{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:46:25Z","timestamp":1792421185918,"version":"4.5.0"},"reference-count":187,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 NS124123"],"award-info":[{"award-number":["R01 NS124123"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.joca.2025.10.009","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T17:41:13Z","timestamp":1761673273000},"page":"193-212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pathophysiological mechanisms linking osteoarthritis and neurodegenerative disease risk"],"prefix":"10.1016","volume":"34","author":[{"given":"Pranav","family":"Prasoon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8364-9571","authenticated-orcid":false,"given":"Kayla L.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0545-5023","authenticated-orcid":false,"given":"Payam A.","family":"Fathi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6541-5069","authenticated-orcid":false,"given":"Shruti","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4833-3820","authenticated-orcid":false,"given":"Sreejita","family":"Arnab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9491-7762","authenticated-orcid":false,"given":"Erin","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6536-4097","authenticated-orcid":false,"given":"Aravind","family":"Meyyappan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8232-1033","authenticated-orcid":false,"given":"Elena J.","family":"Stehle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2078-5565","authenticated-orcid":false,"given":"John R.","family":"Bethea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10264","key":"10.1016\/j.joca.2025.10.009_bib1","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1016\/S0140-6736(20)32230-3","article-title":"Osteoarthritis in 2020 and beyond: a Lancet Commission","volume":"396","author":"Hunter","year":"2020","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.joca.2025.10.009_bib2","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13704","article-title":"Importance of Bmal1 in Alzheimer's disease and associated aging-related diseases: Mechanisms and interventions","volume":"21","author":"Fan","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.joca.2025.10.009_bib3","article-title":"Association between osteoarthritis and the incidence of Parkinson's disease in the United Kingdom","volume":"5","author":"Jacob","year":"2021","journal-title":"Clin. Park Relat. Disord."},{"key":"10.1016\/j.joca.2025.10.009_bib4","article-title":"Causal Relationships Between Osteoarthritis and Senile Central Nerve System Dysfunction: A Bidirectional Two-Sample Mendelian Randomization Study","volume":"13","author":"Cai","year":"2021","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.joca.2025.10.009_bib5","article-title":"Osteoarthritis increases the risk of dementia: a nationwide cohort study in Taiwan","volume":"5","author":"Huang","year":"2015","journal-title":"Sci. Rep."},{"issue":"10182","key":"10.1016\/j.joca.2025.10.009_bib6","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.joca.2025.10.009_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.664443","article-title":"Association of Osteoarthritis With Changes in Structural Neuroimaging Markers Over Time Among Non-demented Older Adults","volume":"13","author":"Wu","year":"2021","journal-title":"Front Aging Neurosci."},{"issue":"4","key":"10.1016\/j.joca.2025.10.009_bib8","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1002\/alz.13016","article-title":"Alzheimer's disease facts and figures","volume":"19","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"2","key":"10.1016\/j.joca.2025.10.009_bib9","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/alz.12694","article-title":"Global estimates on the number of persons across the Alzheimer's disease continuum","volume":"19","author":"Gustavsson","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.joca.2025.10.009_bib10","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.compbiomed.2018.09.008","article-title":"Parkinson's disease: Cause factors, measurable indicators, and early diagnosis","volume":"102","author":"Bhat","year":"2018","journal-title":"Comput. Biol. Med"},{"key":"10.1016\/j.joca.2025.10.009_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.1013745","article-title":"WDR43 is a potential diagnostic biomarker and therapeutic target for osteoarthritis complicated with Parkinson's disease","volume":"16","author":"Heng","year":"2022","journal-title":"Front Cell Neurosci."},{"issue":"8","key":"10.1016\/j.joca.2025.10.009_bib12","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1007\/s00702-017-1686-y","article-title":"Epidemiology of Parkinson's disease","volume":"124","author":"Tysnes","year":"2017","journal-title":"J. Neural Transm. (Vienna)"},{"issue":"2","key":"10.1016\/j.joca.2025.10.009_bib13","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s12016-022-08941-1","article-title":"Inflammaging and Osteoarthritis","volume":"64","author":"Motta","year":"2023","journal-title":"Clin. Rev. Allergy Immunol."},{"issue":"7","key":"10.1016\/j.joca.2025.10.009_bib14","first-page":"679","article-title":"Risk factors for Alzheimer's disease","volume":"62","author":"Ikeda","year":"2010","journal-title":"Brain Nerve"},{"issue":"8","key":"10.1016\/j.joca.2025.10.009_bib15","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.1002\/jcp.26412","article-title":"Potential neuroprotective effect of androst-5-ene-3\u03b2, 17\u03b2-diol (ADIOL) on the striatum, and substantia nigra in Parkinson's disease rat model","volume":"233","author":"Salama","year":"2018","journal-title":"J. Cell Physiol."},{"issue":"7","key":"10.1016\/j.joca.2025.10.009_bib16","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/mdc3.13319","article-title":"The Cholinergic Brain in Parkinson's Disease","volume":"8","author":"Pasquini","year":"2021","journal-title":"Mov. Disord. Clin. Pr."},{"issue":"9","key":"10.1016\/j.joca.2025.10.009_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23094508","article-title":"Pathophysiological Features of Nigral Dopaminergic Neurons in Animal Models of Parkinson's Disease","volume":"23","author":"Guatteo","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.joca.2025.10.009_bib18","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/bmb\/lds038","article-title":"Epidemiology and burden of osteoarthritis","volume":"105","author":"Litwic","year":"2013","journal-title":"Br. Med Bull."},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib19","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41531-023-00624-8","article-title":"A potential patient stratification biomarker for Parkinson\u00b4s disease based on LRRK2 kinase-mediated centrosomal alterations in peripheral blood-derived cells","volume":"10","author":"Naaldijk","year":"2024","journal-title":"NPJ Park. Dis."},{"issue":"20","key":"10.1016\/j.joca.2025.10.009_bib20","doi-asserted-by":"crossref","first-page":"680","DOI":"10.15585\/mmwr.mm7120a2","article-title":"Modifiable Risk Factors for Alzheimer Disease and Related Dementias Among Adults Aged \u226545 Years - United States, 2019","volume":"71","author":"Omura","year":"2022","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"issue":"2","key":"10.1016\/j.joca.2025.10.009_bib21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.14283\/jpad.2019.7","article-title":"Factors Associated with Alzheimer's Disease: An Overview of Reviews","volume":"6","author":"Rochoy","year":"2019","journal-title":"J. Prev. Alzheimers Dis."},{"issue":"9","key":"10.1016\/j.joca.2025.10.009_bib22","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1002\/mds.25458","article-title":"Head injury and risk of Parkinson disease: a systematic review and meta-analysis","volume":"28","author":"Jafari","year":"2013","journal-title":"Mov. Disord."},{"issue":"6","key":"10.1016\/j.joca.2025.10.009_bib23","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/ana.24396","article-title":"Traumatic brain injury in later life increases risk for Parkinson disease","volume":"77","author":"Gardner","year":"2015","journal-title":"Ann. Neurol."},{"issue":"8","key":"10.1016\/j.joca.2025.10.009_bib24","article-title":"Depression in Parkinson's Disease: A Narrative Review","volume":"14","author":"Chikatimalla","year":"2022","journal-title":"Cureus"},{"issue":"4","key":"10.1016\/j.joca.2025.10.009_bib25","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2174\/1570159X17666191016094857","article-title":"Drug Choices and Advancements for Managing Depression in Parkinson's Disease","volume":"18","author":"Assogna","year":"2020","journal-title":"Curr. Neuropharmacol."},{"issue":"21","key":"10.1016\/j.joca.2025.10.009_bib26","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.030780","article-title":"Cardiovascular Disease and Alzheimer's Disease: The Heart-Brain Axis","volume":"12","author":"Saeed","year":"2023","journal-title":"J. Am. Heart Assoc."},{"issue":"2","key":"10.1016\/j.joca.2025.10.009_bib27","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/ene.14076","article-title":"Does Parkinson's disease increase the risk of cardiovascular events? A systematic review and meta-analysis","volume":"27","author":"Alves","year":"2020","journal-title":"Eur. J. Neurol."},{"issue":"8","key":"10.1016\/j.joca.2025.10.009_bib28","first-page":"2369","article-title":"Alcohol and Parkinson's Disease: A Systematic Review and Meta-Analysis","volume":"12","author":"Mitchell","year":"2022","journal-title":"J. Park. Dis."},{"issue":"7","key":"10.1016\/j.joca.2025.10.009_bib29","doi-asserted-by":"crossref","first-page":"7348","DOI":"10.3390\/ijerph120707348","article-title":"Extremely Low Frequency Magnetic Field Exposure and Parkinson's Disease--A Systematic Review and Meta-Analysis of the Data","volume":"12","author":"Huss","year":"2015","journal-title":"Int J. Environ. Res Public Health"},{"issue":"8","key":"10.1016\/j.joca.2025.10.009_bib30","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/art.39707","article-title":"Association Between Overweight and Obesity and Risk of Clinically Diagnosed Knee, Hip, and Hand Osteoarthritis: A Population-Based Cohort Study","volume":"68","author":"Reyes","year":"2016","journal-title":"Arthritis Rheuma"},{"issue":"2","key":"10.1016\/j.joca.2025.10.009_bib31","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10787-011-0118-0","article-title":"Obesity and knee osteoarthritis","volume":"20","author":"Lee","year":"2012","journal-title":"Inflammopharmacology"},{"issue":"2","key":"10.1016\/j.joca.2025.10.009_bib32","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.pmn.2021.08.002","article-title":"Association of Hypertension with Knee Pain Severity Among People with Knee Osteoarthritis","volume":"23","author":"Shi","year":"2022","journal-title":"Pain. Manag Nurs."},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1089\/rej.2017.1917","article-title":"Knee Osteoarthritis and Risk of Hypertension: A Longitudinal Cohort Study","volume":"21","author":"Veronese","year":"2018","journal-title":"Rejuvenation Res"},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib34","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41531-022-00410-y","article-title":"Incidence of Parkinson disease in North America","volume":"8","author":"Willis","year":"2022","journal-title":"NPJ Park. Dis."},{"issue":"5","key":"10.1016\/j.joca.2025.10.009_bib35","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.jamda.2019.11.019","article-title":"Impact of Overweight and Obesity on Functional and Clinical Outcomes of Early Parkinson's Disease","volume":"21","author":"Kim","year":"2020","journal-title":"J. Am. Med Dir. Assoc."},{"issue":"3","key":"10.1016\/j.joca.2025.10.009_bib36","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nrneurol.2017.185","article-title":"Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums","volume":"14","author":"Arnold","year":"2018","journal-title":"Nat. Rev. Neurol."},{"issue":"6","key":"10.1016\/j.joca.2025.10.009_bib37","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202200485R","article-title":"Impaired glucose metabolism underlies articular cartilage degeneration in osteoarthritis","volume":"36","author":"Li","year":"2022","journal-title":"Faseb J."},{"key":"10.1016\/j.joca.2025.10.009_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1319827","article-title":"The role of targeting glucose metabolism in chondrocytes in the pathogenesis and therapeutic mechanisms of osteoarthritis: a narrative review","volume":"15","author":"Pi","year":"2024","journal-title":"Front Endocrinol. (Lausanne)"},{"key":"10.1016\/j.joca.2025.10.009_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fnhum.2020.602360","article-title":"Exploiting Common Aspects of Obesity and Alzheimer's Disease","volume":"14","author":"Tabassum","year":"2020","journal-title":"Front Hum. Neurosci."},{"issue":"12","key":"10.1016\/j.joca.2025.10.009_bib40","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-007568","article-title":"Body mass index and risk of knee osteoarthritis: systematic review and meta-analysis of prospective studies","volume":"5","author":"Zheng","year":"2015","journal-title":"BMJ Open"},{"key":"10.1016\/j.joca.2025.10.009_bib41","article-title":"Adipokine Signaling Pathways in Osteoarthritis","volume":"10","author":"Zhang","year":"2022","journal-title":"Front Bioeng. Biotechnol."},{"issue":"5","key":"10.1016\/j.joca.2025.10.009_bib42","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s11906-021-01146-5","article-title":"Management of Hypertension and Blood Pressure Dysregulation in Patients with Parkinson's Disease-a Systematic Review","volume":"23","author":"Katsi","year":"2021","journal-title":"Curr. Hypertens. Rep."},{"issue":"2","key":"10.1016\/j.joca.2025.10.009_bib43","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/YCO.0000000000000684","article-title":"Hypertension and Alzheimer's disease: is the picture any clearer?","volume":"34","author":"Lennon","year":"2021","journal-title":"Curr. Opin. Psychiatry"},{"issue":"21","key":"10.1016\/j.joca.2025.10.009_bib44","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.4103\/1673-5374.145342","article-title":"New drug treatments show neuroprotective effects in Alzheimer's and Parkinson's diseases","volume":"9","author":"H\u00f6lscher","year":"2014","journal-title":"Neural Regen. Res"},{"issue":"19","key":"10.1016\/j.joca.2025.10.009_bib45","doi-asserted-by":"crossref","first-page":"e1654","DOI":"10.1212\/WNL.0000000000005475","article-title":"Diabetes mellitus and Parkinson disease","volume":"90","author":"Pagano","year":"2018","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.joca.2025.10.009_bib46","doi-asserted-by":"crossref","first-page":"e508","DOI":"10.1016\/S2665-9913(23)00163-7","article-title":"Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021","volume":"5","author":"Collaborators GBDO","year":"2023","journal-title":"Lancet Rheuma"},{"key":"10.1016\/j.joca.2025.10.009_bib47","series-title":"Obesity and Orthopedic Issues. StatPearls. Treasure Island (FL): StatPearls Publishing Copyright \u00a9 2024","author":"Molina","year":"2024"},{"key":"10.1016\/j.joca.2025.10.009_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.114019","article-title":"Effects of obesity on neuroinflammatory and neurochemical parameters in an animal model of reserpine-induced Parkinson's disease","volume":"434","author":"Cavalheiro","year":"2022","journal-title":"Behav. Brain Res"},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib49","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s13075-018-1727-4","article-title":"Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI","volume":"20","author":"Collins","year":"2018","journal-title":"Arthritis Res Ther."},{"key":"10.1016\/j.joca.2025.10.009_bib50","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.clinbiomech.2015.09.017","article-title":"Obesity is associated with higher absolute tibiofemoral contact and muscle forces during gait with and without knee osteoarthritis","volume":"31","author":"Harding","year":"2016","journal-title":"Clin. Biomech. (Bristol Avon)"},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib51","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.cger.2014.08.019","article-title":"Links between osteoarthritis and diabetes: implications for management from a physical activity perspective","volume":"31","author":"Piva","year":"2015","journal-title":"Clin. Geriatr. Med"},{"key":"10.1016\/j.joca.2025.10.009_bib52","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/203901","article-title":"Adipokines and osteoarthritis: novel molecules involved in the pathogenesis and progression of disease","volume":"2011","author":"Conde","year":"2011","journal-title":"Arthritis"},{"issue":"5","key":"10.1016\/j.joca.2025.10.009_bib53","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.bbamcr.2011.01.034","article-title":"The pro- and anti-inflammatory properties of the cytokine interleukin-6","volume":"1813","author":"Scheller","year":"2011","journal-title":"Biochim Biophys. Acta"},{"key":"10.1016\/j.joca.2025.10.009_bib54","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3087475","article-title":"Neuroinflammatory Cytokines Induce Amyloid Beta Neurotoxicity through Modulating Amyloid Precursor Protein Levels\/Metabolism","volume":"2018","author":"Alasmari","year":"2018","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.joca.2025.10.009_bib55","article-title":"Serum levels of proinflammatory cytokines in painful knee osteoarthritis and sensitization","volume":"2015","author":"Imamura","year":"2015","journal-title":"Int J. Inflam."},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib56","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1186\/s12974-019-1669-z","article-title":"Interleukin-1\u03b2 drives NEDD8 nuclear-to-cytoplasmic translocation, fostering parkin activation via NEDD8 binding to the P-ubiquitin activating site","volume":"16","author":"Balasubramaniam","year":"2019","journal-title":"J. Neuroinflamm."},{"issue":"5","key":"10.1016\/j.joca.2025.10.009_bib57","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1007\/s10072-019-04216-4","article-title":"Serum adiponectin levels between patients with Parkinson's disease and those with PSP","volume":"41","author":"Kataoka","year":"2020","journal-title":"Neurol. Sci."},{"issue":"1-2","key":"10.1016\/j.joca.2025.10.009_bib58","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jns.2014.01.021","article-title":"Circulating levels of adipokines in Parkinson's disease","volume":"339","author":"Rocha","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.joca.2025.10.009_bib59","article-title":"Exploring the New Horizon of AdipoQ in Obesity-Related Alzheimer's Dementia","volume":"11","author":"Uddin","year":"2020","journal-title":"Front Physiol."},{"issue":"17","key":"10.1016\/j.joca.2025.10.009_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21176419","article-title":"Adiponectin: The Potential Regulator and Therapeutic Target of Obesity and Alzheimer's Disease","volume":"21","author":"Kim","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.joca.2025.10.009_bib61","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s11011-014-9501-z","article-title":"Obesity as a risk factor for Alzheimer's disease: the role of adipocytokines","volume":"29","author":"Letra","year":"2014","journal-title":"Metab. Brain Dis."},{"issue":"3","key":"10.1016\/j.joca.2025.10.009_bib62","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.yfrne.2014.02.002","article-title":"Sex differences in Parkinson's disease","volume":"35","author":"Gillies","year":"2014","journal-title":"Front Neuroendocr."},{"issue":"5_","key":"10.1016\/j.joca.2025.10.009_bib63","first-page":"S169","article-title":"Role of sex hormones in the development of osteoarthritis","volume":"4","author":"Linn","year":"2012","journal-title":"Pm R."},{"issue":"15","key":"10.1016\/j.joca.2025.10.009_bib64","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22157876","article-title":"Males and Females Have Distinct Molecular Events in the Articular Cartilage during Knee Osteoarthritis","volume":"22","author":"Li","year":"2021","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib65","doi-asserted-by":"crossref","DOI":"10.1002\/gps.5612","article-title":"Sex differences in the incidence and prevalence of young-onset Alzheimer's disease: A meta-analysis","volume":"37","author":"Peeters","year":"2021","journal-title":"Int J. Geriatr. Psychiatry"},{"key":"10.1016\/j.joca.2025.10.009_bib66","first-page":"1","article-title":"TCM. The puzzle of sex, gender and Alzheimer\u2019s disease: Why are women more often affected than men? Personalized Medicine in","volume":"14","author":"Andrew","year":"2018","journal-title":"Women\u2019S. HealthRev."},{"issue":"8","key":"10.1016\/j.joca.2025.10.009_bib67","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41582-018-0032-9","article-title":"Sex differences in Alzheimer disease - the gateway to precision medicine","volume":"14","author":"Ferretti","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.joca.2025.10.009_bib68","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.parkreldis.2019.10.019","article-title":"Sex differences in Parkinson's disease presentation and progression","volume":"69","author":"Abraham","year":"2019","journal-title":"Park. Relat. Disord."},{"issue":"3","key":"10.1016\/j.joca.2025.10.009_bib69","first-page":"501","article-title":"Parkinson's Disease in Women and Men: What's the Difference?","volume":"9","author":"Cerri","year":"2019","journal-title":"J. Park. Dis."},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph18010198","article-title":"Gender Differences and Quality of Life in Parkinson's Disease","volume":"18","author":"Crispino","year":"2020","journal-title":"Int J. Environ. Res Public Health"},{"issue":"5","key":"10.1016\/j.joca.2025.10.009_bib71","article-title":"Interactions Between Diabetes Mellitus and Osteoarthritis: From Animal Studies to Clinical Data","volume":"6","author":"Rios-Arce","year":"2022","journal-title":"JBMR"},{"issue":"12","key":"10.1016\/j.joca.2025.10.009_bib72","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1016\/j.joca.2016.06.019","article-title":"Diabetes-accelerated experimental osteoarthritis is prevented by autophagy activation","volume":"24","author":"Ribeiro","year":"2016","journal-title":"Osteoarthr. Cartil."},{"issue":"5","key":"10.1016\/j.joca.2025.10.009_bib73","article-title":"Data-independent acquisition-based proteomics analysis correlating type 2 diabetes mellitus with osteoarthritis in total knee arthroplasty patients","volume":"101","author":"Zhao","year":"2022","journal-title":"Med. (Baltim. )"},{"issue":"4","key":"10.1016\/j.joca.2025.10.009_bib74","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.3233\/JAD-161256","article-title":"Effects of Regular and Long-Acting Insulin on Cognition and Alzheimer's Disease Biomarkers: A Pilot Clinical Trial","volume":"57","author":"Craft","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.joca.2025.10.009_bib75","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/bs.irn.2020.02.010","article-title":"Cardoso S, Moreira PI. Antidiabetic drugs for Alzheimer's and Parkinson's diseases: Repurposing insulin, metformin, and thiazolidinediones","volume":"155","year":"2020","journal-title":"Int Rev. Neurobiol."},{"issue":"Pt B","key":"10.1016\/j.joca.2025.10.009_bib76","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.neuropharm.2018.01.040","article-title":"Novel dual GLP-1\/GIP receptor agonists show neuroprotective effects in Alzheimer's and Parkinson's disease models","volume":"136","author":"H\u00f6lscher","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.joca.2025.10.009_bib77","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2022.108277","article-title":"Incretin-based drugs as potential therapy for neurodegenerative diseases: current status and perspectives","volume":"239","author":"Ferrari","year":"2022","journal-title":"Pharm. Ther."},{"issue":"3","key":"10.1016\/j.joca.2025.10.009_bib78","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s40263-018-0593-6","article-title":"Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer's and Parkinson's Diseases","volume":"33","author":"Batista","year":"2019","journal-title":"CNS Drugs"},{"key":"10.1016\/j.joca.2025.10.009_bib79","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/bs.irn.2020.03.023","article-title":"S\u00f6derbom G, Zeng BY. The NLRP3 inflammasome as a bridge between neuro-inflammation in metabolic and neurodegenerative diseases","volume":"154","year":"2020","journal-title":"Int Rev. Neurobiol."},{"issue":"3","key":"10.1016\/j.joca.2025.10.009_bib80","doi-asserted-by":"crossref","first-page":"533","DOI":"10.2174\/18715273113126660167","article-title":"Current view from Alzheimer disease to type 2 diabetes mellitus","volume":"13","author":"Rasool","year":"2014","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"3","key":"10.1016\/j.joca.2025.10.009_bib81","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ymgme.2021.01.011","article-title":"Therapies for Alzheimer's disease: a metabolic perspective","volume":"132","author":"Domingues","year":"2021","journal-title":"Mol. Genet Metab."},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13041-022-00986-9","article-title":"Knee osteoarthritis accelerates amyloid beta deposition and neurodegeneration in a mouse model of Alzheimer's disease","volume":"16","author":"Gupta","year":"2023","journal-title":"Mol. Brain"},{"issue":"4","key":"10.1016\/j.joca.2025.10.009_bib83","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.3233\/JAD-220568","article-title":"The Association Between Osteoarthritis with Risk of Dementia and Cognitive Impairment: A Meta-Analysis and Systematic Review","volume":"89","author":"Guo","year":"2022","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.joca.2025.10.009_bib84","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1742-2094-8-112","article-title":"Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice","volume":"8","author":"Kyrkanides","year":"2011","journal-title":"J. Neuroinflamm."},{"issue":"5","key":"10.1016\/j.joca.2025.10.009_bib85","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.3390\/ijms25053044","article-title":"Molecular Mechanisms Linking Osteoarthritis and Alzheimer\u2019s Disease: Shared Pathways, Mechanisms and Breakthrough Prospects","volume":"25","author":"Umoh","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.joca.2025.10.009_bib86","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.mayocp.2016.06.023","article-title":"Reduced Risk of Parkinson Disease in Patients With Rheumatoid Arthritis: A Nationwide Population-Based Study","volume":"91","author":"Sung","year":"2016","journal-title":"Mayo Clin. Proc."},{"issue":"11","key":"10.1016\/j.joca.2025.10.009_bib87","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1002\/acr.24708","article-title":"Association of Osteoarthritis With Increased Risk of Parkinson's Disease: A Population-Based, Longitudinal Follow-Up Study","volume":"74","author":"Feng","year":"2022","journal-title":"Arthritis Care Res (Hoboken)"},{"issue":"1-2","key":"10.1016\/j.joca.2025.10.009_bib88","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2019.100005","article-title":"Osteoarthritis is a neurological disease - an hypothesis","volume":"1","author":"McDougall","year":"2019","journal-title":"Osteoarthr. Cartil. Open"},{"issue":"7","key":"10.1016\/j.joca.2025.10.009_bib89","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/nrrheum.2016.65","article-title":"Ageing and the pathogenesis of osteoarthritis","volume":"12","author":"Loeser","year":"2016","journal-title":"Nat. Rev. Rheuma"},{"issue":"2","key":"10.1016\/j.joca.2025.10.009_bib90","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","article-title":"The role of synovitis in osteoarthritis pathogenesis","volume":"51","author":"Scanzello","year":"2012","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.joca.2025.10.009_bib91","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1159\/000071472","article-title":"Entry of blood-borne cytokines into the central nervous system: effects on cognitive processes","volume":"10","author":"Banks","year":"2002","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.joca.2025.10.009_bib92","first-page":"93","article-title":"Blood\u2013Brain Barrier Transport of Cytokines","volume":"6","author":"Banks","year":"2008"},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib93","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nbd.2009.07.031","article-title":"The blood-brain barrier and immune function and dysfunction","volume":"37","author":"Banks","year":"2010","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib94","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"issue":"3","key":"10.1016\/j.joca.2025.10.009_bib95","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/S0166-2236(00)02088-9","article-title":"Cytokine-induced sickness behaviour: mechanisms and implications","volume":"25","author":"Konsman","year":"2002","journal-title":"Trends Neurosci."},{"issue":"3","key":"10.1016\/j.joca.2025.10.009_bib96","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1002\/jor.23719","article-title":"Accumulation of advanced-glycation end products (AGEs) accelerates arthrogenic joint contracture in immobilized rat knee","volume":"36","author":"Ozawa","year":"2018","journal-title":"J. Orthop. Res"},{"issue":"5-6","key":"10.1016\/j.joca.2025.10.009_bib97","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1159\/000521720","article-title":"Advanced Glycation End Products Induced Mitochondrial Dysfunction of Chondrocytes through Repression of AMPK\u03b1-SIRT1-PGC-1\u03b1 Pathway","volume":"107","author":"Yang","year":"2022","journal-title":"Pharmacology"},{"key":"10.1016\/j.joca.2025.10.009_bib98","article-title":"The role and intervention of mitochondrial metabolism in osteoarthritis","author":"Qi","year":"2023","journal-title":"Mol. Cell. Biochem."},{"issue":"11","key":"10.1016\/j.joca.2025.10.009_bib99","doi-asserted-by":"crossref","first-page":"7504","DOI":"10.1002\/jcp.30386","article-title":"Moderate mechanical stress suppresses the IL-1\u03b2-induced chondrocyte apoptosis by regulating mitochondrial dynamics","volume":"236","author":"Zhang","year":"2021","journal-title":"J. Cell Physiol."},{"issue":"5","key":"10.1016\/j.joca.2025.10.009_bib100","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.jcyt.2020.08.010","article-title":"Mitochondrial DNA from osteoarthritic patients drives functional impairment of mitochondrial activity: a study on transmitochondrial cybrids","volume":"23","author":"Dalmao-Fern\u00e1ndez","year":"2021","journal-title":"Cytotherapy"},{"issue":"9","key":"10.1016\/j.joca.2025.10.009_bib101","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1080\/15548627.2020.1822097","article-title":"Mitophagy in degenerative joint diseases","volume":"17","author":"Sun","year":"2021","journal-title":"Autophagy"},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib102","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/s41392-023-01330-w","article-title":"Osteoarthritis: pathogenic signaling pathways and therapeutic targets","volume":"8","author":"Yao","year":"2023","journal-title":"Signal Transduct. Target Ther."},{"issue":"7","key":"10.1016\/j.joca.2025.10.009_bib103","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070734","article-title":"NF-\u03baB Signaling Pathways in Osteoarthritic Cartilage Destruction","volume":"8","author":"Choi","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.joca.2025.10.009_bib104","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110148","article-title":"Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes","volume":"366","author":"Wang","year":"2022","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.joca.2025.10.009_bib105","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.1069057","article-title":"The potential roles of JAK\/STAT signaling in the progression of osteoarthritis","volume":"13","author":"Zhou","year":"2022","journal-title":"Front Endocrinol. (Lausanne)"},{"issue":"16","key":"10.1016\/j.joca.2025.10.009_bib106","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21165624","article-title":"Involvement of p38 MAPK in Synaptic Function and Dysfunction","volume":"21","author":"Falcicchia","year":"2020","journal-title":"Int J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.joca.2025.10.009_bib107","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19102973","article-title":"Role of Mitogen Activated Protein Kinase Signaling in Parkinson's Disease","volume":"19","author":"Bohush","year":"2018","journal-title":"Int J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.joca.2025.10.009_bib108","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jocn.2013.08.017","article-title":"Peripheral expression of MAPK pathways in Alzheimer's and Parkinson's diseases","volume":"21","author":"Wang","year":"2014","journal-title":"J. Clin. Neurosci."},{"issue":"6","key":"10.1016\/j.joca.2025.10.009_bib109","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12469","article-title":"MAPK inhibitors protect against early\u2011stage osteoarthritis by activating autophagy","volume":"24","author":"Lan","year":"2021","journal-title":"Mol. Med Rep."},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib110","first-page":"1893","article-title":"Modulation of TGF\u2011\u03b2 activity by latent TGF\u2011\u03b2\u2011binding protein 1 in human osteoarthritis fibroblast\u2011like synoviocytes","volume":"17","author":"Wang","year":"2018","journal-title":"Mol. Med Rep."},{"issue":"3","key":"10.1016\/j.joca.2025.10.009_bib111","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.joca.2018.11.005","article-title":"TGF\u03b2i is involved in the chondrogenic differentiation of mesenchymal stem cells and is dysregulated in osteoarthritis","volume":"27","author":"Ruiz","year":"2019","journal-title":"Osteoarthr. Cartil."},{"issue":"20","key":"10.1016\/j.joca.2025.10.009_bib112","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20205002","article-title":"TGF-\u03b2 Signaling in Cellular Senescence and Aging-Related Pathology","volume":"20","author":"Tominaga","year":"2019","journal-title":"Int J. Mol. Sci."},{"issue":"8","key":"10.1016\/j.joca.2025.10.009_bib113","doi-asserted-by":"crossref","DOI":"10.3390\/cells12081204","article-title":"The Multifaceted Role of WNT Signaling in Alzheimer's Disease Onset and Age-Related Progression","volume":"12","author":"Kostes","year":"2023","journal-title":"Cells"},{"issue":"12","key":"10.1016\/j.joca.2025.10.009_bib114","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19123743","article-title":"Wnt\/\u03b2-Catenin Signaling Pathway Governs a Full Program for Dopaminergic Neuron Survival, Neurorescue and Regeneration in the MPTP Mouse Model of Parkinson's Disease","volume":"19","author":"Marchetti","year":"2018","journal-title":"Int J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib115","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41598-019-57011-8","article-title":"Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis","volume":"10","author":"Kania","year":"2020","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.joca.2025.10.009_bib116","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101457","article-title":"STRAP and NME1 Mediate the Neurite Growth-Promoting Effects of the Neurotrophic Factor GDF5","volume":"23","author":"Anantha","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.joca.2025.10.009_bib117","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41413-019-0071-x","article-title":"Inhibition of cyclooxygenase-2 activity in subchondral bone modifies a subtype of osteoarthritis","volume":"7","author":"Tu","year":"2019","journal-title":"Bone Res"},{"key":"10.1016\/j.joca.2025.10.009_bib118","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.909222","article-title":"Identification of miRNA-mRNA Pairs in the Alzheimer's Disease Expression Profile and Explore the Effect of miR-26a-5p\/PTGS2 on Amyloid-\u03b2 Induced Neurotoxicity in Alzheimer's Disease Cell Model","volume":"14","author":"Xie","year":"2022","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.joca.2025.10.009_bib119","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/9412776","article-title":"Analysis of ADORA2A, MTA1, PTGDS, PTGS2, NSF, and HNMT Gene Expression Levels in Peripheral Blood of Patients with Early Stages of Parkinson's Disease","volume":"2023","author":"Semenova","year":"2023","journal-title":"Biomed. Res Int"},{"key":"10.1016\/j.joca.2025.10.009_bib120","article-title":"The role of inflammatory mediators and matrix metalloproteinases (MMPs) in the progression of osteoarthritis","volume":"13","author":"Mukherjee","year":"2024","journal-title":"Biomater. Biosyst."},{"issue":"11","key":"10.1016\/j.joca.2025.10.009_bib121","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14112438","article-title":"Increased Expression and Activity of Brain Cortical cPLA2 Due to Chronic Lipopolysaccharide Administration in Mouse Model of Familial Alzheimer's Disease","volume":"14","author":"Gynther","year":"2022","journal-title":"Pharmaceutics"},{"issue":"41","key":"10.1016\/j.joca.2025.10.009_bib122","doi-asserted-by":"crossref","first-page":"20689","DOI":"10.1073\/pnas.1902958116","article-title":"Parkinson's disease-associated iPLA2-VIA\/PLA2G6 regulates neuronal functions and \u03b1-synuclein stability through membrane remodeling","volume":"116","author":"Mori","year":"2019","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib123","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s13075-018-1660-6","article-title":"GPR120 is an important inflammatory regulator in the development of osteoarthritis","volume":"20","author":"Chen","year":"2018","journal-title":"Arthritis Res Ther."},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib124","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s12872-024-03953-5","article-title":"Cardiomyocyte-specific overexpression of GPR22 ameliorates cardiac injury in mice with acute myocardial infarction","volume":"24","author":"Chang","year":"2024","journal-title":"BMC Cardiovasc Disord."},{"issue":"9","key":"10.1016\/j.joca.2025.10.009_bib125","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1002\/jbmr.1935","article-title":"Targeted disruption of leucine-rich repeat kinase 1 but not leucine-rich repeat kinase 2 in mice causes severe osteopetrosis","volume":"28","author":"Xing","year":"2013","journal-title":"J. Bone Min. Res"},{"issue":"12","key":"10.1016\/j.joca.2025.10.009_bib126","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1007\/s00296-014-3016-0","article-title":"Soluble TNF receptors are produced at sites of inflammation and are inversely associated with self-reported symptoms (WOMAC) in knee osteoarthritis","volume":"34","author":"Sim\u00e3o","year":"2014","journal-title":"Rheuma Int"},{"key":"10.1016\/j.joca.2025.10.009_bib127","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/610813","article-title":"Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF","volume":"2015","author":"Fischer","year":"2015","journal-title":"Oxid. Med Cell Longev."},{"issue":"2","key":"10.1016\/j.joca.2025.10.009_bib128","doi-asserted-by":"crossref","first-page":"134","DOI":"10.2174\/1573397115666190716114738","article-title":"The Association Between Knee Osteoarthritis and HLA-DRB1*0101 in the East of Iran","volume":"16","author":"Kooshkaki","year":"2020","journal-title":"Curr. Rheuma Rev."},{"issue":"36","key":"10.1016\/j.joca.2025.10.009_bib129","article-title":"Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes","volume":"120","author":"Guen","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.joca.2025.10.009_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2021.577543","article-title":"A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson's disease","volume":"354","author":"Huang","year":"2021","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib131","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-45220-1","article-title":"The role of melatonin in amyloid beta-induced inflammation mediated by inflammasome signaling in neuronal cell lines","volume":"13","author":"Nopparat","year":"2023","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.joca.2025.10.009_bib132","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/j.joca.2019.05.006","article-title":"Modulation of the Wnt pathway through inhibition of CLK2 and DYRK1A by lorecivivint as a novel, potentially disease-modifying approach for knee osteoarthritis treatment","volume":"27","author":"Deshmukh","year":"2019","journal-title":"Osteoarthr. Cartil."},{"issue":"9","key":"10.1016\/j.joca.2025.10.009_bib133","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1302\/2046-3758.119.BJR-2022-0075.R1","article-title":"ATF3 as a potential diagnostic marker of early-stage osteoarthritis and its correlation with immune infiltration through bioinformatics analysis","volume":"11","author":"Yang","year":"2022","journal-title":"Bone Jt. Res"},{"issue":"6","key":"10.1016\/j.joca.2025.10.009_bib134","doi-asserted-by":"crossref","first-page":"774","DOI":"10.3390\/brainsci12060774","article-title":"Exploration of the Common Gene Characteristics and Molecular Mechanism of Parkinson\u2019s Disease and Crohn\u2019s Disease from Transcriptome Data","volume":"12","author":"Zheng","year":"2022","journal-title":"Brain Sci."},{"issue":"6","key":"10.1016\/j.joca.2025.10.009_bib135","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1002\/alz.12842","article-title":"Whole-exome rare-variant analysis of Alzheimer's disease and related biomarker traits","volume":"19","author":"K\u00fc\u00e7\u00fckali","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.joca.2025.10.009_bib136","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2019.104603","article-title":"Network-guided analysis of hippocampal proteome identifies novel proteins that colocalize with A\u03b2 in a mice model of early-stage Alzheimer's disease","volume":"132","author":"Aladeokin","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.joca.2025.10.009_bib137","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.174876","article-title":"Cbl-b modulated TrkA ubiquitination and function in the dorsal root ganglion of mice","volume":"921","author":"Chen","year":"2022","journal-title":"Eur. J. Pharm."},{"issue":"3","key":"10.1016\/j.joca.2025.10.009_bib138","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1128\/MCB.20.3.851-867.2000","article-title":"The Cbl proto-oncogene product negatively regulates the Src-family tyrosine kinase Fyn by enhancing its degradation","volume":"20","author":"Andoniou","year":"2000","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.joca.2025.10.009_bib139","doi-asserted-by":"crossref","first-page":"2371","DOI":"10.2147\/IJGM.S456942","article-title":"Integrated Bioinformatics Analysis for Revealing CBL is a Potential Diagnosing Biomarker and Related Immune Infiltration in Parkinson's Disease","volume":"17","author":"Chen","year":"2024","journal-title":"Int J. Gen. Med"},{"issue":"6","key":"10.1016\/j.joca.2025.10.009_bib140","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1302\/2046-3758.136.BJR-2023-0180.R1","article-title":"Cartilage oligomeric matrix protein as a potential biomarker for knee osteoarthritis","volume":"13","author":"Udomsinprasert","year":"2024","journal-title":"Bone Jt. Res"},{"key":"10.1016\/j.joca.2025.10.009_bib141","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2021.105395","article-title":"Advances in protein-protein interaction network analysis for Parkinson's disease","volume":"155","author":"Tomkins","year":"2021","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib142","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1186\/s13075-017-1487-6","article-title":"CX3CL1 promotes MMP-3 production via the CX3CR1, c-Raf, MEK, ERK, and NF-\u03baB signaling pathway in osteoarthritis synovial fibroblasts","volume":"19","author":"Hou","year":"2017","journal-title":"Arthritis Res Ther."},{"issue":"7","key":"10.1016\/j.joca.2025.10.009_bib143","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1007\/s10571-023-01379-9","article-title":"A Study on Autophagy Related Biomarkers in Alzheimer's Disease Based on Bioinformatics","volume":"43","author":"Li","year":"2023","journal-title":"Cell Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.joca.2025.10.009_bib144","first-page":"718","article-title":"The Raf-1 inhibitor GW5074 and the ERK1\/2 pathway inhibitor U0126 ameliorate PC12 cells apoptosis induced by 6-hydroxydopamine","volume":"67","author":"Li","year":"2012","journal-title":"Pharmazie"},{"issue":"11","key":"10.1016\/j.joca.2025.10.009_bib145","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.jfma.2013.09.015","article-title":"A mutation of the Col2a1 gene (G1170S) alters the transgenic murine phenotype and cartilage matrix homeostasis","volume":"113","author":"Yang","year":"2014","journal-title":"J. Formos. Med Assoc."},{"key":"10.1016\/j.joca.2025.10.009_bib146","doi-asserted-by":"crossref","DOI":"10.3389\/fsysb.2023.1085577","article-title":"Alzheimer's Disease Protein Relevance Analysis Using Human and Mouse Model Proteomics Data","volume":"3","author":"Shi","year":"2023","journal-title":"Front Syst. Biol."},{"key":"10.1016\/j.joca.2025.10.009_bib147","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.neuroscience.2016.11.004","article-title":"Genome-wide pathway-based association analysis identifies risk pathways associated with Parkinson's disease","volume":"340","author":"Zhang","year":"2017","journal-title":"Neuroscience"},{"issue":"10","key":"10.1016\/j.joca.2025.10.009_bib148","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1093\/rheumatology\/keaa248","article-title":"A roadmap to target interleukin-6 in osteoarthritis","volume":"59","author":"Wiegertjes","year":"2020","journal-title":"Rheumatol. (Oxf. )"},{"issue":"7","key":"10.1016\/j.joca.2025.10.009_bib149","doi-asserted-by":"crossref","DOI":"10.3390\/cells9071605","article-title":"IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease","volume":"9","author":"Escrig","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.joca.2025.10.009_bib150","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.580068","article-title":"P2X4R Overexpression Upregulates Interleukin-6 and Exacerbates 6-OHDA-Induced Dopaminergic Degeneration in a Rat Model of PD","volume":"12","author":"Ma","year":"2020","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.joca.2025.10.009_bib151","article-title":"PPAR\u03b4 agonist protects against osteoarthritis by activating AKT\/mTOR signaling pathway-mediated autophagy","volume":"15","author":"Sun","year":"2024","journal-title":"Front Pharm."},{"issue":"5","key":"10.1016\/j.joca.2025.10.009_bib152","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0196943","article-title":"Probing the role of PPAR\u03b3 in the regulation of late-onset Alzheimer's disease-associated genes","volume":"13","author":"Barrera","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2025.10.009_bib153","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brainres.2018.09.036","article-title":"Neuroprotective effects of MHY908, a PPAR \u03b1\/\u03b3 dual agonist, in a MPTP-induced Parkinson's disease model","volume":"1704","author":"Lee","year":"2019","journal-title":"Brain Res"},{"issue":"29","key":"10.1016\/j.joca.2025.10.009_bib154","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2207993120","article-title":"NOS inhibition reverses TLR2-induced chondrocyte dysfunction and attenuates age-related osteoarthritis","volume":"120","author":"Shen","year":"2023","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib155","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s13195-020-00714-2","article-title":"p47(phox) deficiency improves cognitive impairment and attenuates tau hyperphosphorylation in mouse models of AD","volume":"12","author":"Gong","year":"2020","journal-title":"Alzheimers Res Ther."},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib156","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s13041-023-00996-1","article-title":"Genetic deletion of nitric oxide synthase 2 ameliorates Parkinson's disease pathology and neuroinflammation in a transgenic mouse model of synucleinopathy","volume":"16","author":"Kim","year":"2023","journal-title":"Mol. Brain"},{"issue":"12","key":"10.1016\/j.joca.2025.10.009_bib157","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1136\/annrheumdis-2021-220000","article-title":"14-3-3 epsilon is an intracellular component of TNFR2 receptor complex and its activation protects against osteoarthritis","volume":"80","author":"Fu","year":"2021","journal-title":"Ann. Rheum. Dis."},{"issue":"37","key":"10.1016\/j.joca.2025.10.009_bib158","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2201137119","article-title":"A TNF receptor 2 agonist ameliorates neuropathology and improves cognition in an Alzheimer's disease mouse model","volume":"119","author":"Ort\u00ed-Casa\u00f1","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib159","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12974-023-02884-w","article-title":"RGS5 augments astrocyte activation and facilitates neuroinflammation via TNF signaling","volume":"20","author":"Yin","year":"2023","journal-title":"J. Neuroinflamm."},{"issue":"3","key":"10.1016\/j.joca.2025.10.009_bib160","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/jor.23263","article-title":"Global molecular changes in a tibial compression induced ACL rupture model of post-traumatic osteoarthritis","volume":"35","author":"Chang","year":"2017","journal-title":"J. Orthop. Res"},{"issue":"s2","key":"10.1016\/j.joca.2025.10.009_bib161","doi-asserted-by":"crossref","first-page":"S299","DOI":"10.3233\/JAD-230314","article-title":"Mitochondria-Related Candidate Genes and Diagnostic Model to Predict Late-Onset Alzheimer's Disease and Mild Cognitive Impairment","volume":"99","author":"Yan","year":"2024","journal-title":"J. Alzheimers Dis."},{"issue":"7886","key":"10.1016\/j.joca.2025.10.009_bib162","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1038\/s41586-021-04059-0","article-title":"Disruption of mitochondrial complex I induces progressive parkinsonism","volume":"599","author":"Gonz\u00e1lez-Rodr\u00edguez","year":"2021","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.joca.2025.10.009_bib163","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3390\/labmed2020008","article-title":"Evaluating Interleukin-6, Tumour Necrosis Factor Alpha, and Myeloperoxidase as Biomarkers in Severe Osteoarthritis Patients: A Biostatistical Perspective","volume":"2","author":"Coleman","year":"2025","journal-title":"LabMed"},{"issue":"2","key":"10.1016\/j.joca.2025.10.009_bib164","article-title":"TNF-\u03b1 Levels Are Increased in Patients with Subjective Cognitive Impairment and Are Negatively Correlated with \u03b2 Amyloid-42","volume":"13","author":"Serafini","year":"2024","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.joca.2025.10.009_bib165","article-title":"The GLP-1 receptor agonist liraglutide inhibits necroptosis and neuroinflammation in a mouse model of Parkinson's disease with diabetes co-morbidity","volume":"19","author":"Zhang","year":"2025","journal-title":"Front Neurosci."},{"issue":"701","key":"10.1016\/j.joca.2025.10.009_bib166","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.abf3535","article-title":"IKK\u03b2-NF-\u03baB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice","volume":"14","author":"Catheline","year":"2021","journal-title":"Sci. Signal"},{"key":"10.1016\/j.joca.2025.10.009_bib167","article-title":"Nanoligomers targeting NF-\u03baB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy","author":"Wahl","year":"2024","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib168","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41531-025-00892-6","article-title":"SVHRSP protects against rotenone-induced neurodegeneration in mice by inhibiting TLR4\/NF-\u03baB-mediated neuroinflammation via gut microbiota","volume":"11","author":"Zhang","year":"2025","journal-title":"npj Park. 's. Dis."},{"issue":"8","key":"10.1016\/j.joca.2025.10.009_bib169","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/hmg\/ddi093","article-title":"A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese","volume":"14","author":"Mototani","year":"2005","journal-title":"Hum. Mol. Genet"},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib170","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s13195-023-01372-w","article-title":"Unraveling the intercellular communication disruption and key pathways in Alzheimer\u2019s disease: an integrative study of single-nucleus transcriptomes and genetic association","volume":"16","author":"Liu","year":"2024","journal-title":"Alzheimer's. Res. Ther."},{"issue":"4","key":"10.1016\/j.joca.2025.10.009_bib171","article-title":"Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion","volume":"12","author":"Shen","year":"2023","journal-title":"Biol. (Basel)"},{"issue":"23","key":"10.1016\/j.joca.2025.10.009_bib172","doi-asserted-by":"crossref","first-page":"4755","DOI":"10.1523\/JNEUROSCI.0140-22.2022","article-title":"Motor Impairments and Dopaminergic Defects Caused by Loss of Leucine-Rich Repeat Kinase Function in Mice","volume":"42","author":"Huang","year":"2022","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib173","doi-asserted-by":"crossref","first-page":"9170","DOI":"10.1038\/s41467-024-53604-8","article-title":"IGF1 drives Wnt-induced joint damage and is a potential therapeutic target for osteoarthritis","volume":"15","author":"Escribano-N\u00fa\u00f1ez","year":"2024","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.joca.2025.10.009_bib174","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1093\/brain\/awx132","article-title":"The Alzheimer\u2019s disease transcriptome mimics the neuroprotective signature of IGF-1 receptor-deficient neurons","volume":"140","author":"George","year":"2017","journal-title":"Brain"},{"issue":"9","key":"10.1016\/j.joca.2025.10.009_bib175","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adk8123","article-title":"Early IGF-1 receptor inhibition in mice mimics preterm human brain disorders and reveals a therapeutic target","volume":"10","author":"Potenzieri","year":"2024","journal-title":"Sci. Adv."},{"issue":"11","key":"10.1016\/j.joca.2025.10.009_bib176","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0206217","article-title":"Deficiency of the pattern-recognition receptor CD14 protects against joint pathology and functional decline in a murine model of osteoarthritis","volume":"13","author":"Sambamurthy","year":"2018","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib177","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3233\/JAD-180904","article-title":"CD14 and Toll-Like Receptor 4 Promote Fibrillar A\u03b242 Uptake by Microglia Through A Clathrin-Mediated Pathway","volume":"68","author":"Fujikura","year":"2019","journal-title":"J. Alzheimers Dis."},{"issue":"4","key":"10.1016\/j.joca.2025.10.009_bib178","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1080\/08923970802278557","article-title":"Expression of TLR4 and CD14 in the central nervous system (CNS) in a MPTP mouse model of Parkinson's-like disease","volume":"30","author":"Panaro","year":"2008","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.joca.2025.10.009_bib179","first-page":"147","article-title":"Forkhead box O3 attenuates osteoarthritis by suppressing ferroptosis through inactivation of NF-\u03baB\/MAPK signaling","volume":"39","author":"Zhao","year":"2023","journal-title":"J. Orthop. Transl."},{"issue":"1","key":"10.1016\/j.joca.2025.10.009_bib180","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.5213\/inj.2142164.082","article-title":"Treadmill Running Improves Spatial Learning Memory Through Inactivation of Nuclear Factor Kappa B\/Mitogen-Activated Protein Kinase Signaling Pathway in Amyloid-\u03b2-Induced Alzheimer Disease Rats","volume":"25","author":"Kim","year":"2021","journal-title":"Int Neurourol. J."},{"issue":"2","key":"10.1016\/j.joca.2025.10.009_bib181","first-page":"67","article-title":"p38 MAPK and PI3K\/AKT Signalling Cascades inParkinson's Disease","volume":"4","author":"Jha","year":"2015","journal-title":"Int J. Mol. Cell Med"},{"issue":"11","key":"10.1016\/j.joca.2025.10.009_bib182","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1302\/2046-3758.711.BJR-2018-0057.R1","article-title":"Mechanical stress contributes to osteoarthritis development through the activation of transforming growth factor beta 1 (TGF-\u03b21)","volume":"7","author":"Zhang","year":"2018","journal-title":"Bone Jt. Res"},{"issue":"12","key":"10.1016\/j.joca.2025.10.009_bib183","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.2174\/1389203719666171129094937","article-title":"Transforming Growth Factor Beta Type I Role in Neurodegeneration: Implications for Alzheimer\u00b4s Disease","volume":"19","author":"Estrada","year":"2018","journal-title":"Curr. Protein Pept. Sci."},{"issue":"17","key":"10.1016\/j.joca.2025.10.009_bib184","doi-asserted-by":"crossref","first-page":"4584","DOI":"10.1523\/JNEUROSCI.2952-16.2017","article-title":"Deficiency in Neuronal TGF-\u03b2 Signaling Leads to Nigrostriatal Degeneration and Activation of TGF-\u03b2 Signaling Protects against MPTP Neurotoxicity in Mice","volume":"37","author":"Tesseur","year":"2017","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.joca.2025.10.009_bib185","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/15548627.2019.1606647","article-title":"MTORC1 coordinates the autophagy and apoptosis signaling in articular chondrocytes in osteoarthritic temporomandibular joint","volume":"16","author":"Yang","year":"2020","journal-title":"Autophagy"},{"issue":"4","key":"10.1016\/j.joca.2025.10.009_bib186","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14463","article-title":"mTOR signaling and Alzheimer's disease: What we know and where we are?","volume":"30","author":"Davoody","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"724","key":"10.1016\/j.joca.2025.10.009_bib187","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.add0499","article-title":"Enhanced mTORC1 signaling and protein synthesis in pathologic \u03b1-synuclein cellular and animal models of Parkinson's disease","volume":"15","author":"Khan","year":"2023","journal-title":"Sci. Transl. Med"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345842501194X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S106345842501194X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:45:01Z","timestamp":1773816301000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S106345842501194X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":187,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S106345842501194X"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2025.10.009","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathophysiological mechanisms linking osteoarthritis and neurodegenerative disease risk","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2025.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}