{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:40:37Z","timestamp":1776688837391,"version":"3.51.2"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jocn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.jocn.2026.112017","type":"journal-article","created":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T23:20:38Z","timestamp":1775690438000},"page":"112017","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Interaction of basal ganglia infarction with bridging therapy vs mechanical thrombectomy on parenchymal hemorrhage: A secondary analysis of the DIRECT-MT trial"],"prefix":"10.1016","volume":"149","author":[{"given":"Rundong","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weilong","family":"Hua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meihua","family":"Huyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yilei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianmin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.jocn.2026.112017_b0005","doi-asserted-by":"crossref","first-page":"6021","DOI":"10.1097\/MS9.0000000000001385","article-title":"Mechanical thrombectomy for AIS from large vessel occlusion - current trends and future perspectives [J]","volume":"85","author":"Parvathy","year":"2023","journal-title":"Ann Med Surg (Lond)"},{"key":"10.1016\/j.jocn.2026.112017_b0010","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.703258","article-title":"Hemorrhagic transformation after ischemic stroke: Mechanisms and Management [J]","volume":"12","author":"Hong","year":"2021","journal-title":"Front Neurol"},{"key":"10.1016\/j.jocn.2026.112017_b0015","doi-asserted-by":"crossref","DOI":"10.1136\/jnis-2024-022323","article-title":"Association between basal ganglia infarction and hemorrhagic transformation after mechanical thrombectomy in acute ischemic stroke: insights from the DIRECT-MT trial [J]","author":"Chen","year":"2025","journal-title":"J Neurointerv Surg"},{"issue":"23","key":"10.1016\/j.jocn.2026.112017_b0020","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.121.022303","article-title":"Intravenous thrombolysis before mechanical thrombectomy for acute ischemic stroke: a meta-analysis [J]","volume":"10","author":"Du","year":"2021","journal-title":"J Am Heart Assoc"},{"issue":"7","key":"10.1016\/j.jocn.2026.112017_b0025","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1007\/s00415-016-8339-1","article-title":"The impact of cerebral microbleeds on intracerebral hemorrhage and poor functional outcome of acute ischemic stroke patients treated with intravenous thrombolysis: a systematic review and meta-analysis [J]","volume":"264","author":"Wang","year":"2017","journal-title":"J Neurol"},{"issue":"21","key":"10.1016\/j.jocn.2026.112017_b0030","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1056\/NEJMoa2001123","article-title":"Endovascular thrombectomy with or without intravenous alteplase in acute stroke [J]","volume":"382","author":"Yang","year":"2020","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.jocn.2026.112017_b0035","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1177\/1747493019882837","article-title":"Direct Intra-arterial thrombectomy in order to Revascularize AIS patients with large vessel occlusion Efficiently in Chinese Tertiary hospitals: a Multicenter randomized clinical Trial (DIRECT-MT)-Protocol [J]","volume":"15","author":"Yang","year":"2020","journal-title":"Int J Stroke"},{"issue":"1","key":"10.1016\/j.jocn.2026.112017_b0040","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3174\/ajnr.A7733","article-title":"FLAIR vascular hyperintensities as a surrogate of collaterals in acute stroke: DWI matters [J]","volume":"44","author":"Legrand","year":"2023","journal-title":"AJNR Am J Neuroradiol"},{"issue":"10","key":"10.1016\/j.jocn.2026.112017_b0045","doi-asserted-by":"crossref","first-page":"2981","DOI":"10.1161\/STROKEAHA.115.010049","article-title":"The Heidelberg bleeding classification: classification of bleeding events after ischemic stroke and reperfusion therapy [J]","volume":"46","author":"von Kummer","year":"2015","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.jocn.2026.112017_b0050","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1161\/STROKEAHA.116.015434","article-title":"Using the National Institutes of Health Stroke Scale [J]","volume":"48","author":"Lyden","year":"2017","journal-title":"Stroke"},{"issue":"9","key":"10.1016\/j.jocn.2026.112017_b0055","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1161\/STROKEAHA.121.034480","article-title":"Standardized nomenclature for modified rankin scale global disability outcomes: consensus recommendations from stroke therapy academic industry roundtable XI [J]","volume":"52","author":"Saver","year":"2021","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.jocn.2026.112017_b0060","doi-asserted-by":"crossref","first-page":"525","DOI":"10.3174\/ajnr.A1408","article-title":"CT angiography clot burden score and collateral score: correlation with clinical and radiologic outcomes in acute middle cerebral artery infarct [J]","volume":"30","author":"Tan","year":"2009","journal-title":"AJNR Am J Neuroradiol"},{"issue":"12","key":"10.1016\/j.jocn.2026.112017_b0065","doi-asserted-by":"crossref","first-page":"e344","DOI":"10.1161\/STR.0000000000000211","volume":"50","author":"Powers","year":"2019","journal-title":"Stroke"},{"issue":"10406","key":"10.1016\/j.jocn.2026.112017_b0070","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0140-6736(23)01142-X","article-title":"Value of intravenous thrombolysis in endovascular treatment for large-vessel anterior circulation stroke: individual participant data meta-analysis of six randomised trials [J]","volume":"402","author":"Majoie","year":"2023","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.jocn.2026.112017_b0075","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1001\/jama.2024.0589","article-title":"Time to treatment with intravenous thrombolysis before thrombectomy and functional outcomes in acute ischemic stroke: a meta-analysis [J]","volume":"331","author":"Kaesmacher","year":"2024","journal-title":"J Am Med Assoc"},{"issue":"3","key":"10.1016\/j.jocn.2026.112017_b0080","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1161\/STROKEAHA.120.030508","article-title":"Bridging may increase the risk of symptomatic intracranial hemorrhage in thrombectomy patients with low Alberta stroke program early computed tomography score [J]","volume":"52","author":"Kaesmacher","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.jocn.2026.112017_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-510X(00)00386-5","article-title":"Brain ischemia and reperfusion: molecular mechanisms of neuronal injury [J]","volume":"179","author":"White","year":"2000","journal-title":"J Neurol Sci"},{"key":"10.1016\/j.jocn.2026.112017_b0090","article-title":"Small-vessel disease in the brain [J]","volume":"27","author":"Singh","year":"2023","journal-title":"Am Heart J Plus"},{"issue":"1","key":"10.1016\/j.jocn.2026.112017_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2024.e00516","article-title":"Blood-brain barrier breakdown in brain ischemia: Insights from MRI perfusion imaging [J]","volume":"22","author":"Sasannia","year":"2025","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.jocn.2026.112017_b0100","article-title":"Blood-brain barrier disruption and hemorrhagic transformation in acute ischemic stroke: systematic review and meta-analysis [J]","volume":"11","author":"Arba","year":"2020","journal-title":"Front Neurol"},{"key":"10.1016\/j.jocn.2026.112017_b0105","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/bs.apha.2017.08.002","article-title":"Matrix metalloproteinases, vascular remodeling, and vascular disease [J]","volume":"81","author":"Wang","year":"2018","journal-title":"Adv Pharmacol"},{"issue":"1","key":"10.1016\/j.jocn.2026.112017_b0110","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.jstrokecerebrovasdis.2009.10.008","article-title":"Matrix metalloproteinase-9 as a marker for acute ischemic stroke: a systematic review [J]","volume":"20","author":"Ramos-Fernandez","year":"2011","journal-title":"J Stroke Cerebrovasc Dis"},{"issue":"13","key":"10.1016\/j.jocn.2026.112017_b0115","doi-asserted-by":"crossref","first-page":"e1361","DOI":"10.1212\/WNL.0000000000200029","article-title":"Mechanical thrombectomy vs bridging therapy for anterior circulation large vessel occlusion stroke: systematic review and meta-analysis [J]","volume":"98","author":"Trifan","year":"2022","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.jocn.2026.112017_b0120","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1161\/STR.0000000000000375","article-title":"2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association\/American Stroke Association [J]","volume":"52","author":"Kleindorfer","year":"2021","journal-title":"Stroke"},{"issue":"2","key":"10.1016\/j.jocn.2026.112017_b0125","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1056\/NEJMoa2503867","article-title":"Intravenous tenecteplase before thrombectomy in stroke [J]","volume":"393","author":"Qiu","year":"2025","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.jocn.2026.112017_b0130","doi-asserted-by":"crossref","first-page":"3928","DOI":"10.1007\/s00415-024-12445-7","article-title":"Efficacy and safety of intravenous tenecteplase compared to alteplase before mechanical thrombectomy in acute ischemic stroke: a meta-analysis [J]","volume":"271","author":"Wu","year":"2024","journal-title":"J Neurol"},{"issue":"1","key":"10.1016\/j.jocn.2026.112017_b0135","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1177\/23969873221150022","article-title":"European Stroke Organisation (ESO) expedited recommendation on tenecteplase for acute ischaemic stroke [J]","volume":"8","author":"Alamowitch","year":"2023","journal-title":"Eur Stroke J"}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586826001682?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0967586826001682?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T11:49:06Z","timestamp":1776685746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0967586826001682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":27,"alternative-id":["S0967586826001682"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2026.112017","relation":{},"ISSN":["0967-5868"],"issn-type":[{"value":"0967-5868","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interaction of basal ganglia infarction with bridging therapy vs mechanical thrombectomy on parenchymal hemorrhage: A secondary analysis of the DIRECT-MT trial","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocn.2026.112017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112017"}}