{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T05:11:38Z","timestamp":1768885898010,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jocn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.jocn.2020.07.014","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T18:01:58Z","timestamp":1594404118000},"page":"80-83","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Locked-In with COVID-19"],"prefix":"10.1016","volume":"79","author":[{"given":"Akshay","family":"Avula","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arshpal","family":"Gill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ra'ed","family":"Nassar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krishna","family":"Nalleballe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suman","family":"Siddamreddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Chalhoub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"13","key":"10.1016\/j.jocn.2020.07.014_b0005","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1056\/NEJMp2002125","article-title":"Defining the epidemiology of Covid-19 \u2013 studies needed","volume":"382","author":"Lipsitch","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jocn.2020.07.014_b0010","unstructured":"COVID-19 CORONAVIRUS PANDEMIC. https:\/\/www.worldometers.info\/coronavirus\/. Accessed."},{"key":"10.1016\/j.jocn.2020.07.014_b0015","doi-asserted-by":"crossref","DOI":"10.1001\/jamaneurol.2020.1127","article-title":"Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China","author":"Mao","year":"2020","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jocn.2020.07.014_b0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2020.04.077","article-title":"COVID-19 presenting as stroke","author":"Avula","year":"2020","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.jocn.2020.07.014_b0025","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMc2009787","article-title":"Large-vessel stroke as a presenting feature of Covid-19 in the young","author":"Oxley","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jocn.2020.07.014_b0030","unstructured":"Kenneth Maiese M. Locked-in Syndrome. Merck Manual Professional Version. http:\/\/www.merckmanuals.com\/professional\/neurologic-disorders\/coma-and-impaired-consciousness\/locked-in-syndrome. Accessed."},{"key":"10.1016\/j.jocn.2020.07.014_b0035","series-title":"Textbook of clinical neurology (third edition)","first-page":"405","article-title":"Chapter 22 \u2013 Neurovascular system","author":"Love","year":"2007"},{"issue":"4","key":"10.1016\/j.jocn.2020.07.014_b0040","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jcgg.2011.08.001","article-title":"\u201cThe locked-in syndrome\u201d: can it be unlocked?","volume":"2","author":"Khanna","year":"2011","journal-title":"J Clin Gerontol Geriatrics"},{"key":"10.1016\/j.jocn.2020.07.014_b0045","article-title":"Incidence of thrombotic complications in critically ill ICU patients with COVID-19","author":"Kloka","year":"2020","journal-title":"Thromb Res"},{"issue":"4","key":"10.1016\/j.jocn.2020.07.014_b0050","article-title":"Corona Virus Disease 2019 (COVID-19) presenting as acute ST elevation myocardial infarction","volume":"12","author":"Siddamreddy","year":"2020","journal-title":"Cureus"},{"key":"10.1016\/j.jocn.2020.07.014_b0055","doi-asserted-by":"crossref","DOI":"10.1093\/eurheartj\/ehaa254","article-title":"Acute pulmonary embolism and COVID-19 pneumonia: a random association?","author":"Danzi","year":"2020","journal-title":"Eur Heart J"},{"key":"10.1016\/j.jocn.2020.07.014_b0060","doi-asserted-by":"crossref","DOI":"10.1111\/jth.14830","article-title":"Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia","author":"Cui","year":"2020","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.jocn.2020.07.014_b0065","doi-asserted-by":"crossref","DOI":"10.1111\/jth.14893","article-title":"Coagulopathy of COVID-19 and antiphospholipid antibodies","author":"Connell","year":"2020","journal-title":"J Thromb Haemost"},{"issue":"17","key":"10.1016\/j.jocn.2020.07.014_b0070","doi-asserted-by":"crossref","DOI":"10.1056\/NEJMc2007575","article-title":"Coagulopathy and antiphospholipid antibodies in patients with Covid-19","volume":"382","author":"Zhang","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jocn.2020.07.014_b0075","article-title":"Risk factors of fatal outcome in hospitalized subjects with coronavirus disease 2019 from a nationwide analysis in China","author":"Chen","year":"2020","journal-title":"Chest"},{"issue":"18","key":"10.1016\/j.jocn.2020.07.014_b0080","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.jocn.2020.07.014_b0085","doi-asserted-by":"crossref","DOI":"10.1002\/ajh.25822","article-title":"Critically Ill COVID-19 infected patients exhibit increased clot waveform analysis parameters consistent with hypercoagulability","author":"Tan","year":"2020","journal-title":"Am J Hematol"},{"key":"10.1016\/j.jocn.2020.07.014_b0090","doi-asserted-by":"crossref","DOI":"10.1055\/s-0040-1714350","article-title":"COVID-19-related severe hypercoagulability in patients admitted to intensive care unit for acute respiratory failure","author":"Spiezia","year":"2020","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.jocn.2020.07.014_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor","author":"Hoffmann","year":"2020","journal-title":"Cell"},{"issue":"10223","key":"10.1016\/j.jocn.2020.07.014_b0100","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"issue":"10","key":"10.1016\/j.jocn.2020.07.014_b0105","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1161\/01.CIR.95.10.2387","article-title":"Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets","volume":"95","author":"Neumann","year":"1997","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.jocn.2020.07.014_b0110","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1164\/ajrccm.182.3.436","article-title":"Severe acute respiratory syndrome and venous thromboembolism in multiple organs","volume":"182","author":"Xiang-Hua","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.jocn.2020.07.014_b0115","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1365-2141.2008.07323.x","article-title":"Virchow and his triad: a question of attribution","volume":"143","author":"Bagot","year":"2008","journal-title":"Br J Haematol"},{"key":"10.1016\/j.jocn.2020.07.014_b0120","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0079-6123(05)50034-7","article-title":"The locked-in syndrome: what is it like to be conscious but paralyzed and voiceless?","volume":"150","author":"Laureys","year":"2005","journal-title":"Prog Brain Res"},{"issue":"9","key":"10.1016\/j.jocn.2020.07.014_b0125","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1097\/CCM.0000000000003259","article-title":"Executive summary: clinical practice guidelines for the prevention and management of pain, agitation\/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU","volume":"46","author":"Devlin","year":"2018","journal-title":"Crit Care Med"},{"key":"10.1016\/j.jocn.2020.07.014_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2020.05.001","article-title":"Association of treatment dose anticoagulation with in-hospital survival among hospitalized patients with COVID-19","author":"Paranjpe","year":"2020","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.jocn.2020.07.014_b0135","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2020006000","article-title":"COVID-19 and its implications for thrombosis and anticoagulation","author":"Connors","year":"2020","journal-title":"Blood"},{"key":"10.1016\/j.jocn.2020.07.014_b0140","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s13023-015-0304-z","article-title":"Quality of life in patients with locked-in syndrome: evolution over a 6-year period","volume":"10","author":"Rousseau","year":"2015","journal-title":"Orphanet J Rare Dis"}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586820313515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586820313515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T21:22:05Z","timestamp":1760822525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0967586820313515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":28,"alternative-id":["S0967586820313515"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2020.07.014","relation":{},"ISSN":["0967-5868"],"issn-type":[{"value":"0967-5868","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Locked-In with COVID-19","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocn.2020.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}