{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T10:39:45Z","timestamp":1784975985795,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ50382"],"award-info":[{"award-number":["2023JJ50382"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371445"],"award-info":[{"award-number":["82371445"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171431"],"award-info":[{"award-number":["82171431"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012269","name":"Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015374","name":"Xiangnan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015374","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021ZD0201803"],"award-info":[{"award-number":["2021ZD0201803"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA0805202"],"award-info":[{"award-number":["2021YFA0805202"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jocn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jocn.2025.111268","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T02:25:37Z","timestamp":1745893537000},"page":"111268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Retinal alterations induced by amyotrophic lateral sclerosis: An analysis using optical coherence tomography"],"prefix":"10.1016","volume":"136","author":[{"given":"Yue","family":"Bu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchun","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cailin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linxin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifeng","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renshi","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beisha","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.jocn.2025.111268_b0005","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S1474-4422(21)00465-8","article-title":"Recent advances in the diagnosis and prognosis of amyotrophic lateral sclerosis","volume":"21","author":"Goutman","year":"2022","journal-title":"Lancet Neurol"},{"issue":"10360","key":"10.1016\/j.jocn.2025.111268_b0010","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0140-6736(22)01272-7","article-title":"Amyotrophic lateral sclerosis","volume":"400","author":"Feldman","year":"2022","journal-title":"Lancet (London, England)"},{"issue":"3","key":"10.1016\/j.jocn.2025.111268_b0015","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/s41573-022-00612-2","article-title":"Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation","volume":"22","author":"Mead","year":"2023","journal-title":"Nat Rev Drug Discov"},{"issue":"9","key":"10.1016\/j.jocn.2025.111268_b0020","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/s41576-023-00592-y","article-title":"Amyotrophic lateral sclerosis: translating genetic discoveries into therapies","volume":"24","author":"Ak\u00e7imen","year":"2023","journal-title":"Nat Rev Genet"},{"issue":"1","key":"10.1016\/j.jocn.2025.111268_b0025","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nrneurol.2012.227","article-title":"The retina as a window to the brain-from eye research to CNS disorders","volume":"9","author":"London","year":"2013","journal-title":"Nat Rev Neurol"},{"issue":"6","key":"10.1016\/j.jocn.2025.111268_b0030","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nrneurol.2014.79","article-title":"Ophthalmic manifestations of inherited neurodegenerative disorders","volume":"10","author":"Kersten","year":"2014","journal-title":"Nat Rev Neurol"},{"issue":"12","key":"10.1016\/j.jocn.2025.111268_b0035","doi-asserted-by":"crossref","first-page":"4160","DOI":"10.1093\/brain\/awac317","article-title":"The use of optical coherence tomography in neurology: a review","volume":"145","author":"Xie","year":"2022","journal-title":"Brain J Neurol"},{"issue":"9","key":"10.1016\/j.jocn.2025.111268_b0040","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1136\/jnnp-2020-325347","article-title":"Retinal imaging in Alzheimer's disease","volume":"92","author":"Cheung","year":"2021","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"2","key":"10.1016\/j.jocn.2025.111268_b0045","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1136\/jnnp-2021-327468","article-title":"Retinal inter-eye difference and atrophy progression in multiple sclerosis diagnostics","volume":"93","author":"Nij Bijvank","year":"2022","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"16","key":"10.1016\/j.jocn.2025.111268_b0050","doi-asserted-by":"crossref","first-page":"e1581","DOI":"10.1212\/WNL.0000000000207727","article-title":"Retinal Optical Coherence Tomography Features Associated With Incident and Prevalent Parkinson Disease","volume":"101","author":"Wagner","year":"2023","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.jocn.2025.111268_b0055","doi-asserted-by":"crossref","first-page":"4478","DOI":"10.1007\/s00415-023-11802-2","article-title":"Neurodegeneration in the retina of motoneuron diseases: a longitudinal study in amyotrophic lateral sclerosis and Kennedy's disease","volume":"270","author":"Miscioscia","year":"2023","journal-title":"J Neurol"},{"issue":"9","key":"10.1016\/j.jocn.2025.111268_b0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185242","article-title":"Retinal thinning in amyotrophic lateral sclerosis patients without ophthalmic disease","volume":"12","author":"Mukherjee","year":"2017","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.jocn.2025.111268_b0065","doi-asserted-by":"crossref","first-page":"e2741","DOI":"10.1002\/brb3.2741","article-title":"Amyotrophic lateral sclerosis and retinal changes in optical coherence tomography: A systematic review and meta-analysis","volume":"12","author":"Nepal","year":"2022","journal-title":"Brain and Behavior"},{"issue":"5","key":"10.1016\/j.jocn.2025.111268_b0070","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"Brooks","year":"2000","journal-title":"Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group On Motor Neuron Diseases"},{"issue":"1\u20132","key":"10.1016\/j.jocn.2025.111268_b0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-510X(99)00210-5","article-title":"The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. BDNF ALS Study Group (Phase III)","volume":"169","author":"Cedarbaum","year":"1999","journal-title":"J Neurol Sci"},{"issue":"Pt 3","key":"10.1016\/j.jocn.2025.111268_b0080","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1093\/brain\/awr351","article-title":"A proposed staging system for amyotrophic lateral sclerosis","volume":"135","author":"Roche","year":"2012","journal-title":"Brain J Neurol"},{"issue":"12","key":"10.1016\/j.jocn.2025.111268_b0085","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci9120337","article-title":"Changes in Retinal OCT and Their Correlations with Neurological Disability in Early ALS Patients, a Follow-Up Study","volume":"9","author":"Rojas","year":"2019","journal-title":"Brain Sci"},{"issue":"10","key":"10.1016\/j.jocn.2025.111268_b0090","doi-asserted-by":"crossref","first-page":"3112","DOI":"10.1016\/j.clnu.2020.01.018","article-title":"Predictive factors for gastrostomy at time of diagnosis and impact on survival in patients with amyotrophic lateral sclerosis","volume":"39","author":"Vergonjeanne","year":"2020","journal-title":"Clinical Nutrition (Edinburgh, Scotland)"},{"key":"10.1016\/j.jocn.2025.111268_b0095","doi-asserted-by":"crossref","first-page":"47","DOI":"10.2147\/EB.S139417","article-title":"Retinal imaging with optical coherence tomography: a biomarker in multiple sclerosis?","volume":"10","author":"Costello","year":"2018","journal-title":"Eye and Brain"},{"issue":"4","key":"10.1016\/j.jocn.2025.111268_b0100","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s00415-018-8787-x","article-title":"In vivo assessment of retinal vessel pathology in amyotrophic lateral sclerosis","volume":"265","author":"Abdelhak","year":"2018","journal-title":"J Neurol"},{"issue":"4","key":"10.1016\/j.jocn.2025.111268_b0105","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1002\/acn3.46","article-title":"Subtle retinal pathology in amyotrophic lateral sclerosis","volume":"1","author":"Ringelstein","year":"2014","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.jocn.2025.111268_b0110","doi-asserted-by":"crossref","first-page":"29187","DOI":"10.1038\/srep29187","article-title":"Macular sub-layer thinning and association with pulmonary function tests in Amyotrophic Lateral Sclerosis","volume":"6","author":"Simonett","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.jocn.2025.111268_b0115","doi-asserted-by":"crossref","unstructured":"H\u00fcbers, A., et al., Retinal involvement in amyotrophic lateral sclerosis: a study with optical coherence tomography and diffusion tensor imaging. Journal of Neural Transmission (Vienna, Austria : 1996), 2016. 123(3): p. 281-287.","DOI":"10.1007\/s00702-015-1483-4"},{"key":"10.1016\/j.jocn.2025.111268_b0120","first-page":"T12","article-title":"Ophthalmic Manifestations of Amyotrophic Lateral Sclerosis (An American Ophthalmological Society Thesis)","volume":"113","author":"Volpe","year":"2015","journal-title":"Trans Am Ophthalmol Soc"},{"issue":"4","key":"10.1016\/j.jocn.2025.111268_b0125","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22041663","article-title":"Retinal Ganglion Cell Loss and Microglial Activation in a SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis","volume":"22","author":"Rojas","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"Suppl","key":"10.1016\/j.jocn.2025.111268_b0130","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0022-510X(96)00073-1","article-title":"Reactive astrogliosis of the spinal cord in amyotrophic lateral sclerosis","volume":"139","author":"Schiffer","year":"1996","journal-title":"J Neurol Sci"},{"issue":"1","key":"10.1016\/j.jocn.2025.111268_b0135","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s40478-022-01448-y","article-title":"M\u00fcller cell degeneration and microglial dysfunction in the Alzheimer's retina","volume":"10","author":"Xu","year":"2022","journal-title":"Acta Neuropathol Commun"},{"issue":"11","key":"10.1016\/j.jocn.2025.111268_b0140","doi-asserted-by":"crossref","DOI":"10.3390\/cells12111450","article-title":"Astrocytes: Dissecting Their Diverse Roles in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia","volume":"12","author":"Valori","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.jocn.2025.111268_b0145","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1110520","article-title":"Retinal fingerprints of ALS in patients: Ganglion cell apoptosis and TDP-43\/p62 misplacement","volume":"15","author":"Pediconi","year":"2023","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.jocn.2025.111268_b0150","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.566858","article-title":"Amyotrophic Lateral Sclerosis: A Neurodegenerative Motor Neuron Disease With Ocular Involvement","volume":"14","author":"Rojas","year":"2020","journal-title":"Front Neurosci"},{"issue":"Suppl 2","key":"10.1016\/j.jocn.2025.111268_b0155","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1007\/BF03160574","article-title":"Glutamate, excitotoxicity and amyotrophic lateral sclerosis","volume":"244","author":"Shaw","year":"1997","journal-title":"J Neurol"},{"key":"10.1016\/j.jocn.2025.111268_b0160","doi-asserted-by":"crossref","unstructured":"I. Boccuni R. Fairless Retinal Glutamate Neurotransmission: From Physiology to Pathophysiological Mechanisms of Retinal Ganglion Cell Degeneration 12 2022 Life (Basel, Switzerland).","DOI":"10.3390\/life12050638"},{"issue":"7","key":"10.1016\/j.jocn.2025.111268_b0165","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s00415-018-8863-2","article-title":"Reduced retinal nerve fiber layer (RNFL) thickness in ALS patients: a window to disease progression","volume":"265","author":"Rohani","year":"2018","journal-title":"J Neurol"},{"issue":"1","key":"10.1016\/j.jocn.2025.111268_b0170","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41531-022-00325-8","article-title":"The macular inner plexiform layer thickness as an early diagnostic indicator for Parkinson's disease","volume":"8","author":"Wang","year":"2022","journal-title":"npj Parkinson's Dis"},{"key":"10.1016\/j.jocn.2025.111268_b0175","doi-asserted-by":"crossref","first-page":"17071","DOI":"10.1038\/nrdp.2017.71","article-title":"Amyotrophic lateral sclerosis","volume":"3","author":"Hardiman","year":"2017","journal-title":"Nat Rev Dis Primers"},{"issue":"11","key":"10.1016\/j.jocn.2025.111268_b0180","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1007\/s00415-020-10094-0","article-title":"The specific pattern of retinal nerve fiber layer thinning in Parkinson's disease: a systematic review and meta-analysis","volume":"268","author":"Huang","year":"2021","journal-title":"J Neurol"},{"issue":"4","key":"10.1016\/j.jocn.2025.111268_b0185","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ophtha.2018.08.009","article-title":"Spectral-Domain OCT Measurements in Alzheimer's Disease: A Systematic Review and Meta-analysis","volume":"126","author":"Chan","year":"2019","journal-title":"Ophthalmology"},{"key":"10.1016\/j.jocn.2025.111268_b0190","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.preteyeres.2016.12.002","article-title":"Improving our understanding, and detection, of glaucomatous damage: An approach based upon optical coherence tomography (OCT)","volume":"57","author":"Hood","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.jocn.2025.111268_b0195","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2174\/1874364101004010022","article-title":"First-visit diagnosis of preperimetric glaucoma","volume":"4","author":"Ophir","year":"2010","journal-title":"The Open Ophthalmology Journal"},{"issue":"8","key":"10.1016\/j.jocn.2025.111268_b0200","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1007\/s00417-024-06394-0","article-title":"Retinal imaging and Alzheimer's disease: a future powered by Artificial Intelligence. Graefe's Archive For Clinical and Experimental Ophthalmology = Albrecht Von","volume":"262","author":"Ashayeri","year":"2024","journal-title":"Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie"},{"issue":"4","key":"10.1016\/j.jocn.2025.111268_b0205","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/08820538.2023.2293030","article-title":"Artificial Intelligence for Multiple Sclerosis Management Using Retinal Images: Pearl, Peaks, and Pitfalls","volume":"39","author":"Farabi Maleki","year":"2024","journal-title":"Semin Ophthalmol"}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586825002401?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586825002401?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T12:56:16Z","timestamp":1762347376000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0967586825002401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":41,"alternative-id":["S0967586825002401"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2025.111268","relation":{},"ISSN":["0967-5868"],"issn-type":[{"value":"0967-5868","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinal alterations induced by amyotrophic lateral sclerosis: An analysis using optical coherence tomography","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocn.2025.111268","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111268"}}