{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:37:42Z","timestamp":1787243862955,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"am","delay-in-days":352,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jocn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.jocn.2022.12.005","type":"journal-article","created":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T18:47:38Z","timestamp":1671475658000},"page":"129-132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder"],"prefix":"10.1016","volume":"107","author":[{"given":"Mamoru","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsusada","family":"Okuno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Lan","family":"Piao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikito","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuichi","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takamasa","family":"Nukui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kinoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Koda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ratna","family":"Dini Haryuni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Mochizuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Nakatsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jocn.2022.12.005_b0005","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1212\/NXI.0000000000000134","article-title":"Update on Biomarkers in Neuromyelitis optica","volume":"2","author":"Melamed","year":"2015","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"10.1016\/j.jocn.2022.12.005_b0010","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1212\/WNL.0000000000001729","article-title":"International Consensus Diagnostic Criteria for Neuromyelitis Optica Spectrum Disorders","volume":"85","author":"Wingerchuk","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2022.12.005_b0015","doi-asserted-by":"crossref","first-page":"410","DOI":"10.4103\/1673-5374.179048","article-title":"Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorders: Some Similarities in Two Distinct Diseases","volume":"11","author":"Yokote","year":"2016","journal-title":"Neural Regen Res"},{"key":"10.1016\/j.jocn.2022.12.005_b0020","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.mayocp.2016.12.014","article-title":"Neuromyelitis Spectrum Disorders","volume":"92","author":"Weinshenker","year":"2017","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.jocn.2022.12.005_b0025","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3389\/fneur.2020.00501","article-title":"Epidemiology of Neuromyelitis Optica Spectrum Disorder and Its Prevalence and Incidence Worldwide","volume":"11","author":"Hor","year":"2020","journal-title":"Front Neurol"},{"key":"10.1016\/j.jocn.2022.12.005_b0030","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1212\/CON.0000000000000742","article-title":"Neuromyelitis Optica Spectrum Disorder and Other Non-Multiple Sclerosis Central Nervous System Inflammatory Diseases","volume":"25","author":"Flanagan","year":"2019","journal-title":"Continuum (Minneap Minn)"},{"key":"10.1016\/j.jocn.2022.12.005_b0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms17030273","article-title":"The Immunology of Neuromyelitis Optica\u2014Current Knowledge, Clinical Implications, Controversies and Future Perspectives","volume":"17","author":"Jasiak-zatonska","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.jocn.2022.12.005_b0040","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.survophthal.2019.08.001","article-title":"Optic Neuritis in the Era of Biomarkers","volume":"65","author":"Chen","year":"2020","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.jocn.2022.12.005_b0045","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3390\/biomedicines7020042","article-title":"Neuromyelitis Optica Spectrum Disorder and Anti-MOG Syndromes","volume":"7","author":"Lana-Peixoto","year":"2019","journal-title":"Biomedicines"},{"key":"10.1016\/j.jocn.2022.12.005_b0050","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1148\/rg.2018170141","article-title":"Neuromyelitis Optica Spectrum Disorders: Spectrum of MR Imaging Findings and Their Differential Diagnosis","volume":"38","author":"Dutra","year":"2018","journal-title":"Radiographics"},{"key":"10.1016\/j.jocn.2022.12.005_b0055","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s12974-019-1674-2","article-title":"Molecular Biomarkers in Multiple Sclerosis","volume":"16","author":"Ziemssen","year":"2019","journal-title":"J Neuroinflamm"},{"key":"10.1016\/j.jocn.2022.12.005_b0060","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1097\/WNR.0b013e32832776f4","article-title":"Astrocytic Necrosis Is Induced by Anti-aquaporin-4 Antibody-Positive Serum","volume":"20","author":"Kinoshita","year":"2009","journal-title":"Neuroreport"},{"key":"10.1016\/j.jocn.2022.12.005_b0065","first-page":"623","article-title":"Neuromyelitis optica: Passive transfer to rats by human immunoglobulin","volume":"386","author":"Kinoshita","year":"2009","journal-title":"BBRC"},{"key":"10.1016\/j.jocn.2022.12.005_b0070","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/ana.21802","article-title":"Intrathecal pathogenic anti-aquaporin-4 antibodies in early neuromyelitis optica","volume":"66","author":"Bennett","year":"2009","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jocn.2022.12.005_b0075","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/ana.21837","article-title":"Neuromyelitis optica: pathogenicity of patient immunoglobulin in vivo","volume":"66","author":"Bradl","year":"2009","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jocn.2022.12.005_b0080","doi-asserted-by":"crossref","first-page":"e1034","DOI":"10.1212\/NXI.0000000000001034","article-title":"Molecular Level Characterization of Circulating Aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum Disorder","volume":"8","author":"Li","year":"2021","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"10.1016\/j.jocn.2022.12.005_b0085","doi-asserted-by":"crossref","first-page":"169","DOI":"10.7861\/clinmedicine.19-2-169","article-title":"Neuromyelitis Optica Spectrum Disorders","volume":"19","author":"Huda","year":"2019","journal-title":"Clin Med (Lond)"},{"key":"10.1016\/j.jocn.2022.12.005_b0090","doi-asserted-by":"crossref","first-page":"e1076","DOI":"10.1212\/NXI.0000000000001076","article-title":"New BBB Model Reveals That IL-6 Blockade Suppressed the BBB Disorder, Preventing Onset of NMOSD","volume":"8","author":"Takeshita","year":"2021","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"10.1016\/j.jocn.2022.12.005_b0095","doi-asserted-by":"crossref","first-page":"285610","DOI":"10.1038\/s41467-020-16625-7","article-title":"Transcriptomics and proteomics reveal a cooperation between interferon and T-helper 17 cells in neuromyelitis optica","volume":"11","author":"Agasing","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.jocn.2022.12.005_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/cei.13041","article-title":"Self-dsDNA in the Pathogenesis of Systemic Lupus Erythematosus","volume":"191","author":"Bai","year":"2018","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.jocn.2022.12.005_b0105","article-title":"Anti-Double Stranded DNA Antibodies: Origin, Pathogenicity, and Targeted Therapies","volume":"1667","author":"Wang","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.jocn.2022.12.005_b0110","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12974-018-1162-0","article-title":"Cerebrospinal Fluid Mitochondrial DNA in Neuromyelitis Optica Spectrum Disorder","volume":"15","author":"Yamashita","year":"2018","journal-title":"J Neuroinflamm"},{"key":"10.1016\/j.jocn.2022.12.005_b0115","doi-asserted-by":"crossref","first-page":"13274","DOI":"10.1038\/s41598-020-70203-x","article-title":"Mitochondrial DNA Enhance Innate Immune Responses in Neuromyelitis Optica by Monocyte Recruitment and Activation","volume":"10","author":"Shimizu","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.jocn.2022.12.005_b0120","doi-asserted-by":"crossref","first-page":"e1149","DOI":"10.1212\/NXI.0000000000001149","article-title":"Cell-Free DNA Derived From Neutrophils Triggers Type 1 Interferon Signature in Neuromyelitis Optica Spectrum Disorder","volume":"9","author":"Murata","year":"2022","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"10.1016\/j.jocn.2022.12.005_b0125","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s13311-015-0400-8","article-title":"Present and Future Therapies in Neuromyelitis Optica Spectrum Disorders","volume":"13","author":"Kleiter","year":"2016","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jocn.2022.12.005_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577387","article-title":"NMOSD acute attack: Understanding, treatment and innovative treatment prospect","volume":"348","author":"Ma","year":"2020","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.jocn.2022.12.005_b0135","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/ana.24554","article-title":"Neuromyelitis optica: Evaluation of 871 attacks and 1,153 treatment courses","volume":"79","author":"Kleiter","year":"2016","journal-title":"Ann Neurol"},{"key":"10.1016\/j.jocn.2022.12.005_b0140","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jns.2011.03.038","article-title":"Cerebrospinal Fluid Findings in aquaporin-4 Antibody Positive Neuromyelitis Optica: Results from 211 Lumbar Punctures","volume":"306","author":"Jarius","year":"2011","journal-title":"J Neurol Sci"}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586822004751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586822004751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T21:32:39Z","timestamp":1760823159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0967586822004751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":28,"alternative-id":["S0967586822004751"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2022.12.005","relation":{},"ISSN":["0967-5868"],"issn-type":[{"value":"0967-5868","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocn.2022.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}