{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T06:40:50Z","timestamp":1792219250978,"version":"4.4.0"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jocn-journal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Clinical Neuroscience"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.jocn.2026.112322","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:12:16Z","timestamp":1792167136000},"page":"112322","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Rethinking the limits: SRS for \u226520 brain metastases with favorable brain and hippocampal doses"],"prefix":"10.1016","volume":"155","author":[{"given":"Alexander","family":"Ho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poonam","family":"Yadav","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Sonabend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Tate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Chandler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej S.","family":"Lesniak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Sita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Kalapurakal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Sachdev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.jocn.2026.112322_b0005","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S1470-2045(09)70263-3","article-title":"Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: a randomised controlled trial","volume":"10","author":"Chang","year":"2009","journal-title":"Lancet Oncol"},{"issue":"1","key":"10.1016\/j.jocn.2026.112322_b0010","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1200\/JCO.2011.41.0639","volume":"31","author":"Soffietti","year":"2013","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.jocn.2026.112322_b0015","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/neuonc\/noae201","article-title":"Stereotactic radiosurgery for 1-10 brain metastases to avoid whole-brain radiotherapy: results of the CYBER-SPACE randomized phase 2 trial","volume":"27","author":"El Shafie","year":"2025","journal-title":"Neuro Oncol"},{"issue":"4","key":"10.1016\/j.jocn.2026.112322_b0020","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1001\/jama.2016.9839","article-title":"Effect of Radiosurgery Alone vs Radiosurgery with whole Brain Radiation Therapy on Cognitive Function in patients with 1 to 3 Brain Metastases: a Randomized Clinical Trial","volume":"316","author":"Brown","year":"2016","journal-title":"J Am Med Assoc"},{"issue":"4","key":"10.1016\/j.jocn.2026.112322_b0025","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1470-2045(14)70061-0","article-title":"Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study","volume":"15","author":"Yamamoto","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.jocn.2026.112322_b0030","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1159\/000493056","article-title":"Stereotactic Radiosurgery for patients with 10 or more Brain Metastases","volume":"34","author":"Yamamoto","year":"2019","journal-title":"Prog Neurol Surg"},{"issue":"5","key":"10.1016\/j.jocn.2026.112322_b0035","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.ijrobp.2019.03.052","article-title":"Initial SRS for patients with 5 to 15 Brain Metastases: results of a Multi-institutional Experience","volume":"104","author":"Hughes","year":"2019","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jocn.2026.112322_b0040","doi-asserted-by":"crossref","first-page":"e380","DOI":"10.1016\/j.wneu.2022.06.057","article-title":"Mean Brain Dose remains Uninfluenced by the Lesion Number for Gamma Knife Stereotactic Radiosurgery for 10+ Metastases","volume":"165","author":"Sita","year":"2022","journal-title":"World Neurosurg"},{"issue":"16_suppl","key":"10.1016\/j.jocn.2026.112322_b0045","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1200\/JCO.2025.43.16_suppl.2011","article-title":"Stereotactic radiation versus hippocampal avoidance whole brain radiation in patients with 5-20 brain metastases: a multicenter, phase 3 randomized trial","volume":"43","author":"Aizer","year":"2025","journal-title":"J Clin Oncol"},{"issue":"4","key":"10.1016\/j.jocn.2026.112322_b0050","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1227\/neu.0000000000002482","article-title":"Single-session Gamma Knife Radiosurgery for patients with 20 or more Brain Metastases","volume":"93","author":"Wei","year":"2023","journal-title":"Neurosurgery"},{"issue":"1","key":"10.1016\/j.jocn.2026.112322_b0055","article-title":"Is Gamma Knife surgery, omitting adjunct whole brain radiation treatment, feasible for patients with 20 or more brain metastases?","volume":"6","author":"Jiani","year":"2024","journal-title":"Neurooncol Adv"},{"issue":"4","key":"10.1016\/j.jocn.2026.112322_b0060","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1016\/j.ijrobp.2010.01.039","article-title":"Hippocampal-sparing whole-brain radiotherapy: a \u201chow-to\u201d technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapy","volume":"78","author":"Gondi","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.jocn.2026.112322_b0065","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S0360-3016(03)00568-6","article-title":"Analysis of tumor control and toxicity in patients who have survived at least one year after radiosurgery for brain metastases","volume":"57","author":"Varlotto","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"2","key":"10.1016\/j.jocn.2026.112322_b0070","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.ijrobp.2005.07.980","article-title":"12 Gy gamma knife radiosurgical volume is a predictor for radiation necrosis in non-AVM intracranial tumors","volume":"64","author":"Korytko","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jocn.2026.112322_b0075","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.wneu.2016.04.089","article-title":"Does Modern Management of Malignant Extracranial Disease Prolong Survival in patients with \u22653 Brain Metastases?","volume":"92","author":"Karlsson","year":"2016","journal-title":"World Neurosurg"},{"issue":"3 Suppl","key":"10.1016\/j.jocn.2026.112322_b0080","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.1016\/j.ijrobp.2009.02.091","article-title":"Radiation dose-volume effects in the brain","volume":"76","author":"Lawrence","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.jocn.2026.112322_b0085","unstructured":"A Prospective Phase III Randomized Trial to Compare Stereotactic Radiosurgery vs. Whole Brain Radiation Therapy for >\/= 4 Newly Diagnosed Non-Melanoma Brain Metastases, I. National Cancer, Editor. 2012."},{"key":"10.1016\/j.jocn.2026.112322_b0090","unstructured":"A Phase III Trial of Stereotactic Radiosurgery Compared With Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) Plus Memantine for 5 or More Brain Metastases, O. Alliance for Clinical Trials in and N.R.G. Oncology, Editors. 2018."}],"container-title":["Journal of Clinical Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096758682600473X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096758682600473X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:50:07Z","timestamp":1792216207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096758682600473X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":18,"alternative-id":["S096758682600473X"],"URL":"https:\/\/doi.org\/10.1016\/j.jocn.2026.112322","relation":{},"ISSN":["0967-5868"],"issn-type":[{"value":"0967-5868","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rethinking the limits: SRS for \u226520 brain metastases with favorable brain and hippocampal doses","name":"articletitle","label":"Article Title"},{"value":"Journal of Clinical Neuroscience","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.jocn.2026.112322","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"112322"}}