{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T07:18:03Z","timestamp":1785568683664,"version":"3.56.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012095","name":"Scottish Government","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jocn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jocn.2025.111247","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T17:02:22Z","timestamp":1744736542000},"page":"111247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["APOE4 and prevalence of degenerative cervical myelopathy: A genetic case-control study in the UK Biobank cohort"],"prefix":"10.1016","volume":"136","author":[{"given":"Renuka","family":"Chintapalli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver D.","family":"Mowforth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin M.","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.jocn.2025.111247_b0005","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1177\/2192568220934496","article-title":"The Prevalence of Asymptomatic and Symptomatic Spinal Cord Compression on Magnetic Resonance Imaging: A Systematic Review and Meta-analysis","volume":"11","author":"Smith","year":"2021","journal-title":"Glob Spine J"},{"key":"10.1016\/j.jocn.2025.111247_b0010","article-title":"Degenerative cervical myelopathy","volume":"360","author":"Davies","year":"2018","journal-title":"BMJ"},{"key":"10.1016\/j.jocn.2025.111247_b0015","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/j.wneu.2016.12.124","article-title":"Comparing Quality of Life in Cervical Spondylotic Myelopathy with Other Chronic Debilitating Diseases Using the Short Form Survey 36-Health Survey","volume":"106","author":"Oh","year":"2017","journal-title":"WORLD Neurosurg"},{"key":"10.1016\/j.jocn.2025.111247_b0020","doi-asserted-by":"crossref","first-page":"122S","DOI":"10.1177\/21925682211039835","article-title":"Establishing the Socio-Economic Impact of Degenerative Cervical Myelopathy Is Fundamental to Improving Outcomes [AO Spine RECODE-DCM Research Priority Number 8]","volume":"12","author":"Davies","year":"2022","journal-title":"Glob Spine J"},{"issue":"Suppl 4","key":"10.1016\/j.jocn.2025.111247_b0025","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1227\/NEU.0000000000000951","article-title":"Degenerative Cervical Myelopathy: A Spectrum of Related Disorders Affecting the Aging Spine","volume":"77","author":"Tetreault","year":"2015","journal-title":"Neurosurgery"},{"key":"10.1016\/j.jocn.2025.111247_b0030","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1097\/BRS.0000000000000919","article-title":"Does Magnetic Resonance Imaging Improve the Predictive Performance of a Validated Clinical Prediction Rule Developed to Evaluate Surgical Outcome in Patients With Degenerative Cervical Myelopathy?","volume":"40","author":"Nouri","year":"2015","journal-title":"Spine"},{"key":"10.1016\/j.jocn.2025.111247_b0035","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1177\/2192568217745519","article-title":"Clinico-Radiographic Discordance: An Evidence-Based Commentary on the Management of Degenerative Cervical Spinal Cord Compression in the Absence of Symptoms or With Only Mild Symptoms of Myelopathy","volume":"8","author":"Witiw","year":"2017","journal-title":"Glob Spine J"},{"key":"10.1016\/j.jocn.2025.111247_b0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0219380","article-title":"A comparison of radiological descriptions of spinal cord compression with quantitative measures, and their role in non-specialist clinical management","volume":"14","author":"Tempest-Mitchell","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.jocn.2025.111247_b0045","doi-asserted-by":"crossref","first-page":"S232","DOI":"10.1097\/BRS.0b013e3182a7eb55","article-title":"Predictive factors affecting outcome after cervical laminoplasty","volume":"38","author":"Yoon","year":"2013","journal-title":"Spine"},{"key":"10.1016\/j.jocn.2025.111247_b0050","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3390\/jcm9010282","article-title":"Genetics of Degenerative Cervical Myelopathy: A Systematic Review and Meta-Analysis of Candidate Gene Studies","volume":"9","author":"Pope","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.jocn.2025.111247_b0055","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1097\/BRS.0b013e3181657cf7","article-title":"Apolipoprotein E gene polymorphism and the risk of cervical myelopathy in patients with chronic spinal cord compression","volume":"33","author":"Setzer","year":"2008","journal-title":"Spine"},{"key":"10.1016\/j.jocn.2025.111247_b0060","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.149227","article-title":"The influence of ApoE4 on the clinical outcomes and pathophysiology of degenerative cervical myelopathy","volume":"6","author":"Desimone","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.jocn.2025.111247_b0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLOS Med"},{"key":"10.1016\/j.jocn.2025.111247_b0070","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s41586-018-0579-z","article-title":"The UK Biobank resource with deep phenotyping and genomic data","volume":"562","author":"Bycroft","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.jocn.2025.111247_b0075","unstructured":"Genetic data 2018. https:\/\/www.ukbiobank.ac.uk\/enable-your-research\/about-our-data\/genetic-data (accessed November 16, 2024)."},{"key":"10.1016\/j.jocn.2025.111247_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102954","article-title":"Apolipoprotein E (APOE) genotype-associated disease risks: a phenome-wide, registry-based, case-control study utilising the UK Biobank","volume":"59","author":"Lumsden","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jocn.2025.111247_b0085","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3171\/2009.7.SPINE08667","article-title":"Effect of apolipoprotein E genotype on the outcome after anterior cervical decompression and fusion in patients with cervical spondylotic myelopathy","volume":"11","author":"Setzer","year":"2009","journal-title":"J Neurosurg Spine"},{"key":"10.1016\/j.jocn.2025.111247_b0090","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature24016","article-title":"ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy","volume":"549","author":"Shi","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.jocn.2025.111247_b0095","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13024-020-0358-9","article-title":"Therapeutic approaches targeting Apolipoprotein E function in Alzheimer\u2019s disease","volume":"15","author":"Williams","year":"2020","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.jocn.2025.111247_b0100","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1084\/jem.20121274","article-title":"Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of A\u03b2 amyloidosis","volume":"209","author":"Kim","year":"2012","journal-title":"J Exp Med"},{"key":"10.1016\/j.jocn.2025.111247_b0105","doi-asserted-by":"crossref","DOI":"10.1212\/NXG.0000000000000323","article-title":"Antisense oligonucleotides: a primer","volume":"5","author":"Scoles","year":"2019","journal-title":"Neurol Genet"},{"key":"10.1016\/j.jocn.2025.111247_b0110","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0002-9440(10)63355-X","article-title":"A synthetic peptide blocking the apolipoprotein E\/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice","volume":"165","author":"Sadowski","year":"2004","journal-title":"Am J Pathol"},{"key":"10.1016\/j.jocn.2025.111247_b0115","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.3233\/JAD-160467","article-title":"ABCA1 Agonist Reverses the ApoE4-Driven Cognitive and Brain Pathologies","volume":"54","author":"Boehm-Cagan","year":"2016","journal-title":"J Alzheimers Dis JAD"}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096758682500219X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096758682500219X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T12:55:17Z","timestamp":1762347317000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096758682500219X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":23,"alternative-id":["S096758682500219X"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2025.111247","relation":{},"ISSN":["0967-5868"],"issn-type":[{"value":"0967-5868","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"APOE4 and prevalence of degenerative cervical myelopathy: A genetic case-control study in the UK Biobank cohort","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocn.2025.111247","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111247"}}