{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:14:24Z","timestamp":1778793264128,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1153663"],"award-info":[{"award-number":["APP1153663"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1163634"],"award-info":[{"award-number":["1163634"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jocn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.jocn.2019.12.042","type":"journal-article","created":{"date-parts":[[2020,1,13]],"date-time":"2020-01-13T13:42:15Z","timestamp":1578922935000},"page":"378-385","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Prevention of peridural adhesions in spinal surgery: Assessing safety and efficacy of Chitogel with Deferiprone in a sheep model"],"prefix":"10.1016","volume":"72","author":[{"given":"Rajan Sundaresan","family":"Vediappan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Mascarenhas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Nguyen-Hoang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Anne Fong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alistair","family":"Jukes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Richter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Bassiouni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Chryssidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Otto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Moratti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alkis","family":"James Psaltis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Vreugde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter-John","family":"Wormald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jocn.2019.12.042_b0005","article-title":"Herniated lumbar disc. BMJ","volume":"2011","author":"Jordan","year":"2011","journal-title":"Clin Evid"},{"key":"10.1016\/j.jocn.2019.12.042_b0010","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jot.2018.02.001","article-title":"Update on biomaterials for prevention of epidural adhesion after lumbar laminectomy","volume":"13","author":"Wang","year":"2018","journal-title":"J Orthop Translat."},{"issue":"2","key":"10.1016\/j.jocn.2019.12.042_b0015","doi-asserted-by":"crossref","first-page":"372","DOI":"10.4184\/asj.2018.12.2.372","article-title":"Failed Back Surgery syndrome: a review article","volume":"12","author":"Daniell","year":"2018","journal-title":"Asian Spine J"},{"issue":"1","key":"10.1016\/j.jocn.2019.12.042_b0020","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1177\/2049463713479096","article-title":"Failed back surgery syndrome \u2013 definition, epidemiology and demographics","volume":"7","author":"Thomson","year":"2013","journal-title":"Br J Pain"},{"issue":"1","key":"10.1016\/j.jocn.2019.12.042_b0025","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1533-2500.2009.00311.x","article-title":"Incidence and severity of epidural fibrosis after back surgery: an endoscopic study","volume":"10","author":"Bosscher","year":"2010","journal-title":"Pain Pract"},{"issue":"2","key":"10.1016\/j.jocn.2019.12.042_b0030","doi-asserted-by":"crossref","first-page":"213","DOI":"10.5527\/wjn.v4.i2.213","article-title":"Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus","volume":"4","author":"Fujii","year":"2015","journal-title":"World J Nephrol"},{"issue":"3","key":"10.1016\/j.jocn.2019.12.042_b0035","doi-asserted-by":"crossref","first-page":"370","DOI":"10.4184\/asj.2015.9.3.370","article-title":"Epidural fibrosis after lumbar disc surgery: prevention and outcome evaluation","volume":"9","author":"Mohi Eldin","year":"2015","journal-title":"Asian Spine J"},{"issue":"6","key":"10.1016\/j.jocn.2019.12.042_b0040","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.suc.2010.08.002","article-title":"Intra-abdominal healing: gastrointestinal tract and adhesions","volume":"90","author":"Munireddy","year":"2010","journal-title":"Surg Clin North Am"},{"issue":"10164","key":"10.1016\/j.jocn.2019.12.042_b0045","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1016\/S0140-6736(18)32190-1","article-title":"Low back pain \u2013 Authors' reply","volume":"392","author":"Foster","year":"2018","journal-title":"Lancet"},{"issue":"10137","key":"10.1016\/j.jocn.2019.12.042_b0050","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1016\/S0140-6736(18)30489-6","article-title":"Prevention and treatment of low back pain: evidence, challenges, and promising directions","volume":"391","author":"Foster","year":"2018","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.jocn.2019.12.042_b0055","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2500\/ajra.2010.24.3422","article-title":"The efficacy of a novel chitosan gel on hemostasis and wound healing after endoscopic sinus surgery","volume":"24","author":"Valentine","year":"2010","journal-title":"Am J Rhinol Allergy"},{"issue":"6","key":"10.1016\/j.jocn.2019.12.042_b0060","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1097\/MLG.0b013e31816ba576","article-title":"Effects of a novel chitosan gel on mucosal wound healing following endoscopic sinus surgery in a sheep model of chronic rhinosinusitis","volume":"118","author":"Athanasiadis","year":"2008","journal-title":"The Laryngoscope."},{"issue":"2","key":"10.1016\/j.jocn.2019.12.042_b0065","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jss.2010.06.028","article-title":"Use of a modified chitosan-dextran gel to prevent peritoneal adhesions in a rat model","volume":"171","author":"Lauder","year":"2011","journal-title":"J Surg Res"},{"issue":"7","key":"10.1016\/j.jocn.2019.12.042_b0070","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/alr.21136","article-title":"A blinded randomized controlled trial evaluating the efficacy of chitosan gel on ostial stenosis following endoscopic sinus surgery","volume":"3","author":"Ngoc Ha","year":"2013","journal-title":"Int Forum Allergy Rhinol"},{"key":"10.1016\/j.jocn.2019.12.042_b0075","unstructured":"https:\/\/www.accessdata.fda.gov\/cdrh_docs\/pdf17\/K172179.pdf."},{"key":"10.1016\/j.jocn.2019.12.042_b0080","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jocn.2017.02.010","article-title":"Chitosan Dextran gel as an anti adhesion agent in a postlaminectomy spinal sheep model","volume":"40","author":"Rajiv","year":"2017","journal-title":"J Clin Neurosci"},{"key":"10.1016\/j.jocn.2019.12.042_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.eml.2019.100510","article-title":"Neural interfaces by hydrogels","author":"Sheng","year":"2019","journal-title":"Extreme Mech Lett"},{"issue":"12","key":"10.1016\/j.jocn.2019.12.042_b0090","doi-asserted-by":"crossref","first-page":"16071","DOI":"10.1038\/natrevmats.2016.71","article-title":"Designing hydrogels for controlled drug delivery","volume":"1","author":"Li","year":"2016","journal-title":"Nat Rev Mater"},{"issue":"7","key":"10.1016\/j.jocn.2019.12.042_b0095","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1056\/NEJM199808133390701","article-title":"Long-term safety and effectiveness of iron-chelation therapy with deferiprone for thalassemia major","volume":"339","author":"Olivieri","year":"1998","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.jocn.2019.12.042_b0100","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1038\/s41598-019-38902-2","article-title":"Deferiprone has anti-inflammatory properties and reduces fibroblast migration in vitro","volume":"9","author":"Ramezanpour","year":"2019","journal-title":"Sci Rep"},{"issue":"6","key":"10.1016\/j.jocn.2019.12.042_b0105","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00481-17","article-title":"A Topical Hydrogel with Deferiprone and Gallium-Protoporphyrin Targets Bacterial Iron Metabolism and Has Antibiofilm Activity","volume":"61","author":"Richter","year":"2017","journal-title":"Antimicrob Agents Chemother."},{"issue":"1","key":"10.1016\/j.jocn.2019.12.042_b0110","first-page":"142","article-title":"Parenchymal pressure inconsistency in different brain areas after kaolin injection into the subarachnoid space of neonatal rats","volume":"28","author":"Vural","year":"2018","journal-title":"Turk Neurosurg"},{"key":"10.1016\/j.jocn.2019.12.042_b0115","doi-asserted-by":"crossref","first-page":"917","DOI":"10.3389\/fmicb.2018.00917","article-title":"Safety and efficacy of topical chitogel- deferiprone-gallium protoporphyrin in sheep model","volume":"9","author":"Ooi","year":"2018","journal-title":"Front Microbiol"},{"issue":"2","key":"10.1016\/j.jocn.2019.12.042_b0120","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/jbm.b.31533","article-title":"Reduction in postlaminectomy epidural adhesions in sheep using a fibrin sealant-based medicated adhesion barrier","volume":"92","author":"Richards","year":"2010","journal-title":"J Biomed Mater Res B Appl Biomater"},{"key":"10.1016\/j.jocn.2019.12.042_b0125","unstructured":"Venables WNR, BD. Modern Applied Statistics with S. Fourth Edition, ISBN 0-387-95457-0. New York: Springer; 2002."},{"issue":"10","key":"10.1016\/j.jocn.2019.12.042_b0130","first-page":"1080","volume":"28","author":"Kim","year":"2003","journal-title":"Spine (Phila Pa 1976)"},{"issue":"8","key":"10.1016\/j.jocn.2019.12.042_b0135","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/BRS.0b013e3182309af7","article-title":"Oxiplex reduces leg pain, back pain, and associated symptoms after lumbar discectomy","volume":"37","author":"Rhyne","year":"2012","journal-title":"Spine (Phila Pa 1976)"},{"key":"10.1016\/j.jocn.2019.12.042_b0140","unstructured":"https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2011\/021825lbl.pdf."},{"issue":"6","key":"10.1016\/j.jocn.2019.12.042_b0145","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1097\/00007632-199006000-00022","volume":"15","author":"Songer","year":"1990","journal-title":"Spine (Phila Pa 1976)"},{"issue":"3","key":"10.1016\/j.jocn.2019.12.042_b0150","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0015-0282(16)54197-1","article-title":"The use of an amniotic membrane graft to prevent postoperative adhesions**Supported in part by a grant from the Clayton Foundation, Houston, Texas","volume":"55","author":"Young","year":"1991","journal-title":"Fertil Sterility"},{"issue":"5","key":"10.1016\/j.jocn.2019.12.042_b0155","doi-asserted-by":"crossref","first-page":"599","DOI":"10.3171\/2018.4.SPINE171164","article-title":"Effects of silk solution against laminectomy-induced dural adhesion formation and inflammation in a rat model","volume":"29","author":"Cho","year":"2018","journal-title":"J Neurosurg Spine."},{"issue":"5","key":"10.1016\/j.jocn.2019.12.042_b0160","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2500\/ajra.2014.28.4069","article-title":"The use of chitosan-dextran gel shows anti-inflammatory, antibiofilm, and antiproliferative properties in fibroblast cell culture","volume":"28","author":"Paramasivan","year":"2014","journal-title":"Am J Rhinol Allergy."},{"issue":"3","key":"10.1016\/j.jocn.2019.12.042_b0165","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/j.1742-481X.2012.00971.x","article-title":"Wound healing by topical application of antioxidant iron chelators: kojic acid and deferiprone","volume":"10","author":"Mohammadpour","year":"2013","journal-title":"Int Wound J."},{"issue":"2","key":"10.1016\/j.jocn.2019.12.042_b0170","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.yexmp.2015.07.008","article-title":"Inhibitory effect of iron withdrawal by chelation on the growth of human and murine mammary carcinoma and fibrosarcoma cells","volume":"99","author":"Power Coombs","year":"2015","journal-title":"Exp Mol Pathol"},{"issue":"2","key":"10.1016\/j.jocn.2019.12.042_b0175","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3390\/jdb3020057","article-title":"Roles of antioxidative enzymes in wound healing","volume":"3","author":"Kurahashi","year":"2015","journal-title":"J Dev Biol"},{"key":"10.1016\/j.jocn.2019.12.042_b0180","doi-asserted-by":"crossref","unstructured":"Gordon-Evans W. Dorsal Laminectomy. Complications in Small Animal Surgery. 2016.","DOI":"10.1002\/9781119421344.ch85"}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586819317643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586819317643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T20:47:35Z","timestamp":1778791655000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0967586819317643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":36,"alternative-id":["S0967586819317643"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2019.12.042","relation":{},"ISSN":["0967-5868"],"issn-type":[{"value":"0967-5868","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prevention of peridural adhesions in spinal surgery: Assessing safety and efficacy of Chitogel with Deferiprone in a sheep model","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocn.2019.12.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2019 Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}