{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T00:40:00Z","timestamp":1760834400692,"version":"build-2065373602"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jocn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.jocn.2010.11.005","type":"journal-article","created":{"date-parts":[[2011,4,21]],"date-time":"2011-04-21T17:08:13Z","timestamp":1303405693000},"page":"816-820","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["The effects of valproic acid and levetiracetam on chicken embryos"],"prefix":"10.1016","volume":"18","author":[{"given":"Ercan","family":"Tureci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziya","family":"Asan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mediha","family":"Eser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taner","family":"Tanriverdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faruk","family":"Alkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamir","family":"Erdincler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jocn.2010.11.005_b0005","doi-asserted-by":"crossref","first-page":"305","DOI":"10.2217\/fnl.09.2","article-title":"Surgical modalities in temporal lobe epilepsy: advantages, disadvantages and outcomes","volume":"4","author":"Olivier","year":"2009","journal-title":"Future Neurol"},{"key":"10.1016\/j.jocn.2010.11.005_b0010","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/S0140-6736(72)92209-X","article-title":"Maternal epilepsy and abnormalities of the fetus and newborn","volume":"308","author":"Speidel","year":"1972","journal-title":"Lancet"},{"key":"10.1016\/j.jocn.2010.11.005_b0015","first-page":"111","article-title":"The effects of meloxicam on neural tube development in the early stage of chick embryos","volume":"20","author":"Cetinkal","year":"2010","journal-title":"Turk Neurosurg"},{"key":"10.1016\/j.jocn.2010.11.005_b0020","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1056\/NEJM200104123441504","article-title":"The teratogenicity of anticonvulsant drugs","volume":"344","author":"Holmes","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jocn.2010.11.005_b0025","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/bdrb.20134","article-title":"Altered axial skeletal development","volume":"80","author":"Tyl","year":"2007","journal-title":"Birth Defects Res B"},{"key":"10.1016\/j.jocn.2010.11.005_b0030","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1056\/NEJM198906223202505","article-title":"Pattern of malformations in the children of women treated with carbamazepine during pregnancy","volume":"320","author":"Jones","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jocn.2010.11.005_b0035","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1111\/j.1528-1167.2006.00894.x","article-title":"Seizures and antiepileptic drugs: does exposure alter normal brain development?","volume":"47","author":"Marsh","year":"2006","journal-title":"Epilepsia"},{"key":"10.1016\/j.jocn.2010.11.005_b0040","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/ajmg.1320190308","article-title":"The fetal valproate syndrome","volume":"19","author":"DiLiberti","year":"1984","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jocn.2010.11.005_b0045","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1046\/j.1528-1157.2001.44300.x","article-title":"Repeated neural tube defects and valproate monotherapy suggest a pharmacogenetic abnormality","volume":"42","author":"Duncan","year":"2001","journal-title":"Epilepsia"},{"key":"10.1016\/j.jocn.2010.11.005_b0050","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0890-6238(91)90017-A","article-title":"Diurnal variation of folate concentrations in mouse embryo and plasma: the protective effect of folinic acid on valproic acid induced teratogenicity is time dependent","volume":"5","author":"Wegner","year":"1991","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.jocn.2010.11.005_b0055","doi-asserted-by":"crossref","first-page":"36734","DOI":"10.1074\/jbc.M101287200","article-title":"Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer and teratogen","volume":"276","author":"Phiel","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jocn.2010.11.005_b0060","doi-asserted-by":"crossref","first-page":"27586","DOI":"10.1074\/jbc.M303740200","article-title":"Valproate induces replication-independent active DNA demethylation","volume":"278","author":"Detich","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.jocn.2010.11.005_b0065","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.reprotox.2007.04.005","article-title":"Embryonic cardiac arrhythmia and generation of reactive oxygen species: common teratogenic mechanism for IKr blocking drugs","volume":"24","author":"Danielsson","year":"2007","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.jocn.2010.11.005_b0070","first-page":"137","article-title":"The novel antiepileptic drug levetiracetam (ucb LO59) appears to act via a specific binding site in CNS membranes","volume":"14","author":"Noyer","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.jocn.2010.11.005_b0075","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1212\/01.wnl.0000244491.48937.55","article-title":"Levetiracetam in pregnancy: preliminary experience from the UK Epilepsy and Pregnancy Register","volume":"67","author":"Hunt","year":"2006","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2010.11.005_b0080","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1046\/j.1528-1157.2003.21503.x","article-title":"Developmental outcome of levetiracetam, its major metabolites in humans, 2-pyrrolidinone N-butyric acid, and its enantiomer (R)-\u03b1-ethyl-oxo-pyrrolidinone acetamide in a mouse model of teratogenicity","volume":"44","author":"Isoherranen","year":"2003","journal-title":"Epilepsia"},{"key":"10.1016\/j.jocn.2010.11.005_b0085","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.expneurol.2005.01.006","article-title":"Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain","volume":"193","author":"Manthey","year":"2005","journal-title":"Exp Neurol"},{"key":"10.1016\/j.jocn.2010.11.005_b0090","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/aja.1001950404","article-title":"A series of normal stages in the development of the chick embryo","volume":"195","author":"Hamburger","year":"1992","journal-title":"Dev Dyn"},{"key":"10.1016\/j.jocn.2010.11.005_b0095","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1474-4422(05)70224-6","article-title":"Birth defects after prenatal exposure to anti-epileptic drugs","volume":"4","author":"Perucca","year":"2005","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jocn.2010.11.005_b0100","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.ncl.2004.07.004","article-title":"Pregnancy in women who have epilepsy","volume":"22","author":"Pennell","year":"2004","journal-title":"Neurol Clin"},{"issue":"Suppl. 4","key":"10.1016\/j.jocn.2010.11.005_b0105","first-page":"S31","article-title":"The importance of monotherapy in pregnancy","volume":"60","author":"Pennell","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2010.11.005_b0110","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1055\/s-2008-1079337","article-title":"Teratogenicity of antiepileptic medications","volume":"28","author":"Kluger","year":"2008","journal-title":"Semin Neurol"},{"key":"10.1016\/j.jocn.2010.11.005_b0115","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.eplepsyres.2009.09.019","article-title":"Antiepileptic drugs and brain development","volume":"88","author":"Ikonomidou","year":"2010","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jocn.2010.11.005_b0120","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1080\/10408440591007403","article-title":"Mode of action: inhibition of histone deacetylase, altering WNT-dependent gene expression, and regulation of beta-catenin-developmental effects of valproic acid","volume":"35","author":"Wiltse","year":"2005","journal-title":"Crit Rev Toxicol"},{"issue":"Suppl. 5","key":"10.1016\/j.jocn.2010.11.005_b0125","first-page":"S32","article-title":"Mechanisms of teratogenesis: folic acid and antiepileptic therapy","volume":"42","author":"Dansky","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2010.11.005_b0130","doi-asserted-by":"crossref","first-page":"15089","DOI":"10.1073\/pnas.222550499","article-title":"Antiepileptic drugs and apoptotic neurodegeneration in the developing brain","volume":"99","author":"Bittigau","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.jocn.2010.11.005_b0135","first-page":"17","article-title":"Alteration of embryonic folate metabolism by valproic acid during organogenesis: implication for mechanism of teratogenesis","volume":"42","author":"Wegner","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2010.11.005_b0140","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.reprotox.2007.04.004","article-title":"Embryonic oxidative stress as a mechanism of teratogenesis with special emphasis on diabetic embryopathy","volume":"24","author":"Ornoy","year":"2007","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.jocn.2010.11.005_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2009.02.014","article-title":"Valproic acid in pregnancy: how much are we endangering the embryo and fetus","volume":"28","author":"Ornoy","year":"2009","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.jocn.2010.11.005_b0150","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.eplepsyres.2007.11.005","article-title":"Increased oxidative stress in epileptic children treated with valproic acid","volume":"78","author":"Verrotti","year":"2008","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jocn.2010.11.005_b0155","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1185\/030079905X43640","article-title":"Safety of the newer antiepileptic drug oxcarbazepine during pregnancy","volume":"21","author":"Montouris","year":"2005","journal-title":"Curr Med Res Opin"},{"key":"10.1016\/j.jocn.2010.11.005_b0160","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1528-1157.1997.tb01480.x","article-title":"Maternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis associated with maternal epilepsy","volume":"38","author":"Samren","year":"1997","journal-title":"Epilepsia"},{"key":"10.1016\/j.jocn.2010.11.005_b0165","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/BF00177911","article-title":"Behavioral teratogenicity of valproic acid: selective effects on behavior after prenatal exposure to rats","volume":"92","author":"Vorhees","year":"1987","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.jocn.2010.11.005_b0170","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1124\/jpet.107.126250","article-title":"Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy","volume":"323","author":"Kim","year":"2007","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586810008246?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586810008246?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T21:14:50Z","timestamp":1760822090000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0967586810008246"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0967586810008246"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2010.11.005","relation":{},"ISSN":["0967-5868"],"issn-type":[{"type":"print","value":"0967-5868"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effects of valproic acid and levetiracetam on chicken embryos","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocn.2010.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}