{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:34:56Z","timestamp":1778754896639,"version":"3.51.4"},"reference-count":13,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","jocn-journal.com","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.jocn.2025.111270","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T09:13:56Z","timestamp":1745313236000},"page":"111270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Critical appraisal of: \u201cexpression of SARS-CoV-2 spike protein in cerebral arteries: implications for hemorrhagic stroke post-mRNA vaccination\u201d"],"prefix":"10.1016","volume":"136","author":[{"given":"Ahmed","family":"Mueed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abia","family":"Shariq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manaal","family":"Ashar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"136","key":"10.1016\/j.jocn.2025.111270_b0005","article-title":"Expression of SARS-CoV-2 spike protein in cerebral Arteries: implications for hemorrhagic stroke Post-mRNA vaccination","volume":"3","author":"Ota","year":"2025","journal-title":"J Clin Neurosci Off J Neurosurg Soc Australas"},{"issue":"12","key":"10.1016\/j.jocn.2025.111270_b0010","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.1038\/s41591-021-01556-7","article-title":"Neurological complications after first dose of COVID-19 vaccines and SARS-CoV-2 infection","volume":"27","author":"Patone","year":"2021","journal-title":"Nat Med"},{"issue":"6","key":"10.1016\/j.jocn.2025.111270_b0015","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.cell.2022.01.018","article-title":"Immune imprinting, breadth of variant recognition, and germinal center response in human SARS-CoV-2 infection and vaccination","volume":"185","author":"R\u00f6ltgen","year":"2022","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.jocn.2025.111270_b0020","doi-asserted-by":"crossref","first-page":"e487","DOI":"10.1093\/cid\/ciac722","article-title":"Persistent circulating severe acute respiratory syndrome coronavirus 2 spike is associated with post-acute coronavirus disease 2019 sequelae","volume":"76","author":"Swank","year":"2023","journal-title":"Clin Infect Dis Off Publ Infect Dis Soc Am"},{"key":"10.1016\/j.jocn.2025.111270_b0025","unstructured":"World Health Organization. Global Vaccine Safety Blueprint 2.0 (2021\u20132030): Enhancing vaccine pharmacovigilance capacity in low- and middle-income countries. World Health Organization; 2021."},{"issue":"27","key":"10.1016\/j.jocn.2025.111270_b0030","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.jocn.2025.111270_b0035","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S1474-4422(13)70124-8","article-title":"Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration","volume":"12","author":"Wardlaw","year":"2013","journal-title":"Lancet Neurol"},{"issue":"22","key":"10.1016\/j.jocn.2025.111270_b0040","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1056\/NEJMoa2104840","article-title":"Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination","volume":"384","author":"Greinacher","year":"2021","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.jocn.2025.111270_b0045","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.stemcr.2021.02.008","article-title":"SARS-CoV-2 infects human pluripotent stem cell-derived cardiomyocytes, impairing electrical and mechanical function","volume":"16","author":"Marchiano","year":"2021","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.jocn.2025.111270_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.anndiagpath.2020.151682","article-title":"Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein","volume":"51","author":"Nuovo","year":"2021","journal-title":"Ann Diagn Pathol"},{"key":"10.1016\/j.jocn.2025.111270_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.103104","article-title":"Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology","volume":"61","author":"Bussani","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.jocn.2025.111270_b0060","unstructured":"National Institutes of Health. Consideration of Sex as a Biological Variable in NIH-funded Research. 2015. Report No.: NIH Guide Notice NOT-OD-15-102."},{"issue":"1","key":"10.1016\/j.jocn.2025.111270_b0065","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/trstmh\/tru167","article-title":"Sex-based differences in immune function and responses to vaccination","volume":"109","author":"Klein","year":"2015","journal-title":"Trans R Soc Trop Med Hyg"}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586825002425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586825002425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T11:17:09Z","timestamp":1747135029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0967586825002425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":13,"alternative-id":["S0967586825002425"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2025.111270","relation":{},"ISSN":["0967-5868"],"issn-type":[{"value":"0967-5868","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Critical appraisal of: \u201cexpression of SARS-CoV-2 spike protein in cerebral arteries: implications for hemorrhagic stroke post-mRNA vaccination\u201d","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocn.2025.111270","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"111270"}}