{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T22:10:36Z","timestamp":1760825436938,"version":"build-2065373602"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jocn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.jocn.2022.01.030","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T21:02:15Z","timestamp":1645563735000},"page":"235-239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Linac-based hypofractionated stereotactic radiotherapy for metastases involving the brainstem"],"prefix":"10.1016","volume":"98","author":[{"given":"Michael","family":"Ortiz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Herbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Busha","family":"Hika","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Biedermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia","family":"Wexler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Scott","family":"Litofsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.jocn.2022.01.030_b0005","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s00415-002-0870-6","article-title":"Management of brain metastases","volume":"249","author":"Soffietti","year":"2002","journal-title":"J Neurol"},{"issue":"2","key":"10.1016\/j.jocn.2022.01.030_b0010","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF02303562","article-title":"Management of metastatic brain tumors","volume":"1","author":"Sawaya","year":"1994","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"10.1016\/j.jocn.2022.01.030_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nec.2010.08.007","article-title":"Epidemiology of metastatic brain tumors","volume":"22","author":"Fox","year":"2011","journal-title":"Neurosurg Clin N Am"},{"issue":"1","key":"10.1016\/j.jocn.2022.01.030_b0020","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s11912-011-0203-y","article-title":"Epidemiology of brain metastases","volume":"14","author":"Nayak","year":"2012","journal-title":"Curr Oncol Rep"},{"issue":"7","key":"10.1016\/j.jocn.2022.01.030_b0025","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1001\/jamaoncol.2021.1262","article-title":"Efficacy and Safety of Stereotactic Radiosurgery for Brainstem Metastases: A Systematic Review and Meta-analysis","volume":"7","author":"Chen","year":"2021","journal-title":"JAMA Oncol"},{"issue":"2","key":"10.1016\/j.jocn.2022.01.030_b0030","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ijrobp.2009.07.1750","article-title":"Stereotactic radiosurgery for single brainstem metastases: the cleveland clinic experience","volume":"78","author":"Koyfman","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.jocn.2022.01.030_b0035","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1227\/NEU.0b013e31821d31de","article-title":"Outcomes and prognostic factors for patients with brainstem metastases undergoing stereotactic radiosurgery","volume":"69","author":"Hatiboglu","year":"2011","journal-title":"Neurosurgery"},{"issue":"2","key":"10.1016\/j.jocn.2022.01.030_b0040","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11060-007-9458-4","article-title":"Gamma knife radiosurgery for brainstem metastases: the UCSF experience","volume":"86","author":"Kased","year":"2008","journal-title":"J Neurooncol"},{"issue":"2","key":"10.1016\/j.jocn.2022.01.030_b0045","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ijrobp.2016.06.009","article-title":"Stereotactic radiosurgery for brainstem metastases: an international cooperative study to define response and toxicity","volume":"96","author":"Trifiletti","year":"2016","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.jocn.2022.01.030_b0050","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1227\/01.NEU.0000325726.72815.22","article-title":"Radiation tolerance limits of the brainstem","volume":"63","author":"Sharma","year":"2008","journal-title":"Neurosurgery"},{"issue":"3","key":"10.1016\/j.jocn.2022.01.030_b0055","doi-asserted-by":"crossref","first-page":"S36","DOI":"10.1016\/j.ijrobp.2009.08.078","article-title":"Radiation associated brainstem injury","volume":"76","author":"Mayo","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1016\/j.jocn.2022.01.030_b0060","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2217\/cns-2017-0029","article-title":"Brainstem metastases treated with Gamma Knife stereotactic radiosurgery: the Indiana University Health experience","volume":"7","author":"Patel","year":"2018","journal-title":"CNS Oncol"},{"issue":"1","key":"10.1016\/j.jocn.2022.01.030_b0065","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11060-009-0073-4","article-title":"The role of stereotactic radiosurgery in the management of patients with newly diagnosed brain metastases: A systematic review and evidence-based clinical practice guideline","volume":"96","author":"Linskey","year":"2010","journal-title":"J Neurooncol"},{"issue":"3","key":"10.1016\/j.jocn.2022.01.030_b0070","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S0360-3016(97)00734-7","article-title":"The integral biologically effective dose to predict brain stem toxicity of hypofractionated stereotactic radiotherapy","volume":"40","author":"Clark","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"4","key":"10.1016\/j.jocn.2022.01.030_b0075","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.adro.2017.07.006","article-title":"Fractionated stereotactic radiation therapy for intact brain metastases","volume":"2","author":"Marcrom","year":"2017","journal-title":"Adv Radiat Oncol"},{"issue":"4","key":"10.1016\/j.jocn.2022.01.030_b0080","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0360-3016(96)00619-0","article-title":"Recursive partitioning analysis (RPA) of prognostic factors in three Radiation Therapy Oncology Group (RTOG) brain metastases trials","volume":"37","author":"Gaspar","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.jocn.2022.01.030_b0085","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s11060-015-1927-6","article-title":"Brainstem metastases treated with stereotactic radiosurgery: safety, efficacy and dose response","volume":"125","author":"Trifiletti","year":"2015","journal-title":"J Neurooncol"},{"issue":"1","key":"10.1016\/j.jocn.2022.01.030_b0090","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s11060-012-0868-6","article-title":"Stereotactic radiosurgery and fractionated stereotactic radiotherapy: Comparison of efficacy and toxicity in 260 patients with brain metastases","volume":"109","author":"Fokas","year":"2012","journal-title":"J Neurooncol"},{"issue":"2","key":"10.1016\/j.jocn.2022.01.030_b0095","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ijrobp.2006.08.081","article-title":"Stereotactic radiosurgery for brainstem metastases: survival, tumor control and patient outcomes","volume":"67","author":"Hussain","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jocn.2022.01.030_b0100","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1748-717X-7-107","article-title":"Prescription dose and fractionation predict improved survival after stereotactic radiotherapy for brainstem metastases","volume":"7","author":"Leeman","year":"2012","journal-title":"Radiat Oncol"},{"issue":"2","key":"10.1016\/j.jocn.2022.01.030_b0105","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.surneu.2008.01.029","article-title":"Brain stem metastases treated with radiosurgery: prognostic factors of survival and life expectancy estimation","volume":"71","author":"Lorenzoni","year":"2009","journal-title":"Surg Neurol"},{"issue":"6","key":"10.1016\/j.jocn.2022.01.030_b0110","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1007\/s00415-009-5034-5","article-title":"Radiological progression of cerebral metastases after radiosurgery: assessment of perfusion MRI for differentiating between necrosis and recurrence","volume":"256","author":"Hoefnagels","year":"2009","journal-title":"J Neurol"},{"issue":"2","key":"10.1016\/j.jocn.2022.01.030_b0115","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s11060-014-1556-5","article-title":"Local control after fractionated stereotactic radiation therapy for brain metastases","volume":"120","author":"Rajakesari","year":"2014","journal-title":"J Neurooncol"},{"issue":"4","key":"10.1016\/j.jocn.2022.01.030_b0120","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.ijrobp.2012.09.008","article-title":"Clinical outcomes of biological effective dose-based fractionated stereotactic radiation therapy for metastatic brain tumors from non-small cell lung cancer","volume":"85","author":"Matsuyama","year":"2013","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"11","key":"10.1016\/j.jocn.2022.01.030_b0125","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00066-007-1714-1","article-title":"Hypofractionated stereotactic radiotherapy for brain metastasesHypofraktionierte stereotaktische Radiotherapie von Hirnmetastasen \u2013 Ergebnisse dreier Dosiskonzepte","volume":"183","author":"Fahrig","year":"2007","journal-title":"Strahlenther Onkol"},{"issue":"2","key":"10.1016\/j.jocn.2022.01.030_b0130","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11060-014-1388-3","article-title":"Fractionated stereotactic radiosurgery for patients with brain metastases","volume":"117","author":"Minniti","year":"2014","journal-title":"J Neurooncol"},{"issue":"1","key":"10.1016\/j.jocn.2022.01.030_b0135","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-12-497","article-title":"Hypofractionated stereotactic radiotherapy of limited brain metastases: A single-centre individualized treatment approach","volume":"12","author":"M\u00e4rtens","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.jocn.2022.01.030_b0140","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/1748-717X-8-135","article-title":"Hypofractionated radiosurgery for intact or resected brain metastases: Defining the optimal dose and fractionation","volume":"8","author":"Eaton","year":"2013","journal-title":"Radiat Oncol"},{"issue":"4","key":"10.1016\/j.jocn.2022.01.030_b0145","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1227\/NEU.0b013e31821d31de","article-title":"Outcomes and prognostic factors for patients with brainstem metastases undergoing stereotactic radiosurgery","volume":"69","author":"Hatiboglu","year":"2011","journal-title":"Neurosurgery"},{"issue":"4","key":"10.1016\/j.jocn.2022.01.030_b0150","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1227\/NEU.0b013e31823c40fe","article-title":"Accelerator-based stereotactic radiosurgery for brainstem metastases","volume":"70","author":"Lin","year":"2012","journal-title":"Neurosurgery"},{"issue":"1","key":"10.1016\/j.jocn.2022.01.030_b0155","first-page":"40","article-title":"Gamma knife stereotactic radiosurgery in the treatment of brainstem metastases: The MD Anderson experience","volume":"2","author":"Voong","year":"2015","journal-title":"Neurooncol Pract"},{"key":"10.1016\/j.jocn.2022.01.030_b0160","doi-asserted-by":"crossref","first-page":"e757","DOI":"10.1016\/j.wneu.2018.07.263","article-title":"Toxicity of Radiosurgery for Brainstem Metastases","volume":"119","author":"Patel","year":"2018","journal-title":"World Neurosurg"}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586822000376?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586822000376?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T21:30:56Z","timestamp":1760823056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0967586822000376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":32,"alternative-id":["S0967586822000376"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2022.01.030","relation":{},"ISSN":["0967-5868"],"issn-type":[{"type":"print","value":"0967-5868"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Linac-based hypofractionated stereotactic radiotherapy for metastases involving the brainstem","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocn.2022.01.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}