{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:42:48Z","timestamp":1790275368788,"version":"4.1.0"},"reference-count":171,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,4,1]],"date-time":"2005-04-01T00:00:00Z","timestamp":1112313600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2005,4]]},"DOI":"10.1016\/j.jocn.2004.03.011","type":"journal-article","created":{"date-parts":[[2005,4,4]],"date-time":"2005-04-04T14:28:51Z","timestamp":1112624931000},"page":"221-230","source":"Crossref","is-referenced-by-count":42,"title":["Imaginem oblivionis: the prospects of neuroimaging for early detection of Alzheimer's disease"],"prefix":"10.1016","volume":"12","author":[{"given":"Victor L.","family":"Villemagne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.C.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Macfarlane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.E.","family":"Novakovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.L.","family":"Masters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jocn.2004.03.011_BIB1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1001\/archneur.1985.04060100083029","article-title":"Diagnosis of Alzheimer's disease","volume":"42","author":"Khachaturian","year":"1985","journal-title":"Arch. Neurol."},{"issue":"Suppl 1","key":"10.1016\/j.jocn.2004.03.011_BIB2","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1212\/WNL.51.1_Suppl_1.S2","article-title":"Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities","volume":"51","author":"Cummings","year":"1998","journal-title":"Neurology"},{"issue":"Suppl 6","key":"10.1016\/j.jocn.2004.03.011_BIB3","doi-asserted-by":"crossref","first-page":"M313","DOI":"10.1093\/gerona\/51A.6.M313","article-title":"Neuropathologic diagnostic outcomes from a cohort of outpatients with suspected dementia","volume":"51","author":"Larson","year":"1996","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB4","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/00002093-199601040-00002","article-title":"Accuracy of clinical diagnosis of Alzheimer disease and clinical features of patients with non-Alzheimer disease neuropathology","volume":"10","author":"Rasmusson","year":"1996","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.jocn.2004.03.011_BIB5","unstructured":"American Psychiatric Association DSM-IV: Diagnostic and Statistical Manual (fourth edn). DSM-IV: Diagnostic and Statistical Manual (fourth edn). American Psychiatric Association, Washington, DC; 1994"},{"key":"10.1016\/j.jocn.2004.03.011_BIB6","unstructured":"International Classification of Diseases (ICD-10): Classification of Mental and Behavioural Disorders (10th edn). World Health Organization, Geneva, Switzerland; 1992"},{"key":"10.1016\/j.jocn.2004.03.011_BIB7","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB8","first-page":"93","article-title":"Mild cognitive impairment: transition between aging and Alzheimer's disease","volume":"15","author":"Petersen","year":"2000","journal-title":"Neurologia"},{"key":"10.1016\/j.jocn.2004.03.011_BIB9","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1001\/jama.1995.03520400044042","article-title":"Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals","volume":"273","author":"Petersen","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.jocn.2004.03.011_BIB10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild cognitive impairment: clinical characterization and outcome","volume":"56","author":"Petersen","year":"1999","journal-title":"Arch. Neurol."},{"issue":"5","key":"10.1016\/j.jocn.2004.03.011_BIB11","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0197-4580(02)00192-6","article-title":"Two novel presenilin-1 mutations (Y256S and Q222H) are associated with early-onset Alzheimer's disease","volume":"24","author":"Miklossy","year":"2003","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.jocn.2004.03.011_BIB12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0361-9230(03)00067-4","article-title":"Causative and susceptibility genes for Alzheimer's disease: a review","volume":"61","author":"Rocchi","year":"2003","journal-title":"Brain Res. Bull."},{"issue":"8","key":"10.1016\/j.jocn.2004.03.011_BIB13","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1056\/NEJM199802193380804","article-title":"Utility of the apolipoprotein E genotype in the diagnosis of Alzheimer's disease: Alzheimer's Disease Centers Consortium on apolipoprotein E and Alzheimer's disease","volume":"338","author":"Mayeux","year":"1998","journal-title":"N. Engl. J. Med."},{"issue":"5123","key":"10.1016\/j.jocn.2004.03.011_BIB14","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.jocn.2004.03.011_BIB15","series-title":"Dementia","year":"2000"},{"key":"10.1016\/j.jocn.2004.03.011_BIB16","series-title":"Alzheimer Disease: Epidemiology, Neuropathology and Clinics. Morphology of Alzheimer Disease and Related Disorders","first-page":"61","year":"1990"},{"issue":"5300","key":"10.1016\/j.jocn.2004.03.011_BIB17","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1126\/science.275.5300.630","article-title":"Alzheimer's disease: genotypes, phenotypes, and treatments","volume":"275","author":"Selkoe","year":"1997","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB18","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1385\/JMN:19:3:289","article-title":"Tau neurofibrillary pathology and microtubule stability","volume":"19","author":"Michaelis","year":"2002","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.jocn.2004.03.011_BIB19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-3-7091-7508-8_8","article-title":"Neuropathology of Alzheimer's disease: a critical update","volume":"54","author":"Jellinger","year":"1998","journal-title":"J. Neural. Transm. Suppl."},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB20","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0733-8619(05)70229-2","article-title":"Neuropathology of Alzheimer's disease and related disorders","volume":"18","author":"Perl","year":"2000","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.jocn.2004.03.011_BIB21","series-title":"Pathological Diagnosis of Alzheimer's Disease. The Early Diagnosis of Alzheimer's Disease","first-page":"65","author":"Geula","year":"2000"},{"issue":"2\u20134","key":"10.1016\/j.jocn.2004.03.011_BIB22","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/BF02935560","article-title":"The molecular pathology of amyloid deposition in Alzheimer's disease","volume":"5","author":"Martins","year":"1991","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB23","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1750-3639.1991.tb00667.x","article-title":"Amyloid precursor protein (APP) and beta A4 amyloid in the etiology of Alzheimer's disease: precursor\u2013product relationships in the derangement of neuronal function","volume":"1","author":"Beyreuther","year":"1991","journal-title":"Brain Pathol."},{"issue":"1","key":"10.1016\/j.jocn.2004.03.011_BIB24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3233\/JAD-2001-3112","article-title":"Wisniewski and the amyloid theory of Alzheimer's disease","volume":"3","author":"Masters","year":"2001","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.jocn.2004.03.011_BIB25","series-title":"The Early Diagnosis of Alzheimer's Disease. The Pathophysiology of Alzheimer's Disease","first-page":"83","author":"Selkoe","year":"2000"},{"issue":"8829","key":"10.1016\/j.jocn.2004.03.011_BIB26","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/0140-6736(92)92890-R","article-title":"Detection in life of confirmed Alzheimer's idsease using a simple measurement of medial temporal lobe atrophy by computed tomography","volume":"340","author":"Jobst","year":"1992","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB27","first-page":"203","article-title":"Structural neuroimaging of Alzheimer's disease and other dementias","volume":"13","author":"Scheltens","year":"2001","journal-title":"Aging"},{"issue":"2","key":"10.1016\/j.jocn.2004.03.011_BIB28","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1159\/000017223","article-title":"Medial temporal lobe width on CT scanning in Alzheimer's disease; comparison with vascular dementia, depression and dementia with Lewy bodies","volume":"11","author":"O'Brien","year":"2000","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"1","key":"10.1016\/j.jocn.2004.03.011_BIB29","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0197-4580(98)00007-4","article-title":"Volumes of the entorhinal and perirhinal cortices in Alzheimer's disease","volume":"19","author":"Juottonen","year":"1998","journal-title":"Neurobiol. Aging"},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB30","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1136\/jnnp.71.4.441","article-title":"Magnetic resonance imaging of the entorhinal cortex and hippocampus in mild cognitive impairment and Alzheimer's disease","volume":"71","author":"Du","year":"2001","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jocn.2004.03.011_BIB31","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1034\/j.1600-0404.107.s179.10.x","article-title":"A critical discussion of the role of neuroimaging in mild cognitive impairment","volume":"179","author":"Wolf","year":"2003","journal-title":"Acta Neurol. Scand. Suppl."},{"issue":"9","key":"10.1016\/j.jocn.2004.03.011_BIB32","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1212\/WNL.54.9.1760","article-title":"Usefulness of MRI measures of entorhinal cortex versus hippocampus in AD","volume":"54","author":"Xu","year":"2000","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB33","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1159\/000051258","article-title":"A comparison of medial and lateral temporal lobe atrophy in dementia with Lewy bodies and Alzheimer's disease: magnetic resonance imaging volumetric study","volume":"12","author":"Barber","year":"2001","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"2","key":"10.1016\/j.jocn.2004.03.011_BIB34","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/S1053-8119(02)00026-5","article-title":"Early diagnosis of Alzheimer's disease; contribution of structural neuroimaging","volume":"18","author":"Chetelat","year":"2003","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.jocn.2004.03.011_BIB35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S1474-4422(02)00002-9","article-title":"Structural magnetic resonance imaging in the practical assessment of dementia: beyond exclusion","volume":"1","author":"Scheltens","year":"2002","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB36","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/1531-8249(200004)47:4<430::AID-ANA5>3.0.CO;2-I","article-title":"Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease","volume":"47","author":"Killiany","year":"2000","journal-title":"Ann. Neurol."},{"issue":"8","key":"10.1016\/j.jocn.2004.03.011_BIB37","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1212\/WNL.58.8.1188","article-title":"MRI measures of entorhinal cortex vs hippocampus in preclinical AD","volume":"58","author":"Killiany","year":"2002","journal-title":"Neurology"},{"issue":"2","key":"10.1016\/j.jocn.2004.03.011_BIB38","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1148\/radiol.2262011600","article-title":"Neuroimaging and early diagnosis of Alzheimer disease: a look to the future","volume":"226","author":"Petrella","year":"2003","journal-title":"Radiology"},{"issue":"Suppl 1","key":"10.1016\/j.jocn.2004.03.011_BIB39","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S1041610297004900","article-title":"Contribution of structural neuroimaging to the early diagnosis of Alzheimer's disease","volume":"9","author":"de Leon","year":"1997","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.jocn.2004.03.011_BIB40","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1111\/j.1749-6632.2000.tb06730.x","article-title":"From healthy aging to early Alzheimer's disease: in vivo detection of entorhinal cortex atrophy","volume":"911","author":"De Toledo-Morrell","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"9146","key":"10.1016\/j.jocn.2004.03.011_BIB41","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0140-6736(05)74869-8","article-title":"MRI of entorhinal cortex in mild Alzheimer's disease","volume":"353","author":"Bobinski","year":"1999","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.jocn.2004.03.011_BIB42","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0197-4580(01)00271-8","article-title":"MRI-derived entorhinal and hippocampal atrophy in incipient and very mild Alzheimer's disease","volume":"22","author":"Dickerson","year":"2001","journal-title":"Neurobiol. Aging"},{"issue":"1\u20132","key":"10.1016\/j.jocn.2004.03.011_BIB43","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1006\/mgme.2001.3236","article-title":"Application of positron emission tomography for evaluation of metabolism and blood flow in human brain: normal development, aging, dementia, and stroke","volume":"74","author":"Silverman","year":"2001","journal-title":"Mol. Genet. Metab."},{"issue":"6625","key":"10.1016\/j.jocn.2004.03.011_BIB44","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/386608a0","article-title":"Transient and sustained activity in a distributed neural system for human working memory","volume":"386","author":"Courtney","year":"1997","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.jocn.2004.03.011_BIB45","first-page":"1727","article-title":"Dynamic susceptibility contrast MR imaging of regional cerebral blood volume in Alzheimer disease: a promising alternative to nuclear medicine","volume":"19","author":"Harris","year":"1998","journal-title":"AJNR Am. J. Neuroradiol."},{"issue":"6","key":"10.1016\/j.jocn.2004.03.011_BIB46","first-page":"1030","article-title":"Diffusion and perfusion MR imaging in cases of Alzheimer's disease: correlations with cortical atrophy and lesion load","volume":"22","author":"Bozzao","year":"2001","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.jocn.2004.03.011_BIB47","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2165\/00023210-200014060-00004","article-title":"Brain magnetic resonance spectroscopy: role in assessing outcomes in Alzheimer's disease","volume":"14","author":"Doraiswamy","year":"2000","journal-title":"CNS Drugs"},{"issue":"5","key":"10.1016\/j.jocn.2004.03.011_BIB48","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1212\/WNL.55.5.684","article-title":"Proton MR spectroscopy detects a relative decrease of N-acetylaspartate in the medial temporal lobe of patients with AD","volume":"55","author":"Jessen","year":"2000","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.jocn.2004.03.011_BIB49","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/0730-725X(93)90249-D","article-title":"Alzheimer's disease histologically proven studied by MRI and MRS: two cases","volume":"11","author":"Longo","year":"1993","journal-title":"Magn. Reson. Imaging"},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB50","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1523\/JNEUROSCI.13-04-01460.1993","article-title":"Activity of neurons in anterior inferior temporal cortex during a short-term memory task","volume":"13","author":"Miller","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jocn.2004.03.011_BIB51","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0006-3223(97)00242-4","article-title":"In vivo proton magnetic resonance spectroscopy of Alzheimer's disease in the parietal and temporal lobes","volume":"42","author":"Frederick","year":"1997","journal-title":"Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.jocn.2004.03.011_BIB52","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1212\/WNL.42.8.1578","article-title":"Acetyl-l-aspartate and other amino acid metabolites in Alzheimer's disease brain: a preliminary proton nuclear magnetic resonance study","volume":"42","author":"Klunk","year":"1992","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB53","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1007\/BF00230654","article-title":"An in vitro 1H nuclear magnetic resonance study of the temporoparietal cortex of Alzheimer brains","volume":"102","author":"Mohanakrishnan","year":"1995","journal-title":"Exp. Brain Res."},{"issue":"10","key":"10.1016\/j.jocn.2004.03.011_BIB54","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1176\/ajp.154.10.1459","article-title":"Brain proton magnetic resonance spectroscopy (H-MRS) in Alzheimer's disease: changes after treatment with xanomeline, an M1 selective cholinergic agonist","volume":"154","author":"Satlin","year":"1997","journal-title":"Am. J. Psychiatry"},{"issue":"836","key":"10.1016\/j.jocn.2004.03.011_BIB55","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1259\/bjr.70.836.9486060","article-title":"Brain MR spectroscopy at 1.0 tesla","volume":"70","author":"Waldman","year":"1997","journal-title":"Br. J. Radiol."},{"issue":"1","key":"10.1016\/j.jocn.2004.03.011_BIB56","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1148\/radiology.219.1.r01ap14101","article-title":"Mild cognitive impairment and Alzheimer disease: regional diffusivity of water","volume":"219","author":"Kantarci","year":"2001","journal-title":"Radiology"},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB57","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1136\/jnnp.69.4.528","article-title":"Loss of connectivity in Alzheimer's disease: an evaluation of white matter tract integrity with colour coded MR diffusion tensor imaging","volume":"69","author":"Rose","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB58","first-page":"661","article-title":"PET: the merging of biology and imaging into molecular imaging","volume":"41","author":"Phelps","year":"2000","journal-title":"J. Nucl. Med."},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB59","first-page":"611","article-title":"Brain SPECT in neurology and psychiatry","volume":"42","author":"Camargo","year":"2001","journal-title":"J. Nucl. Med."},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB60","first-page":"391","article-title":"Differential diagnosis of Alzheimer's disease with PET","volume":"35","author":"Salmon","year":"1994","journal-title":"J. Nucl. Med."},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB61","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1001\/archpsyc.1997.01830150083012","article-title":"The course of psychopathologic features in mild to moderate Alzheimer disease","volume":"54","author":"Devanand","year":"1997","journal-title":"Arch. Gen. Psychiatry"},{"issue":"9","key":"10.1016\/j.jocn.2004.03.011_BIB62","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1212\/WNL.56.9.1143","article-title":"Practice parameter: diagnosis of dementia (an evidence based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"56","author":"Knopman","year":"2001","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB63","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S1536-1632(02)00016-1","article-title":"Added clinical benefit of incorporating 2-deoxy-2-[18F]fluoro-d-glucose with positron emission tomography into the clinical evaluation of patients with cognitive impairment","volume":"4","author":"Silverman","year":"2002","journal-title":"Mol. Imaging Biol."},{"issue":"1","key":"10.1016\/j.jocn.2004.03.011_BIB64","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0304-3940(95)11270-7","article-title":"Deficits in cerebral glucose metabolism demonstrated by positron emission tomography in individuals at risk of familial Alzheimer's disease","volume":"186","author":"Kennedy","year":"1995","journal-title":"Neurosci. Lett."},{"issue":"12","key":"10.1016\/j.jocn.2004.03.011_BIB65","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1001\/jama.1995.03520360056039","article-title":"Apolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease","volume":"273","author":"Small","year":"1995","journal-title":"JAMA"},{"issue":"17","key":"10.1016\/j.jocn.2004.03.011_BIB66","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1001\/jama.286.17.2120","article-title":"Positron emission tomography in evaluation of dementia: regional brain metabolism and long-term outcome","volume":"286","author":"Silverman","year":"2001","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.jocn.2004.03.011_BIB67","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1007\/s00259-003-1194-1","article-title":"Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study","volume":"30","author":"Drzezga","year":"2003","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"10.1016\/j.jocn.2004.03.011_BIB68","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1136\/jnnp.64.3.306","article-title":"A clinical role for 99mTc- HMPAO SPECT in the investigation of dementia?","volume":"64","author":"Talbot","year":"1998","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"5","key":"10.1016\/j.jocn.2004.03.011_BIB69","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1136\/jnnp.69.5.661","article-title":"Alzheimer's disease and frontotemporal dementia are differentiated by discriminant analysis applied to Tc HmPAO SPECT data","volume":"69","author":"Charpentier","year":"2000","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.jocn.2004.03.011_BIB70","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1159\/000017250","article-title":"Frontotemporal dementia can be distinguished from Alzheimer's disease and subcortical white matter dementia by an anterior-to-posterior rCBFSPET ratio","volume":"11","author":"Sjogren","year":"2000","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.jocn.2004.03.011_BIB71","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1212\/WNL.53.2.413","article-title":"Regional cerebral blood flow difference between dementia with Lewy bodies and AD","volume":"53","author":"Ishii","year":"1999","journal-title":"Neurology"},{"issue":"5","key":"10.1016\/j.jocn.2004.03.011_BIB72","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1212\/WNL.56.5.643","article-title":"Occipital hypoperfusion on SPECT in dementia with Lewy bodies but not AD","volume":"56","author":"Lobotesis","year":"2001","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.jocn.2004.03.011_BIB73","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1212\/WNL.56.7.950","article-title":"SPECT perfusion imaging in the diagnosis of Alzheimer's disease: a clinicalpathologic study","volume":"56","author":"Jagust","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2004.03.011_BIB74","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1017\/S1041610298005389","volume":"10","author":"Jobst","year":"1998","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.jocn.2004.03.011_BIB75","first-page":"23","article-title":"Lack of prognostic significance of SPECT abnormalities in non-demented elderly subjects with memory loss","volume":"26","author":"McKelvey","year":"1999","journal-title":"Can. J. Neurol. Sci."},{"issue":"6","key":"10.1016\/j.jocn.2004.03.011_BIB76","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1212\/WNL.50.6.1563","article-title":"Preclinical prediction of Alzheimer's disease using SPECT","volume":"50","author":"Johnson","year":"1998","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.jocn.2004.03.011_BIB77","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1212\/WNL.56.11.1545","article-title":"Presenilin-1-associated abnormalities in regional cerebral perfusion","volume":"56","author":"Johnson","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2004.03.011_BIB78","series-title":"Neuronal Nicotinic Receptors: Pharmacology and Therapeutic Opportunities","first-page":"235","article-title":"Nicotine and related compounds as PET and SPECT ligands","author":"Villemagne","year":"1998"},{"key":"10.1016\/j.jocn.2004.03.011_BIB79","first-page":"165","article-title":"Nicotine receptors in the brain of patients with Alzheimer's disease. Studies with 11C-nicotine and positron emission tomography","volume":"376","author":"Nordberg","year":"1991","journal-title":"Acta Radiol. Suppl."},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB80","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0006-3223(00)01112-4","article-title":"Imaging brain cholinergic activity with positron emission tomography: its role in the evaluation of cholinergic treatments in Alzheimer's dementia","volume":"49","author":"Volkow","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.jocn.2004.03.011_BIB81","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1034\/j.1600-0404.2000.00304.x","article-title":"Ligands for in vivo imaging of nicotinic receptor subtypes in Alzheimer brain","volume":"176","author":"Sihver","year":"2000","journal-title":"Acta Neurol. Scand. Suppl."},{"issue":"11","key":"10.1016\/j.jocn.2004.03.011_BIB82","first-page":"1737","article-title":"Imaging nicotinic acetylcholine receptors with PET and [F-18]-FPH, a [F-18]-labeled analog of epibatidine","volume":"38","author":"Villemagne","year":"1997","journal-title":"J. Nucl. Med."},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB83","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/(SICI)1098-2396(199708)26:4<392::AID-SYN7>3.0.CO;2-1","article-title":"[125\/123I]IPH: a radioiodinated analog of epibatidine for in vivo studies of nicotinic acetylcholine receptors","volume":"26","author":"Musachio","year":"1997","journal-title":"Synapse"},{"issue":"2","key":"10.1016\/j.jocn.2004.03.011_BIB84","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0969-8051(98)00101-2","article-title":"Synthesis of an I-123 analog of A-85380 and preliminary SPECT imaging of nicotinic receptors in baboon","volume":"26","author":"Musachio","year":"1999","journal-title":"Nucl. Med. Biol."},{"key":"10.1016\/j.jocn.2004.03.011_BIB85","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1749-6632.1993.tb23022.x","article-title":"In vivo detection of neurotransmitter changes in Alzheimer's disease","volume":"695","author":"Nordberg","year":"1993","journal-title":"Ann. N. Y. Acad. Sc."},{"issue":"2","key":"10.1016\/j.jocn.2004.03.011_BIB86","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0166-4328(93)90138-G","article-title":"Clinical studies in Alzheimer patients with positron emission tomography","volume":"57","author":"Nordberg","year":"1993","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB87","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00002093-199809000-00017","article-title":"Long-term tacrine treatment in three mild Alzheimer patients: effects on nicotinic receptors, cerebral blood flow, glucose metabolism, EEG, and cognitive abilities","volume":"12","author":"Nordberg","year":"1998","journal-title":"Alzheimer Dis. Assoc. Disord."},{"issue":"2","key":"10.1016\/j.jocn.2004.03.011_BIB88","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1159\/000106611","article-title":"Imaging of nicotinic and muscarinic receptors in Alzheimer's disease: effect of tacrine treatment","volume":"8","author":"Nordberg","year":"1997","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"10.1016\/j.jocn.2004.03.011_BIB89","first-page":"62","article-title":"Effect of long-term treatment with tacrine (THA) in Alzheimer's disease as visualized by PET","volume":"149","author":"Nordberg","year":"1993","journal-title":"Acta Neurol. Scand. Suppl."},{"issue":"6","key":"10.1016\/j.jocn.2004.03.011_BIB90","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0197-4580(92)90099-J","article-title":"Tacrine restores cholinergic nicotinic receptors and glucose metabolism in Alzheimer patients as visualized by positron emission tomography","volume":"13","author":"Nordberg","year":"1992","journal-title":"Neurobiol. Aging"},{"issue":"6","key":"10.1016\/j.jocn.2004.03.011_BIB91","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M","article-title":"Soluble pool of A\u03b2 amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease","volume":"46","author":"McLean","year":"1999","journal-title":"Ann. Neurol."},{"issue":"14","key":"10.1016\/j.jocn.2004.03.011_BIB92","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1097\/00001756-199909290-00007","article-title":"Mapping biochemistry to metabolism: FDG\u2013PET and amyloid burden in Alzheimer's disease","volume":"10","author":"Mega","year":"1999","journal-title":"Neuroreport"},{"issue":"2","key":"10.1016\/j.jocn.2004.03.011_BIB93","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1002\/ana.410380219","article-title":"Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy","volume":"38","author":"Greenberg","year":"1995","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB94","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3233\/JAD-2001-3305","article-title":"Amyloid Abeta levels in Alzheimer's disease \u2013 a diagnostic tool and the key to understanding the natural history of Abeta?","volume":"3","author":"McLean","year":"2001","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.jocn.2004.03.011_BIB95","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0197-4580(00)00237-2","article-title":"Visualization of fibrillar amyloid deposits in living, transgenic Caenorhabditis elegans animals using the sensitive amyloid dye, X-34","volume":"22","author":"Link","year":"2001","journal-title":"Neurobiol. Aging"},{"issue":"6","key":"10.1016\/j.jocn.2004.03.011_BIB96","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0197-4580(94)90050-7","article-title":"Development of small molecule probes for the beta-amyloid protein of Alzheimer's disease","volume":"15","author":"Klunk","year":"1994","journal-title":"Neurobiol. Aging"},{"issue":"9","key":"10.1016\/j.jocn.2004.03.011_BIB97","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1097\/00004647-200209000-00001","article-title":"Imaging amyloid-beta deposits in vivo","volume":"22","author":"Bacskai","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"9","key":"10.1016\/j.jocn.2004.03.011_BIB98","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1093\/jnen\/61.9.797","article-title":"Imaging A\u03b2 plaques in living transgenic mice with multiphoton microscopy and methoxy-X04, a systemically administered Congo red derivative","volume":"61","author":"Klunk","year":"2002","journal-title":"J. Neuropath. Exp. Neurol."},{"issue":"13","key":"10.1016\/j.jocn.2004.03.011_BIB99","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/S0024-3205(01)01232-2","article-title":"Uncharged thioflavin-T derivatives bind to amyloid-beta protein with high affinity and readily enter the brain","volume":"69","author":"Klunk","year":"2001","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.jocn.2004.03.011_BIB100","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1523\/JNEUROSCI.23-06-02086.2003","article-title":"The binding of 2-(4'-methylaminophenyl)benzothiazole to postmortem brain homogenates is dominated by the amyloid component","volume":"23","author":"Klunk","year":"2003","journal-title":"J. Neurosci."},{"issue":"21","key":"10.1016\/j.jocn.2004.03.011_BIB101","doi-asserted-by":"crossref","first-page":"12462","DOI":"10.1073\/pnas.2034101100","article-title":"Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice","volume":"100","author":"Bacskai","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB102","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0960-894X(01)00734-X","article-title":"A lipophilic thioflavin-T derivative for positron emission tomography (PET) imaging of amyloid in brain","volume":"12","author":"Mathis","year":"2002","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"13","key":"10.1016\/j.jocn.2004.03.011_BIB103","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1021\/jm030026b","article-title":"Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents","volume":"46","author":"Mathis","year":"2003","journal-title":"J. Med. Chem."},{"issue":"1\u20132","key":"10.1016\/j.jocn.2004.03.011_BIB104","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/s12031-002-0004-8","article-title":"Synthesis and evaluation of 2-(3\u2032-iodo-4\u2032-aminophenyl)-6-hydroxybenzothiazole for in vivo quantitation of amyloid deposits in Alzheimer's disease","volume":"19","author":"Wang","year":"2002","journal-title":"J. Mol. Neurosci."},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB105","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1385\/JMN:20:3:255","article-title":"Effects of lipophilicity on the affinity and nonspecific binding of iodinated benzothiazole derivatives","volume":"20","author":"Wang","year":"2003","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.jocn.2004.03.011_BIB106","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1126\/science.297.5582.752b","article-title":"Long-awaited technique spots Alzheimer's toxin","volume":"297","author":"Helmuth","year":"2002","journal-title":"Science"},{"issue":"Suppl 1","key":"10.1016\/j.jocn.2004.03.011_BIB107","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1002\/jlcr.2580440110","article-title":"Lipophilic 11C-labelled thioflavin-T analogues for imaging amyloid plaques in Alzheimer's disease","volume":"44","author":"Mathis","year":"2001","journal-title":"J. Label. Cpd. Radiopharm."},{"key":"10.1016\/j.jocn.2004.03.011_BIB108","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1002\/ana.20009","article-title":"Imaging brain amyloid in Alzheimer's disease with Pittsburgh compound-B","volume":"55","author":"Klunk","year":"2004","journal-title":"Ann. Neurol."},{"issue":"12","key":"10.1016\/j.jocn.2004.03.011_BIB109","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1021\/jm010045q","article-title":"Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates","volume":"44","author":"Zhuang","year":"2001","journal-title":"J. Med. Chem."},{"issue":"50","key":"10.1016\/j.jocn.2004.03.011_BIB110","doi-asserted-by":"crossref","first-page":"12740","DOI":"10.1021\/ja0167147","article-title":"Novel stilbenes as probes for amyloid plaques","volume":"123","author":"Kung","year":"2001","journal-title":"J. Am. Chem. Soc."},{"issue":"13","key":"10.1016\/j.jocn.2004.03.011_BIB111","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.1073\/pnas.97.13.7609","article-title":"In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease","volume":"97","author":"Skovronsky","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1\u20132","key":"10.1016\/j.jocn.2004.03.011_BIB112","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s12031-002-0003-9","article-title":"Radioiodinated styrylbenzene derivatives as potential SPECT imaging agents for amyloid plaque detection in Alzheimer's disease","volume":"19","author":"Kung","year":"2002","journal-title":"J. Mol. Neurosci."},{"issue":"8","key":"10.1016\/j.jocn.2004.03.011_BIB113","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0969-8051(01)00264-5","article-title":"IBOX(2-(4\u2032-dimethylaminophenyl)-6-iodobenzoxazole): a ligand for imaging amyloid plaques in the brain","volume":"28","author":"Zhuang","year":"2001","journal-title":"Nucl. Med. Biol."},{"issue":"14","key":"10.1016\/j.jocn.2004.03.011_BIB114","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1021\/jm010161t","article-title":"Isomerization of (Z,Z) to (E,E)1-bromo-2, 5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene in strong base: probes for amyloid plaques in the brain","volume":"44","author":"Lee","year":"2001","journal-title":"J. Med. Chem."},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB115","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0002-9440(10)61769-5","article-title":"The fluorescent Congo red derivative (trans,trans)-1-bromo-2, 5-bis-(3-hydroxycarbonyl-4-hydroxy)styrylbenzene (BSB) labels diverse \u03b2-pleated sheet structures in postmortem human neurodegenerative disease brains","volume":"159","author":"Schmidt","year":"2001","journal-title":"Am. J. Pathol."},{"issue":"2","key":"10.1016\/j.jocn.2004.03.011_BIB116","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1021\/jm020351j","article-title":"Structure\u2013activity relationship of imidazo[1, 2-a]pyridines as ligands for detecting beta-amyloid plaques in the brain","volume":"46","author":"Zhuang","year":"2003","journal-title":"J. Med. Chem."},{"issue":"2","key":"10.1016\/j.jocn.2004.03.011_BIB117","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0006-8993(02)03436-4","article-title":"IMPY: an improved thioflavin-T derivative for in vivo labeling of beta-amyloid plaques","volume":"956","author":"Kung","year":"2002","journal-title":"Brain Res. Bull."},{"issue":"6","key":"10.1016\/j.jocn.2004.03.011_BIB118","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0969-8051(02)00326-8","article-title":"Benzofuran derivatives as Abeta-aggregate-specific imaging agents for Alzheimer's disease","volume":"29","author":"Ono","year":"2002","journal-title":"Nucl. Med. Biol."},{"issue":"6","key":"10.1016\/j.jocn.2004.03.011_BIB119","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0969-8051(03)00049-0","article-title":"11C-labeled stilbene derivatives as Abeta-aggregate-specific PET imaging agents for Alzheimer's disease","volume":"30","author":"Ono","year":"2003","journal-title":"Nucl. Med. Biol."},{"issue":"1","key":"10.1016\/j.jocn.2004.03.011_BIB120","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1385\/JMN:20:1:15","article-title":"Detection of amyloid plaques by radioligands for Abeta40 and Abeta42: potential imaging agents in Alzheimer's patients","volume":"20","author":"Kung","year":"2003","journal-title":"J. Mol. Neurosci."},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB121","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1385\/JMN:20:3:249","article-title":"Characterization of radioiodinated ligand binding to amyloid beta plaques..;","volume":"20","author":"Kung","year":"2003","journal-title":"J. Mol. Neurosci."},{"issue":"6","key":"10.1016\/j.jocn.2004.03.011_BIB122","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0969-8051(03)00050-7","article-title":"Dimethylamino-fluorenes: ligands for detecting beta-amyloid plaques in the brain","volume":"30","author":"Lee","year":"2003","journal-title":"Nucl. Med. Biol."},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB123","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0306-4522(02)00907-7","article-title":"In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2- naphthyl]ethylidene)malononitrile","volume":"117","author":"Agdeppa","year":"2003","journal-title":"Neuroscience"},{"issue":"24","key":"10.1016\/j.jocn.2004.03.011_BIB124","doi-asserted-by":"crossref","first-page":"RC189","DOI":"10.1523\/JNEUROSCI.21-24-j0004.2001","article-title":"Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for \u03b2-amyloid plaques in Alzheimer's disease","volume":"21","author":"Agdeppa","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.jocn.2004.03.011_BIB125","first-page":"S194","article-title":"PET imaging of tangles and plaques in Alzheimer disease with a highly lipophilic probe","volume":"42","author":"Barrio","year":"1999","journal-title":"J. Label. Compd. Radiopharm."},{"issue":"1","key":"10.1016\/j.jocn.2004.03.011_BIB126","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/00019442-200201000-00004","article-title":"Localisation of neurofibrillary tangles and \u03b2-amyloid plaques in the brains of living patients with Alzheimer's disease","volume":"10","author":"Shoghi-Jadid","year":"2002","journal-title":"Am. J. Ger. Psychiatry"},{"issue":"22","key":"10.1016\/j.jocn.2004.03.011_BIB127","doi-asserted-by":"crossref","first-page":"8029","DOI":"10.1523\/JNEUROSCI.23-22-08029.2003","article-title":"Molecular-imaging probe 2-(1-[6-[(2-fluoroethyl)(methyl) amino]-2-naphthyl]ethylidene) malononitrile labels prion plaques in vitro","volume":"23","author":"Bresjanac","year":"2003","journal-title":"J. Neurosci."},{"issue":"Suppl 1","key":"10.1016\/j.jocn.2004.03.011_BIB128","first-page":"65P","article-title":"In vivo and in vitro labeling of plaques and tangles in the brain of an Alzheimer's disease patient: a case study","volume":"42","author":"Agdeppa","year":"2001","journal-title":"J. Nucl. Med."},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB129","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1385\/JMN:19:3:321","article-title":"In vivo brain imaging of tangle burden in humans","volume":"19","author":"Small","year":"2002","journal-title":"J. Mol. Neurosci."},{"issue":"12","key":"10.1016\/j.jocn.2004.03.011_BIB130","first-page":"2184","article-title":"Development of a monoclonal antibody specific for \u03b2\/A4 amyloid in Alzheimer's disease brain for application to in vivo imaging of amyloid angiopathy","volume":"33","author":"Majocha","year":"1992","journal-title":"J. Nucl. Med."},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB131","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00005072-199407000-00009","article-title":"Labelling of cerebral amyloid in vivo with a monoclonal antibody","volume":"53","author":"Walker","year":"1994","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"6","key":"10.1016\/j.jocn.2004.03.011_BIB132","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0197-4580(02)00121-5","article-title":"Related amyloid binding ligands as Alzheimer's disease therapies","volume":"23","author":"Lee","year":"2002","journal-title":"Neurobiol. Aging"},{"issue":"2","key":"10.1016\/j.jocn.2004.03.011_BIB133","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1021\/bc010066z","article-title":"Noninvasive imaging of peripherally injected Alzheimer's disease type synthetic A beta amyloid in vivo","volume":"13","author":"Marshall","year":"2002","journal-title":"Bioconjug. Chem."},{"issue":"12","key":"10.1016\/j.jocn.2004.03.011_BIB134","doi-asserted-by":"crossref","first-page":"5462","DOI":"10.1073\/pnas.89.12.5462","article-title":"Reversible in vitro growth of Alzheimer disease beta-amyloid plaques by deposition of labeled amyloid protein","volume":"89","author":"Maggio","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.jocn.2004.03.011_BIB135","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1749-6632.2000.tb06358.x","article-title":"Prospects for noninvasive imaging of brain amyloid beta in Alzheimer's disease","volume":"903","author":"Friedland","year":"2000","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"15\u201317","key":"10.1016\/j.jocn.2004.03.011_BIB136","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1097\/00001756-199611040-00040","article-title":"Intra-arterial infusion of [125I]A beta 1\u201340 labels amyloid deposits in the aged primate brain in vivo","volume":"7","author":"Ghilardi","year":"1996","journal-title":"Neuroreport"},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB137","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1021\/bc9901393","article-title":"Abeta(1\u201340) peptide radiopharmaceuticals for brain amyloid imaging: (111)In chelation, conjugation to poly(ethylene glycol)-biotin linkers, and autoradiography with Alzheimer's disease brain sections","volume":"11","author":"Kurihara","year":"2000","journal-title":"Bioconjug. Chem."},{"issue":"22","key":"10.1016\/j.jocn.2004.03.011_BIB138","doi-asserted-by":"crossref","first-page":"10227","DOI":"10.1073\/pnas.92.22.10227","article-title":"Vector-mediated delivery of 125I-labeled beta-amyloid peptide A beta 1\u201340 through the blood\u2013brain barrier and binding to Alzheimer disease amyloid of the A beta 1\u201340\/vector complex","volume":"92","author":"Saito","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"8","key":"10.1016\/j.jocn.2004.03.011_BIB139","first-page":"1044","article-title":"Labeling of cerebral amyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice","volume":"43","author":"Shi","year":"2002","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.jocn.2004.03.011_BIB140","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/jlcr.716","article-title":"A novel probe for imaging amyloid-b: synthesis of F-18 labelled BF-108, an Acridine orange analog","volume":"46","author":"Shimadzu","year":"2003","journal-title":"J. Label. Compd. Radiopharm."},{"issue":"6","key":"10.1016\/j.jocn.2004.03.011_BIB141","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1523\/JNEUROSCI.23-06-02212.2003","article-title":"In vivo imaging of reactive oxygen species specifically associated with thioflavine S-positive amyloid plaques by multiphoton microscopy","volume":"23","author":"McLellan","year":"2003","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB142","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1001\/archneur.57.4.454","article-title":"Prospects for pharmacological intervention in Alzheimer disease","volume":"57","author":"Emilien","year":"2000","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.jocn.2004.03.011_BIB143","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1527-3458.2003.tb00254.x","article-title":"The neuropharmacological basis for the use of memantine in the treatment of Alzheimer's disease","volume":"9","author":"Rogawski","year":"2003","journal-title":"CNS Drug Rev."},{"key":"10.1016\/j.jocn.2004.03.011_BIB144","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3109\/13506120308998993","article-title":"Challenges of targeting A\u03b2 fibrillogenesis and other protein folding disorders","volume":"10","author":"LeVine III","year":"2003","journal-title":"Amyloid: J. Protein Fold. Disord."},{"issue":"2","key":"10.1016\/j.jocn.2004.03.011_BIB145","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1006\/exnr.1999.7085","article-title":"The levels of soluble versus insoluble brain A\u03b2 distinguish Alzheimer's disease from normal and pathologic aging","volume":"158","author":"Wang","year":"1999","journal-title":"Exp. Neurol."},{"issue":"6740","key":"10.1016\/j.jocn.2004.03.011_BIB146","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/22124","article-title":"Immunization with amyloid-\u03b2 attenuates Alzheimer-disease-like pathology in the PDAPP mouse","volume":"400","author":"Schenk","year":"1999","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.jocn.2004.03.011_BIB147","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S0896-6273(01)00317-8","article-title":"Treatment with a copper-zinc chelator markedly and rapidly inhibits \u03b2-amyloid accumulation in Alzheimer's disease transgenic mice","volume":"30","author":"Cherny","year":"2001","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB148","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1002\/1531-8249(200010)48:4<567::AID-ANA3>3.0.CO;2-W","article-title":"Nasal administration of amyloid-\u03b2 peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease","volume":"48","author":"Weiner","year":"2000","journal-title":"Ann. Neurol."},{"issue":"6815","key":"10.1016\/j.jocn.2004.03.011_BIB149","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/35050110","article-title":"A\u03b2-peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease","volume":"408","author":"Janus","year":"2000","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.jocn.2004.03.011_BIB150","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/78682","article-title":"Peripherally administered antibodies against amyloid \u03b2 peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease","volume":"6","author":"Bard","year":"2000","journal-title":"Nat. Med."},{"issue":"15","key":"10.1016\/j.jocn.2004.03.011_BIB151","doi-asserted-by":"crossref","first-page":"8850","DOI":"10.1073\/pnas.151261398","article-title":"Peripheral anti-A\u03b2 antibody alters CNS and plasma A\u03b2 clearance and decreases brain A\u03b2 burden in a mouse model of Alzheimer's disease","volume":"98","author":"DeMattos","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"33","key":"10.1016\/j.jocn.2004.03.011_BIB152","doi-asserted-by":"crossref","first-page":"23223","DOI":"10.1074\/jbc.274.33.23223","article-title":"Aqueous dissolution of Alzheimer's disease A\u03b2 amyloid deposits by biometal depletion","volume":"274","author":"Cherny","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"21","key":"10.1016\/j.jocn.2004.03.011_BIB153","doi-asserted-by":"crossref","first-page":"12817","DOI":"10.1074\/jbc.273.21.12817","article-title":"Dramatic aggregation of Alzheimer A\u03b2 by Cu(II) is induced by conditions representing physiological acidosis","volume":"273","author":"Atwood","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB154","first-page":"777","article-title":"Copper catalyzed oxidation of Alzheimer A\u03b2","volume":"46","author":"Atwood","year":"2000","journal-title":"Cell. Mol. Biol."},{"issue":"24","key":"10.1016\/j.jocn.2004.03.011_BIB155","doi-asserted-by":"crossref","first-page":"7609","DOI":"10.1021\/bi990438f","article-title":"The A\u03b2 peptide of Alzheimer's disease directly produces hydrogen peroxide through metal ion reduction","volume":"38","author":"Huang","year":"1999","journal-title":"Biochemistry"},{"issue":"52","key":"10.1016\/j.jocn.2004.03.011_BIB156","doi-asserted-by":"crossref","first-page":"37111","DOI":"10.1074\/jbc.274.52.37111","article-title":"Cu(II) potentiation of Alzheimer A\u03b2 neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction","volume":"274","author":"Huang","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"26","key":"10.1016\/j.jocn.2004.03.011_BIB157","doi-asserted-by":"crossref","first-page":"19439","DOI":"10.1074\/jbc.C000165200","article-title":"Evidence that the \u03b2-amyloid plaques of Alzheimer's disease represent the redox-silencing and entombment of A\u03b2 by zinc","volume":"275","author":"Cuajungco","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"5177","key":"10.1016\/j.jocn.2004.03.011_BIB158","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1126\/science.8073293","article-title":"Rapid induction of Alzheimer A\u03b2 amyloid formation by zinc","volume":"265","author":"Bush","year":"1994","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.jocn.2004.03.011_BIB159","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0022-510X(98)00092-6","article-title":"Copper, iron and zinc in Alzheimer's disease senile plaques","volume":"158","author":"Lovell","year":"1998","journal-title":"J. Neurol. Sci."},{"issue":"20","key":"10.1016\/j.jocn.2004.03.011_BIB160","doi-asserted-by":"crossref","first-page":"11193","DOI":"10.1073\/pnas.2135061100","article-title":"Copper, beta-amyloid, and Alzheimer's disease: tapping a sensitive connection","volume":"100","author":"Bush","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"4","key":"10.1016\/j.jocn.2004.03.011_BIB161","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0166-2236(03)00067-5","article-title":"The metallobiology of Alzheimer's disease","volume":"26","author":"Bush","year":"2003","journal-title":"Trends Neurosci."},{"issue":"23","key":"10.1016\/j.jocn.2004.03.011_BIB162","doi-asserted-by":"crossref","first-page":"20466","DOI":"10.1074\/jbc.M100175200","article-title":"Alzheimer's disease amyloid-\u03b2 binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits","volume":"276","author":"Curtain","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.jocn.2004.03.011_BIB163","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/0470868694.ch4","article-title":"Specific metal-catalysed protein oxidation reactions in chronic degenerative disorders of ageing: focus on Alzheimer's disease and age-related cataracts","volume":"235","author":"Bush","year":"2001","journal-title":"Novartis Found. Symp."},{"issue":"6","key":"10.1016\/j.jocn.2004.03.011_BIB164","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0197-4580(02)00120-3","article-title":"Metal complexing agents as therapies for Alzheimer's disease","volume":"23","author":"Bush","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.jocn.2004.03.011_BIB165","doi-asserted-by":"crossref","unstructured":"Padmanabhan G, et al. Clioquinol. In: Klauss E, Florey E (eds.). Analytical Profiles of Drug Substances. Academic Press, New York; 1989: 57\u201390","DOI":"10.1016\/S0099-5428(08)60669-3"},{"key":"10.1016\/j.jocn.2004.03.011_BIB166","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1001\/archneur.60.12.1685","article-title":"Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting a amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial","volume":"60","author":"Ritchie","year":"2003","journal-title":"Arch. Neurol."},{"issue":"9","key":"10.1016\/j.jocn.2004.03.011_BIB167","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1212\/WNL.56.9.1154","article-title":"Practice parameter: management of dementia (an evidence-based review) \u2013 report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"56","author":"Doody","year":"2001","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.jocn.2004.03.011_BIB168","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1212\/WNL.56.9.1133","article-title":"Practice parameter: early detection of dementia: mild cognitive impairment (an evidence-based review)-report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"56","author":"Petersen","year":"2001","journal-title":"Neurology"},{"issue":"Suppl 1","key":"10.1016\/j.jocn.2004.03.011_BIB169","first-page":"71P","article-title":"Prognostic value of regional brain metabolism in evaluation of dementia","volume":"40","author":"Silverman","year":"1999","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.jocn.2004.03.011_BIB170","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1586\/14737159.4.1.63","article-title":"Accuracy of early diagnosis and its impact on the management and course of Alzheimer's disease","volume":"4","author":"Chang","year":"2004","journal-title":"Expert Rev. Mol. Diagn."},{"issue":"2","key":"10.1016\/j.jocn.2004.03.011_BIB171","first-page":"253","article-title":"Evaluating early dementia with and without assessment of regional cerebral metabolism by PET: a comparison of predicted costs and benefits","volume":"43","author":"Silverman","year":"2002","journal-title":"J. Nucl. Med."}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586804000785?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586804000785?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,6]],"date-time":"2020-04-06T17:42:24Z","timestamp":1586194944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0967586804000785"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4]]},"references-count":171,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,4]]}},"alternative-id":["S0967586804000785"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2004.03.011","relation":{},"ISSN":["0967-5868"],"issn-type":[{"value":"0967-5868","type":"print"}],"subject":[],"published":{"date-parts":[[2005,4]]}}}