{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T05:10:07Z","timestamp":1749359407015,"version":"3.41.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jocn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.jocn.2024.110768","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T18:10:19Z","timestamp":1722276619000},"page":"110768","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Decreased timing to vasospasm prophylaxis improves outcomes among patients with aneurysmal subarachnoid hemorrhage (aSAH) on prehospital CCBs, ARBs, or ACE-inhibitors"],"prefix":"10.1016","volume":"127","author":[{"given":"Donald","family":"Frei","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Jarvis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasaman","family":"Pirahanchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas","family":"Wenz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Nieberlein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"DiSalvo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Bar-Or","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.jocn.2024.110768_b0005","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1161\/STROKEAHA.109.547331","article-title":"Sample size estimates for clinical trials of vasospasm in subarachnoid hemorrhage","volume":"40","author":"Kreiter","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.jocn.2024.110768_b0010","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1159\/000354755","article-title":"Current options for the management of aneurysmal subarachnoid hemorrhage-induced cerebral vasospasm: A comprehensive review of the literature","volume":"2","author":"Dabus","year":"2014","journal-title":"Interv Neurol"},{"key":"10.1016\/j.jocn.2024.110768_b0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11910-014-0521-1","article-title":"Rescue therapy for refractory vasospasm after subarachnoid hemorrhage","volume":"15","author":"Durrant","year":"2015","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.1016\/j.jocn.2024.110768_b0020","first-page":"E314","article-title":"2023 Guideline for the Management of patients with aneurysmal subarachnoid hemorrhage: A guideline from the American Heart Association\/American Stroke Association","volume":"54","author":"Hoh","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.jocn.2024.110768_b0025","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1161\/STROKEAHA.108.544700","article-title":"Defining vasospasm after subarachnoid hemorrhage: What is the most clinically relevant definition?","volume":"40","author":"Frontera","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.jocn.2024.110768_b0030","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1161\/STROKEAHA.110.597914","article-title":"Cerebral infarction after subarachnoid hemorrhage contributes to poor outcome by vasospasm-dependent and -independent effects","volume":"42","author":"Vergouwen","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.jocn.2024.110768_b0035","doi-asserted-by":"crossref","first-page":"465","DOI":"10.2176\/nmc.oa.2013-0169","article-title":"Risk factors associated with cerebral vasospasm following aneurysmal subarachnoid hemorrhage","volume":"54","author":"Inagawa","year":"2014","journal-title":"Neurol Med Chir (Tokyo)"},{"key":"10.1016\/j.jocn.2024.110768_b0040","first-page":"21","article-title":"Prediction of symptomatic vasospasm after subarachnoid hemorrhage: The modified fisher scale","volume":"59","author":"Frontera","year":"2006","journal-title":"Neurosurgery"},{"key":"10.1016\/j.jocn.2024.110768_b0045","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1161\/STROKEAHA.107.496802","article-title":"Calcium antagonists for aneurysmal subarachnoid hemorrhage","volume":"39","author":"Mees","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.jocn.2024.110768_b0050","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1161\/01.STR.0000254601.74596.0f","article-title":"Effect of nicardipine prolonged-release implants on cerebral vasospasm and clinical outcome after severe aneurysmal subarachnoid hemorrhage A prospective, randomized, double-blind phase IIa study","volume":"38","author":"Barth","year":"2007","journal-title":"Stroke"},{"key":"10.1016\/j.jocn.2024.110768_b0055","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1136\/bmj.298.6674.636","article-title":"Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial","volume":"298","author":"Pickard","year":"1989","journal-title":"Br Med J"},{"key":"10.1016\/j.jocn.2024.110768_b0060","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3171\/jns.1993.78.4.0537","article-title":"A randomized controlled trial of high-dose intravenous nicardipine in aneurysmal subarachnoid hemorrhage A report of the Cooperative Aneurysrn Study","volume":"78","author":"Haley","year":"1993","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jocn.2024.110768_b0065","article-title":"Calcium antagonists for aneurysmal subarachnoid haemorrhage","author":"Dorhout Mees","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.jocn.2024.110768_b0070","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00228-011-1100-x","article-title":"Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage","volume":"68","author":"Liu","year":"2012","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1016\/j.jocn.2024.110768_b0075","article-title":"The effects of calcium channel blockers in the prevention of stroke in adults with hypertension: A meta-analysis of data from 273,543 participants in 31 randomized controlled trials","volume":"8","author":"Chen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.jocn.2024.110768_b0080","unstructured":"Sanders GD, Coeytaux R, Dolor RJ, Hasselblad V, Patel UD, Powers B, et al. Angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor antagonists (ARBs), and direct renin inhibitors for treating essential hypertension: an update. Angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor antagonists (ARBs), and direct renin inhibitors for treating essential hypertension: An update 2011:368."},{"key":"10.1016\/j.jocn.2024.110768_b0085","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/BF00051613","article-title":"Pharmacological aspects of calcium channel blockers","volume":"10","author":"Scholz","year":"1997","journal-title":"Cardiovasc Drugs Ther"},{"key":"10.1016\/j.jocn.2024.110768_b0090","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1161\/STR.0b013e3182587839","article-title":"Guidelines for the management of aneurysmal subarachnoid hemorrhage: A guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"43","author":"Connolly","year":"2012","journal-title":"Stroke"},{"key":"10.1016\/j.jocn.2024.110768_b0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12028-023-01713-5","article-title":"Guidelines for the neurocritical care management of aneurysmal subarachnoid hemorrhage","volume":"39","author":"Treggiari","year":"2023","journal-title":"Neurocrit Care"},{"key":"10.1016\/j.jocn.2024.110768_b0100","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1177\/1971400915626429","article-title":"Intra-arterial nimodipine for cerebral vasospasm after subarachnoid haemorrhage: Influence on clinical course and predictors of clinical outcomes","volume":"29","author":"Bashir","year":"2016","journal-title":"Neuroradiol J"},{"key":"10.1016\/j.jocn.2024.110768_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fneur.2019.01161","article-title":"Nimodipine-induced blood pressure changes can predict delayed cerebral ischemia","volume":"10","author":"Fischer","year":"2019","journal-title":"Front Neurol"},{"key":"10.1016\/j.jocn.2024.110768_b0110","doi-asserted-by":"crossref","unstructured":"Petruk KC, West M, Mohr G, Weir BKA, Benoit BG, Gentili F, et al. Nimodipine treatment in poor-grade aneurysm patients Results of a multicenter double-blind placebo-controlled trial. 1988;68.","DOI":"10.3171\/jns.1988.68.4.0505"},{"key":"10.1016\/j.jocn.2024.110768_b0115","doi-asserted-by":"crossref","unstructured":"Claassen J, Bernardini GL, Kreiter K, Bates J, Du YE, Copeland D, et al. Effect of cisternal and ventricular blood on risk of delayed cerebral ischemia after subarachnoid hemorrhage The Fisher Scale revisited. 2001.","DOI":"10.1161\/hs0901.095677"},{"key":"10.1016\/j.jocn.2024.110768_b0120","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1161\/01.STR.23.2.205","article-title":"The International Cooperative Study on the timing of aneurysm surgery","volume":"23","author":"Haley","year":"1992","journal-title":"Stroke"},{"key":"10.1016\/j.jocn.2024.110768_b0125","unstructured":"Treggiari-Venzi MM, Suter PM, Romand J-A. Review of medical prevention of vasospasm after aneurysmal subarachnoid hemorrhage: A problem of neurointensive care. n.d."},{"key":"10.1016\/j.jocn.2024.110768_b0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/462491","article-title":"Medical management of cerebral vasospasm following aneurysmal subarachnoid hemorrhage: A review of current and emerging therapeutic interventions","volume":"2013","author":"Adamczyk","year":"2013","journal-title":"Neurol Res Int"},{"key":"10.1016\/j.jocn.2024.110768_b0135","doi-asserted-by":"crossref","DOI":"10.1186\/s13054-016-1447-6","article-title":"Management of delayed cerebral ischemia after subarachnoid hemorrhage","volume":"20","author":"Francoeur","year":"2016","journal-title":"Crit Care"},{"key":"10.1016\/j.jocn.2024.110768_b0140","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1177\/1060028018778751","article-title":"Impact of early versus late intravenous followed by oral nimodipine treatment on the occurrence of delayed cerebral ischemia among patients with aneurysm subarachnoid hemorrhage","volume":"52","author":"Samseethong","year":"2018","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.jocn.2024.110768_b0145","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1161\/01.STR.0000133132.76983.8e","article-title":"Predictors of cerebral infarction in aneurysmal subarachnoid hemorrhage","volume":"35","author":"Rabinstein","year":"2004","journal-title":"Stroke"},{"key":"10.1016\/j.jocn.2024.110768_b0150","unstructured":"Biondi A, Ricciardi GK, Puybasset L, Abdennour L, Longo M, Chiras J, et al. Intra-arterial nimodipine for the treatment of symptomatic cerebral vasospasm after aneurysmal subarachnoid hemorrhage: preliminary results. n.d."},{"key":"10.1016\/j.jocn.2024.110768_b0155","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.3174\/ajnr.A1005","article-title":"Intra-arterial nimodipine for severe cerebral vasospasm after aneurysmal subarachnoid hemorrhage: Influence on clinical course and cerebral perfusion","volume":"29","author":"H\u00e4nggi","year":"2008","journal-title":"Am J Neuroradiol"},{"key":"10.1016\/j.jocn.2024.110768_b0160","doi-asserted-by":"crossref","unstructured":"Cho W-S, Kang H-S, Kim JE, Kwon K, Oh CW, Son J, et al. Intra-arterial nimodipine infusion for cerebral vasospasm in patients with aneurysmal subarachnoid hemorrhage. 2011; 17.","DOI":"10.1177\/159101991101700205"},{"key":"10.1016\/j.jocn.2024.110768_b0165","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3940(96)12492-7","article-title":"High affinity block by nimodipine of the internal calcium elevation in chronically depolarized rate cerebellar granule neurons","volume":"29","author":"Marchetti","year":"1996","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.jocn.2024.110768_b0170","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3171\/jns.1988.68.3.0393","article-title":"Dose-escalation study of intravenous nicardipine in patients with aneurysmal subarachnoid hemorrhage","volume":"68","author":"Flamm","year":"1988","journal-title":"J Neurosurg"},{"key":"10.1016\/j.jocn.2024.110768_b0175","doi-asserted-by":"crossref","first-page":"e834","DOI":"10.1016\/j.wneu.2019.08.001","article-title":"Does Nimodipine interruption due to high catecholamine doses lead to a greater incidence of delayed cerebral ischemia in the setting of aneurysmal subarachnoid hemorrhage?","volume":"132","author":"Hern\u00e1ndez-Dur\u00e1n","year":"2019","journal-title":"World Neurosurg"},{"key":"10.1016\/j.jocn.2024.110768_b0180","doi-asserted-by":"crossref","unstructured":"Kerschbaumer J, Freyschlag CF, Petr O, Adage T, Breitenbach JJ, Wessels L, et al. A randomized, single ascending dose safety, tolerability and pharmacokinetics study of NicaPlant\u00ae in aneurysmal subarachnoid hemorrhage patients undergoing clipping. Brain Spine 2023;3. https:\/\/doi.org\/10.1016\/j.bas.2023.102673.","DOI":"10.1016\/j.bas.2023.102673"},{"key":"10.1016\/j.jocn.2024.110768_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.106020","article-title":"Nicardipine prolonged release implants for prevention of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: A meta-analysis","volume":"30","author":"Akbik","year":"2021","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.jocn.2024.110768_b0190","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/571328","article-title":"Cerebral vasospasm pharmacological treatment: An update","volume":"2013","author":"Siasios","year":"2013","journal-title":"Neurol Res Int"},{"key":"10.1016\/j.jocn.2024.110768_b0195","doi-asserted-by":"crossref","unstructured":"Laskowitz DT, Kolls BJ. Neuroprotection in subarachnoid hemorrhage. Stroke 2010;41. https:\/\/doi.org\/10.1161\/STROKEAHA.110.595090.","DOI":"10.1161\/STROKEAHA.110.595090"}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586824002959?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586824002959?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T04:45:53Z","timestamp":1749357953000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0967586824002959"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":39,"alternative-id":["S0967586824002959"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2024.110768","relation":{},"ISSN":["0967-5868"],"issn-type":[{"type":"print","value":"0967-5868"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decreased timing to vasospasm prophylaxis improves outcomes among patients with aneurysmal subarachnoid hemorrhage (aSAH) on prehospital CCBs, ARBs, or ACE-inhibitors","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocn.2024.110768","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"110768"}}