{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:14:19Z","timestamp":1793394859017,"version":"4.5.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AR077019"],"award-info":[{"award-number":["R01AR077019"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AR079206"],"award-info":[{"award-number":["P30AR079206"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AR060364"],"award-info":[{"award-number":["R01AR060364"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["1R21AR085242"],"award-info":[{"award-number":["1R21AR085242"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AR064251"],"award-info":[{"award-number":["R01AR064251"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG049617"],"award-info":[{"award-number":["AG049617"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AR078268"],"award-info":[{"award-number":["R01AR078268"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["SCR_025458"],"award-info":[{"award-number":["SCR_025458"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AR076487"],"award-info":[{"award-number":["R21AR076487"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AR082016"],"award-info":[{"award-number":["R21AR082016"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR080035"],"award-info":[{"award-number":["R01AR080035"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AR080502"],"award-info":[{"award-number":["R21AR080502"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19NS130608"],"award-info":[{"award-number":["U19NS130608"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["UC2 AR082186"],"award-info":[{"award-number":["UC2 AR082186"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["UC2AR081025"],"award-info":[{"award-number":["UC2AR081025"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008590","name":"Dr. Ralph and Marian Falk Medical Research Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000090","name":"Congressionally Directed Medical Research Programs","doi-asserted-by":"publisher","award":["HT94252310327"],"award-info":[{"award-number":["HT94252310327"]}],"id":[{"id":"10.13039\/100000090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.joca.2025.08.013","type":"journal-article","created":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T06:29:46Z","timestamp":1756535386000},"page":"589-600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Cross-platform transcriptomic data integration identifies an overactive neuro-immune signature in human osteoarthritis synovium"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1262-0613","authenticated-orcid":false,"given":"Michael D.","family":"Newton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7815-2387","authenticated-orcid":false,"given":"Hannah","family":"Swahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9859-7199","authenticated-orcid":false,"given":"Dana E.","family":"Orange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4098-9090","authenticated-orcid":false,"given":"Joseph B.","family":"Lesnak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6971-6221","authenticated-orcid":false,"given":"Theodore J.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1428-0384","authenticated-orcid":false,"given":"Anne-Marie","family":"Malfait","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4486-5757","authenticated-orcid":false,"given":"Rachel E.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6299-8799","authenticated-orcid":false,"given":"Martin K.","family":"Lotz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4523-6012","authenticated-orcid":false,"given":"Tristan","family":"Maerz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2025.08.013_bib1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","article-title":"Synovial inflammation in osteoarthritis progression","volume":"18","author":"Sanchez-Lopez","year":"2022","journal-title":"Nat. Rev. Rheuma"},{"key":"10.1016\/j.joca.2025.08.013_bib2","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1136\/ard.2011.150243","article-title":"Presence of MRI-detected joint effusion and synovitis increases the risk of cartilage loss in knees without osteoarthritis at 30-month follow-up: the MOST study","volume":"70","author":"Roemer","year":"2011","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.joca.2025.08.013_bib3","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.joca.2015.09.013","article-title":"Synovitis and the risk of knee osteoarthritis: the MOST Study","volume":"24","author":"Felson","year":"2016","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2025.08.013_bib4","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1136\/ard.2009.121426","article-title":"Relation of synovitis to knee pain using contrast-enhanced MRIs","volume":"69","author":"Baker","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.joca.2025.08.013_bib5","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/art.39488","article-title":"Association of joint inflammation with pain sensitization in knee osteoarthritis: the multicenter osteoarthritis study","volume":"68","author":"Neogi","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.joca.2025.08.013_bib6","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1002\/art.38965","article-title":"Association of pain in knee osteoarthritis with distinct patterns of synovitis","volume":"67","author":"de Lange-Brokaar","year":"2015","journal-title":"Arthritis Rheuma"},{"key":"10.1016\/j.joca.2025.08.013_bib7","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.joca.2019.12.002","article-title":"Association between bone marrow lesions & synovitis and symptoms in symptomatic knee osteoarthritis","volume":"28","author":"Perry","year":"2020","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2025.08.013_bib8","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1136\/annrheumdis-2014-205348","article-title":"Adalimumab in patients with hand osteoarthritis refractory to analgesics and NSAIDs: a randomised, multicentre, double-blind, placebo-controlled trial","volume":"74","author":"Chevalier","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.joca.2025.08.013_bib9","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1136\/annrheumdis-2020-218547","article-title":"Efficacy of tocilizumab in patients with hand osteoarthritis: double blind, randomised, placebo-controlled, multicentre trial","volume":"80","author":"Richette","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.joca.2025.08.013_bib10","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1136\/annrheumdis-2018-213336","article-title":"Phase IIa, placebo-controlled, randomised study of lutikizumab, an anti-interleukin-1alpha and anti-interleukin-1beta dual variable domain immunoglobulin, in patients with erosive hand osteoarthritis","volume":"78","author":"Kloppenburg","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.joca.2025.08.013_bib11","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.joca.2024.06.015","article-title":"Association between synovial tissue damage and pain in late-stage knee osteoarthritis: a cross-sectional study","volume":"32","author":"Philpott","year":"2024","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2025.08.013_bib12","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41586-023-06708-y","article-title":"Deconstruction of rheumatoid arthritis synovium defines inflammatory subtypes","volume":"623","author":"Zhang","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.joca.2025.08.013_bib13","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1136\/annrheumdis-2021-221763","article-title":"Osteoarthritis endotype discovery via clustering of biochemical marker data","volume":"81","author":"Angelini","year":"2022","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.joca.2025.08.013_bib14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.joca.2023.11.019","article-title":"Three decades of advancements in osteoarthritis research: insights from transcriptomic, proteomic, and metabolomic studies","volume":"32","author":"Rai","year":"2024","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2025.08.013_bib15","doi-asserted-by":"crossref","DOI":"10.3389\/fragi.2022.836791","article-title":"RNAseq of osteoarthritic synovial tissues: systematic literary review","volume":"3","author":"Moore","year":"2022","journal-title":"Front Aging"},{"key":"10.1016\/j.joca.2025.08.013_bib16","article-title":"Identification of SCRG1 as a potential therapeutic target for human synovial inflammation","volume":"13","author":"Liu","year":"2022","journal-title":"Front Immunol."},{"key":"10.1016\/j.joca.2025.08.013_bib17","article-title":"Identification of key hub genes in knee osteoarthritis through integrated bioinformatics analysis","volume":"14","author":"Xu","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.joca.2025.08.013_bib18","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cger.2021.11.013","article-title":"The genesis of pain in osteoarthritis: inflammation as a mediator of osteoarthritis pain","volume":"38","author":"Wood","year":"2022","journal-title":"Clin. Geriatr. Med."},{"key":"10.1016\/j.joca.2025.08.013_bib19","article-title":"Neuroimmune interactions and osteoarthritis pain: focus on macrophages","volume":"6","author":"Geraghty","year":"2021","journal-title":"Pain. Rep."},{"key":"10.1016\/j.joca.2025.08.013_bib20","doi-asserted-by":"crossref","first-page":"eadk3506","DOI":"10.1126\/scitranslmed.adk3506","article-title":"Synovial fibroblast gene expression is associated with sensory nerve growth and pain in rheumatoid arthritis","volume":"16","author":"Bai","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.joca.2025.08.013_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103618","article-title":"Synovial tissue from sites of joint pain in knee osteoarthritis patients exhibits a differential phenotype with distinct fibroblast subsets","volume":"72","author":"Nanus","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.joca.2025.08.013_bib22","doi-asserted-by":"crossref","DOI":"10.1186\/ar2485","article-title":"Identification of intra-group, inter-individual, and gene-specific variances in mRNA expression profiles in the rheumatoid arthritis synovial membrane","volume":"10","author":"Huber","year":"2008","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.joca.2025.08.013_bib23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1152\/physiolgenomics.00004.2010","article-title":"Molecular signatures and new candidates to target the pathogenesis of rheumatoid arthritis","volume":"42","author":"Ungethuem","year":"2010","journal-title":"Physiol. Genom."},{"key":"10.1016\/j.joca.2025.08.013_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/ar4526","article-title":"Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation","volume":"16","author":"Woetzel","year":"2014","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.joca.2025.08.013_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0167076","article-title":"Functional tissue analysis reveals successful cryopreservation of human osteoarthritic synovium","volume":"11","author":"Broeren","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2025.08.013_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2023.100379","article-title":"Pathological tissue formation and degradation biomarkers correlate with patient reported pain outcomes: an explorative study","volume":"5","author":"Bay-Jensen","year":"2023","journal-title":"Osteoarthr. Cartil. Open"},{"key":"10.1016\/j.joca.2025.08.013_bib27","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.4049\/jimmunol.1601988","article-title":"CD40L-dependent pathway is active at various stages of rheumatoid arthritis disease progression","volume":"198","author":"Guo","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.joca.2025.08.013_bib28","article-title":"Gene expression profiles analyzed using integrating rna sequencing, and microarray reveals increased inflammatory response, proliferation, and osteoclastogenesis in pigmented villonodular synovitis","volume":"12","author":"Zhao","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.joca.2025.08.013_bib29","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"Voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.joca.2025.08.013_bib30","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3389\/fgene.2018.00636","article-title":"Comparison of RNA-Seq and microarray gene expression platforms for the toxicogenomic evaluation of liver from short-term rat toxicity studies","volume":"9","author":"Rao","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.joca.2025.08.013_bib31","doi-asserted-by":"crossref","first-page":"6980","DOI":"10.1038\/s41598-021-86465-y","article-title":"Powerful p-value combination methods to detect incomplete association","volume":"11","author":"Yoon","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.joca.2025.08.013_bib32","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1111\/j.1420-9101.2011.02297.x","article-title":"Optimally weighted Z-test is a powerful method for combining probabilities in meta-analysis","volume":"24","author":"Zaykin","year":"2011","journal-title":"J. Evolut. Biol."},{"key":"10.1016\/j.joca.2025.08.013_bib33","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2016","journal-title":"bioRxiv"},{"key":"10.1016\/j.joca.2025.08.013_bib34","article-title":"ClusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.joca.2025.08.013_bib35","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/nmeth.4463","article-title":"SCENIC: single-cell regulatory network inference and clustering","volume":"14","author":"Aibar","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.joca.2025.08.013_bib36","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.joca.2025.08.013_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1232","article-title":"Obesity defined molecular endotypes in the synovium of patients with osteoarthritis provides a rationale for therapeutic targeting of fibroblast subsets","volume":"13","author":"Wijesinghe","year":"2023","journal-title":"Clin. Transl. Med."},{"key":"10.1016\/j.joca.2025.08.013_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67730-y","article-title":"Synovial cell cross-talk with cartilage plays a major role in the pathogenesis of osteoarthritis","volume":"10","author":"Chou","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.joca.2025.08.013_bib39","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41467-018-02892-y","article-title":"Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis","volume":"9","author":"Mizoguchi","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.joca.2025.08.013_bib40","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adf4590","article-title":"Single-cell atlas of human infrapatellar fat pad and synovium implicates APOE signaling in osteoarthritis pathology","volume":"16","author":"Tang","year":"2024","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.joca.2025.08.013_bib41","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abe1648","article-title":"A ligand-receptor interactome platform for discovery of pain mechanisms and therapeutic targets","volume":"14","author":"Wangzhou","year":"2021","journal-title":"Sci. Signal."},{"key":"10.1016\/j.joca.2025.08.013_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj8186","article-title":"Spatial transcriptomics of dorsal root ganglia identifies molecular signatures of human nociceptors","volume":"14","author":"Tavares-Ferreira","year":"2022","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.joca.2025.08.013_bib43","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adj9173","article-title":"Harmonized cross-species cell atlases of trigeminal and dorsal root ganglia","volume":"10","author":"Bhuiyan","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.joca.2025.08.013_bib44","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.aanat.2018.09.007","article-title":"Quantitative MRI analysis of infrapatellar and suprapatellar fat pads in normal controls, moderate and end-stage osteoarthritis","volume":"221","author":"Fontanella","year":"2019","journal-title":"Ann. Anat. Anat. Anz."},{"key":"10.1016\/j.joca.2025.08.013_bib45","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baz046","article-title":"PanglaoDB: a web server for exploration of mouse and human single-cell RNA sequencing data","volume":"2019","author":"Franz\u00e9n","year":"2019","journal-title":"Database"},{"key":"10.1016\/j.joca.2025.08.013_bib46","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1002\/jor.24580","article-title":"Fibrotic changes in the infrapatellar fat pad induce new vessel formation and sensory nerve fiber endings that associate prolonged pain","volume":"38","author":"Onuma","year":"2020","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.joca.2025.08.013_bib47","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.joca.2023.07.012","article-title":"Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury","volume":"32","author":"Bergman","year":"2024","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2025.08.013_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2024.1429124","article-title":"Intra-articular sprouting of nociceptors accompanies progressive osteoarthritis: comparative evidence in four murine models","volume":"18","author":"Obeidat","year":"2024","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.joca.2025.08.013_bib49","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.joca.2022.07.003","article-title":"Time course and localization of nerve growth factor expression and sensory nerve growth during progression of knee osteoarthritis in rats","volume":"30","author":"Aso","year":"2022","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2025.08.013_bib50","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.joca.2023.10.009","article-title":"Comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features","volume":"32","author":"Boutet","year":"2024","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2025.08.013_bib51","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.clim.2012.12.011","article-title":"Immunopathogenesis of osteoarthritis","volume":"146","author":"Haseeb","year":"2013","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.joca.2025.08.013_bib52","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s13075-020-02410-w","article-title":"Proinflammatory T cell polarization is already present in patients with early knee osteoarthritis","volume":"23","author":"Rosshirt","year":"2021","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.joca.2025.08.013_bib53","article-title":"Immunological profiling in knee osteoarthritis: treg dysfunction as key driver of pain","volume":"2024","author":"Binvignat","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.joca.2025.08.013_bib54","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/ni.3691","article-title":"Mechanisms and consequences of Jak\u2013STAT signaling in the immune system","volume":"18","author":"Villarino","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.joca.2025.08.013_bib55","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s13075-024-03309-6","article-title":"Targeting STAT6-mediated synovial macrophage activation improves pain in experimental knee osteoarthritis","volume":"26","author":"Blackler","year":"2024","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.joca.2025.08.013_bib56","doi-asserted-by":"crossref","first-page":"4590","DOI":"10.1038\/s41467-024-48397-9","article-title":"FLI1 promotes IFN-\u03b3-induced kynurenine production to impair anti-tumor immunity","volume":"15","author":"Chen","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.joca.2025.08.013_bib57","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143950","article-title":"The druggable transcription factor Fli-1 regulates T cell immunity and tolerance in graft-versus-host disease","volume":"132","author":"Schutt","year":"2022","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.joca.2025.08.013_bib58","article-title":"Vitamin D and immune regulation: antibacterial, antiviral, anti-inflammatory","volume":"5","author":"L Bishop","year":"2021","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.joca.2025.08.013_bib59","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/3494937","article-title":"Vitamin D as a principal factor in mediating rheumatoid arthritis-derived immune response","volume":"2019","author":"Aslam","year":"2019","journal-title":"BioMed. Res. Int."},{"key":"10.1016\/j.joca.2025.08.013_bib60","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.767512","article-title":"The expression of inflammasomes NLRP1 and NLRP3, toll-like receptors, and vitamin D receptor in synovial fibroblasts from patients with different types of knee arthritis","volume":"12","author":"Sakalyte","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.joca.2025.08.013_bib61","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1016\/j.joca.2024.02.034","article-title":"Mapping the joint-nerve interactome of the knee: an integrative approach for identifying new strategies for the control of joint pain","volume":"32","author":"Malfait","year":"2024","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2025.08.013_bib62","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/brain\/aww314","article-title":"Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia","volume":"140","author":"Stokowska","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.joca.2025.08.013_bib63","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.tins.2020.07.008","article-title":"How do sensory neurons sense danger signals?","volume":"43","author":"Donnelly","year":"2020","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.joca.2025.08.013_bib64","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1002\/dneu.20931","article-title":"Regulation of axonal outgrowth and pathfinding by integrin\u2013ECM interactions","volume":"71","author":"Myers","year":"2011","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.joca.2025.08.013_bib65","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0896-6273(00)80562-0","article-title":"Regulation of class I MHC gene expression in the developing and mature CNS by neural activity","volume":"21","author":"Corriveau","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.joca.2025.08.013_bib66","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1126\/science.290.5499.2155","article-title":"Functional requirement for class I MHC in CNS development and plasticity","volume":"290","author":"Huh","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.joca.2025.08.013_bib67","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nm.4052","article-title":"MHC class I protects motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis (ALS)","volume":"22","author":"Song","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.joca.2025.08.013_bib68","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.neuron.2010.01.035","article-title":"The immune protein CD3\u03b6 is required for normal development of neural circuits in the retina","volume":"65","author":"Xu","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.joca.2025.08.013_bib69","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1091\/mbc.e07-09-0947","article-title":"The signaling adaptor protein CD3\u03b6 is a negative regulator of dendrite development in young neurons","volume":"19","author":"Baudouin","year":"2008","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.joca.2025.08.013_bib70","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1126\/science.1242077","article-title":"Human LilrB2 is a \u03b2-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer\u2019s model","volume":"341","author":"Kim","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.joca.2025.08.013_bib71","article-title":"CXCL16 mediates nociception and inflammation in murine post-traumatic osteoarthritis","volume":"2025","author":"Lammlin","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.joca.2025.08.013_bib72","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fncel.2014.00193","article-title":"Trasmembrane chemokines CX3CL1 and CXCL16 drive interplay between neurons, microglia and astrocytes to counteract pMCAO and excitotoxic neuronal death","volume":"8","author":"Rosito","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.joca.2025.08.013_bib73","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.bja.2024.10.019","article-title":"Sprouting sympathetic fibres release CXCL16 and norepinephrine to synergistically mediate sensory neuronal hyperexcitability in a rodent model of neuropathic pain","volume":"134","author":"Wang","year":"2025","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.joca.2025.08.013_bib74","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13075-021-02486-y","article-title":"The role of intra-articular neuronal CCR2 receptors in knee joint pain associated with experimental osteoarthritis in mice","volume":"23","author":"Ishihara","year":"2021","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.joca.2025.08.013_bib75","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/s41586-024-07237-y","article-title":"CGRP sensory neurons promote tissue healing via neutrophils and macrophages","volume":"628","author":"Lu","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.joca.2025.08.013_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2019.100005","article-title":"Osteoarthritis is a neurological disease\u2013an hypothesis","volume":"1","author":"McDougall","year":"2019","journal-title":"Osteoarthr. Cartil. Open"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458425011239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458425011239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:18:42Z","timestamp":1780028322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458425011239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":76,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S1063458425011239"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2025.08.013","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cross-platform transcriptomic data integration identifies an overactive neuro-immune signature in human osteoarthritis synovium","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2025.08.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}