{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T21:40:27Z","timestamp":1760823627951,"version":"build-2065373602"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jocn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.jocn.2021.09.022","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T18:00:08Z","timestamp":1631901608000},"page":"106-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Multinodular plexiform tumors of major peripheral nerves: A practical overview"],"prefix":"10.1016","volume":"93","author":[{"given":"Cosimo","family":"Sturd\u00e0","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Pennisi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quintino Giorgio","family":"D'Alessandris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierpaolo","family":"Mattogno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Granata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Gessi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liverana","family":"Lauretti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jocn.2021.09.022_b0005","doi-asserted-by":"crossref","unstructured":"Mindell ER. Enzinger and Weiss\u2019s Soft Tissue Tumors. 4th ed.: The Journal of Bone and Joint Surgery-American Volume 2001;83:1778. https:\/\/doi.org\/10.2106\/00004623-200111000-00036.","DOI":"10.2106\/00004623-200111000-00036"},{"year":"2000","series-title":"International Agency for Research on Cancer, editors","author":"Kleihues","key":"10.1016\/j.jocn.2021.09.022_b0010"},{"issue":"5","key":"10.1016\/j.jocn.2021.09.022_b0015","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.humpath.2007.10.029","article-title":"Plexiform schwannoma: a clinicopathologic overview with emphasis on the head and neck region","volume":"39","author":"Berg","year":"2008","journal-title":"Hum Pathol"},{"issue":"3","key":"10.1016\/j.jocn.2021.09.022_b0020","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1046\/j.1365-2559.1998.00336.x","article-title":"Phenotypic diversity of neurofibromatosis 2: association with plexiform schwannoma","volume":"32","author":"Ishida","year":"1998","journal-title":"Histopathology"},{"key":"10.1016\/j.jocn.2021.09.022_b0025","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1365-2559.1986.tb02595.x","article-title":"Benign plexiform (multinodular) schwannoma: a rare tumour unassociated with neurofibromatosis","volume":"10","author":"Fletcher","year":"1986","journal-title":"Histopathology"},{"key":"10.1016\/j.jocn.2021.09.022_b0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humpath.2017.05.010","article-title":"Histopathologic evaluation of atypical neurofibromatous tumors and their transformation into malignant peripheral nerve sheath tumor in patients with neurofibromatosis 1\u2014a consensus overview","volume":"67","author":"Miettinen","year":"2017","journal-title":"Hum Pathol"},{"issue":"1","key":"10.1016\/j.jocn.2021.09.022_b0035","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1212\/WNL.54.1.71","article-title":"Population-based analysis of sporadic and type 2 neurofibromatosis-associated meningiomas and schwannomas","volume":"54","author":"Antinheimo","year":"2000","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.jocn.2021.09.022_b0040","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/00129492-200501000-00016","article-title":"Incidence of Vestibular Schwannoma and Neurofibromatosis 2 in the North West of England over a 10-year Period: Higher Incidence than Previously Thought","volume":"26","author":"Evans","year":"2005","journal-title":"Otology & Neurotology"},{"issue":"12","key":"10.1016\/j.jocn.2021.09.022_b0045","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1007\/s00415-006-0347-0","article-title":"News on the genetics, epidemiology, medical care and translational research of Schwannomas","volume":"253","author":"Hanemann","year":"2006","journal-title":"J Neurol"},{"issue":"5","key":"10.1016\/j.jocn.2021.09.022_b0050","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1097\/00005072-197809000-00165","article-title":"Benign plexiform schwannoma, a lesion distinct from plexiform neurofibroma","volume":"37","author":"Harkin","year":"1978","journal-title":"J Neurolpathol Exp Neurol"},{"issue":"2","key":"10.1016\/j.jocn.2021.09.022_b0055","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3171\/2009.5.JNS09244","article-title":"Multinodular\/plexiform (multifascicular) schwannomas of major peripheral nerves: an underrecognized part of the spectrum of schwannomas","volume":"112","author":"H\u00e9bert-Blouin","year":"2010","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jocn.2021.09.022_b0060","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.revmed.2008.01.008","article-title":"Chronic sciatic pain caused by sciatic nerve schwannoma","volume":"29","author":"Blanchard","year":"2008","journal-title":"Rev Med Interne"},{"key":"10.1016\/j.jocn.2021.09.022_b0065","unstructured":"Chiodi E, Centanni F, Gattazzo D, Morini G. [Plexiform schwannomatosis of the tibial nerve: study with MR and surgical findings in a case]. Radiol Med 1998;95:107\u201310."},{"key":"10.1016\/j.jocn.2021.09.022_b0070","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/BF00713373","article-title":"Plexiform neurilemmoma: a clinicopathological and immunohistochemical analysis of 23 tumours from 20 patients","volume":"411","author":"Iwashita","year":"1987","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"key":"10.1016\/j.jocn.2021.09.022_b0075","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0363-5023(81)80054-8","article-title":"Multifocal neurilemmomas of median and ulnar nerves of the same extremity\u2013case report","volume":"6","author":"Lewis","year":"1981","journal-title":"J Hand Surg Am"},{"issue":"4","key":"10.1016\/j.jocn.2021.09.022_b0080","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1212\/WNL.46.4.1072","article-title":"Schwannomatosis: a clinical and pathologic study","volume":"46","author":"MacCollin","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2021.09.022_b0085","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1302\/0301-620X.80B4.0800657","article-title":"Multiple schwannomas in the peripheral nerves","volume":"80","author":"Ogose","year":"1998","journal-title":"J Bone Joint Surg Br"},{"issue":"2","key":"10.1016\/j.jocn.2021.09.022_b0090","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0090-3019(87)90091-7","article-title":"Ulnar neuropathy in a patient with multiple schwannomas of the ulnar nerve","volume":"28","author":"Shank","year":"1987","journal-title":"Surg Neurol"},{"issue":"4","key":"10.1016\/j.jocn.2021.09.022_b0095","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/J.JHSB.2005.04.008","article-title":"Multiple plexiform schwannoma of the hand and forearm: a long-term follow-up","volume":"30","author":"Talwalkar","year":"2005","journal-title":"J Hand Surg Br"},{"issue":"10","key":"10.1016\/j.jocn.2021.09.022_b0100","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1097\/00000478-200310000-00004","article-title":"Congenital and childhood plexiform (multinodular) cellular schwannoma: a troublesome mimic of malignant peripheral nerve sheath tumor","volume":"27","author":"Woodruff","year":"2003","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.jocn.2021.09.022_b0105","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s002560000310","article-title":"Schwannomatosis of the sciatic nerve","volume":"30","author":"Yamamoto","year":"2001","journal-title":"Skeletal Radiol"},{"key":"10.1016\/j.jocn.2021.09.022_b0110","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1001\/archderm.1989.01670150121022","article-title":"Multiple cutaneous plexiform schwannomas with tumors of the central nervous system","volume":"125","author":"Rongioletti","year":"1989","journal-title":"Arch Dermatol"},{"year":"2019","series-title":"Enzinger & weiss\u2019s soft tissue tumors","author":"Goldblum","key":"10.1016\/j.jocn.2021.09.022_b0115"},{"year":"2007","series-title":"Tumors of the central nervous system","author":"Burger","key":"10.1016\/j.jocn.2021.09.022_b0120"},{"issue":"11","key":"10.1016\/j.jocn.2021.09.022_b0125","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1056\/NEJM198803173181106","article-title":"Neurofibromatosis 2 (bilateral acoustic neurofibromatosis)","volume":"318","author":"Martuza","year":"1988","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.jocn.2021.09.022_b0130","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1097\/00000372-199406000-00011","article-title":"Plexiform schwannoma","volume":"16","author":"Megahed","year":"1994","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.jocn.2021.09.022_b0135","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/S0344-0338(11)81103-9","article-title":"Immunohistochemistry of Schwann cell markers, intermediate filaments and extracellular matrix components","volume":"189","author":"Guarino","year":"1993","journal-title":"Pathol Res Pract"},{"issue":"12","key":"10.1016\/j.jocn.2021.09.022_b0140","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/gcc.20921","article-title":"Atypical neurofibromas in neurofibromatosis type 1 are premalignant tumors","volume":"50","author":"Beert","year":"2011","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.jocn.2021.09.022_b0145","doi-asserted-by":"crossref","first-page":"362","DOI":"10.3171\/jns.1994.81.3.0362","article-title":"Neural sheath tumors of major nerves","volume":"81","author":"Donner","year":"1994","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jocn.2021.09.022_b0150","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3171\/jns.2005.102.2.0246","article-title":"A series of 397 peripheral neural sheath tumors: 30-year experience at Louisiana State University Health Sciences Center","volume":"102","author":"Kim","year":"2005","journal-title":"J Neurosurg"},{"issue":"10","key":"10.1016\/j.jocn.2021.09.022_b0155","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/BF01411304","article-title":"Peripheral nerve schwannomas\u2013an analysis of 16 patients","volume":"139","author":"Oberle","year":"1997","journal-title":"Acta Neurochir (Wien)"},{"issue":"6","key":"10.1016\/j.jocn.2021.09.022_b0160","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/J.JHSB.2006.06.008","article-title":"The relationship between pre-operative symptoms, operative findings and postoperative complications in schwannomas","volume":"31","author":"Sawada","year":"2006","journal-title":"J Hand Surg Br"},{"key":"10.1016\/j.jocn.2021.09.022_b0165","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/(SICI)1096-8628(19990326)89:1<23::AID-AJMG6>3.0.CO;2-#","article-title":"Pathology of tumors of the peripheral nerve sheath in type 1 neurofibromatosis","volume":"89","author":"Woodruff","year":"1999","journal-title":"Am J Med Genet"},{"key":"10.1016\/j.jocn.2021.09.022_b0170","first-page":"103","article-title":"Plexiform neurofibroma: report of an unusual presentation","volume":"41","author":"Nguyen","year":"1990","journal-title":"Can Assoc Radiol J"},{"issue":"2","key":"10.1016\/j.jocn.2021.09.022_b0175","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0002-9440(10)63992-2","article-title":"Tumorigenic properties of neurofibromin-deficient neurofibroma Schwann cells","volume":"158","author":"Muir","year":"2001","journal-title":"Am J Pathol"}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586821004781?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586821004781?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T21:27:31Z","timestamp":1760822851000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0967586821004781"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":35,"alternative-id":["S0967586821004781"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2021.09.022","relation":{},"ISSN":["0967-5868"],"issn-type":[{"type":"print","value":"0967-5868"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multinodular plexiform tumors of major peripheral nerves: A practical overview","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocn.2021.09.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}