{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:17:01Z","timestamp":1792016221180,"version":"4.4.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T00:00:00Z","timestamp":1783123200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012041","name":"Arthritis UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018955","name":"Leeds Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oarsijournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Osteoarthritis and Cartilage"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.joca.2026.07.002","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:26:48Z","timestamp":1783438008000},"page":"1539-1549","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Systemic biomarkers of treatment response to methotrexate in people with painful knee osteoarthritis: A biological substudy of the PROMOTE randomised controlled clinical trial"],"prefix":"10.1016","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-6679-3232","authenticated-orcid":false,"given":"Jiahao","family":"Liang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2295-3713","authenticated-orcid":false,"given":"Artemis","family":"Papadaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0526-7797","authenticated-orcid":false,"given":"Jennifer","family":"Alderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3412-5712","authenticated-orcid":false,"given":"Tonia L.","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3478-5665","authenticated-orcid":false,"given":"Philip G.","family":"Conaghan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9917-1269","authenticated-orcid":false,"given":"Sarah R.","family":"Kingsbury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6066-7590","authenticated-orcid":false,"given":"Fiona E.","family":"Watt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joca.2026.07.002_bib1","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/art.42089","article-title":"Prevalence trends of site-specific osteoarthritis from 1990 to 2019: findings from the global burden of disease study 2019","volume":"74","author":"Long","year":"2022","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.joca.2026.07.002_bib2","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1002\/art.39488","article-title":"Association of joint inflammation with pain sensitization in knee osteoarthritis: the multicenter osteoarthritis study","volume":"68","author":"Neogi","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.joca.2026.07.002_bib3","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1136\/annrheumdis-2014-205894","article-title":"Synovitis in knee osteoarthritis: a precursor of disease?","volume":"75","author":"Atukorala","year":"2016","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.joca.2026.07.002_bib4","doi-asserted-by":"crossref","first-page":"2422","DOI":"10.1002\/art.39731","article-title":"Semiquantitative imaging biomarkers of knee osteoarthritis progression: data from the foundation for the national institutes of health osteoarthritis biomarkers consortium","volume":"68","author":"Collins","year":"2016","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.joca.2026.07.002_bib5","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1136\/ard.2009.121426","article-title":"Relation of synovitis to knee pain using contrast-enhanced MRIs","volume":"69","author":"Baker","year":"2010","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.joca.2026.07.002_bib6","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","article-title":"The role of synovitis in osteoarthritis pathogenesis","volume":"51","author":"Scanzello","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.joca.2026.07.002_bib7","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s13075-017-1229-9","article-title":"Synovitis in osteoarthritis: current understanding with therapeutic implications","volume":"19","author":"Mathiessen","year":"2017","journal-title":"Arthritis Res. Ther."},{"issue":"3","key":"10.1016\/j.joca.2026.07.002_bib8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3892\/mmr.2022.12615","article-title":"Cartilage tissue engineering: from proinflammatory and anti\u2011inflammatory cytokines to osteoarthritis treatments (Review)","volume":"25","author":"Liu","year":"2022","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.joca.2026.07.002_bib9","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1136\/annrheumdis-2016-210426","article-title":"CCL2\/CCR2, but not CCL5\/CCR5, mediates monocyte recruitment, inflammation and cartilage destruction in osteoarthritis","volume":"76","author":"Raghu","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.joca.2026.07.002_bib10","doi-asserted-by":"crossref","first-page":"20602","DOI":"10.1073\/pnas.1209294110","article-title":"CCR2 chemokine receptor signaling mediates pain in experimental osteoarthritis","volume":"109","author":"Miller","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.joca.2026.07.002_bib11","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/art.22369","article-title":"The role of T cells in the pathogenesis of osteoarthritis","volume":"56","author":"Sakkas","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.joca.2026.07.002_bib12","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.joca.2024.05.008","article-title":"Repurposing drugs for the treatment of osteoarthritis","volume":"32","author":"Kuswanto","year":"2024","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2026.07.002_bib13","doi-asserted-by":"crossref","DOI":"10.1177\/1759720X221090297","article-title":"Repurposed and investigational disease-modifying drugs in osteoarthritis (DMOADs)","volume":"14","author":"Oo","year":"2022","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"10.1016\/j.joca.2026.07.002_bib14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/s41584-020-0373-9","article-title":"Methotrexate and its mechanisms of action in inflammatory arthritis","volume":"16","author":"Cronstein","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.joca.2026.07.002_bib15","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1002\/art.30457","article-title":"Increased sensitivity to apoptosis induced by methotrexate is mediated by JNK","volume":"63","author":"Spurlock","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.joca.2026.07.002_bib16","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.joca.2012.08.027","article-title":"Synovial inflammation, immune cells and their cytokines in osteoarthritis: a review","volume":"20","author":"de Lange-Brokaar","year":"2012","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2026.07.002_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.113074","article-title":"Application and pharmacological mechanism of methotrexate in rheumatoid arthritis","volume":"150","author":"Zhao","year":"2022","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.joca.2026.07.002_bib18","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.7326\/M24-0303","article-title":"Pain Reduction With Oral Methotrexate in Knee Osteoarthritis: A Randomized, Placebo-Controlled Clinical Trial","volume":"177","author":"Kingsbury","year":"2024","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.joca.2026.07.002_bib19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s13063-015-0602-8","article-title":"Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trial","volume":"16","author":"Kingsbury","year":"2015","journal-title":"Trials"},{"key":"10.1016\/j.joca.2026.07.002_bib20","doi-asserted-by":"crossref","first-page":"509","DOI":"10.7326\/M20-0527","article-title":"Effects of Interleukin-1beta Inhibition on Incident Hip and Knee Replacement: Exploratory Analyses From a Randomized, Double-Blind, Placebo-Controlled Trial","volume":"173","author":"Schieker","year":"2020","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.joca.2026.07.002_bib21","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1001\/jama.2018.3060","article-title":"Trends in Obesity and Severe Obesity Prevalence in US Youth and Adults by Sex and Age, 2007-2008 to 2015-2016","volume":"319","author":"Hales","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.joca.2026.07.002_bib22","article-title":"Interferon-gamma modulates articular chondrocyte and osteoblast metabolism through protein kinase R-independent and dependent mechanisms","volume":"32","author":"Gilbert","year":"2022","journal-title":"Biochem. Biophys. Rep."},{"key":"10.1016\/j.joca.2026.07.002_bib23","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/03009740600588186","article-title":"The effect of methotrexate (MTX) on expression of signalling lymphocytic activation molecule (SLAM) in patients with rheumatoid arthritis (RA) and its role in the regulation of cytokine production","volume":"35","author":"Morita","year":"2006","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.joca.2026.07.002_bib24","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1016\/j.joca.2009.02.011","article-title":"Local cytokine profiles in knee osteoarthritis: elevated synovial fluid interleukin-15 differentiates early from end-stage disease","volume":"17","author":"Scanzello","year":"2009","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2026.07.002_bib25","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1155\/2013\/176278","article-title":"Serum interleukin-15 levels are associated with severity of pain in patients with knee osteoarthritis","volume":"35","author":"Sun","year":"2013","journal-title":"Dis. Markers"},{"key":"10.1016\/j.joca.2026.07.002_bib26","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.3389\/fimmu.2020.01385","article-title":"IL-15 and IL15RA in Osteoarthritis: Association With Symptoms and Protease Production, but Not Structural Severity","volume":"11","author":"Warner","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.joca.2026.07.002_bib27","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.4049\/jimmunol.173.2.1463","article-title":"de Ayala and E. Martin-Mola. IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate","volume":"173","author":"Miranda-Carus","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.joca.2026.07.002_bib28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.cyto.2015.12.002","article-title":"Serum proteomic analysis identifies interleukin 16 as a biomarker for clinical response during early treatment of rheumatoid arthritis","volume":"78","author":"Murota","year":"2016","journal-title":"Cytokine"},{"key":"10.1016\/j.joca.2026.07.002_bib29","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1177\/19476035231168387","article-title":"IL16 Regulates Osteoarthritis Progression as a Target Gene of Novel-miR-81","volume":"15","author":"Luo","year":"2024","journal-title":"Cartilage"},{"key":"10.1016\/j.joca.2026.07.002_bib30","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1038\/s41467-023-39919-y","article-title":"Increased body mass index is linked to systemic inflammation through altered chromatin co-accessibility in human preadipocytes","volume":"14","author":"Garske","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.joca.2026.07.002_bib31","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.4049\/jimmunol.162.7.4293","article-title":"IL-16 as an anti-inflammatory cytokine in rheumatoid synovitis","volume":"162","author":"Klimiuk","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.joca.2026.07.002_bib32","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3892\/br.2012.42","article-title":"TNF inhibitor therapy for rheumatoid arthritis","volume":"1","author":"Ma","year":"2013","journal-title":"Biomed. Rep."},{"key":"10.1016\/j.joca.2026.07.002_bib33","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.joca.2010.08.016","article-title":"Circulating levels of IL-6 and TNF-\u03b1 are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults","volume":"18","author":"Stannus","year":"2010","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2026.07.002_bib34","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.joca.2018.02.899","article-title":"A randomised double-blind placebo-controlled crossover trial of HUMira (adalimumab) for erosive hand OsteoaRthritis - the HUMOR trial","volume":"26","author":"Aitken","year":"2018","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2026.07.002_bib35","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.3349\/ymj.2015.56.5.1379","article-title":"Efficacy of direct injection of etanercept into knee joints for pain in moderate and severe knee osteoarthritis","volume":"56","author":"Ohtori","year":"2015","journal-title":"Yonsei Med. J."},{"key":"10.1016\/j.joca.2026.07.002_bib36","doi-asserted-by":"crossref","first-page":"e648","DOI":"10.1016\/S2665-9913(21)00116-8","article-title":"Clinical and molecular associations with outcomes at 2 years after acute knee injury: a longitudinal study in the Knee Injury Cohort at the Kennedy (KICK)","volume":"3","author":"Garriga","year":"2021","journal-title":"Lancet Rheumatol."},{"key":"10.1016\/j.joca.2026.07.002_bib37","article-title":"Serum levels of proinflammatory cytokines in painful knee osteoarthritis and sensitization","volume":"2015","author":"Imamura","year":"2015","journal-title":"Int. J. Inflam."},{"key":"10.1016\/j.joca.2026.07.002_bib38","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1097\/j.pain.0000000000000908","article-title":"Biomarker of extracellular matrix remodelling C1M and proinflammatory cytokine interleukin 6 are related to synovitis and pain in end-stage knee osteoarthritis patients","volume":"158","author":"Radojcic","year":"2017","journal-title":"Pain"},{"key":"10.1016\/j.joca.2026.07.002_bib39","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.joca.2006.10.010","article-title":"Elevated high-sensitivity C-reactive protein levels are associated with local inflammatory findings in patients with osteoarthritis","volume":"15","author":"Pearle","year":"2007","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.joca.2026.07.002_bib40","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1136\/ard.2004.029892","article-title":"Value of C reactive protein in the assessment of erosive osteoarthritis of the hand","volume":"64","author":"Punzi","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.joca.2026.07.002_bib41","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1177\/1759720X12455959","article-title":"Significance of C-reactive protein in osteoarthritis and total knee arthroplasty outcomes","volume":"4","author":"Smith","year":"2012","journal-title":"Ther. Adv. Musculoskelet. Dis."},{"key":"10.1016\/j.joca.2026.07.002_bib42","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1196\/annals.1351.019","article-title":"Epidemiological aspects of rheumatoid arthritis: the sex ratio","volume":"1069","author":"Kvien","year":"2006","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.joca.2026.07.002_bib43","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12891-018-1938-5","article-title":"Identification of pain categories associated with change in pain in patients receiving placebo: data from two phase 3 randomized clinical trials in symptomatic knee osteoarthritis","volume":"19","author":"Bihlet","year":"2018","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.joca.2026.07.002_bib44","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1002\/art.40840","article-title":"A Phase II Trial of Lutikizumab, an Anti-Interleukin-1alpha\/beta Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis","volume":"71","author":"Fleischmann","year":"2019","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.joca.2026.07.002_bib45","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1002\/art.41315","article-title":"Lorecivivint, a Novel Intraarticular CDC-like Kinase 2 and Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase 1A Inhibitor and Wnt Pathway Modulator for the Treatment of Knee Osteoarthritis: A Phase II Randomized Trial","volume":"72","author":"Yazici","year":"2020","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.joca.2026.07.002_bib46","doi-asserted-by":"crossref","first-page":"4721","DOI":"10.1038\/s41467-026-71632-4","article-title":"Large-scale molecular endotype discovery in synovial fluid reveals osteoarthritis as a single biological continuum","volume":"17","author":"Perry","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.joca.2026.07.002_bib47","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.joca.2019.12.005","article-title":"The molecular profile of synovial fluid changes upon joint distraction and is associated with clinical response in knee osteoarthritis","volume":"28","author":"Watt","year":"2020","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.joca.2026.07.002_bib48","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/s13063-020-04901-2","article-title":"A comparison of approaches for combining predictive markers for personalised treatment recommendations","volume":"22","author":"Pierce","year":"2021","journal-title":"Trials"},{"key":"10.1016\/j.joca.2026.07.002_bib49","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1093\/rheumatology\/kew201","article-title":"Harmonising data collection from osteoarthritis studies to enable stratification: recommendations on core data collection from an Arthritis Research UK clinical studies group","volume":"55","author":"Kingsbury","year":"2016","journal-title":"Rheumatology"},{"key":"10.1016\/j.joca.2026.07.002_bib50","doi-asserted-by":"crossref","first-page":"e635","DOI":"10.1016\/S2665-9913(22)00136-9","article-title":"Research priorities to reduce the impact of musculoskeletal disorders: a priority setting exercise with the child health and nutrition research initiative method","volume":"4","author":"Paskins","year":"2022","journal-title":"Lancet Rheumatol."}],"container-title":["Osteoarthritis and Cartilage"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458426009751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1063458426009751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:14:06Z","timestamp":1789085646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1063458426009751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":50,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1063458426009751"],"URL":"https:\/\/doi.org\/10.1016\/j.joca.2026.07.002","relation":{},"ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic biomarkers of treatment response to methotrexate in people with painful knee osteoarthritis: A biological substudy of the PROMOTE randomised controlled clinical trial","name":"articletitle","label":"Article Title"},{"value":"Osteoarthritis and Cartilage","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joca.2026.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd on behalf of Osteoarthritis Research Society International.","name":"copyright","label":"Copyright"}]}}