{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T18:32:46Z","timestamp":1793817166990,"version":"4.6.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.joca.2024.05.006","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T01:59:11Z","timestamp":1717120751000},"page":"1273-1282","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["A standardized approach to evaluation and reporting of synovial histopathology in two surgically induced murine models of osteoarthritis"],"prefix":"10.1016","volume":"32","author":[{"given":"Alia M.","family":"Obeidat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Yeon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Burt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baofeng","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shingo","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2727-8171","authenticated-orcid":false,"given":"Rui","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel E.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Little","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Malfait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla R.","family":"Scanzello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.joca.2024.05.006_bib1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/art.30137","article-title":"Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms","volume":"63","author":"Scanzello","year":"2011","journal-title":"Arthritis Rheum"},{"issue":"8","key":"10.1016\/j.joca.2024.05.006_bib2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.pmrj.2013.04.014","article-title":"The multicenter osteoarthritis study: opportunities for rehabilitation research","volume":"5","author":"Segal","year":"2013","journal-title":"PM&R"},{"issue":"3","key":"10.1016\/j.joca.2024.05.006_bib3","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/art.39488","article-title":"Association of joint inflammation with pain sensitization in knee osteoarthritis: the multicenter osteoarthritis study: MRI LESIONS AND SENSITIZATION IN KNEE OA","volume":"68","author":"Neogi","year":"2016","journal-title":"Arthritis Rheumatol"},{"issue":"9","key":"10.1016\/j.joca.2024.05.006_bib4","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.joca.2024.05.006_bib5","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.pain.2011.09.007","article-title":"Partial medial meniscectomy produces osteoarthritis pain-related behaviour in female C57BL\/6 mice","volume":"153","author":"Knights","year":"2012","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.joca.2024.05.006_bib6","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.joca.2012.04.014","article-title":"Musculoskeletal changes following non-invasive knee injury using a novel mouse model of post-traumatic osteoarthritis","volume":"20","author":"Christiansen","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"7","key":"10.1016\/j.joca.2024.05.006_bib7","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nrrheum.2014.46","article-title":"Mouse models of osteoarthritis: modelling risk factors and assessing outcomes","volume":"10","author":"Fang","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2024.05.006_bib8","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative \u2013 recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"issue":"12","key":"10.1016\/j.joca.2024.05.006_bib9","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1002\/art.38876","article-title":"Depletion of protease-activated receptor 2 but not protease-activated receptor 1 may confer protection against osteoarthritis in mice through extracartilaginous mechanisms: mechanism of OA protection in PAR-2 \u2212\/\u2212 mice","volume":"66","author":"Jackson","year":"2014","journal-title":"Arthritis Rheumatol"},{"issue":"7","key":"10.1016\/j.joca.2024.05.006_bib10","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.joca.2020.04.009","article-title":"Differential patterns of pathology in and interaction between joint tissues in long-term osteoarthritis with different initiating causes: phenotype matters","volume":"28","author":"Zaki","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"10.1016\/j.joca.2024.05.006_bib11","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s00393-005-0704-x","article-title":"[Synovialitis score: histopathological grading system for chronic rheumatic and non-rheumatic synovialitis]","volume":"64","author":"Krenn","year":"2005","journal-title":"Z Rheumatol"},{"issue":"4","key":"10.1016\/j.joca.2024.05.006_bib12","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: discrimination between chronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology"},{"issue":"7","key":"10.1016\/j.joca.2024.05.006_bib13","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.joca.2011.04.011","article-title":"Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee","volume":"19","author":"Lewis","year":"2011","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.05.006_bib14","first-page":"12","article-title":"Comparison of Kindlin-2 deficiency-stimulated osteoarthritis-like lesions induced by Prg4 versus Aggrecan transgene in mice","volume":"41","author":"Yao","year":"2023","journal-title":"J Orthop Transl"},{"key":"10.1016\/j.joca.2024.05.006_bib15","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.83069","article-title":"Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis","volume":"12","author":"Yao","year":"2023","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.joca.2024.05.006_bib16","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40169-018-0215-4","article-title":"Pros and cons of mouse models for studying osteoarthritis","volume":"7","author":"Bapat","year":"2018","journal-title":"Clin Transl Med"},{"issue":"10","key":"10.1016\/j.joca.2024.05.006_bib17","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.joca.2010.07.008","article-title":"Anatomical distribution of synovitis in knee osteoarthritis and its association with joint effusion assessed on non-enhanced and contrast-enhanced MRI","volume":"18","author":"Roemer","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"issue":"2","key":"10.1016\/j.joca.2024.05.006_bib18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","article-title":"The role of synovitis in osteoarthritis pathogenesis","volume":"51","author":"Scanzello","year":"2012","journal-title":"Bone"},{"issue":"11","key":"10.1016\/j.joca.2024.05.006_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206217","article-title":"Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis","volume":"13","author":"Sambamurthy","year":"2018","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.joca.2024.05.006_bib20","first-page":"363","article-title":"Animal models of osteoarthritis","volume":"1","author":"Bendele","year":"2001","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"5","key":"10.1016\/j.joca.2024.05.006_bib21","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","article-title":"Synovial inflammation in osteoarthritis progression","volume":"18","author":"Sanchez-Lopez","year":"2022","journal-title":"Nat Rev Rheumatol"},{"issue":"11","key":"10.1016\/j.joca.2024.05.006_bib22","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1007\/s00402-021-03889-x","article-title":"The histopathological synovitis score is influenced by biopsy location in patients with knee osteoarthritis","volume":"142","author":"Mussawy","year":"2021","journal-title":"Arch Orthop Trauma Surg"},{"issue":"1","key":"10.1016\/j.joca.2024.05.006_bib23","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1038\/s41598-018-36909-9","article-title":"Pro-resolving lipid mediator ameliorates obesity induced osteoarthritis by regulating synovial macrophage polarisation","volume":"9","author":"Sun","year":"2019","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.joca.2024.05.006_bib24","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/art.42441","article-title":"Targeting synovial lymphatic function as a novel therapeutic intervention for age-related osteoarthritis in mice","volume":"75","author":"Lin","year":"2023","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"10.1016\/j.joca.2024.05.006_bib25","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1002\/jor.23671","article-title":"Chemokine receptor-7 (CCR7) deficiency leads to delayed development of joint damage and functional deficits in a murine model of osteoarthritis","volume":"36","author":"Sambamurthy","year":"2018","journal-title":"J Orthop Res"},{"key":"10.1016\/j.joca.2024.05.006_bib26","doi-asserted-by":"crossref","first-page":"S113","DOI":"10.1016\/j.joca.2010.05.026","article-title":"Basic methods in histopathology of joint tissues","volume":"18","author":"Schmitz","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.05.006_bib27","article-title":"Synovial fibrosis involvement in osteoarthritis","volume":"8","author":"Zhang","year":"2021","journal-title":"Front Med"},{"issue":"1","key":"10.1016\/j.joca.2024.05.006_bib28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13075-024-03309-6","article-title":"Targeting STAT6-mediated synovial macrophage activation improves pain in experimental knee osteoarthritis","volume":"26","author":"Blackler","year":"2024","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"10.1016\/j.joca.2024.05.006_bib29","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/ard-2022-222773","article-title":"Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis","volume":"82","author":"Knights","year":"2023","journal-title":"Ann Rheum Dis"},{"issue":"11","key":"10.1016\/j.joca.2024.05.006_bib30","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.joca.2019.07.012","article-title":"The nociceptive innervation of the normal and osteoarthritic mouse knee","volume":"27","author":"Obeidat","year":"2019","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1016\/j.joca.2024.05.006_bib31","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.joca.2021.01.006","article-title":"Optimization of histologic grading schemes in spontaneous and surgically-induced murine models of osteoarthritis","volume":"29","author":"Armstrong","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.joca.2024.05.006_bib32","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/art.38965","article-title":"Association of pain in knee osteoarthritis with distinct patterns of synovitis","volume":"67","author":"De Lange-Brokaar","year":"2015","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"10.1016\/j.joca.2024.05.006_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.rdc.2012.10.004","article-title":"Epidemiology of osteoarthritis","volume":"39","author":"Neogi","year":"2013","journal-title":"Rheum Dis Clin North Am"},{"issue":"1","key":"10.1016\/j.joca.2024.05.006_bib34","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3899\/jrheum.150355","article-title":"Cross-sectional and longitudinal associations between knee joint effusion synovitis and knee pain in older adults","volume":"43","author":"Wang","year":"2016","journal-title":"J Rheumatol"},{"issue":"10","key":"10.1016\/j.joca.2024.05.006_bib35","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/j.joca.2013.12.013","article-title":"Degree of synovitis on MRI by comprehensive whole knee semi-quantitative scoring method correlates with histologic and macroscopic features of synovial tissue inflammation in knee osteoarthritis","volume":"22","author":"de Lange-Brokaar","year":"2014","journal-title":"Osteoarthritis Cartilage"},{"issue":"5","key":"10.1016\/j.joca.2024.05.006_bib36","first-page":"633","article-title":"Subtyping of osteoarthritic synoviopathy","volume":"20","author":"Oehler","year":"2002","journal-title":"Clin Exp Rheumatol"},{"issue":"11","key":"10.1016\/j.joca.2024.05.006_bib37","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nrrheum.2010.159","article-title":"The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis","volume":"6","author":"Sellam","year":"2010","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2024.05.006_bib38","article-title":"Intra-articular sprouting of nociceptors accompanies progressive osteoarthritis: comparative evidence in four murine models","author":"Obeidat","year":"2023","journal-title":"Front Neuroanat"},{"issue":"10","key":"10.1016\/j.joca.2024.05.006_bib39","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1002\/art.42530","article-title":"Age-associated changes in knee osteoarthritis, pain-related behaviors, and dorsal root ganglia immunophenotyping of male and female mice","volume":"75","author":"Geraghty","year":"2023","journal-title":"Arthritis Rheumatol"},{"issue":"4","key":"10.1016\/j.joca.2024.05.006_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2023.100416","article-title":"Imaging mass cytometry reveals tissue-specific cellular immune phenotypes in the mouse knee following ACL injury","volume":"5","author":"South","year":"2023","journal-title":"Osteoarthr Cartil Open"},{"issue":"12","key":"10.1016\/j.joca.2024.05.006_bib41","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/j.joca.2023.07.013","article-title":"Streamlining quantitative joint-wide medial femoro-tibial histopathological scoring of mouse post-traumatic knee osteoarthritis models","volume":"31","author":"Haubruck","year":"2023","journal-title":"Osteoarthritis Cartilage"},{"issue":"4","key":"10.1016\/j.joca.2024.05.006_bib42","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1002\/art.39529","article-title":"Ablation of perlecan domain 1 heparan sulfate reduces progressive cartilage degradation, synovitis, and osteophyte size in a preclinical model of posttraumatic osteoarthritis","volume":"68","author":"Shu","year":"2016","journal-title":"Arthritis Rheumatol"},{"issue":"1","key":"10.1016\/j.joca.2024.05.006_bib43","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1186\/s13075-018-1762-1","article-title":"Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups","volume":"20","author":"on behalf of EULAR Synovitis Study Group and OMERACT Synovial Tissue Special Interest Group","year":"2018","journal-title":"Arthritis Res Ther"},{"issue":"9","key":"10.1016\/j.joca.2024.05.006_bib44","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.joca.2013.05.011","article-title":"The influence of synovial inflammation and hyperplasia on symptomatic outcomes up to 2 years post-operatively in patients undergoing partial meniscectomy","volume":"21","author":"Scanzello","year":"2013","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458424012056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458424012056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T20:33:38Z","timestamp":1759350818000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458424012056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["S1063458424012056"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2024.05.006","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A standardized approach to evaluation and reporting of synovial histopathology in two surgically induced murine models of osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2024.05.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}