{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T15:19:42Z","timestamp":1783523982113,"version":"3.55.0"},"reference-count":97,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR079713"],"award-info":[{"award-number":["R01AR079713"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","oarsijournal.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.joca.2024.09.010","type":"journal-article","created":{"date-parts":[[2024,10,5]],"date-time":"2024-10-05T06:20:46Z","timestamp":1728109246000},"page":"196-206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Emerging evidence of artemin\/GFR\u03b13 signaling in musculoskeletal pain"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2133-8345","authenticated-orcid":false,"given":"Ankita","family":"Gupta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh K.","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B. Duncan X.","family":"Lascelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2024.09.010_bib1","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(18)32279-7","article-title":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"GBD 2017 Disease and Injury Incidence and Prevalence Collaborators","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.joca.2024.09.010_bib2","series-title":"Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education, and Research","author":"Institute of Medicine (US) Committee on Advancing Pain Research, Care, and Education","year":"2011"},{"key":"10.1016\/j.joca.2024.09.010_bib3","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","article-title":"Central sensitization: implications for the diagnosis and treatment of pain","volume":"152","author":"Woolf","year":"2011","journal-title":"Pain"},{"key":"10.1016\/j.joca.2024.09.010_bib4","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1186\/s12889-018-5740-y","article-title":"Comorbid symptoms of depression and musculoskeletal pain and risk of long term sickness absence","volume":"18","author":"Melkevik","year":"2018","journal-title":"BMC Public Health"},{"key":"10.1016\/j.joca.2024.09.010_bib5","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11916-012-0286-7","article-title":"Anxiety and fear-avoidance in musculoskeletal pain","volume":"16","author":"Lucchetti","year":"2012","journal-title":"Curr Pain Headache Rep"},{"key":"10.1016\/j.joca.2024.09.010_bib6","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1136\/jech-2019-212734","article-title":"Influence of sleep problems and co-occurring musculoskeletal pain on long-term prognosis of chronic low back pain: the HUNT Study","volume":"74","author":"Skarpsno","year":"2020","journal-title":"J Epidemiol Community Health"},{"key":"10.1016\/j.joca.2024.09.010_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugpo.2021.103392","article-title":"Changes in characteristics of drug overdose death trends during the COVID-19 pandemic","volume":"98","author":"DiGennaro","year":"2021","journal-title":"Int J Drug Policy"},{"key":"10.1016\/j.joca.2024.09.010_bib8","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.tcb.2004.05.011","article-title":"Rita Levi-Montalcini: the discovery of nerve growth factor and modern neurobiology","volume":"14","author":"Aloe","year":"2004","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.joca.2024.09.010_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1186\/1479-5876-10-239","article-title":"Nerve growth factor: from the early discoveries to the potential clinical use","volume":"10","author":"Aloe","year":"2012","journal-title":"J Transl Med"},{"key":"10.1016\/j.joca.2024.09.010_bib10","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.2147\/JPR.S247472","article-title":"Nerve growth factor signaling and its contribution to pain","volume":"13","author":"Barker","year":"2020","journal-title":"J Pain Res"},{"key":"10.1016\/j.joca.2024.09.010_bib11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1515\/revneuro-2022-0037","article-title":"Involvement of nerve growth factor (NGF) in chronic neuropathic pain \u2013 a systematic review","volume":"34","author":"Reis","year":"2022","journal-title":"Rev Neurosci"},{"issue":"Suppl 107","key":"10.1016\/j.joca.2024.09.010_bib12","first-page":"85","article-title":"Current status of nerve growth factor antibodies for the treatment of osteoarthritis pain","volume":"35","author":"Miller","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.joca.2024.09.010_bib13","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12860","article-title":"The role of glial cell line-derived neurotrophic factor family member artemin in neurological disorders and cancers","volume":"53","author":"Zhu","year":"2020","journal-title":"Cell Prolif"},{"key":"10.1016\/j.joca.2024.09.010_bib14","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00441-020-03227-4","article-title":"Glial cell line-derived neurotrophic factors (GFLs) and small molecules targeting RET receptor for the treatment of pain and Parkinson's disease","volume":"382","author":"Mahato","year":"2020","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.joca.2024.09.010_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1146\/annurev.ne.19.030196.001445","article-title":"Physiology of the neurotrophins","volume":"19","author":"Lewin","year":"1996","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib16","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0896-6273(02)00774-2","article-title":"Artemin is a vascular-derived neurotropic factor for developing sympathetic neurons","volume":"35","author":"Honma","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.joca.2024.09.010_bib17","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1038\/nrn2057","article-title":"Specification and connectivity of neuronal subtypes in the sensory lineage","volume":"8","author":"Marmigere","year":"2007","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib18","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S0896-6273(00)80649-2","article-title":"Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex","volume":"21","author":"Baloh","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.joca.2024.09.010_bib19","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/dvdy.10294","article-title":"Developmental changes in neurite outgrowth responses of dorsal root and sympathetic ganglia to GDNF, neurturin, and artemin","volume":"227","author":"Yan","year":"2003","journal-title":"Dev Dyn"},{"key":"10.1016\/j.joca.2024.09.010_bib20","doi-asserted-by":"crossref","first-page":"3685","DOI":"10.1242\/dev.128.19.3685","article-title":"Multiple effects of artemin on sympathetic neurone generation, survival and growth","volume":"128","author":"Andres","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.joca.2024.09.010_bib21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.brainresbull.2004.10.012","article-title":"The GDNF family members neurturin, artemin and persephin promote the morphological differentiation of cultured ventral mesencephalic dopaminergic neurons","volume":"68","author":"Zihlmann","year":"2005","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.joca.2024.09.010_bib22","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1038\/s41598-017-01772-7","article-title":"Interactome and reciprocal activation of pathways in topical mesenchymal stem cells and the recipient cerebral cortex following traumatic brain injury","volume":"7","author":"Lam","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.joca.2024.09.010_bib23","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1046\/j.1432-1327.1999.00925.x","article-title":"Enovin, a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. Existence and tissue-specific expression of different splice variants","volume":"266","author":"Masure","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.joca.2024.09.010_bib24","doi-asserted-by":"crossref","first-page":"6801","DOI":"10.1021\/bi060035x","article-title":"Artemin crystal structure reveals insights into heparan sulfate binding","volume":"45","author":"Silvian","year":"2006","journal-title":"Biochemistry"},{"key":"10.1016\/j.joca.2024.09.010_bib25","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/mcne.1999.0817","article-title":"In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin\/artemin","volume":"15","author":"Rosenblad","year":"2000","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib26","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S0092-8674(03)00435-5","article-title":"The neural cell adhesion molecule NCAM is an alternative signaling receptor for GDNF family ligands","volume":"113","author":"Paratcha","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.joca.2024.09.010_bib27","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1083\/jcb.201009136","article-title":"Heparan sulfate proteoglycan syndecan-3 is a novel receptor for GDNF, neurturin, and artemin","volume":"192","author":"Bespalov","year":"2011","journal-title":"J Cell Biol"},{"key":"10.1016\/j.joca.2024.09.010_bib28","doi-asserted-by":"crossref","first-page":"12543","DOI":"10.1523\/JNEUROSCI.5765-12.2013","article-title":"Artemin, a glial cell line-derived neurotrophic factor family member, induces TRPM8-dependent cold pain","volume":"33","author":"Lippoldt","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fnmol.2019.00047","article-title":"Artemin and an artemin-derived peptide, artefin, induce neuronal survival, and differentiation through Ret and NCAM","volume":"12","author":"Ilieva","year":"2019","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib30","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.brainres.2008.06.119","article-title":"Overexpression of artemin in the tongue increases expression of TRPV1 and TRPA1 in trigeminal afferents and causes oral sensitivity to capsaicin and mustard oil","volume":"1230","author":"Elitt","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.joca.2024.09.010_bib31","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1097\/j.pain.0000000000000322","article-title":"Involvement of peripheral artemin signaling in tongue pain: possible mechanism in burning mouth syndrome","volume":"156","author":"Shinoda","year":"2015","journal-title":"Pain"},{"key":"10.1016\/j.joca.2024.09.010_bib32","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1136\/gut.2006.105528","article-title":"The neurotrophic factor artemin influences the extent of neural damage and growth in chronic pancreatitis","volume":"56","author":"Ceyhan","year":"2007","journal-title":"Gut"},{"key":"10.1016\/j.joca.2024.09.010_bib33","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.jaci.2012.05.027","article-title":"Artemin causes hypersensitivity to warm sensation, mimicking warmth-provoked pruritus in atopic dermatitis","volume":"130","author":"Murota","year":"2012","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.joca.2024.09.010_bib34","first-page":"286","article-title":"Dermal fibroblasts in atopic dermatitis skin lesion synthesize ARTEMIN reactive with peripheral nerve","volume":"19","author":"Murota","year":"2008","journal-title":"Dermatitis\u00ae"},{"key":"10.1016\/j.joca.2024.09.010_bib35","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ni.3614","article-title":"The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin","volume":"18","author":"Hidaka","year":"2017","journal-title":"Nat Immunol"},{"key":"10.1016\/j.joca.2024.09.010_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039411","article-title":"Local gene expression changes after UV-irradiation of human skin","volume":"7","author":"Weinkauf","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2024.09.010_bib37","doi-asserted-by":"crossref","first-page":"6682","DOI":"10.1038\/s41598-021-85976-y","article-title":"Serum artemin is not correlated with sensitivity within dogs with naturally occurring osteoarthritis pain","volume":"11","author":"Gupta","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.joca.2024.09.010_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.738976","article-title":"Investigating the role of artemin and its cognate receptor, GFRalpha3, in osteoarthritis pain","volume":"16","author":"Minnema","year":"2022","journal-title":"Front Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib39","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3389\/fnins.2020.00077","article-title":"Correlation of artemin and GFRalpha3 with osteoarthritis pain: early evidence from naturally occurring osteoarthritis-associated chronic pain in dogs","volume":"14","author":"Minnema","year":"2020","journal-title":"Front Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib40","unstructured":"Minnema LM. The Role of GFR\u03b13\/Artemin in Chronic Osteoarthritis-Associated Pain. Ph.D. thesis, North Carolina State University; 2020."},{"key":"10.1016\/j.joca.2024.09.010_bib41","doi-asserted-by":"crossref","first-page":"5801","DOI":"10.1073\/pnas.95.10.5801","article-title":"GFRalpha3 is an orphan member of the GDNF\/neurturin\/persephin receptor family","volume":"95","author":"Baloh","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joca.2024.09.010_bib42","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3349\/ymj.2004.45.2.306","article-title":"Expression of down stream molecules of RET (p-ERK, p-p38 MAPK, p-JNK and p-AKT) in papillary thyroid carcinomas","volume":"45","author":"Shin","year":"2004","journal-title":"Yonsei Med J"},{"key":"10.1016\/j.joca.2024.09.010_bib43","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0304-3835(03)00456-7","article-title":"RET and neuroendocrine tumors","volume":"204","author":"Ichihara","year":"2004","journal-title":"Cancer Lett"},{"key":"10.1016\/j.joca.2024.09.010_bib44","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/cbf.1436","article-title":"Artemin activates axonal growth via SFK and ERK-dependent signalling pathways in mature dorsal root ganglia neurons","volume":"26","author":"Jeong","year":"2008","journal-title":"Cell Biochem Funct"},{"key":"10.1016\/j.joca.2024.09.010_bib45","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.mcn.2015.03.004","article-title":"Neurite outgrowth in normal and injured primary sensory neurons reveals different regulation by nerve growth factor (NGF) and artemin","volume":"65","author":"Wong","year":"2015","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib46","doi-asserted-by":"crossref","first-page":"6238","DOI":"10.1073\/pnas.94.12.6238","article-title":"Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins","volume":"94","author":"Sanicola","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joca.2024.09.010_bib47","doi-asserted-by":"crossref","first-page":"3953","DOI":"10.1523\/JNEUROSCI.22-10-03953.2002","article-title":"Glial cell line-derived neurotrophic factor promotes the survival of early postnatal spinal motor neurons in the lateral and medial motor columns in slice culture","volume":"22","author":"Rakowicz","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib48","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1529-8027.2006.00106.x","article-title":"Artemin has potent neurotrophic actions on injured C-fibres","volume":"11","author":"Bennett","year":"2006","journal-title":"J Peripher Nerv Syst"},{"key":"10.1016\/j.joca.2024.09.010_bib49","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1021\/bi049247p","article-title":"Glial cell line-derived neurotrophic factor (GDNF) receptor alpha-1 (GFR alpha 1) is highly selective for GDNF versus artemin","volume":"44","author":"Carmillo","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.joca.2024.09.010_bib50","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1074\/jbc.M006157200","article-title":"Determinants of ligand binding specificity in the glial cell line-derived neurotrophic factor family receptor alpha S","volume":"276","author":"Scott","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joca.2024.09.010_bib51","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1523\/JNEUROSCI.4552-06.2007","article-title":"Glial cell line-derived neurotrophic factor and neurturin inhibit neurite outgrowth and activate RhoA through GFR alpha 2b, an alternatively spliced isoform of GFR alpha 2","volume":"27","author":"Yoong","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib52","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1046\/j.0953-816x.2001.01596.x","article-title":"GFRalpha3 is expressed predominantly in nociceptive sensory neurons","volume":"13","author":"Orozco","year":"2001","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib53","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1002\/cne.1380","article-title":"GDNF and NGF family members and receptors in human fetal and adult spinal cord and dorsal root ganglia","volume":"440","author":"Josephson","year":"2001","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.joca.2024.09.010_bib54","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuroscience.2017.11.047","article-title":"Human vs. mouse nociceptors \u2013 similarities and differences","volume":"387","author":"Rostock","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.joca.2024.09.010_bib55","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2018.06.021","article-title":"Molecular architecture of the mouse nervous system","volume":"174","author":"Zeisel","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.joca.2024.09.010_bib56","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj8186","article-title":"Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors","volume":"14","author":"Tavares-Ferreira","year":"2022","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.joca.2024.09.010_bib57","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1016\/j.joca.2023.06.003","article-title":"Artemin sensitizes nociceptors that innervate the osteoarthritic joint to produce pain","volume":"31","author":"Morgan","year":"2023","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.09.010_bib58","doi-asserted-by":"crossref","first-page":"4899","DOI":"10.1523\/JNEUROSCI.0421-18.2018","article-title":"GDNF, neurturin, and artemin activate and sensitize bone afferent neurons and contribute to inflammatory bone pain","volume":"38","author":"Nencini","year":"2018","journal-title":"J Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib59","first-page":"2771","article-title":"Convergence of peptidergic and non-peptidergic protein markers in the human dorsal root ganglion and spinal dorsal horn","volume":"529","author":"Shiers","year":"2021","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.joca.2024.09.010_bib60","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1093\/brain\/awac266","article-title":"RNA profiling of human dorsal root ganglia reveals sex differences in mechanisms promoting neuropathic pain","volume":"146","author":"Ray","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.joca.2024.09.010_bib61","doi-asserted-by":"crossref","first-page":"8578","DOI":"10.1523\/JNEUROSCI.2185-06.2006","article-title":"Artemin overexpression in skin enhances expression of TRPV1 and TRPA1 in cutaneous sensory neurons and leads to behavioral sensitivity to heat and cold","volume":"26","author":"Elitt","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib62","doi-asserted-by":"crossref","first-page":"8588","DOI":"10.1523\/JNEUROSCI.1726-06.2006","article-title":"Glial cell line-derived neurotrophic factor family members sensitize nociceptors in vitro and produce thermal hyperalgesia in vivo","volume":"26","author":"Malin","year":"2006","journal-title":"J Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib63","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12990-015-0004-7","article-title":"Peripherally increased artemin is a key regulator of TRPA1\/V1 expression in primary afferent neurons","volume":"11","author":"Ikeda-Miyagawa","year":"2015","journal-title":"Mol Pain"},{"key":"10.1016\/j.joca.2024.09.010_bib64","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.jpain.2015.03.014","article-title":"Artemin immunotherapy is effective in preventing and reversing cystitis-induced bladder hyperalgesia via TRPA1 regulation","volume":"16","author":"DeBerry","year":"2015","journal-title":"J Pain"},{"key":"10.1016\/j.joca.2024.09.010_bib65","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1097\/j.pain.0000000000002831","article-title":"Molecular taxonomy of nociceptors and pruriceptors","volume":"164","author":"Kupari","year":"2023","journal-title":"Pain"},{"key":"10.1016\/j.joca.2024.09.010_bib66","unstructured":"Regeneron Pharmaceuticals Inc. UNITED STATES SECURITIES AND EXCHANGE COMMISSION, Form 8K; 2019 \u3008https:\/\/investor.regeneron.com\/static-files\/3c233731-2ff1-41dd-a8f7-e57d3e0f8a54\u3009."},{"key":"10.1016\/j.joca.2024.09.010_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2024.103267","article-title":"Diverse immunological dysregulation, chronic inflammation, and impaired erythropoiesis in long COVID patients with chronic fatigue syndrome","volume":"147","author":"Saito","year":"2024","journal-title":"J Autoimmun"},{"key":"10.1016\/j.joca.2024.09.010_bib68","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abh2169","article-title":"A single-cell type transcriptomics map of human tissues","volume":"7","author":"Karlsson","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.joca.2024.09.010_bib69","doi-asserted-by":"crossref","DOI":"10.1126\/science.aal3321","article-title":"A subcellular map of the human proteome","volume":"356","author":"Thul","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.joca.2024.09.010_bib70","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.joca.2024.09.010_bib71","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.neulet.2013.04.007","article-title":"Artemin-GFRalpha3 interactions partially contribute to acute inflammatory hypersensitivity","volume":"545","author":"Thornton","year":"2013","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.joca.2024.09.010_bib72","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1744-8069-7-41","article-title":"Inhibition of TRPA1 channel activity in sensory neurons by the glial cell line-derived neurotrophic factor family member, artemin","volume":"7","author":"Yoshida","year":"2011","journal-title":"Mol Pain"},{"key":"10.1016\/j.joca.2024.09.010_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynpai.2023.100136","volume":"14","author":"Somersan-Karakaya","year":"2023","journal-title":"Neurobiol Pain"},{"key":"10.1016\/j.joca.2024.09.010_bib74","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00190-19","article-title":"Aryl hydrocarbon receptor directly regulates artemin gene expression","volume":"39","author":"Edamitsu","year":"2019","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.joca.2024.09.010_bib75","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1073\/pnas.1603294113","article-title":"Inflammatory and neuropathic cold allodynia are selectively mediated by the neurotrophic factor receptor GFRalpha3","volume":"113","author":"Lippoldt","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joca.2024.09.010_bib76","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0896-6273(01)00585-2","article-title":"NGF utilizes c-Ret via a novel GFL-independent, inter-RTK signaling mechanism to maintain the trophic status of mature sympathetic neurons","volume":"33","author":"Tsui-Pierchala","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.joca.2024.09.010_bib77","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0896-6273(01)80031-3","article-title":"GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion","volume":"23","author":"Nishino","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.joca.2024.09.010_bib78","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.679034","article-title":"Glial cell line-derived neurotrophic factor family ligands, players at the interface of neuroinflammation and neuroprotection: focus onto the glia","volume":"15","author":"Kotliarova","year":"2021","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib79","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1038\/nm944","article-title":"Multiple actions of systemic artemin in experimental neuropathy","volume":"9","author":"Gardell","year":"2003","journal-title":"Nat Med"},{"key":"10.1016\/j.joca.2024.09.010_bib80","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.pain.2013.11.007","article-title":"Artemin induced functional recovery and reinnervation after partial nerve injury","volume":"155","author":"Wang","year":"2014","journal-title":"Pain"},{"key":"10.1016\/j.joca.2024.09.010_bib81","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/01926230490431475","article-title":"The candidate neuroprotective agent artemin induces autonomic neural dysplasia without preventing peripheral nerve dysfunction","volume":"32","author":"Bolon","year":"2004","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.joca.2024.09.010_bib82","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/nn2069","article-title":"Persistent restoration of sensory function by immediate or delayed systemic artemin after dorsal root injury","volume":"11","author":"Wang","year":"2008","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.joca.2024.09.010_bib83","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/bcp.12941","article-title":"Pharmacokinetics and pharmacodynamics of multiple doses of BG00010, a neurotrophic factor with anti-hyperalgesic effects, in patients with sciatica","volume":"82","author":"Okkerse","year":"2016","journal-title":"Br J Clin Pharmacol"},{"key":"10.1016\/j.joca.2024.09.010_bib84","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0125034","article-title":"First-in-human, double-blind, placebo-controlled, randomized, dose-escalation study of BG00010, a glial cell line-derived neurotrophic factor family member, in subjects with unilateral sciatica","volume":"10","author":"Rolan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2024.09.010_bib85","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1097\/j.pain.0000000000000983","article-title":"Safety and efficacy of neublastin in painful lumbosacral radiculopathy: a randomized, double-blinded, placebo-controlled phase 2 trial using Bayesian adaptive design (the SPRINT trial)","volume":"158","author":"Backonja","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.joca.2024.09.010_bib86","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ejphar.2014.05.048","article-title":"Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis","volume":"738","author":"Ishikawa","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.joca.2024.09.010_bib87","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.tips.2004.04.008","article-title":"Pain-like behaviours in animals \u2013 how human are they?","volume":"25","author":"Blackburn-Munro","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.joca.2024.09.010_bib88","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/ejp.1315","article-title":"Sequestration of artemin reduces inflammation-induced activation and sensitization of bone marrow nociceptors in a rodent model of carrageenan-induced inflammatory bone pain","volume":"23","author":"Nencini","year":"2019","journal-title":"Eur J Pain"},{"key":"10.1016\/j.joca.2024.09.010_bib89","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1001\/jama.2020.22171","article-title":"Diagnosis and treatment of hip and knee osteoarthritis: a review","volume":"325","author":"Katz","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.joca.2024.09.010_bib90","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.09.010_bib91","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1002\/j.1532-2149.2013.00332.x","article-title":"The prevalence of widespread central hypersensitivity in chronic pain patients","volume":"17","author":"Schliessbach","year":"2013","journal-title":"Eur J Pain"},{"key":"10.1016\/j.joca.2024.09.010_bib92","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/acr.20373","article-title":"Pain sensitivity and pain reactivity in osteoarthritis","volume":"63","author":"Lee","year":"2011","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.joca.2024.09.010_bib93","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1097\/j.pain.0000000000000521","article-title":"Widespread somatosensory sensitivity in naturally occurring canine model of osteoarthritis","volume":"157","author":"Knazovicky","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.joca.2024.09.010_bib94","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1016\/j.pain.2013.05.039","article-title":"Patterns of multisite pain and associations with risk factors","volume":"154","author":"Coggon","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.joca.2024.09.010_bib95","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1002\/art.42530","article-title":"Age-associated changes in knee osteoarthritis, pain-related behaviors, and dorsal root ganglia immunophenotyping of male and female mice","volume":"75","author":"Geraghty","year":"2023","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.joca.2024.09.010_bib96","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1186\/s13075-015-0747-6","article-title":"On the predictive utility of animal models of osteoarthritis","volume":"17","author":"Malfait","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.joca.2024.09.010_bib97","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.joca.2020.01.008","article-title":"Microarray analyses of the dorsal root ganglia support a role for innate neuro-immune pathways in persistent pain in experimental osteoarthritis","volume":"28","author":"Miller","year":"2020","journal-title":"Osteoarthritis Cartilage"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458424014043?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458424014043?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T10:48:00Z","timestamp":1737629280000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458424014043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":97,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S1063458424014043"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2024.09.010","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Emerging evidence of artemin\/GFR\u03b13 signaling in musculoskeletal pain","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2024.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}