{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:46:36Z","timestamp":1791405996682,"version":"4.3.3"},"reference-count":17,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,2,1]],"date-time":"2009-02-01T00:00:00Z","timestamp":1233446400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2009,2]]},"DOI":"10.1016\/j.jocn.2008.04.009","type":"journal-article","created":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T08:59:25Z","timestamp":1229504365000},"page":"277-282","source":"Crossref","is-referenced-by-count":48,"title":["Interaction between \u03b2-amyloid protein and heparan sulfate proteoglycans from the cerebral capillary basement membrane in Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"16","author":[{"given":"Hajime","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Ghazizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuo","family":"Oguro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oichi","family":"Kawanami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jocn.2008.04.009_bib1","doi-asserted-by":"crossref","first-page":"13170","DOI":"10.1073\/pnas.93.23.13170","article-title":"Evidence that the 42-and 40-amino acid forms of amyloid \u03b2 protein are generated from the beta-amyloid precursor protein by different protease activities","volume":"93","author":"Citron","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jocn.2008.04.009_bib2","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jocn.2003.12.007","article-title":"Alzheimer\u2019s disease pathogenesis and therapeutic interventions","volume":"11","author":"Parihar","year":"1994","journal-title":"J Clin Neurosc"},{"key":"10.1016\/j.jocn.2008.04.009_bib3","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1385\/JMN:17:2:137","article-title":"Intracellular mechanism of amyloid accumulation and pathogenesis in Alzheimer\u2019s disease","volume":"17","author":"Glabe","year":"2001","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.jocn.2008.04.009_bib4","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1749-6632.1996.tb34439.x","article-title":"The role of heparan sulfate proteoglycans in the pathogenesis of Alzheimer\u2019s disease","volume":"777","author":"Small","year":"1996","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.jocn.2008.04.009_bib5","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/(SICI)1098-1136(199710)21:2<228::AID-GLIA6>3.0.CO;2-2","article-title":"Localization of perlecan (or a perlecan-related macromolecule) to isolated microglia in vitro and to microglia\/macrophages following infusion of \u03b2-amyloid protein into rodent hippocampus","volume":"21","author":"Miller","year":"1997","journal-title":"Glia"},{"key":"10.1016\/j.jocn.2008.04.009_bib6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1006\/exnr.1996.0069","article-title":"Identification in immunolocalization of a new class of proteoglycan (keratan sulfate) to the neuritic plaques of Alzheimer\u2019s disease","volume":"138","author":"Snow","year":"1996","journal-title":"J Exp Neurol"},{"key":"10.1016\/j.jocn.2008.04.009_bib7","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1172\/JCI108491","article-title":"The glycosaminoglycans of the human artery and their changes in atherosclerosis","volume":"58","author":"Stevens","year":"1976","journal-title":"J Clin Invest"},{"key":"10.1016\/j.jocn.2008.04.009_bib8","first-page":"337","article-title":"Heparan sulfate proteoglycan in diffuse plaques of hippocampus but not of cerebellum in Alzheimer\u2019s disease brain","volume":"144","author":"Snow","year":"1994","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jocn.2008.04.009_bib9","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1523\/JNEUROSCI.11-11-03679.1991","article-title":"Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer\u2019s disease","volume":"11","author":"Perry","year":"1991","journal-title":"J Neurosci"},{"key":"10.1016\/j.jocn.2008.04.009_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0306-4522(92)90482-H","article-title":"Acetylcholinesterase and its association with heparan sulphate proteoglycans in cortical amyloid deposits of Alzheimer\u2019s disease","volume":"51","author":"Kalaria","year":"1992","journal-title":"J Neurosci"},{"key":"10.1016\/j.jocn.2008.04.009_bib11","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S1474-4422(03)00484-8","article-title":"Heparan sulphate proteoglycan in Alzheimer\u2019s disease and amyloid-related disorders","volume":"2","author":"van Horssen","year":"2003","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jocn.2008.04.009_bib12","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1046\/j.1432-1327.1999.00957.x","article-title":"Interactions of Alzheimer amyloid-\u03b2 peptides with glycosaminoglycans effects on fibril nucleation and growth","volume":"266","author":"McLaurin","year":"1999","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.jocn.2008.04.009_bib13","doi-asserted-by":"crossref","first-page":"17005","DOI":"10.1074\/jbc.272.27.17005","article-title":"\u03b2 (1\u201340) prevents heparanase-catalyzed degradation of heparan sulfate glycosaminoglycans and proteoglycans in vitro","volume":"272","author":"Bame","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jocn.2008.04.009_bib14","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/glia.10178","article-title":"Astrocytic expression of the Alzheimer\u2019s disease \u03b2-secretase (BACE1) is stimulus-dependent","volume":"41","author":"Hartlage-R\u00fcbsamen","year":"2003","journal-title":"Glia"},{"key":"10.1016\/j.jocn.2008.04.009_bib15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1083\/jcb.200303059","article-title":"Heparan sulfate regulates amyloid precursor protein processing by BACE, the Alzheimer\u2019s \u03b2-secretase","volume":"163","author":"Scholefield","year":"2003","journal-title":"J Cell Biol"},{"key":"10.1016\/j.jocn.2008.04.009_bib16","first-page":"135","article-title":"Microglia in human diseases, with an emphasis on acquired immune deficiency syndrome","volume":"64","author":"Dickson","year":"1991","journal-title":"Lab Invest."},{"key":"10.1016\/j.jocn.2008.04.009_bib17","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/BF00334667","article-title":"Migration of perivascular cells into the neuropil and their involvement in \u03b2-amyloid plaque formation","volume":"85","author":"Wisniewski","year":"1993","journal-title":"Acta Neuropathol"}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586808001872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586808001872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T07:15:47Z","timestamp":1557990947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0967586808001872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,2]]}},"alternative-id":["S0967586808001872"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2008.04.009","relation":{},"ISSN":["0967-5868"],"issn-type":[{"value":"0967-5868","type":"print"}],"subject":[],"published":{"date-parts":[[2009,2]]}}}