{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T03:12:49Z","timestamp":1791947569149,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["849200003"],"award-info":[{"award-number":["849200003"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.joca.2025.03.006","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T03:24:50Z","timestamp":1744255490000},"page":"1237-1245","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Associations between testosterone and knee and hand osteoarthritis among males and females from the general population"],"prefix":"10.1016","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2348-3936","authenticated-orcid":false,"given":"Ingrid A.","family":"Szilagyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1293-6346","authenticated-orcid":false,"given":"Dieuwke","family":"Schiphof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Layal","family":"Chaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4809-0044","authenticated-orcid":false,"given":"Cindy G.","family":"Boer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Aribas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5976-6519","authenticated-orcid":false,"given":"Maryam","family":"Kavousi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Arfan","family":"Ikram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sita M.A.","family":"Bierma-Zeinstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce B.J.","family":"van Meurs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2025.03.006_bib1","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.joca.2025.03.006_bib2","first-page":"483","article-title":"Hormone changes associated with the menopausal transition","volume":"61","author":"Su","year":"2009","journal-title":"Minerva Ginecol"},{"key":"10.1016\/j.joca.2025.03.006_bib3","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1093\/rheumatology\/kep194","article-title":"No clear association between female hormonal aspects and osteoarthritis of the hand, hip and knee: a systematic review","volume":"48","author":"de Klerk","year":"2009","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.joca.2025.03.006_bib4","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1097\/j.pain.0000000000000535","article-title":"Lower sex hormone levels are associated with more chronic musculoskeletal pain in community-dwelling elderly women","volume":"157","author":"de Kruijf","year":"2016","journal-title":"Pain"},{"key":"10.1016\/j.joca.2025.03.006_bib5","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.steroids.2010.10.010","article-title":"Reexamination of testosterone, dihydrotestosterone, estradiol and estrone levels across the menstrual cycle and in postmenopausal women measured by liquid chromatography-tandem mass spectrometry","volume":"76","author":"Rothman","year":"2011","journal-title":"Steroids"},{"key":"10.1016\/j.joca.2025.03.006_bib6","doi-asserted-by":"crossref","first-page":"e225","DOI":"10.1016\/S2665-9913(23)00060-7","article-title":"The influence of sex hormones on musculoskeletal pain and osteoarthritis","volume":"5","author":"Gulati","year":"2023","journal-title":"Lancet Rheumatol"},{"key":"10.1016\/j.joca.2025.03.006_bib7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/13685538.2018.1504914","article-title":"Mobility and biomechanical functions in the aging male: testosterone and the locomotive syndrome","volume":"23","author":"Fink","year":"2020","journal-title":"Aging Male"},{"key":"10.1016\/j.joca.2025.03.006_bib8","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1093\/humrep\/deu198","article-title":"The striking similarities in the metabolic associations of female androgen excess and male androgen deficiency","volume":"29","author":"Escobar-Morreale","year":"2014","journal-title":"Hum Reprod"},{"key":"10.1016\/j.joca.2025.03.006_bib9","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/gerona\/gls068","article-title":"The role of androgens and estrogens on healthy aging and longevity","volume":"67","author":"Horstman","year":"2012","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.joca.2025.03.006_bib10","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1093\/oxfordjournals.aje.a008655","article-title":"Association of bone mineral density and sex hormone levels with osteoarthritis of the hand and knee in premenopausal women","volume":"143","author":"Sowers","year":"1996","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.joca.2025.03.006_bib11","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1093\/rheumatology\/keg073","article-title":"Factors affecting knee cartilage volume in healthy men","volume":"42","author":"Cicuttini","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.joca.2025.03.006_bib12","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1136\/ard.2004.029355","article-title":"Factors influencing longitudinal change in knee cartilage volume measured from magnetic resonance imaging in healthy men","volume":"64","author":"Hanna","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2025.03.006_bib13","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s12603-011-0152-z","article-title":"Basal growth hormone concentration increased following a weight loss focused dietary intervention in older overweight and obese women","volume":"16","author":"Miller","year":"2012","journal-title":"J Nutr Health Aging"},{"key":"10.1016\/j.joca.2025.03.006_bib14","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s10654-020-00640-5","article-title":"Objectives, design and main findings until 2020 from the Rotterdam Study","volume":"35","author":"Ikram","year":"2020","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.joca.2025.03.006_bib15","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1210\/jcem.84.10.6079","article-title":"A critical evaluation of simple methods for the estimation of free testosterone in serum","volume":"84","author":"Vermeulen","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.joca.2025.03.006_bib16","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1136\/annrheumdis-2011-201178","article-title":"Association of atherosclerosis with presence and progression of osteoarthritis: the Rotterdam Study","volume":"72","author":"Hoeven","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2025.03.006_bib17","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteo-arthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2025.03.006_bib18","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1136\/ard.2007.079020","article-title":"Differences in descriptions of Kellgren and Lawrence grades of knee osteoarthritis","volume":"67","author":"Schiphof","year":"2008","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.joca.2025.03.006_bib19","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.6547","article-title":"Assessment of mortality disparities by wealth relative to other measures of socioeconomic status among US adults","volume":"5","author":"Glei","year":"2022","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.joca.2025.03.006_bib20","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF01537606","article-title":"The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults","volume":"20","author":"Radloff","year":"1991","journal-title":"J Youth Adolesc"},{"key":"10.1016\/j.joca.2025.03.006_bib21","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1007\/s10654-015-0082-x","article-title":"The Rotterdam Study: 2016 objectives and design update","volume":"30","author":"Hofman","year":"2015","journal-title":"Eur J Epidemiol"},{"key":"10.1016\/j.joca.2025.03.006_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/eci.13866","article-title":"Sex steroids and sex steroid-binding globulin levels amongst middle-aged and elderly men and women from general population","volume":"52","author":"Aribas","year":"2022","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.joca.2025.03.006_bib23","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1007\/s00125-017-4346-8","article-title":"Age at natural menopause and risk of type 2 diabetes: a prospective cohort study","volume":"60","author":"Muka","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.joca.2025.03.006_bib24","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.atherosclerosis.2015.02.013","article-title":"Bone health and coronary artery calcification: the Rotterdam Study","volume":"241","author":"Campos-Obando","year":"2015","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.joca.2025.03.006_bib25","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1093\/rheumatology\/keab378","article-title":"Towards sex-specific osteoarthritis risk models: evaluation of risk factors for knee osteoarthritis in males and females","volume":"61","author":"Szilagyi","year":"2022","journal-title":"Rheumatology (Oxford)"},{"issue":"11","key":"10.1016\/j.joca.2025.03.006_bib26","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1093\/ntr\/ntac066","article-title":"A systematic review and meta-analysis of smoking and circulating sex hormone levels among premenopausal women","volume":"24","author":"Ihenacho","year":"2022","journal-title":"Nicotine Tob Res"},{"key":"10.1016\/j.joca.2025.03.006_bib27","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1001\/jama.295.11.1288","article-title":"Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis","volume":"295","author":"Ding","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.joca.2025.03.006_bib28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tem.2011.09.005","article-title":"Sex hormone-binding globulin and type 2 diabetes mellitus","volume":"23","author":"Le","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.joca.2025.03.006_bib29","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1186\/s12891-021-04511-2","article-title":"Association of depressive symptoms and risk of knee pain: the moderating effect of sex","volume":"22","author":"Hu","year":"2021","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.joca.2025.03.006_bib30","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/humupd\/dmt038","article-title":"The effect of combined oral contraception on testosterone levels in healthy women: a systematic review and meta-analysis","volume":"20","author":"Zimmerman","year":"2014","journal-title":"Hum Reprod Update"},{"key":"10.1016\/j.joca.2025.03.006_bib31","series-title":"R: A language and environment for statistical","author":"Team RC","year":"2021"},{"key":"10.1016\/j.joca.2025.03.006_bib32","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.semarthrit.2006.12.008","article-title":"The relationship between endogenous testosterone, preandrogens, and sex hormone binding globulin and knee joint structure in women at midlife","volume":"37","author":"Hanna","year":"2007","journal-title":"Semin Arthritis Rheum"},{"key":"10.1016\/j.joca.2025.03.006_bib33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0009-8981(77)90276-5","article-title":"Study on the binding of dihydrotestosterone, testosterone and oestradiol with sex hormone binding globulin","volume":"80","author":"Mean","year":"1977","journal-title":"Clin Chim Acta"},{"key":"10.1016\/j.joca.2025.03.006_bib34","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1210\/jc.2015-4106","article-title":"Low free testosterone is associated with hypogonadal signs and symptoms in men with normal total testosterone","volume":"101","author":"Antonio","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.joca.2025.03.006_bib35","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1097\/j.pain.0000000000001985","article-title":"Testosterone protects against the development of widespread muscle pain in mice","volume":"161","author":"Lesnak","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.joca.2025.03.006_bib36","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nn.4053","article-title":"Different immune cells mediate mechanical pain hypersensitivity in male and female mice","volume":"18","author":"Sorge","year":"2015","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.joca.2025.03.006_bib37","doi-asserted-by":"crossref","first-page":"15450","DOI":"10.1523\/JNEUROSCI.3859-11.2011","article-title":"Spinal cord Toll-like receptor 4 mediates inflammatory and neuropathic hypersensitivity in male but not female mice","volume":"31","author":"Sorge","year":"2011","journal-title":"J Neurosci"},{"key":"10.1016\/j.joca.2025.03.006_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.881500","article-title":"Innate immunity at the core of sex differences in osteoarthritic pain?","volume":"13","author":"Valdrighi","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.joca.2025.03.006_bib39","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1016\/j.joca.2017.01.015","article-title":"Associations between endogenous sex hormones and MRI structural changes in patients with symptomatic knee osteoarthritis","volume":"25","author":"Jin","year":"2017","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2025.03.006_bib40","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/acr.24074","article-title":"Total serum testosterone and Western Ontario and McMaster Universities Osteoarthritis Index Pain and Function among older men and women with severe knee osteoarthritis","volume":"72","author":"Freystaetter","year":"2020","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.joca.2025.03.006_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.maturitas.2024.108174","article-title":"Associations between low sex steroid concentrations and incidence of knee and hip replacement for osteoarthritis in community-dwelling older women","volume":"193","author":"Zeng","year":"2025","journal-title":"Maturitas"},{"key":"10.1016\/j.joca.2025.03.006_bib42","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.joca.2018.05.006","article-title":"Is local or central adiposity more strongly associated with incident knee osteoarthritis than the body mass index in men or women?","volume":"26","author":"Culvenor","year":"2018","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.joca.2025.03.006_bib43","unstructured":"Stringa N, Brahimaj A, Trajanoska K, Kiefte-de Jong JC, Ikram MA, Laven JSE, et al. Endogenous sex steroid levels and SHBG relate with 5-year changes in body composition in postmenopausal women. Novel Risk Markers for Type 2 Diabetes: 167."},{"key":"10.1016\/j.joca.2025.03.006_bib44","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1161\/CIRCRESAHA.117.311681","article-title":"Associations of endogenous estradiol and testosterone levels with plaque composition and risk of stroke in subjects with carotid atherosclerosis","volume":"122","author":"Glisic","year":"2018","journal-title":"Circ Res"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458425008787?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458425008787?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:55:54Z","timestamp":1790826954000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458425008787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S1063458425008787"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2025.03.006","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations between testosterone and knee and hand osteoarthritis among males and females from the general population","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2025.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}