{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T14:03:34Z","timestamp":1781100214836,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"State Agency of Research","doi-asserted-by":"publisher","award":["PCI2024-153490"],"award-info":[{"award-number":["PCI2024-153490"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008666","name":"Marathon Foundation of Tv3","doi-asserted-by":"publisher","award":["202321-31"],"award-info":[{"award-number":["202321-31"]}],"id":[{"id":"10.13039\/100008666","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/19\/35\/34374"],"award-info":[{"award-number":["FS\/19\/35\/34374"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008530","name":"European Regional Development Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008530","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI24\/00844"],"award-info":[{"award-number":["PI24\/00844"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019256","name":"NIHR Great Ormond Street Hospital Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Cardiovascular Magnetic Resonance"],"published-print":{"date-parts":[[2026]]},"DOI":"10.1016\/j.jocmr.2026.102689","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T16:20:25Z","timestamp":1768494025000},"page":"102689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extracellular volume fraction associates with long-term outcome in patients with severe symptomatic aortic stenosis: 10-year outcomes of the Regression of Myocardial Fibrosis After Aortic Valve Replacement study"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5333-1194","authenticated-orcid":false,"given":"Nikoo","family":"Aziminia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George D.","family":"Thornton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sucharitha","family":"Chadalavada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Kozor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Schofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kush P.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kellman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhodri","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sveeta","family":"Badiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Cortina Borja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arantxa","family":"Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1560-7414","authenticated-orcid":false,"given":"Thomas A.","family":"Treibel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"19","key":"10.1016\/j.jocmr.2026.102689_bib1","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.jacc.2012.02.093","article-title":"Calcific aortic stenosis: a disease of the valve and the myocardium","volume":"60","author":"Dweck","year":"2012","journal-title":"J Am Coll Cardiol"},{"issue":"6","key":"10.1016\/j.jocmr.2026.102689_bib2","first-page":"524","article-title":"2021 ESC\/EACTS guidelines for the management of valvular heart disease: developed by the task force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"75","author":"Vahanian","year":"2022","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"issue":"5","key":"10.1016\/j.jocmr.2026.102689_bib3","first-page":"e72","article-title":"2020 ACC\/AHA guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines","volume":"143","author":"Otto","year":"2021","journal-title":"Circulation"},{"key":"10.1016\/j.jocmr.2026.102689_bib4","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ijcard.2016.10.003","article-title":"A meta-analysis and meta-regression of long-term outcomes of transcatheter versus surgical aortic valve replacement for severe aortic stenosis","volume":"225","author":"Villablanca","year":"2016","journal-title":"Int J Cardiol"},{"issue":"8","key":"10.1016\/j.jocmr.2026.102689_bib5","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/eurheartj\/ehx353","article-title":"Reappraising myocardial fibrosis in severe aortic stenosis: an invasive and non-invasive study in 133 patients","volume":"39","author":"Treibel","year":"2018","journal-title":"Eur Heart J"},{"issue":"16","key":"10.1016\/j.jocmr.2026.102689_bib6","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1093\/eurheartj\/ehx001","article-title":"Comparison of exercise testing and CMR measured myocardial perfusion reserve for predicting outcome in asymptomatic aortic stenosis: the PRognostic Importance of MIcrovascular Dysfunction in Aortic Stenosis (PRIMID AS) Study","volume":"38","author":"Singh","year":"2017","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1016\/j.jocmr.2026.102689_bib7","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12968-016-0308-4","article-title":"Cardiac T1 mapping and extracellular volume (ECV) in clinical practice: a comprehensive review","volume":"18","author":"Haaf","year":"2016","journal-title":"J Cardiovasc Magn Reson"},{"issue":"12","key":"10.1016\/j.jocmr.2026.102689_bib8","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.124.017425","article-title":"Left ventricular hypertrophy in aortic stenosis: early cell and matrix regression 2 months post-aortic valve replacement","volume":"17","author":"Bennett","year":"2024","journal-title":"Circ Cardiovasc Imaging"},{"issue":"6","key":"10.1016\/j.jocmr.2026.102689_bib9","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jacc.2021.05.047","article-title":"Markers of myocardial damage predict mortality in patients with aortic stenosis","volume":"78","author":"Kwak","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"10.1016\/j.jocmr.2026.102689_bib10","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jacc.2017.12.035","article-title":"Reverse myocardial remodeling following valve replacement in patients with aortic stenosis","volume":"71","author":"Treibel","year":"2018","journal-title":"J Am Coll Cardiol"},{"issue":"8","key":"10.1016\/j.jocmr.2026.102689_bib11","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.116.005066","article-title":"Occult transthyretin cardiac amyloid in severe calcific aortic stenosis: prevalence and prognosis in patients undergoing surgical aortic valve replacement","volume":"9","author":"Treibel","year":"2016","journal-title":"Circ Cardiovasc Imaging"},{"issue":"2","key":"10.1016\/j.jocmr.2026.102689_bib12","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1161\/CIRCULATIONAHA.109.930636","article-title":"Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis","volume":"122","author":"Flett","year":"2010","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.jocmr.2026.102689_bib13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1532-429X-16-2","article-title":"T1-mapping in the heart: accuracy and precision","volume":"16","author":"Kellman","year":"2014","journal-title":"J Cardiovasc Magn Reson"},{"issue":"1","key":"10.1016\/j.jocmr.2026.102689_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.echo.2008.11.029","article-title":"Echocardiographic assessment of valve stenosis: EAE\/ASE recommendations for clinical practice","volume":"22","author":"Baumgartner","year":"2009","journal-title":"J Am Soc Echocardiogr"},{"issue":"7","key":"10.1016\/j.jocmr.2026.102689_bib15","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.jcmg.2017.08.025","article-title":"Sex dimorphism in the myocardial response to aortic stenosis","volume":"11","author":"Treibel","year":"2018","journal-title":"JACC Cardiovasc Imaging"},{"issue":"22","key":"10.1016\/j.jocmr.2026.102689_bib16","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1093\/eurheartj\/ehae067","article-title":"Myocardial scar and remodelling predict long-term mortality in severe aortic stenosis beyond 10 years","volume":"45","author":"Thornton","year":"2024","journal-title":"Eur Heart J"},{"issue":"14","key":"10.1016\/j.jocmr.2026.102689_bib17","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1002\/sim.5647","article-title":"A unified inference procedure for a class of measures to assess improvement in risk prediction systems with survival data","volume":"32","author":"Uno","year":"2013","journal-title":"Stat Med"},{"key":"10.1016\/j.jocmr.2026.102689_bib18","unstructured":"Uno H,\u00a0Cai T. survIDINRI: IDI and NRI for comparing competing risk prediction models with censored survival data; 2022. R package."},{"issue":"18","key":"10.1016\/j.jocmr.2026.102689_bib19","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1056\/NEJMoa1114705","article-title":"Registry of transcatheter aortic-valve implantation in high-risk patients","volume":"366","author":"Gilard","year":"2012","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.jocmr.2026.102689_bib20","first-page":"413","article-title":"The relationship between heart-failure hospitalization and mortality in patients receiving transcatheter aortic valve replacement","volume":"35","author":"Nazzari","year":"2019","journal-title":"Can J Cardiol"},{"issue":"3","key":"10.1016\/j.jocmr.2026.102689_bib21","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.athoracsur.2019.11.058","article-title":"Readmission after surgical aortic valve replacement in the United States","volume":"110","author":"Khoury","year":"2020","journal-title":"Ann Thorac Surg"},{"issue":"10","key":"10.1016\/j.jocmr.2026.102689_bib22","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1016\/j.jcmg.2020.05.029","article-title":"Identifying cardiac amyloid in aortic stenosis: ECV quantification by CT in TAVR patients","volume":"13","author":"Scully","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"issue":"6","key":"10.1016\/j.jocmr.2026.102689_bib23","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jacc.2021.05.047","article-title":"Markers of myocardial damage predict mortality in patients with aortic stenosis","volume":"78","author":"Kwak","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1016\/j.jocmr.2026.102689_bib24","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1001\/jamacardio.2024.5593","article-title":"Sex-specific association of myocardial fibrosis with mortality in patients with aortic stenosis","volume":"10","author":"Kwak","year":"2025","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.jocmr.2026.102689_bib25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.yjmcc.2015.11.005","article-title":"Aging and the cardiac collagen matrix: novel mediators of fibrotic remodelling","volume":"93","author":"Horn","year":"2016","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"10.1016\/j.jocmr.2026.102689_bib26","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1148\/radiol.2015150982","article-title":"Adverse left ventricular remodeling and age assessed with cardiac MR\u00a0imaging: the multi-ethnic study of atherosclerosis","volume":"278","author":"Eng","year":"2016","journal-title":"Radiology"},{"issue":"3","key":"10.1016\/j.jocmr.2026.102689_bib27","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.jtcvs.2021.11.055","article-title":"Atrial fibrillation in severe aortic stenosis: prognostic value and results of aortic valve replacement","volume":"166","author":"Kubala","year":"2023","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"45","key":"10.1016\/j.jocmr.2026.102689_bib28","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1093\/eurheartj\/ehx381","article-title":"Staging classification of aortic stenosis based on the extent of cardiac damage","volume":"38","author":"G\u00e9n\u00e9reux","year":"2017","journal-title":"Eur Heart J"},{"issue":"8","key":"10.1016\/j.jocmr.2026.102689_bib29","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.3390\/diagnostics11081422","article-title":"Pericardial NT-Pro-BNP and GDF-15 as biomarkers of atrial fibrillation and atrial matrix remodeling in aortic stenosis","volume":"11","author":"Fragao-Marques","year":"2021","journal-title":"Diagnostics (Basel)"},{"issue":"8","key":"10.1016\/j.jocmr.2026.102689_bib30","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1093\/ehjqcco\/qcad004","article-title":"The impact of atrial fibrillation on prognosis in aortic stenosis","volume":"9","author":"Laenens","year":"2023","journal-title":"Eur Heart J Qual Care Clin Outcomes"},{"issue":"3","key":"10.1016\/j.jocmr.2026.102689_bib31","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.jcmg.2019.06.014","article-title":"Sex-related differences in the extent of myocardial fibrosis in patients with aortic valve stenosis","volume":"13","author":"Tastet","year":"2020","journal-title":"JACC Cardiovasc Imaging"},{"issue":"6","key":"10.1016\/j.jocmr.2026.102689_bib32","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.jacc.2021.05.047","article-title":"Markers of myocardial damage predict mortality in patients with aortic stenosis","volume":"78","author":"Kwak","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"18","key":"10.1016\/j.jocmr.2026.102689_bib33","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1161\/CIRCULATIONAHA.117.032839","article-title":"Myocardial scar and mortality in severe aortic stenosis","volume":"138","author":"Musa","year":"2018","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.jocmr.2026.102689_bib34","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1093\/ehjci\/jeac089","article-title":"Comprehensive myocardial characterization using cardiac magnetic resonance associates with outcomes in low gradient severe aortic stenosis","volume":"24","author":"Fukui","year":"2023","journal-title":"Eur Heart J Cardiovasc Imaging"}],"container-title":["Journal of Cardiovascular Magnetic Resonance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097664726000074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1097664726000074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T13:29:09Z","timestamp":1781098149000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1097664726000074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026]]}},"alternative-id":["S1097664726000074"],"URL":"https:\/\/doi.org\/10.1016\/j.jocmr.2026.102689","relation":{},"ISSN":["1097-6647"],"issn-type":[{"value":"1097-6647","type":"print"}],"subject":[],"published":{"date-parts":[[2026]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extracellular volume fraction associates with long-term outcome in patients with severe symptomatic aortic stenosis: 10-year outcomes of the Regression of Myocardial Fibrosis After Aortic Valve Replacement study","name":"articletitle","label":"Article Title"},{"value":"Journal of Cardiovascular Magnetic Resonance","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocmr.2026.102689","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Society for Cardiovascular Magnetic Resonance.","name":"copyright","label":"Copyright"}],"article-number":"102689"}}