{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:14:30Z","timestamp":1791393270367,"version":"4.3.3"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["-715986"],"award-info":[{"award-number":["-715986"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["2017-0243"],"award-info":[{"award-number":["2017-0243"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["-742881"],"award-info":[{"award-number":["-742881"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["-720931"],"award-info":[{"award-number":["-720931"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["681712"],"award-info":[{"award-number":["681712"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska Lakaresallskapet","doi-asserted-by":"publisher","award":["SLS-884901"],"award-info":[{"award-number":["SLS-884901"]}],"id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["2019-0228"],"award-info":[{"award-number":["2019-0228"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsradet","doi-asserted-by":"publisher","award":["2017-00915"],"award-info":[{"award-number":["2017-00915"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsradet","doi-asserted-by":"publisher","award":["2018-02532"],"award-info":[{"award-number":["2018-02532"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jocn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.jocn.2021.04.030","type":"journal-article","created":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T13:15:21Z","timestamp":1620825321000},"page":"113-121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Circulating brain injury biomarkers increase after endoscopic surgery for pituitary tumors"],"prefix":"10.1016","volume":"89","author":[{"given":"Tobias","family":"Hall\u00e9n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casper","family":"Hammarstrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Farahmand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Charlotte","family":"Olofsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Jakobsson Ung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Jakobsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Bergquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudmundur","family":"Johannsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Skoglund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jocn.2021.04.030_b0005","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1227\/01.NEU.0000223437.51435.6E","article-title":"Pathobiology of pituitary adenomas and carcinomas","volume":"59","author":"Scheithauer","year":"2006","journal-title":"Neurosurgery"},{"key":"10.1016\/j.jocn.2021.04.030_b0010","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1227\/NEU.0000000000001067","article-title":"Headache in patients with pituitary lesions: a longitudinal cohort study","volume":"78","author":"Rizzoli","year":"2016","journal-title":"Neurosurgery"},{"key":"10.1016\/j.jocn.2021.04.030_b0015","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev.pathol.4.110807.092259","article-title":"The pathogenesis of pituitary tumors","volume":"4","author":"Asa","year":"2009","journal-title":"Annu Rev Pathol"},{"key":"10.1016\/j.jocn.2021.04.030_b0020","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1210\/er.2006-0002","article-title":"Craniopharyngiomas","volume":"27","author":"Karavitaki","year":"2006","journal-title":"Endocr Rev"},{"key":"10.1016\/j.jocn.2021.04.030_b0025","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.3171\/2015.8.JNS151282","article-title":"The long-term recurrence of Rathke's cleft cysts as predicted by histology but not by surgical procedure","volume":"125","author":"Kinoshita","year":"2016","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jocn.2021.04.030_b0030","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-2008-1058909","article-title":"Microsurgical management of giant pituitary tumors","volume":"6","author":"King","year":"1996","journal-title":"Skull Base Surgery"},{"key":"10.1016\/j.jocn.2021.04.030_b0035","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3171\/JNS\/2008\/108\/3\/0525","article-title":"Early results of surgery in patients with nonfunctioning pituitary adenoma and analysis of the risk of tumor recurrence","volume":"108","author":"Losa","year":"2008","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jocn.2021.04.030_b0040","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1210\/jc.2015-1475","article-title":"Excess mortality in women and young adults with non-functioning pituitary adenoma - a Swedish nationwide study","volume":"100","author":"Olsson","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jocn.2021.04.030_b0045","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/jc.2014-3525","article-title":"Excess mortality and morbidity in patients with craniopharyngioma, especially in patients with childhood-onset - a population-based study in Sweden","volume":"100","author":"Olsson","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jocn.2021.04.030_b0050","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11102-017-0854-2","article-title":"Management of non-functioning pituitary adenomas: surgery","volume":"21","author":"Penn","year":"2018","journal-title":"Pituitary"},{"key":"10.1016\/j.jocn.2021.04.030_b0055","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1477-7819-12-94","article-title":"Endoscopic versus microscopic transsphenoidal pituitary adenoma surgery: a meta-analysis","volume":"12","author":"Gao","year":"2014","journal-title":"World J Surg Oncol"},{"key":"10.1016\/j.jocn.2021.04.030_b0060","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1365-2265.2012.04449.x","article-title":"Current treatment protocols can offer a normal or near-normal quality of life in the majority of patients with non-functioning pituitary adenomas","volume":"78","author":"Capatina","year":"2012","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.jocn.2021.04.030_b0065","doi-asserted-by":"crossref","first-page":"3364","DOI":"10.1210\/jc.2006-0003","article-title":"Quality of life is decreased after treatment for nonfunctioning pituitary macroadenoma","volume":"91","author":"Dekkers","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jocn.2021.04.030_b0070","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1210\/jc.2010-2742","article-title":"Patients previously treated for nonfunctioning pituitary macroadenomas have disturbed sleep characteristics, circadian movement rhythm, and subjective sleep quality","volume":"96","author":"Biermasz","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jocn.2021.04.030_b0075","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1210\/jc.2014-2602","article-title":"Determinants of altered sleep-wake rhythmicity in patients treated for nonfunctioning pituitary macroadenomas","volume":"99","author":"Joustra","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.jocn.2021.04.030_b0080","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1365-2265.2004.02196.x","article-title":"High prevalence of long-term cardiovascular, neurological and psychosocial morbidity after treatment for craniopharyngioma","volume":"62","author":"Pereira","year":"2005","journal-title":"Clin Endocrinol"},{"key":"10.1016\/j.jocn.2021.04.030_b0085","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/ijo.2016.195","article-title":"Efficacy and safety of bariatric surgery for craniopharyngioma-related hypothalamic obesity: a matched case-control study with 2 years of follow-up","volume":"41","author":"Wijnen","year":"2017","journal-title":"Int J Obes (Lond)"},{"key":"10.1016\/j.jocn.2021.04.030_b0090","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41582-018-0058-z","article-title":"Neurofilaments as biomarkers in neurological disorders","volume":"14","author":"Khalil","year":"2018","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jocn.2021.04.030_b0095","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrneurol.2016.127","article-title":"Fluid biomarkers for mild traumatic brain injury and related conditions","volume":"12","author":"Zetterberg","year":"2016","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jocn.2021.04.030_b0100","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.resuscitation.2012.07.027","article-title":"Tau proteins in serum predict neurological outcome after hypoxic brain injury from cardiac arrest: results of a pilot study","volume":"84","author":"Randall","year":"2013","journal-title":"Resuscitation"},{"key":"10.1016\/j.jocn.2021.04.030_b0105","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.dadm.2016.05.005","article-title":"Update on ultrasensitive technologies to facilitate research on blood biomarkers for central nervous system disorders","volume":"3","author":"Andreasson","year":"2016","journal-title":"Alzheimers Dement (Amst)"},{"key":"10.1016\/j.jocn.2021.04.030_b0110","doi-asserted-by":"crossref","first-page":"300","DOI":"10.3389\/fneur.2017.00300","article-title":"Serial sampling of serum protein biomarkers for monitoring human traumatic brain injury dynamics: a systematic review","volume":"8","author":"Thelin","year":"2017","journal-title":"Front Neurol"},{"key":"10.1016\/j.jocn.2021.04.030_b0115","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1212\/WNL.0000000000003912","article-title":"Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sports","volume":"88","author":"Shahim","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2021.04.030_b0120","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1089\/neu.2016.4496","article-title":"Serum neurofilament light protein as a marker for diffuse axonal injury: results from a case series study","volume":"34","author":"Ljungqvist","year":"2017","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jocn.2021.04.030_b0125","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1373\/clinchem.2004.039719","article-title":"Serum S-100B as an indicator of early postoperative deterioration after meningioma surgery","volume":"51","author":"Stranjalis","year":"2005","journal-title":"Clin Chem"},{"key":"10.1016\/j.jocn.2021.04.030_b0130","doi-asserted-by":"crossref","first-page":"R141","DOI":"10.1186\/cc5058","article-title":"Early postoperative serum S100 beta levels predict ongoing brain damage after meningioma surgery: a prospective observational study","volume":"10","author":"Einav","year":"2006","journal-title":"Crit Care"},{"key":"10.1016\/j.jocn.2021.04.030_b0135","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0022-3999(94)00125-O","article-title":"The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue","volume":"39","author":"Smets","year":"1995","journal-title":"J Psychosom Res"},{"key":"10.1016\/j.jocn.2021.04.030_b0140","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1212\/WNL.0000000000003154","article-title":"Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia","volume":"87","author":"Rohrer","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2021.04.030_b0145","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2288-1-6","article-title":"The use of percentage change from baseline as an outcome in a controlled trial is statistically inefficient: a simulation study","volume":"1","author":"Vickers","year":"2001","journal-title":"BMC Med Res Methodol"},{"key":"10.1016\/j.jocn.2021.04.030_b0150","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0006-8993(71)90668-8","article-title":"An acidic protein isolated from fibrous astrocytes","volume":"28","author":"Eng","year":"1971","journal-title":"Brain Res"},{"key":"10.1016\/j.jocn.2021.04.030_b0155","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/clinchem\/45.1.138","article-title":"Measurement of glial fibrillary acidic protein in human blood: analytical method and preliminary clinical results","volume":"45","author":"Missler","year":"1999","journal-title":"Clin Chem"},{"key":"10.1016\/j.jocn.2021.04.030_b0160","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrneurol.2013.9","article-title":"Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood","volume":"9","author":"Zetterberg","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.jocn.2021.04.030_b0165","doi-asserted-by":"crossref","unstructured":"Dadas A, Washington J, Diaz-Arrastia R, Janigro D. Biomarkers in traumatic brain injury (TBI): a review. Neuropsychiatr Dis Treat 2018;14:2989\u20133000. http:\/\/dx.doi.org\/10.2147%2FNDT.S125620","DOI":"10.2147\/NDT.S125620"},{"key":"10.1016\/j.jocn.2021.04.030_b0170","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.wneu.2015.10.066","article-title":"Glial fibrillary acidic protein and ubiquitin C-terminal hydrolase-L1 as outcome predictors in traumatic brain injury","volume":"87","author":"Takala","year":"2016","journal-title":"World Neurosurg"},{"key":"10.1016\/j.jocn.2021.04.030_b0175","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1089\/neu.2018.5952","article-title":"Early levels of glial fibrillary acidic protein and neurofilament light protein in predicting the outcome of mild traumatic brain injury","volume":"36","author":"Hossain","year":"2019","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.jocn.2021.04.030_b0180","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1177\/37.2.2492045","article-title":"Distribution of tau proteins in the normal human central and peripheral nervous system","volume":"37","author":"Trojanowski","year":"1989","journal-title":"J Histochem Cytochem Off J Histochem Soc"},{"key":"10.1016\/j.jocn.2021.04.030_b0185","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.pneurobio.2011.04.006","article-title":"Biomarker-based dissection of neurodegenerative diseases","volume":"95","author":"Olsson","year":"2011","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.jocn.2021.04.030_b0190","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1212\/WNL.0000000000003246","article-title":"Plasma tau in Alzheimer disease","volume":"87","author":"Mattsson","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2021.04.030_b0195","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1001\/archneur.63.9.1277","article-title":"Neurochemical aftermath of amateur boxing","volume":"63","author":"Zetterberg","year":"2006","journal-title":"Arch Neurol"},{"key":"10.1016\/j.jocn.2021.04.030_b0200","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1001\/jamaneurol.2014.367","article-title":"Blood biomarkers for brain injury in concussed professional ice hockey players","volume":"71","author":"Shahim","year":"2014","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jocn.2021.04.030_b0205","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1007\/s00018-004-4268-8","article-title":"Neurofilament proteins in neurodegenerative diseases","volume":"61","author":"Liu","year":"2004","journal-title":"Cell Mol Life Sci CMLS"},{"key":"10.1016\/j.jocn.2021.04.030_b0210","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1001\/jamaneurol.2017.4913","article-title":"Association of changes in plasma neurofilament light and tau levels with anesthesia and surgery: results from the capacity and Arcadian studies","volume":"75","author":"Evered","year":"2018","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.jocn.2021.04.030_b0215","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.bja.2020.04.085","article-title":"Human plasma biomarker responses to inhalational general anaesthesia without surgery","volume":"125","author":"Deiner","year":"2020","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.jocn.2021.04.030_b0220","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.3233\/JAD-191165","article-title":"Cardiac surgery is associated with biomarker evidence of neuronal damage","volume":"74","author":"Alifier","year":"2020","journal-title":"J Alzheimers Dis"}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586821001971?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586821001971?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T16:46:42Z","timestamp":1778518002000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0967586821001971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":44,"alternative-id":["S0967586821001971"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2021.04.030","relation":{},"ISSN":["0967-5868"],"issn-type":[{"value":"0967-5868","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating brain injury biomarkers increase after endoscopic surgery for pituitary tumors","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocn.2021.04.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}