.1016\/j.joca.2024.01.005_bib67","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.joca.2020.05.010","article-title":"Contribution of nerves within osteochondral channels to osteoarthritis knee pain in humans and rats","volume":"28","author":"Aso","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib68","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.joca.2018.12.012","article-title":"Molecular expression patterns in the synovium and their association with advanced symptomatic knee osteoarthritis","volume":"27","author":"Wyatt","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib69","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1093\/rheumatology\/keq188","article-title":"Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis","volume":"49","author":"Walsh","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.joca.2024.01.005_bib70","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/art.40820","article-title":"Associations of symptomatic knee osteoarthritis with histopathologic features in subchondral bone","volume":"71","author":"Aso","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2024.01.005_bib71","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.joca.2022.07.003","article-title":"Time course and localization of nerve growth factor expression and sensory nerve growth during progression of knee osteoarthritis in rats","volume":"30","author":"Aso","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib72","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/art.39523","article-title":"Nociceptive sensitizers are regulated in damaged joint tissues, including articular cartilage, when osteoarthritic mice display pain behavior","volume":"68","author":"Driscoll","year":"2016","journal-title":"Arthritis Rheumatol (Hoboken, N.J.)"},{"key":"10.1016\/j.joca.2024.01.005_bib73","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1136\/annrheumdis-2017-211396","article-title":"Microarray analysis of bone marrow lesions in osteoarthritis demonstrates upregulation of genes implicated in osteochondral turnover, neurogenesis and inflammation","volume":"76","author":"Kuttapitiya","year":"2017","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2024.01.005_bib74","doi-asserted-by":"crossref","first-page":"S138","DOI":"10.1097\/j.pain.0000000000001923","article-title":"Peripheral pain mechanisms in osteoarthritis","volume":"161","author":"Vincent","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.joca.2024.01.005_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107553","article-title":"Targeting neurotrophic factors: novel approaches to musculoskeletal pain","volume":"211","author":"Malfait","year":"2020","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.joca.2024.01.005_bib76","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.joca.2019.07.012","article-title":"The nociceptive innervation of the normal and osteoarthritic mouse knee","volume":"27","author":"Obeidat","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib77","article-title":"Intra-articular sprouting of nociceptors accompanies progressive osteoarthritis: comparative evidence in four murine models","author":"Obeidat","year":"2023","journal-title":"BioRxiv preprint"},{"key":"10.1016\/j.joca.2024.01.005_bib78","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1172\/JCI121561","article-title":"Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain","volume":"129","author":"Zhu","year":"2019","journal-title":"J Clin Invest"},{"key":"10.1016\/j.joca.2024.01.005_bib79","doi-asserted-by":"crossref","first-page":"20602","DOI":"10.1073\/pnas.1209294110","article-title":"CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis","volume":"109","author":"Miller","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joca.2024.01.005_bib80","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.joca.2016.10.008","article-title":"CCL2 and CCR2 regulate pain-related behaviour and early gene expression in post-traumatic murine osteoarthritis but contribute little to chondropathy","volume":"25","author":"Miotla Zarebska","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib81","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.joca.2016.11.004","article-title":"Role of the C-C chemokine receptor-2 in a murine model of injury-induced osteoarthritis","volume":"25","author":"Longobardi","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib82","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-021-02486-y","article-title":"The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice","volume":"23","author":"Ishihara","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2024.01.005_bib83","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1038\/s41467-023-38241-x","article-title":"Piezo2 expressing nociceptors mediate mechanical sensitization in experimental osteoarthritis","volume":"14","author":"Obeidat","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.joca.2024.01.005_bib84","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41584-019-0221-y","article-title":"Therapeutic options for targeting inflammatory osteoarthritis pain","volume":"15","author":"Conaghan","year":"2019","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2024.01.005_bib85","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.joca.2021.02.007","article-title":"Comparison of joint degeneration and pain in male and female mice in DMM model of osteoarthritis","volume":"29","author":"Hwang","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib86","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.joca.2019.11.003","article-title":"Pain and knee damage in male and female mice in the medial meniscal transection-induced osteoarthritis","volume":"28","author":"Temp","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib87","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/j.joca.2018.03.008","article-title":"Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR\/Ort mice","volume":"26","author":"Javaheri","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib88","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1002\/art.42530","article-title":"Age-associated changes in knee osteoarthritis, pain-related behaviors, and dorsal root ganglia immunophenotyping of male and female mice","volume":"75","author":"Geraghty","year":"2023","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2024.01.005_bib89","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.joca.2018.08.019","article-title":"CGRP blockade by galcanezumab was not associated with reductions in signs and symptoms of knee osteoarthritis in a randomized clinical trial","volume":"26","author":"Jin","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.01.005_bib90","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1523\/JNEUROSCI.1137-21.2022","article-title":"A female-specific role for calcitonin gene-related peptide (CGRP) in rodent pain models","volume":"42","author":"Paige","year":"2022","journal-title":"J Neurosci"},{"key":"10.1016\/j.joca.2024.01.005_bib91","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13292","article-title":"Pain modulatory network is influenced by sex and age in a healthy state and during osteoarthritis progression in rats","volume":"20","author":"Da Silva","year":"2021","journal-title":"Aging Cell"},{"key":"10.1016\/j.joca.2024.01.005_bib92","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.semarthrit.2019.09.018","article-title":"Mechanoflammation in osteoarthritis pathogenesis","volume":"49","author":"Vincent","year":"2019","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.01.005_bib93","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1093\/rheumatology\/41.12.1413","article-title":"Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes","volume":"41","author":"Iannone","year":"2002","journal-title":"Rheumatology (Oxford, England)"},{"key":"10.1016\/j.joca.2024.01.005_bib94","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nrrheum.2017.78","article-title":"Osteoarthritis: nerve ablation - a new treatment for OA pain?","volume":"13","author":"Walsh","year":"2017","journal-title":"Nat Rev Rheumatol"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458424000219?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458424000219?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T05:49:48Z","timestamp":1722059388000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458424000219"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":94,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S1063458424000219"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2024.01.005","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular pathogenesis of OA pain: Past, present, and future","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2024.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}