{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T06:33:27Z","timestamp":1776839607783,"version":"3.51.2"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","jocn-journal.com","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1016\/j.jocn.2015.07.011","type":"journal-article","created":{"date-parts":[[2015,10,30]],"date-time":"2015-10-30T13:26:07Z","timestamp":1446211567000},"page":"34-37","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Is carbamazepine a human teratogen?"],"prefix":"10.1016","volume":"23","author":[{"given":"F.J.E.","family":"Vajda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.J.","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Lander","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.J.","family":"Eadie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jocn.2015.07.011_b0005","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1002\/ajmg.a.35438","article-title":"Antiepileptic drugs and pregnancy outcomes","volume":"158A","author":"Wlodarczyk","year":"2011","journal-title":"Am J Med Genet A"},{"key":"10.1016\/j.jocn.2015.07.011_b0010","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.jocn.2006.08.015","article-title":"The Australian antiepileptic drug in pregnancy register: aspects of data collection and analysis","volume":"14","author":"Vajda","year":"2007","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.jocn.2015.07.011_b0015","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1600-0404.2009.01260.x","article-title":"Changing patterns of antiepileptic drug use in pregnant Australian women","volume":"121","author":"Vajda","year":"2010","journal-title":"Acta Neurol Scandinav"},{"key":"10.1016\/j.jocn.2015.07.011_b0020","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1016\/j.jocn.2013.11.049","article-title":"The Australian register of antiepileptic drugs in pregnancy \u2013 changes with time in its epileptic population","volume":"21","author":"Vajda","year":"2014","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.jocn.2015.07.011_b0025","series-title":"Birth Defects in Victoria 1983\u20131998, Perinatal Data Collection Unit, 2008","author":"Riley","year":"2000"},{"key":"10.1016\/j.jocn.2015.07.011_b0030","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/1531-8249(199911)46:5<739::AID-ANA9>3.0.CO;2-2","article-title":"Antiepileptic drug regimens and major congenital abnormalities in the offspring","volume":"46","author":"Samr\u00e9n","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jocn.2015.07.011_b0035","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/jnnp.2005.074203","article-title":"Malformation risk of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register","volume":"77","author":"Morrow","year":"2006","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.jocn.2015.07.011_b0040","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/epi.12001","article-title":"Recurrence risk of congenital malformations in infants exposed to antiepileptic drugs in utero","volume":"54","author":"Campbell","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.jocn.2015.07.011_b0045","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1528-1167.2012.03625.x","article-title":"Teratogenesis in repeated pregnancies in antiepileptic drug-treated women","volume":"54","author":"Vajda","year":"2013","journal-title":"Epilepsia"},{"key":"10.1016\/j.jocn.2015.07.011_b0050","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1651-2227.2004.tb00701.x","article-title":"Major malformations in infants exposed to antiepileptic drugs in utero, with emphasis on carbamazepine and valproic acid: a nation-wide, population-based register study","volume":"93","author":"Wide","year":"2004","journal-title":"Acta Pediatr"},{"key":"10.1016\/j.jocn.2015.07.011_b0055","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1474-4422(05)70224-6","article-title":"Birth defects after prenatal exposure to antiepileptic drugs","volume":"4","author":"Perucca","year":"2005","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jocn.2015.07.011_b0060","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/S1474-4422(11)70107-7","article-title":"Dose-dependent risk of malformation with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry","volume":"10","author":"Tomson","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jocn.2015.07.011_b0065","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1212\/WNL.0b013e31827f0874","article-title":"Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers","volume":"80","author":"Mahwinney","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2015.07.011_b0070","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00415-013-7239-x","article-title":"Fetal growth restriction and birth defects with newer and older antiepileptic drugs during pregnancy","volume":"261","author":"Veiby","year":"2014","journal-title":"J Neurol"},{"key":"10.1016\/j.jocn.2015.07.011_b0075","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.reprotox.2014.02.004","article-title":"The fetal safety of levetiracetam","volume":"46","author":"Chaudhry","year":"2014","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.jocn.2015.07.011_b0080","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0920-1211(98)00084-9","article-title":"Congenital malformations due to antiepileptic drugs","volume":"33","author":"Kaneko","year":"1999","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jocn.2015.07.011_b0085","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1056\/NEJM200104123441504","article-title":"The teratogenicity of anticonvulsant drugs","volume":"344","author":"Holmes","year":"2001","journal-title":"N Eng J Med"},{"key":"10.1016\/j.jocn.2015.07.011_b0090","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1212\/WNL.57.2.321","article-title":"Is carbamazepine teratogenic? A prospective controlled study of 210 pregnancies","volume":"57","author":"Diav-Citrin","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2015.07.011_b0095","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1212\/01.WNL.0000044157.28073.DC","article-title":"Major malformations in offspring of women with epilepsy","volume":"60","author":"Kaaja","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2015.07.011_b0100","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1212\/01.WNL.0000163771.96962.1F","article-title":"Antiepileptic drug use of women with epilepsy and congenital malformations in the offspring","volume":"64","author":"Artama","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2015.07.011_b0140","first-page":"357","article-title":"Risk of major malformations among infants exposed to carbamazepine during pregnancy","volume":"79","author":"Hernandez-Diaz","year":"2007","journal-title":"Birth Defects Res (Part A)"},{"key":"10.1016\/j.jocn.2015.07.011_b0110","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.seizure.2009.11.008","article-title":"Pregnancy with epilepsy: obstetric and neonatal outcome of a controlled study","volume":"19","author":"Mawer","year":"2010","journal-title":"Seizure"},{"key":"10.1016\/j.jocn.2015.07.011_b0115","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1001\/archneurol.2011.133","article-title":"Fetal effects of anticonvulsant polytherapies","volume":"68","author":"Holmes","year":"2011","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jocn.2015.07.011_b0120","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1111\/j.1528-1157.1997.tb01480.x","article-title":"Maternal use of antiepileptic drugs and the risk of major congenital malformations: a joint European prospective study of human teratogenesis associated with maternal epilepsy","volume":"38","author":"Samr\u00e9n","year":"1997","journal-title":"Epilepsia"},{"key":"10.1016\/j.jocn.2015.07.011_b0125","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0890-6238(01)00199-X","article-title":"The teratogenic effect of carbamazepine: a meta-analysis of 1255 exposures","volume":"16","author":"Matalon","year":"2002","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.jocn.2015.07.011_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.eplepsyres.2008.04.022","article-title":"Pregnancy outcomes in women with epilepsy: a systematic review and analysis of published pregnancy registers and cohorts","volume":"81","author":"Meador","year":"2008","journal-title":"Epilepsy Res"},{"key":"10.1016\/j.jocn.2015.07.011_b0135","doi-asserted-by":"crossref","first-page":"c6581","DOI":"10.1136\/bmj.c6581","article-title":"Intrauterine exposure to carbamazepine and specific congenital malformations: systematic review and case\u2013control study","volume":"341","author":"Jentink","year":"2010","journal-title":"Br Med J"}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096758681500435X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096758681500435X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,18]],"date-time":"2018-09-18T01:52:08Z","timestamp":1537235528000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096758681500435X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1]]},"references-count":27,"alternative-id":["S096758681500435X"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2015.07.011","relation":{},"ISSN":["0967-5868"],"issn-type":[{"value":"0967-5868","type":"print"}],"subject":[],"published":{"date-parts":[[2016,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is carbamazepine a human teratogen?","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocn.2015.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}