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Rep."},{"issue":"1","key":"10.1016\/j.joca.2026.09.014_bib139","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.joca.2016.07.021","article-title":"Lubricin\/proteoglycan 4 increases in both experimental and naturally occurring equine osteoarthritis","volume":"25","author":"Reesink","year":"2017","journal-title":"Osteoarthr. Cartil."},{"issue":"1","key":"10.1016\/j.joca.2026.09.014_bib140","article-title":"Synovial fluid lubricin increases in spontaneous canine cruciate ligament rupture","volume":"10","author":"Wang","year":"2020","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.joca.2026.09.014_bib141","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1177\/0363546516686965","article-title":"Intra-articular recombinant human proteoglycan 4 mitigates cartilage damage after destabilization of the medial meniscus in the yucatan minipig","volume":"45","author":"Waller","year":"2017","journal-title":"Am. J. 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Med."},{"issue":"1","key":"10.1016\/j.joca.2026.09.014_bib148","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/jbmr.508","article-title":"Proteoglycan 4: a dynamic regulator of skeletogenesis and parathyroid hormone skeletal anabolism","volume":"27","author":"Novince","year":"2012","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.joca.2026.09.014_bib149","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1177\/0022034515613508","article-title":"Excess BMP signaling in heterotopic cartilage forming in Prg4-null TMJ Discs","volume":"95","author":"Bechtold","year":"2016","journal-title":"J. Dent. 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