{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:47:49Z","timestamp":1780678069416,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Densitometry"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1016\/j.jocd.2017.03.005","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T23:00:24Z","timestamp":1501887624000},"page":"227-235","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Role of APOE Gene in Bone Mineral Density and Incidence of Bone Fractures in Brazilian Postmenopausal Women"],"prefix":"10.1016","volume":"21","author":[{"given":"Leticia S.","family":"Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neuza Felix","family":"Rochette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Fran\u00e7a","family":"Pedrosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafaella P. Lopes","family":"Magnago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodiano B. Freire","family":"Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Luiz H.","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irani do Carmo F.","family":"Fin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio R.","family":"Eis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jones B.","family":"Graceli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia B.A.","family":"Rangel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian V.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jocd.2017.03.005_bib0010","author":"National Osteoporosis Foundation\u2014NOF"},{"issue":"4","key":"10.1016\/j.jocd.2017.03.005_bib0015","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00006416-199207000-00005","article-title":"Osteoporosis: the silent disease","volume":"11","author":"Liscum","year":"1992","journal-title":"Orth Nurs"},{"issue":"17","key":"10.1016\/j.jocd.2017.03.005_bib0020","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1001\/jama.1992.03490170075028","article-title":"Bone gain in young adult women","volume":"268","author":"Recker","year":"1992","journal-title":"JAMA"},{"key":"10.1016\/j.jocd.2017.03.005_bib0025","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.jocd.2013.01.004","article-title":"Selection of women aged 50-64Yr for bone density measurement","volume":"16","author":"Leslie","year":"2013","journal-title":"J Clin Densitom"},{"key":"10.1016\/j.jocd.2017.03.005_bib0030","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1161\/01.ATV.20.11.2346","article-title":"Role of lipids in osteoporosis","volume":"20","author":"Parhami","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"10.1016\/j.jocd.2017.03.005_bib9000","article-title":"Long-term hormone therapy for perimenopausal and postmenopausal women","author":"Marjoribanks","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jocd.2017.03.005_bib0035","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/nrendo.2013.17","article-title":"Postmenopausal hormone therapy: risks and benefits","volume":"9","author":"Rozenberg","year":"2013","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"10.1016\/j.jocd.2017.03.005_bib0040","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.gene.2012.10.041","article-title":"Association between osteoporosis and polymorphisms of the bone Gla protein, estrogen receptor 1, collagen 1-A1 and calcitonin receptor genes in Turkish postmenopausal women","volume":"515","author":"Tural","year":"2013","journal-title":"Gene"},{"key":"10.1016\/j.jocd.2017.03.005_bib0045","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1677\/joe.0.1770147","article-title":"Review: molecular studies of identification of genes for osteoporosis: the 2002 update","volume":"177","author":"Liu","year":"2003","journal-title":"J Endocrinol"},{"issue":"3","key":"10.1016\/j.jocd.2017.03.005_bib0050","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1359\/jbmr.061113","article-title":"Incidence and economic burden of osteoporotic fractures in the United States, 2005\u20132025","volume":"22","author":"Burge","year":"2007","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.jocd.2017.03.005_bib0055","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1007\/s001980170124","article-title":"Osteoporosis and apolipoprotein E genotype in older adults: the Rancho Bernardo study","volume":"12","author":"von M\u00fchlen","year":"2001","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.jocd.2017.03.005_sr0060","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.maturitas.2004.01.008","article-title":"Apolipoprotein E polymorphisms is not associated with spinal bone mineral density in peri and postmenopausal Greek women","volume":"48","author":"Efsthatiadou","year":"2005","journal-title":"Maturitas"},{"key":"10.1016\/j.jocd.2017.03.005_sr0065","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/jgs.12147","article-title":"Geriatric syndromes and incident disability in older women: results from the women's health initiative observational study","volume":"61","author":"Rosso","year":"2013","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.jocd.2017.03.005_bib0065","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s001980200096","article-title":"Effects of gender and age on the association of apolipoprotein E4 with bone mineral density, bone turnover and the risk of fractures in older people","volume":"13","author":"Pluijim","year":"2002","journal-title":"Osteoporos Int"},{"issue":"4","key":"10.1016\/j.jocd.2017.03.005_bib0070","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/00365510310001177","article-title":"Association between polymorphisms of apolipoprotein E, bone mineral density of the lower forearm, quantitative ultrasound of the calcaneus and osteoporotic fractures in postmenopausal women with hip or lower forearm fracture","volume":"63","author":"Snnels","year":"2003","journal-title":"Scand J Clin Lab Invest"},{"issue":"4","key":"10.1016\/j.jocd.2017.03.005_bib0075","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1007\/BF03345178","article-title":"Apolipoprotein E4 allele is associated with low bone density in postmenopausal women","volume":"26","author":"Zajickova","year":"2003","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.jocd.2017.03.005_bib0080","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00223-004-0034-z","article-title":"APOE haplotypes influence bone mineral density in Caucasian males but not females","volume":"v.75","author":"Long","year":"2004","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.jocd.2017.03.005_bib0085","doi-asserted-by":"crossref","first-page":"1192S","DOI":"10.1093\/jn\/126.suppl_4.1192S","article-title":"Transport of vitamin K to bone in humans","volume":"126","author":"Kohlmeier","year":"1996","journal-title":"J Nutr"},{"key":"10.1016\/j.jocd.2017.03.005_bib0090","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0083-6729(07)00017-9","article-title":"Diagnosis of osteoporosis with vitamin K as a new biochemical marker","volume":"78","author":"Heiss","year":"2008","journal-title":"Vitam Horm"},{"key":"10.1016\/j.jocd.2017.03.005_bib0095","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1161\/01.ATV.16.10.1250","article-title":"Apolipoprotein E alleles and risk of coronary disease. A meta analysis","volume":"16","author":"Wilson","year":"1996","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"9","key":"10.1016\/j.jocd.2017.03.005_bib0100","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1359\/JBMR.040605","article-title":"ApoE gene polymorphisms, BMD, and fracture risk in elderly men and women: the Rotterdam Study","volume":"19","author":"Schofs","year":"2004","journal-title":"J Bone Miner Res"},{"issue":"4","key":"10.1016\/j.jocd.2017.03.005_bib0105","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.maturitas.2010.08.006","article-title":"Evaluation of PvuII and XbaI polymorphisms in the estrogen receptor alpha gene (ESR1) in relation to menstrual cycle timing and reproductive parameters in postmenopausal women","volume":"67","author":"Silva","year":"2010","journal-title":"Maturitas"},{"key":"10.1016\/j.jocd.2017.03.005_bib0110","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.neurobiolaging.2003.12.023","article-title":"APOE genotype accounts for the vast majority of AD risk and AD pathology","volume":"25","author":"Raber","year":"2004","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.jocd.2017.03.005_bib0115","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1359\/jbmr.1997.12.7.1083","article-title":"Relationship of bone turnover to bone density and fractures","volume":"12","author":"Melton","year":"1997","journal-title":"J Bone Miner Res"},{"issue":"6","key":"10.1016\/j.jocd.2017.03.005_bib9005","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1536\/ihj.39.785","article-title":"Familial hyper cholesteronemia in Utah with novel C54S mutations in LDL gene","volume":"39","author":"Emi","year":"1998","journal-title":"Jpn Heart J"},{"issue":"3","key":"10.1016\/j.jocd.2017.03.005_bib0120","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bone.2010.05.028","article-title":"Association between an intronic apolipoprotein E polymorphism and bone mineral density in Singaporean Chinese females","volume":"47","author":"Tong","year":"2010","journal-title":"Bone"},{"issue":"4","key":"10.1016\/j.jocd.2017.03.005_bib0125","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s00198-010-1311-5","article-title":"Associations of APOE gene polymorphisms with bone mineral density and fracture risk: a meta-analysis","volume":"22","author":"Peter","year":"2011","journal-title":"Osteoporos Int"},{"issue":"6","key":"10.1016\/j.jocd.2017.03.005_bib9010","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1590\/S1516-89132011000600010","article-title":"Prevalence of Estrogen Receptor Alpha PvuII (c454- 397T>C) and XbaI (c454A>G) Polymorphisms in a Population of Brazilian Women","volume":"54","author":"Ara\u00fajo","year":"2011","journal-title":"Braz Arch Biol Technol"},{"issue":"3","key":"10.1016\/j.jocd.2017.03.005_bib0130","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.maturitas.2010.06.017","article-title":"A susceptible haplotype within APOE gene influences BMD and intensifies the osteoporosis risk in postmenopausal women of Northwest India","volume":"67","author":"Puneetpal","year":"2010","journal-title":"Maturitas"},{"issue":"7","key":"10.1016\/j.jocd.2017.03.005_bib0135","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1177\/154405910608500703","article-title":"Bone remodeling in post-menopausal osteoporosis","volume":"85","author":"Lerner","year":"2006","journal-title":"J Dent Res"},{"key":"10.1016\/j.jocd.2017.03.005_bib0140","article-title":"Prevention and management of osteoporosis: report of a WHO Scientific Group","volume":"921","author":"World Health Organization\u2014WHO","year":"2010","journal-title":"Tech Rep Ser"},{"issue":"2 Suppl 1","key":"10.1016\/j.jocd.2017.03.005_bib0145","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bone.2005.11.024","article-title":"Osteoporosis: a still increasing prevalence","volume":"38","author":"Reginster","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.jocd.2017.03.005_sr0155","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s00774-004-0593-0","article-title":"The prevalence of ApoE4 genotype and its relationship to bone mineral density in Hong Kong Chinese","volume":"23","author":"Wong","year":"2005","journal-title":"J Bone Miner Metab"},{"key":"10.1016\/j.jocd.2017.03.005_sr0160","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00198-002-1361-4","article-title":"Bone mineral density may be related to atherosclerosis in hemodialyasis patients","volume":"14","author":"Nakashima","year":"2003","journal-title":"Osteoporos Int"},{"issue":"2","key":"10.1016\/j.jocd.2017.03.005_bib0155","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.bone.2011.07.015","article-title":"The role of apolipoprotein E in bone metabolism","volume":"50","author":"Niemeier","year":"2012","journal-title":"Bone"},{"issue":"2","key":"10.1016\/j.jocd.2017.03.005_bib0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0169266","article-title":"Effects of SNPs c454-397T>C (PvuII) and c454-351A>G (XbaI) of estrogen receptor alpha (ESR1) gene to serum lipid profile changes in elderly women depends on age, BMI and breast cancer","volume":"12","author":"Gomes-Rochette","year":"2017","journal-title":"PLoS One"}],"container-title":["Journal of Clinical Densitometry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094695016301950?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1094695016301950?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T21:41:19Z","timestamp":1761082879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1094695016301950"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["S1094695016301950"],"URL":"https:\/\/doi.org\/10.1016\/j.jocd.2017.03.005","relation":{},"ISSN":["1094-6950"],"issn-type":[{"value":"1094-6950","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of APOE Gene in Bone Mineral Density and Incidence of Bone Fractures in Brazilian Postmenopausal Women","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Densitometry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocd.2017.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The International Society for Clinical Densitometry.","name":"copyright","label":"Copyright"}]}}