{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:32:02Z","timestamp":1792801922672,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T00:00:00Z","timestamp":1761264000000},"content-version":"vor","delay-in-days":296,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL158077"],"award-info":[{"award-number":["R01 HL158077"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiovascular Magnetic Resonance"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.jocmr.2025.101981","type":"journal-article","created":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T19:33:26Z","timestamp":1761593606000},"page":"101981","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exercise cardiovascular magnetic resonance myocardial dynamic index: A non-invasive imaging marker associated with cardiac dyspnea"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4062-4550","authenticated-orcid":false,"given":"Fahime","family":"Ghanbari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel A.","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long H.","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connie W.","family":"Tsao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M.","family":"Robbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa M.","family":"Gopal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Systrom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron B.","family":"Waxman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren J.","family":"Manning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1963-7138","authenticated-orcid":false,"given":"Reza","family":"Nezafat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jocmr.2025.101981_bib1","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1164\/rccm.201111-2042ST","article-title":"An official American Thoracic Society statement: update on the mechanisms, assessment, and management of dyspnea","volume":"185","author":"Parshall","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.jocmr.2025.101981_bib2","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1177\/2047487317709605","article-title":"Invasive cardiopulmonary exercise testing in the evaluation of unexplained dyspnea: insights from a multidisciplinary dyspnea center","volume":"24","author":"Huang","year":"2017","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.jocmr.2025.101981_bib3","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1002\/ejhf.2601","volume":"24","author":"Guazzi","year":"2022","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.jocmr.2025.101981_bib4","first-page":"e895","article-title":"2022 AHA\/ACC\/HFSA Guideline for the management of heart failure: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"145","author":"Heidenreich","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.jocmr.2025.101981_bib5","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1016\/j.chest.2020.05.552","article-title":"Performance and interpretation of invasive hemodynamic exercise testing","volume":"158","author":"Jain","year":"2020","journal-title":"Chest"},{"key":"10.1016\/j.jocmr.2025.101981_bib6","first-page":"834","article-title":"The differential diagnosis of dyspnea","volume":"113","author":"Berliner","year":"2016","journal-title":"Dtsch Arztebl Int"},{"key":"10.1016\/j.jocmr.2025.101981_bib7","article-title":"A simplified approach to discriminate between healthy subjects and patients with heart failure using cardiac magnetic resonance myocardial deformation imaging","volume":"2","author":"Witt","year":"2024","journal-title":"Eur Heart J Imaging Methods Pract"},{"key":"10.1016\/j.jocmr.2025.101981_bib8","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1016\/j.jacc.2023.01.049","article-title":"Heart failure with preserved ejection fraction: JACC scientific statement","volume":"81","author":"Borlaug","year":"2023","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jocmr.2025.101981_bib9","first-page":"S244","article-title":"Cardiovascular response to exercise","volume":"277","author":"Laughlin","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.jocmr.2025.101981_bib10","doi-asserted-by":"crossref","first-page":"12","DOI":"10.31083\/j.rcm2301012","article-title":"Importance of right heart catheterization in advanced heart failure management","volume":"23","author":"Cochran","year":"2022","journal-title":"Rev Cardiovasc Med"},{"key":"10.1016\/j.jocmr.2025.101981_bib11","doi-asserted-by":"crossref","DOI":"10.1007\/s11936-021-00904-7","article-title":"Invasive hemodynamic and metabolic evaluation of HFpEF","volume":"23","author":"Finet","year":"2021","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"10.1016\/j.jocmr.2025.101981_bib12","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.cardfail.2023.08.009","article-title":"Standardization of the right heart catheterization and the emerging role of advanced hemodynamics in heart failure","volume":"29","author":"Grinstein","year":"2023","journal-title":"J Card Fail"},{"key":"10.1016\/j.jocmr.2025.101981_bib13","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.jchf.2024.03.020","article-title":"Practical guidance for hemodynamic assessment by right heart catheterization in management of heart failure","volume":"12","author":"Rajagopalan","year":"2024","journal-title":"JACC Heart Fail"},{"key":"10.1016\/j.jocmr.2025.101981_bib14","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrcardio.2014.83","article-title":"The pathophysiology of heart failure with preserved ejection fraction","volume":"11","author":"Borlaug","year":"2014","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.jocmr.2025.101981_bib15","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1053\/euhj.2000.2011","article-title":"Comparison of left ventricular ejection fraction and volumes in heart failure by echocardiography, radionuclide ventriculography and cardiovascular magnetic resonance; are they interchangeable?","volume":"21","author":"Bellenger","year":"2000","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jocmr.2025.101981_bib16","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12968-020-00652-w","article-title":"Exercise cardiovascular magnetic resonance: development, current utility and future applications","volume":"22","author":"Craven","year":"2020","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.jocmr.2025.101981_bib17","article-title":"Free-breathing single-beat exercise CMR with generative AI for evaluation of volumetric and functional cardiac indices: a reproducibility study","volume":"27","author":"Ghanbari","year":"2025","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.jocmr.2025.101981_bib18","doi-asserted-by":"crossref","DOI":"10.1148\/ryct.240272","article-title":"Free-breathing, highly accelerated, single-beat, multisection cardiac cine MRI with generative artificial intelligence","volume":"7","author":"Ghanbari","year":"2025","journal-title":"Radiol Cardiothorac Imaging"},{"key":"10.1016\/j.jocmr.2025.101981_bib19","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1093\/eurheartj\/ehz552","article-title":"Invasive left ventricle pressure-volume analysis: overview and practical clinical implications","volume":"41","author":"Bastos","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jocmr.2025.101981_bib20","series-title":"Physiology of the heart","author":"Katz","year":"2010"},{"key":"10.1016\/j.jocmr.2025.101981_bib21","series-title":"Textbook of clinical hemodynamics E-Book: textbook of clinical hemodynamics E-book","author":"Ragosta","year":"2017"},{"key":"10.1016\/j.jocmr.2025.101981_bib22","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1161\/01.RES.49.5.1082","article-title":"Equal oxygen consumption rates of isovolumic and ejecting contractions with equal systolic pressure-volume areas in canine left ventricle","volume":"49","author":"Suga","year":"1981","journal-title":"Circ Res"},{"key":"10.1016\/j.jocmr.2025.101981_bib23","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s44161-021-00007-3","article-title":"A guide for assessment of myocardial stiffness in health and disease","volume":"1","author":"Villalobos Lizardi","year":"2022","journal-title":"Nat Cardiovasc Res"},{"key":"10.1016\/j.jocmr.2025.101981_bib24","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1002\/ehf2.13979","article-title":"Exercise haemodynamics in heart failure with preserved ejection fraction: a systematic review and meta-analysis","volume":"9","author":"Baratto","year":"2022","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.jocmr.2025.101981_bib25","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.120.007555","article-title":"Current limitations of invasive exercise hemodynamics for the diagnosis of heart failure with preserved ejection fraction","volume":"14","author":"Baratto","year":"2021","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jocmr.2025.101981_bib26","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/jmri.24239","article-title":"CMR reference values for left ventricular volumes, mass, and ejection fraction using computer-aided analysis: the Framingham Heart Study","volume":"39","author":"Chuang","year":"2014","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jocmr.2025.101981_bib27","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cardfail.2021.07.012","article-title":"Hemodynamics for the heart failure clinician: a state-of-the-art review","volume":"28","author":"Hsu","year":"2022","journal-title":"J Card Fail"},{"key":"10.1016\/j.jocmr.2025.101981_bib28","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12968-020-00683-3","article-title":"Reference ranges (\"normal values\") for cardiovascular magnetic resonance (CMR) in adults and children: 2020 update","volume":"22","author":"Kawel-Boehm","year":"2020","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.jocmr.2025.101981_bib29","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1093\/eurheartj\/ehz641","article-title":"How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC)","volume":"40","author":"Pieske","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jocmr.2025.101981_bib30","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCHEARTFAILURE.117.004750","article-title":"Pulmonary capillary wedge pressure patterns during exercise predict exercise capacity and incident heart failure","volume":"11","author":"Eisman","year":"2018","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jocmr.2025.101981_bib31","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jocmr.2025.101981_bib32","volume":"32","author":"Evans","year":"1996"},{"key":"10.1016\/j.jocmr.2025.101981_bib33","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.018822","article-title":"Revisiting and implementing the weber and ventilatory functional classifications in heart failure by cardiopulmonary imaging phenotyping","volume":"10","author":"Guazzi","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"10.1016\/j.jocmr.2025.101981_bib34","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.ccl.2011.03.003","article-title":"Invasive hemodynamic assessment in heart failure","volume":"29","author":"Borlaug","year":"2011","journal-title":"Cardiol Clin"},{"key":"10.1016\/j.jocmr.2025.101981_bib35","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1161\/CIRCHEARTFAILURE.112.000216","article-title":"Effects of exercise on left ventricular systolic and diastolic properties in patients with heart failure and a preserved ejection fraction versus heart failure and a reduced ejection fraction","volume":"6","author":"Zile","year":"2013","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jocmr.2025.101981_bib36","series-title":"Cardiovascular physiology concepts","author":"Klabunde","year":"2011"},{"key":"10.1016\/j.jocmr.2025.101981_bib37","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1161\/CIRCHEARTFAILURE.109.930701","article-title":"Exercise hemodynamics enhance diagnosis of early heart failure with preserved ejection fraction","volume":"3","author":"Borlaug","year":"2010","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.jocmr.2025.101981_bib38","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S0895-7061(04)00818-0","article-title":"Association of inappropriate left ventricular mass with systolic and diastolic dysfunction: the HyperGEN study","volume":"17","author":"de Simone","year":"2004","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.jocmr.2025.101981_bib39","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/S0735-1097(84)80289-2","article-title":"Left ventricular diastolic function in hypertension: relation to left ventricular mass and systolic function","volume":"3","author":"Fouad","year":"1984","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jocmr.2025.101981_bib40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s12968-019-0564-1","article-title":"Prognostic value of novel imaging parameters derived from standard cardiovascular magnetic resonance in high risk patients with systemic light chain amyloidosis","volume":"21","author":"Arenja","year":"2019","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1016\/j.jocmr.2025.101981_bib41","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1093\/ehjci\/jew324","article-title":"Myocardial contraction fraction derived from cardiovascular magnetic resonance cine images-reference values and performance in patients with heart failure and left ventricular hypertrophy","volume":"18","author":"Arenja","year":"2017","journal-title":"Eur Heart J Cardiovasc Imaging"},{"key":"10.1016\/j.jocmr.2025.101981_bib42","first-page":"984","article-title":"Left ventricular concentric remodeling is associated with decreased global and regional systolic function: the Multi-Ethnic Study of Atherosclerosis","volume":"112","author":"Rosen","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.jocmr.2025.101981_bib43","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/CIRCULATIONAHA.104.481465","article-title":"Contractile behavior of the left ventricle in diastolic heart failure: with emphasis on regional systolic function","volume":"113","author":"Aurigemma","year":"2006","journal-title":"Circulation"},{"key":"10.1016\/j.jocmr.2025.101981_bib44","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2020-001346","article-title":"Can myocardial work indices contribute to the exploration of patients with cardiac amyloidosis?","volume":"7","author":"Roger-Roll\u00e9","year":"2020","journal-title":"Open Heart"},{"key":"10.1016\/j.jocmr.2025.101981_bib45","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1093\/eurheartj\/ehs016","article-title":"A novel clinical method for quantification of regional left ventricular pressure-strain loop area: a non-invasive index of myocardial work","volume":"33","author":"Russell","year":"2012","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jocmr.2025.101981_bib46","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.118.008493","article-title":"Noninvasive quantification of pressure-volume loops from brachial pressure and cardiovascular magnetic resonance","volume":"12","author":"Seemann","year":"2019","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.jocmr.2025.101981_bib47","doi-asserted-by":"crossref","DOI":"10.1111\/echo.15758","article-title":"From ejection fraction, to myocardial strain, and myocardial work in echocardiography: clinical impact and controversies","volume":"41","author":"Dell'Angela","year":"2024","journal-title":"Echocardiography"},{"key":"10.1016\/j.jocmr.2025.101981_bib48","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/jmri.27580","article-title":"Exercise cardiovascular magnetic resonance: a review","volume":"55","author":"Trankle","year":"2022","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.jocmr.2025.101981_bib49","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1161\/CIRCULATIONAHA.120.051542","article-title":"Exercise stress real-time cardiac magnetic resonance imaging for noninvasive characterization of heart failure with preserved ejection fraction: the HFpEF-stress trial","volume":"143","author":"Backhaus","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jocmr.2025.101981_bib50","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/s44161-021-00005-5","article-title":"Identification of patients with preclinical heart failure with preserved ejection fraction using the H(2)FPEF score","volume":"1","author":"Koepp","year":"2022","journal-title":"Nat Cardiovasc Res"},{"key":"10.1016\/j.jocmr.2025.101981_bib51","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12968-020-0598-4","article-title":"The application of exercise stress cardiovascular magnetic resonance in patients with suspected dilated cardiomyopathy","volume":"22","author":"Le","year":"2020","journal-title":"J Cardiovasc Magn Reson"}],"container-title":["Journal of Cardiovascular Magnetic Resonance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097664725001437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097664725001437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T13:46:28Z","timestamp":1770039988000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097664725001437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025]]}},"alternative-id":["S1097664725001437"],"URL":"https:\/\/doi.org\/10.1016\/j.jocmr.2025.101981","relation":{},"ISSN":["1097-6647"],"issn-type":[{"value":"1097-6647","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exercise cardiovascular magnetic resonance myocardial dynamic index: A non-invasive imaging marker associated with cardiac dyspnea","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiovascular Magnetic Resonance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocmr.2025.101981","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of Society for Cardiovascular Magnetic Resonance.","name":"copyright","label":"Copyright"}],"article-number":"101981"}}