{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T01:47:02Z","timestamp":1793065622517,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:00:00Z","timestamp":1733184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2022R1I1A1A01054359"],"award-info":[{"award-number":["2022R1I1A1A01054359"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2016R1A3B1906090"],"award-info":[{"award-number":["2016R1A3B1906090"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.joca.2024.11.010","type":"journal-article","created":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T03:30:24Z","timestamp":1733196624000},"page":"426-436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fibroblast growth factor 7 (FGF7) causes cartilage destruction, subchondral bone remodeling, and the premature growth plate closure in mice"],"prefix":"10.1016","volume":"33","author":[{"given":"Youngnim","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Sun","family":"Kwak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seul Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-181X","authenticated-orcid":false,"given":"Jang-Soo","family":"Chun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2024.11.010_bib1","article-title":"Osteoarthritis: toward a comprehensive understanding of pathological mechanism","volume":"17","author":"Chen","year":"2017","journal-title":"Bone Res"},{"key":"10.1016\/j.joca.2024.11.010_bib2","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41584-023-00966-w","article-title":"Matrix metalloproteinases in arthritis: towards precision medicine","volume":"19","author":"Grillet","year":"2023","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2024.11.010_bib3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1002\/art.22337","article-title":"Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3","volume":"56","author":"Blom","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.11.010_bib4","doi-asserted-by":"crossref","first-page":"3723","DOI":"10.1002\/art.25002","article-title":"Matrix metalloproteinase 13-deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development","volume":"60","author":"Little","year":"2009","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.11.010_bib5","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/nature03369","article-title":"Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis","volume":"434","author":"Glasson","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.joca.2024.11.010_bib6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3892\/mmr.2022.12615","article-title":"Cartilage tissue engineering from proinflammatory and ant-inflammatory cytokines to osteoarthritis treatment (review)","volume":"25","author":"Liu","year":"2022","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.joca.2024.11.010_bib7","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nm.2153","article-title":"Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction","volume":"16","author":"Yang","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.joca.2024.11.010_bib8","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.cell.2014.01.007","article-title":"Regulation of the catabolic cascade in osteoarthritis by the zinc-ZIP8-MTF1 axis","volume":"156","author":"Kim","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.joca.2024.11.010_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2020.607764","article-title":"Subchondral bone remodeling: a therapeutic target for osteoarthritis","volume":"8","author":"Zhu","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.joca.2024.11.010_bib10","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1302\/2046-3758.129.BJR-2023-0081.R1","article-title":"The role of cells and signal pathways in subchondral bone in osteoarthritis","volume":"12","author":"Luo","year":"2023","journal-title":"Bone Joint Res"},{"key":"10.1016\/j.joca.2024.11.010_bib11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fbioe.2018.00018","article-title":"Recent insights into the contribution of the changing hypertrophic chondrocyte phenotype in the development and progression of osteoarthritis","volume":"6","author":"Ripmeester","year":"2018","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.joca.2024.11.010_bib12","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.joca.2021.07.003","article-title":"Tyrosine kinases regulate chondrocyte hypertrophy: promising drug targets for osteoarthritis","volume":"29","author":"Ferrao Blanco","year":"2021","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.11.010_bib13","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41584-020-0469-2","article-title":"Fibroblast growth factor signaling in osteoarthritis and cartilage repair","volume":"16","author":"Xie","year":"2020","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.joca.2024.11.010_bib14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2474-11-19","article-title":"Analysis of meniscal degeneration and meniscal gene expression","volume":"11","author":"Sun","year":"2010","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.joca.2024.11.010_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121804","article-title":"The role of fibroblast growth factor 7 in cartilage development and diseases","volume":"326","author":"Zhang","year":"2023","journal-title":"Life Sci"},{"key":"10.1016\/j.joca.2024.11.010_bib16","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthritis Cartilage"},{"issue":"3","key":"10.1016\/j.joca.2024.11.010_bib17","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative \u2013 recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.11.010_bib18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: discrimination between chronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology"},{"key":"10.1016\/j.joca.2024.11.010_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-66979-7","article-title":"Histological scoring system for subchondral bone changes in murine models of joint aging and osteoarthritis","volume":"10","author":"Nagira","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.joca.2024.11.010_bib20","doi-asserted-by":"crossref","first-page":"2892","DOI":"10.1210\/en.2013-2175","article-title":"Evidence that estrogen hastens epiphyseal fusion and cessation of longitudinal bone growth by irreversibly depleting the number of resting zone progenitor cells in female rabbits","volume":"155","author":"Nilsson","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.joca.2024.11.010_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41419-018-1284-4","article-title":"CYTL1 regulates bone homeostasis in mice by modulating osteogenesis of mesenchymal stem cells and osteoclastogenesis of bone marrow-derived macrophages","volume":"10","author":"Shin","year":"2019","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.joca.2024.11.010_bib22","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1016321","article-title":"Accuracy of in vivo microCT imaging in assessing the microstructural properties of the mouse tibia subchondral bone","volume":"13","author":"Oliviero","year":"2023","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.joca.2024.11.010_bib23","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/jbmr.1583","article-title":"Misexpression of Dickkopf-1 in endothelial cells, but not in chondrocytes or hypertrophic chondrocytes, causes defects in endochondral ossification","volume":"27","author":"Oh","year":"2012","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joca.2024.11.010_bib24","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1002\/art.30451","article-title":"Interleukin-6 plays an essential role in hypoxia-inducible factor 2\u03b1-induced experimental osteoarthritic cartilage destruction in mice","volume":"63","author":"Ryu","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.11.010_bib25","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/nprot.2008.95","article-title":"Primary culture and phenotyping of murine chondrocytes","volume":"3","author":"Gosset","year":"2008","journal-title":"Nat Protoc"},{"key":"10.1016\/j.joca.2024.11.010_bib26","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00441-002-0562-7","article-title":"Redifferentiation of dedifferentiated human chondrocytes in high-density cultures","volume":"308","author":"Schulze-Tanzil","year":"2002","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.joca.2024.11.010_bib27","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1016\/j.joca.2015.03.024","article-title":"Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes","volume":"23","author":"Nagai","year":"2015","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.11.010_bib28","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/s41586-019-0920-1","article-title":"The CH25H-CYP7B1-ROR\u03b1 axis of cholesterol metabolism regulates osteoarthritis","volume":"566","author":"Choi","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.joca.2024.11.010_bib29","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/561459","article-title":"The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis","volume":"2014","author":"Wojdasiewicz","year":"2014","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.joca.2024.11.010_bib30","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.3390\/ijms21186665","article-title":"Hedgehog signaling in skeletal development: roles of indian hedgehog and the mode of its action","volume":"21","author":"Ohba","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.joca.2024.11.010_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.mbplus.2021.100088","article-title":"Runx2 is required for hypertrophic chondrocyte mediated degradation of cartilage matrix during endochondral ossification","volume":"12","author":"Rashid","year":"2021","journal-title":"Matrix Biol Plus"},{"key":"10.1016\/j.joca.2024.11.010_bib32","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.3390\/ijms19071875","article-title":"FGF family: from drug development to clinical application","volume":"19","author":"Hui","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.joca.2024.11.010_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.367","article-title":"FGFR families: biological functions and therapeutic interventions in tumors","volume":"4","author":"Liu","year":"2023","journal-title":"MedComm"},{"key":"10.1016\/j.joca.2024.11.010_bib34","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.mcna.2008.09.006","article-title":"Role of bone in osteoarthritis pathogenesis","volume":"93","author":"Goldring","year":"2009","journal-title":"Med Clin North Am"},{"key":"10.1016\/j.joca.2024.11.010_bib35","article-title":"The biology of normal bone remodelling","volume":"26","author":"Katsimbri","year":"2017","journal-title":"Eur J Cancer Care"},{"key":"10.1016\/j.joca.2024.11.010_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2022.997838","article-title":"Suppressor of fused-restrained Hedgehog signaling in chondrocytes is critical for epiphyseal growth plate maintenance and limb elongation in juvenile mice","volume":"10","author":"Xiu","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"10.1016\/j.joca.2024.11.010_bib37","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2019152118","article-title":"SOX9 keeps growth plates and articular cartilage healthy by inhibiting chondrocyte dedifferentiation\/osteoblastic redifferentiation","volume":"118","author":"Haseeb","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.joca.2024.11.010_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204172","article-title":"Exogenous C-type natriuretic peptide restores normal growth and prevents early growth plate closure in its deficient rats","volume":"13","author":"Hirota","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2024.11.010_bib39","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.2353\/ajpath.2009.081173","article-title":"Transient activation of Wnt\/\u03b2-catenin signaling induces abnormal growth plate closure and articular cartilage thickening in postnatal mice","volume":"175","author":"Yuasa","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.joca.2024.11.010_bib40","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/jcb.20389","article-title":"Over-expression of fibroblast growth factor-2 causes defective bone mineralization and osteopenia in transgenic mice","volume":"95","author":"Sobue","year":"2005","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.joca.2024.11.010_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.734988","article-title":"Characterisation of growth plate dynamics in murine models of osteoarthritis","volume":"12","author":"Samvelyan","year":"2021","journal-title":"Front Endocrinol"},{"key":"10.1016\/j.joca.2024.11.010_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67518-0","article-title":"Disorganization of chondrocyte columns in the growth plate does not aggravate experimental osteoarthritis in mice","volume":"10","author":"Lamuedra","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.joca.2024.11.010_bib43","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/art.39508","article-title":"Endochondral growth defect and deployment of transient chondrocyte behaviors underlie osteoarthritis onset in a natural murine model","volume":"68","author":"Staines","year":"2016","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.joca.2024.11.010_bib44","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1080\/03008200600883146","article-title":"Transient exposure of fibroblast growth factor-2 induced proliferative but not destructive change in mouse knee joints","volume":"47","author":"Jingushi","year":"2006","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.joca.2024.11.010_bib45","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.joca.2022.09.010","article-title":"Intra-articular kinetics of a cartilage targeting cationic PEGylated protein for applications in drug delivery","volume":"31","author":"He","year":"2023","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2024.11.010_bib46","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/19476035221128084","article-title":"Analysis of association between morphometric parameters of growth plate and bone growth of tibia in mice and humans","volume":"13","author":"Wilson","year":"2022","journal-title":"Cartilage"},{"key":"10.1016\/j.joca.2024.11.010_bib47","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1128\/MCB.00291-13","article-title":"ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes","volume":"33","author":"Hall","year":"2013","journal-title":"Mol Cell Biol"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345842401478X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345842401478X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T22:22:02Z","timestamp":1778797322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S106345842401478X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S106345842401478X"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2024.11.010","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fibroblast growth factor 7 (FGF7) causes cartilage destruction, subchondral bone remodeling, and the premature growth plate closure in mice","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2024.11.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}