{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:58:22Z","timestamp":1791377902891,"version":"4.3.2"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jocn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.jocn.2025.111137","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T20:09:10Z","timestamp":1740082150000},"page":"111137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Clinical characteristics of late-onset neuromyelitis optica spectrum disorder in China"],"prefix":"10.1016","volume":"135","author":[{"given":"Qingli","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jocn.2025.111137_b0005","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S1474-4422(07)70216-8","article-title":"The spectrum of neuromyelitis optica","volume":"6","author":"Wingerchuk","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.jocn.2025.111137_b0010","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/S0140-6736(04)17551-X","article-title":"A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis","volume":"364","author":"Lennon","year":"2004","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.jocn.2025.111137_b0015","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1212\/WNL.0000000000011153","article-title":"Worldwide incidence and prevalence of neuromyelitis optica: a systematic review","volume":"96","author":"Papp","year":"2021","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.jocn.2025.111137_b0020","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1002\/acn3.51404","article-title":"Mortality of neuromyelitis optica spectrum disorders in a","volume":"8","author":"Du","year":"2021","journal-title":"Chinese populationAnn Clin Transl Neurol"},{"issue":"7","key":"10.1016\/j.jocn.2025.111137_b0025","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1007\/s00415-023-11634-0","article-title":"Update on the diagnosis and treatment of neuromyelits optica spectrum disorders (NMOSD)-revised recommendations of the Neuromyelitis Optica Study Group (NEMOS). Part I: Diagnosis and differential diagnosis","volume":"270","author":"Jarius","year":"2023","journal-title":"J Neurol"},{"issue":"12","key":"10.1016\/j.jocn.2025.111137_b0030","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1212\/WNL.0b013e3181f39a66","article-title":"Long-term follow-up of neuromyelitis optica with a pediatric onset","volume":"75","author":"Collongues","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.jocn.2025.111137_b0035","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/s41582-018-0112-x","article-title":"Myelin oligodendrocyte glycoprotein antibodies in neurological disease","volume":"15","author":"Reindl","year":"2019","journal-title":"Nat Rev Neurol"},{"issue":"431","key":"10.1016\/j.jocn.2025.111137_b0040","article-title":"Age at onset predicts outcome in aquaporin-4-IgG positive neuromyelitis optica spectrum disorder from a United Kingdom population","volume":"15","author":"Papathanasiou","year":"2021","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.jocn.2025.111137_b0045","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1177\/1352458513515085","article-title":"Characterization of neuromyelitis optica and neuromyelitis optica spectrum disorder patients with a late onset","volume":"20","author":"Collongues","year":"2014","journal-title":"Mult Scler"},{"key":"10.1016\/j.jocn.2025.111137_b0050","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1093\/brain\/awz054","article-title":"Outcome prediction models in AQP4-IgG positive neuromyelitis optica spectrum disorders","volume":"142","author":"Palace","year":"2019","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.jocn.2025.111137_b0055","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1007\/s40120-019-0143-2","article-title":"LateOnset of Neuromyelitis Optica Spectrum Disorders","volume":"8","author":"Fragoso","year":"2019","journal-title":"Neurol Ther"},{"issue":"4","key":"10.1016\/j.jocn.2025.111137_b0060","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/ene.15239","article-title":"Late onset neuromyelitis optica spectrum disorder with anti-aquaporin 4 and anti-myelin oligodendrocyte glycoprotein antibodies","volume":"29","author":"Wang","year":"2022","journal-title":"Eur J Neurol"},{"issue":"6","key":"10.1016\/j.jocn.2025.111137_b0065","doi-asserted-by":"crossref","first-page":"e607","DOI":"10.1212\/NXI.0000000000000607","article-title":"Late-onset neuromyelitis optica spectrum disorder: the importance of autoantibody serostatus","volume":"6","author":"Sepulveda","year":"2019","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"13","key":"10.1016\/j.jocn.2025.111137_b0070","article-title":"Relatively early andlate-onset neuromyelitis optica spectrum disorder in central china: clinical characteristics and prognostic features","volume":"14","author":"Yu","year":"2022","journal-title":"Front Neurol"},{"key":"10.1016\/j.jocn.2025.111137_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2023.104517","article-title":"Clinical characteristics oflate-onset neuromyelitis optica spectrum disorder","volume":"70","author":"Min","year":"2023","journal-title":"Mult Scler Relat Disord"},{"issue":"13","key":"10.1016\/j.jocn.2025.111137_b0080","article-title":"Age of onset correlates with clinical characteristics and prognostic outcomes in neuromyelitis optica spectrum disorder","volume":"8","author":"Hu","year":"2022","journal-title":"Front Immunol"},{"issue":"5","key":"10.1016\/j.jocn.2025.111137_b0085","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1007\/s00415-020-09699-2","article-title":"Clinical features and prognosis of late-onset neuromyelitis optica spectrum disorders in a Latin American cohort","volume":"267","author":"Carnero Contentti","year":"2020","journal-title":"J Neurol"},{"key":"10.1016\/j.jocn.2025.111137_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2022.103845","article-title":"Late onset neuromyelitis optica spectrum disorders (LONMOSD) from a nationwide Portuguese study: anti-AQP4 positive, anti-MOG positive and seronegative subgroups","volume":"63","author":"Santos","year":"2022","journal-title":"Mult Scler Relat Disord"},{"issue":"2","key":"10.1016\/j.jocn.2025.111137_b0095","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1212\/WNL.0000000000001729","article-title":"International consensus diagnostic criteria for neuromyelitis optica spectrum disorders","volume":"85","author":"Wingerchuk","year":"2015","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.jocn.2025.111137_b0100","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1093\/brain\/awac016","article-title":"How patients with multiple sclerosis acquiredisability","volume":"145","author":"Lublin","year":"2022","journal-title":"Brain"},{"issue":"2","key":"10.1016\/j.jocn.2025.111137_b0105","article-title":"Incidence of neuromyelitis optica spectrum disorder (NMOSD) inChina: a national population-based study","volume":"6","author":"Tian","year":"2020","journal-title":"Lancet Reg Health West Pac"},{"key":"10.1016\/j.jocn.2025.111137_b0110","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.autrev.2005.09.008","article-title":"Aging of the immune system: a risk factor for autoimmunity?","volume":"5","author":"Prelog","year":"2006","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.jocn.2025.111137_b0115","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1191\/0961203303lu383ed","article-title":"Autoimmunity and geriatrics: clinical significance of autoimmune manifestations in the elderly","volume":"12","author":"Ramos- Casals","year":"2003","journal-title":"Lupus"},{"key":"10.1016\/j.jocn.2025.111137_b0120","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3389\/fimmu.2013.00131","article-title":"The Janus head of T cell aging-autoimmunity and immunodeficiency","volume":"4","author":"Goronzy","year":"2013","journal-title":"Front Immunol"},{"key":"10.1016\/j.jocn.2025.111137_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2020.102515","article-title":"Clinical characteristics of very late-onset neuromyelitis optica spectrum disorder","volume":"46","author":"Cai","year":"2020","journal-title":"Mult Scler Relat Disord"},{"issue":"13(24)","key":"10.1016\/j.jocn.2025.111137_b0130","doi-asserted-by":"crossref","first-page":"25729","DOI":"10.18632\/aging.203790","article-title":"Factors influencing serum neurofilament light chain levels in normal aging","volume":"18","author":"Koini","year":"2021","journal-title":"Aging (Albany NY)"},{"issue":"15","key":"10.1016\/j.jocn.2025.111137_b0135","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12883-015-0417-y","article-title":"Late-onset neuromyelitis optica spectrum disorder in AQP4-seropositivepatients in a Chinese population","volume":"4","author":"Mao","year":"2015","journal-title":"BMC Neurol"},{"issue":"1","key":"10.1016\/j.jocn.2025.111137_b0140","article-title":"Steroid-induced hiccups in a patient managed for pseudo foster-kennedy syndrome: a case report of good outcome with the use of gabapentin","volume":"13","author":"Egbu","year":"2021","journal-title":"Cureus"},{"issue":"4","key":"10.1016\/j.jocn.2025.111137_b0145","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/ana.26858","article-title":"Time to disability milestones and annualized relapse rates in NMOSD and MOGAD","volume":"95","author":"Duchow","year":"2024","journal-title":"Ann Neurol"},{"issue":"8","key":"10.1016\/j.jocn.2025.111137_b0150","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.1111\/ene.14901","article-title":"Very late onset neuromyelitis optica spectrum disorders","volume":"28","author":"Nakahara","year":"2021","journal-title":"Eur J Neurol"}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586825001092?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586825001092?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T12:54:37Z","timestamp":1762347277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0967586825001092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":30,"alternative-id":["S0967586825001092"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2025.111137","relation":{},"ISSN":["0967-5868"],"issn-type":[{"value":"0967-5868","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical characteristics of late-onset neuromyelitis optica spectrum disorder in China","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocn.2025.111137","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"111137"}}