{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:12:06Z","timestamp":1778199126379,"version":"3.51.4"},"reference-count":51,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T00:00:00Z","timestamp":1763683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"UK Research and Innovation Medical Research Council","doi-asserted-by":"publisher","award":["JXR 10641"],"award-info":[{"award-number":["JXR 10641"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001271","name":"Chartered Institute of Management Accountants","doi-asserted-by":"publisher","award":["MR\/P020941\/1"],"award-info":[{"award-number":["MR\/P020941\/1"]}],"id":[{"id":"10.13039\/501100001271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Arthritis UK","doi-asserted-by":"publisher","award":["19424"],"award-info":[{"award-number":["19424"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012041","name":"Arthritis UK","doi-asserted-by":"publisher","award":["22043"],"award-info":[{"award-number":["22043"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010089","name":"JGW Patterson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010089","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000377","name":"The Dunhill Medical Trust","doi-asserted-by":"publisher","award":["R476\/0516"],"award-info":[{"award-number":["R476\/0516"]}],"id":[{"id":"10.13039\/501100000377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.joca.2025.11.005","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:43:26Z","timestamp":1763538206000},"page":"405-416","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptomic profiling confirms microRNA-140 is more functional in joint development than in disease"],"prefix":"10.1016","volume":"34","author":[{"given":"Yao","family":"Hao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0440-7604","authenticated-orcid":false,"given":"Hua","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jamie","family":"Soul","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynne M.","family":"Overman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven N.","family":"Lisgo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Coxhead","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna A.","family":"Pir\u00f3g","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2619-0896","authenticated-orcid":false,"given":"Ian M.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9158-8246","authenticated-orcid":false,"given":"Matt J.","family":"Barter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise N.","family":"Reynard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7078-6745","authenticated-orcid":false,"given":"David A.","family":"Young","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2025.11.005_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.cell.2004.12.035","article-title":"Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets","volume":"120","author":"Lewis","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.joca.2025.11.005_bib2","doi-asserted-by":"crossref","first-page":"R169","DOI":"10.1093\/hmg\/ddq367","article-title":"Analysis of microRNA knockouts in mice","volume":"19","author":"Park","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.joca.2025.11.005_bib3","doi-asserted-by":"crossref","first-page":"10898","DOI":"10.1073\/pnas.0504834102","article-title":"The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb","volume":"102","author":"Harfe","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.joca.2025.11.005_bib4","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1073\/pnas.0707900105","article-title":"Dicer-dependent pathways regulate chondrocyte proliferation and differentiation","volume":"105","author":"Kobayashi","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.joca.2025.11.005_bib5","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.joca.2015.02.015","article-title":"Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage","volume":"23","author":"Kobayashi","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2025.11.005_bib6","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41591-019-0353-2","article-title":"Gain-of-function mutation of microRNA-140 in human skeletal dysplasia","volume":"25","author":"Grigelioniene","year":"2019","journal-title":"Nat. Med"},{"key":"10.1016\/j.joca.2025.11.005_bib7","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1101\/gad.1915510","article-title":"MicroRNA-140 plays dual roles in both cartilage development and homeostasis","volume":"24","author":"Miyaki","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.joca.2025.11.005_bib8","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.joca.2017.06.002","article-title":"Intra-articular injection of microRNA-140 (miRNA-140) alleviates osteoarthritis (OA) progression by modulating extracellular matrix (ECM) homeostasis in rats","volume":"25","author":"Si","year":"2017","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2025.11.005_bib9","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1038\/s41467-019-10177-1","article-title":"Wwp2 maintains cartilage homeostasis through regulation of Adamts5","volume":"10","author":"Mokuda","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.joca.2025.11.005_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003740","article-title":"Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks","volume":"3","author":"Iliopoulos","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2025.11.005_bib11","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.05005","article-title":"Predicting effective microRNA target sites in mammalian mRNAs","volume":"4","author":"Agarwal","year":"2015","journal-title":"Elife"},{"issue":"120","key":"10.1016\/j.joca.2025.11.005_bib12","first-page":"40","article-title":"The function of microRNAs in cartilage and osteoarthritis","volume":"37","author":"Swingler","year":"2019","journal-title":"Clin. Exp. Rheuma"},{"key":"10.1016\/j.joca.2025.11.005_bib13","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1261\/rna.075176.120","article-title":"microRNA-seq of cartilage reveals an overabundance of miR-140-3p which contains functional isomiRs","volume":"26","author":"Woods","year":"2020","journal-title":"RNA"},{"key":"10.1016\/j.joca.2025.11.005_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003746","article-title":"Cauli: a mouse strain with an Ift140 mutation that results in a skeletal ciliopathy modelling Jeune syndrome","volume":"9","author":"Miller","year":"2013","journal-title":"PLoS Genet"},{"key":"10.1016\/j.joca.2025.11.005_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054633","article-title":"Disease progression and phasic changes in gene expression in a mouse model of osteoarthritis","volume":"8","author":"Loeser","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.joca.2025.11.005_bib16","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.050583","article-title":"Comparative transcriptomic analysis of articular cartilage of post-traumatic osteoarthritis models","volume":"17","author":"Gilbert","year":"2024","journal-title":"Dis. Model Mech."},{"key":"10.1016\/j.joca.2025.11.005_bib17","doi-asserted-by":"crossref","first-page":"W415","DOI":"10.1093\/nar\/gkae456","article-title":"WebGestalt 2024: faster gene set analysis and new support for metabolomics and multi-omics","volume":"52","author":"Elizarraras","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.joca.2025.11.005_bib18","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.joca.2007.03.006","article-title":"The surgical destabilization of the medial meniscus (DMM) model of osteoarthritis in the 129\/SvEv mouse","volume":"15","author":"Glasson","year":"2007","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2025.11.005_bib19","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1002\/art.38681","article-title":"Glycogen synthase kinase 3 inhibition stimulates human cartilage destruction and exacerbates murine osteoarthritis","volume":"66","author":"Litherland","year":"2014","journal-title":"Arthritis Rheuma"},{"issue":"3","key":"10.1016\/j.joca.2025.11.005_bib20","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2025.11.005_bib21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2025.11.005_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.ocarto.2023.100409","article-title":"Establishment of a uniform histological evaluation method for early stage osteophytes in the destabilization of the medial meniscus mouse model","volume":"5","author":"Jono","year":"2023","journal-title":"Osteoarthr. Cartil. Open"},{"key":"10.1016\/j.joca.2025.11.005_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-66979-7","article-title":"Histological scoring system for subchondral bone changes in murine models of joint aging and osteoarthritis","volume":"10","author":"Nagira","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.joca.2025.11.005_bib24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s41587-023-01767-y","article-title":"Dictionary learning for integrative, multimodal and scalable single-cell analysis","volume":"42","author":"Hao","year":"2024","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.joca.2025.11.005_bib25","doi-asserted-by":"crossref","first-page":"6077","DOI":"10.1038\/s41467-020-19894-4","article-title":"muscat detects subpopulation-specific state transitions from multi-sample multi-condition single-cell transcriptomics data","volume":"11","author":"Crowell","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.joca.2025.11.005_bib26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.joca.2025.11.005_bib27","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.joca.2025.11.005_bib28","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1093\/hmg\/ddm155","article-title":"Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP","volume":"16","author":"Pirog-Garcia","year":"2007","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.joca.2025.11.005_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2024.117273","article-title":"microRNA-324 mediates bone homeostasis and the regulation of osteoblast and osteoclast differentiation and activity","volume":"190","author":"Hayman","year":"2025","journal-title":"Bone"},{"key":"10.1016\/j.joca.2025.11.005_bib30","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/s41556-018-0077-4","article-title":"Dissecting the roles of miR-140 and its host gene","volume":"20","author":"Inui","year":"2018","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.joca.2025.11.005_bib31","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1128\/MCB.05178-11","article-title":"Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling","volume":"31","author":"Nakamura","year":"2011","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.joca.2025.11.005_bib32","doi-asserted-by":"crossref","first-page":"E3291","DOI":"10.1073\/pnas.1302797110","article-title":"let-7 and miR-140 microRNAs coordinately regulate skeletal development","volume":"110","author":"Papaioannou","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.joca.2025.11.005_bib33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.omtn.2019.10.032","article-title":"miR-140 attenuates the progression of early-stage osteoarthritis by retarding chondrocyte senescence","volume":"19","author":"Si","year":"2020","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.joca.2025.11.005_bib34","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.joca.2025.11.005_bib35","doi-asserted-by":"crossref","DOI":"10.1126\/science.aav1741","article-title":"The biochemical basis of microRNA targeting efficacy","volume":"366","author":"McGeary","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.joca.2025.11.005_bib36","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1038\/s41598-018-21184-5","article-title":"Early changes of articular cartilage and subchondral bone in The DMM mouse model of osteoarthritis","volume":"8","author":"Fang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.joca.2025.11.005_bib37","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.joca.2025.11.005_bib38","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1038\/nmeth.1267","article-title":"Detecting microRNA binding and siRNA off-target effects from expression data","volume":"5","author":"van Dongen","year":"2008","journal-title":"Nat. Methods"},{"key":"10.1016\/j.joca.2025.11.005_bib39","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.ymgme.2018.04.014","article-title":"Delayed development of ossification centers in the tibia of prenatal and early postnatal MPS VII mice","volume":"124","author":"Jiang","year":"2018","journal-title":"Mol. Genet Metab."},{"key":"10.1016\/j.joca.2025.11.005_bib40","doi-asserted-by":"crossref","first-page":"D147","DOI":"10.1093\/nar\/gkae1072","article-title":"miRTarBase 2025: updates to the collection of experimentally validated microRNA-target interactions","volume":"53","author":"Cui","year":"2025","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.joca.2025.11.005_bib41","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17121987","article-title":"Tools for sequence-based miRNA target prediction: what to choose?","volume":"17","author":"Riffo-Campos","year":"2016","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.joca.2025.11.005_bib42","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1136\/annrheumdis-2020-218350","article-title":"Identification of the skeletal progenitor cells forming osteophytes in osteoarthritis","volume":"79","author":"Roelofs","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.joca.2025.11.005_bib43","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1093\/jbmr\/zjae144","article-title":"The G protein-coupled receptor ADGRG6 maintains mouse growth plate homeostasis through IHH signaling","volume":"39","author":"Bian","year":"2024","journal-title":"J. Bone Min. Res"},{"key":"10.1016\/j.joca.2025.11.005_bib44","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/nyas.13407","article-title":"Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?","volume":"1401","author":"Marchev","year":"2017","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.joca.2025.11.005_bib45","doi-asserted-by":"crossref","first-page":"R200","DOI":"10.1016\/S0960-9822(02)00749-2","article-title":"Notch cleavage: Nicastrin helps Presenilin make the final cut","volume":"12","author":"Lai","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.joca.2025.11.005_bib46","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nm1716","article-title":"Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation","volume":"14","author":"Hilton","year":"2008","journal-title":"Nat. Med"},{"key":"10.1016\/j.joca.2025.11.005_bib47","doi-asserted-by":"crossref","first-page":"ra71","DOI":"10.1126\/scisignal.aaa3792","article-title":"A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis","volume":"8","author":"Liu","year":"2015","journal-title":"Sci. Signal"},{"key":"10.1016\/j.joca.2025.11.005_bib48","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/ng.82","article-title":"MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis","volume":"40","author":"Eberhart","year":"2008","journal-title":"Nat. Genet"},{"key":"10.1016\/j.joca.2025.11.005_bib49","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15388-4","article-title":"Deep sequencing and analyses of miRNAs, isomiRs and miRNA induced silencing complex (miRISC)-associated miRNome in primary human chondrocytes","volume":"7","author":"Haseeb","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.joca.2025.11.005_bib50","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1261\/rna.079013.121","article-title":"Reversing the miRNA -5p\/-3p stoichiometry reveals physiological roles and targets of miR-140 miRNAs","volume":"28","author":"Young","year":"2022","journal-title":"RNA"},{"key":"10.1016\/j.joca.2025.11.005_bib51","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/nrrheum.2011.129","article-title":"Cartilage biology in osteoarthritis--lessons from developmental biology","volume":"7","author":"Pitsillides","year":"2011","journal-title":"Nat. Rev. Rheuma"}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458425012294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458425012294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T23:58:50Z","timestamp":1778198330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458425012294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S1063458425012294"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2025.11.005","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptomic profiling confirms microRNA-140 is more functional in joint development than in disease","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2025.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}