{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:37:04Z","timestamp":1790627824512,"version":"4.1.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,13]],"date-time":"2019-08-13T00:00:00Z","timestamp":1565654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1]]},"abstract":"\n Purpose:<\/jats:title>\n To evaluate the effect of preoperative 0.09% bromfenac ophthalmic solution for the reduction of intraoperative miosis and pain in patients who have undergone femtosecond laser-assisted cataract surgery.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n This prospective randomized clinical study included 65 patients with senile cataracts in the absence of significant ocular comorbidity. The patients received 0.09% bromfenac ophthalmic solution or control placebo twice a day for 3 days before surgery. Pupil diameter was measured at the initiation and finalization of femtosecond laser-assisted cataract surgery, and pain quantification was assessed by an analogous pain scale after one day of follow-up.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n A total of 65 patients were randomly divided into two groups. Five patients were excluded due to defective coupling with the laser interface. Each of the 60 patients was randomized to receive preoperative topical treatment with either 0.09% bromfenac or 0.1% sodium hyaluronate. Baseline characteristics were similar between groups for age and gender. The mean change in horizontal and vertical pupil diameter from the preoperative to post-femtosecond laser measurements were significantly less in the bromfenac group than in the placebo group (0.43 \u00b1 0.6 vs. 1.71 \u00b1 0.9,\n P<\/jats:italic>\n < 0.001 and 0.40 \u00b1 0.6 vs. 1.78 \u00b1 0.9,\n P<\/jats:italic>\n < 0.001, respectively). Compared with untreated patients, the quantification of pain one day after the procedure was significantly lower in the 0.09% bromfenac group (46.7% with a score of 3 vs. 50% with a score of 1,\n P<\/jats:italic>\n < 0.001, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n The maintenance of pupil dilation and the prevention of miosis were more effective in the 0.09% bromfenac group than in the control group. Likewise, the greater control of postoperative pain represented an additional significant benefit.<\/jats:p>\n <\/jats:sec>","DOI":"10.1016\/j.joco.2019.07.007","type":"journal-article","created":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T16:32:10Z","timestamp":1568651530000},"page":"32-37","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Topical Bromfenac Sodium in Femtosecond Laser-Assisted Cataract Surgery"],"prefix":"10.4103","volume":"32","author":[{"given":"Mar\u00eda Camila","family":"Aguilar Sierra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Alvarado-Villacorta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia Palacio","family":"Pastrana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20240910","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0149-2918(00)88323-X","article-title":"Efficacy and safety profile of ketorolac 0.5% ophthalmic solution in the prevention of surgically induced miosis during cataract surgery","volume":"21","author":"Stewart","year":"1999","journal-title":"Clin Ther"},{"key":"R2-5-20240910","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/j.jcrs.2013.05.034","article-title":"Femtosecond laser-assisted cataract surgery in eyes with a small pupil","volume":"39","author":"Conrad-Hengerer","year":"2013","journal-title":"J Cataract Refract Surg"},{"key":"R3-5-20240910","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.jcrs.2014.10.027","article-title":"Pupil-size alterations induced by photodisruption during femtosecond laser-assisted cataract surgery","volume":"41","author":"Jun","year":"2015","journal-title":"J Cataract Refract Surg"},{"key":"R4-5-20240910","doi-asserted-by":"crossref","first-page":"e534","DOI":"10.1111\/aos.13022","article-title":"Safety of femtosecond laser-assisted cataract surgery: Assessment of aqueous humour and lens capsule","volume":"94","author":"Yu","year":"2016","journal-title":"Acta Ophthalmol"},{"key":"R5-5-20240910","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.jcrs.2013.09.002","article-title":"Femtosecond laser-assisted cataract surgery","volume":"39","author":"Donaldson","year":"2013","journal-title":"J Cataract Refract Surg"},{"key":"R6-5-20240910","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0886-3350(01)01115-4","article-title":"Topical ketorolac tromethamine 0.5% versus diclofenac sodium 0.1% to inhibit miosis during cataract surgery","volume":"28","author":"Srinivasan","year":"2002","journal-title":"J Cataract Refract 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surgery","volume":"10","author":"Sharma","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"R10-5-20240910","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/j.ophtha.2006.12.029","article-title":"Bromfenac ophthalmic solution 0.09% (Xibrom) for postoperative ocular pain and inflammation","volume":"114","author":"Donnenfeld","year":"2007","journal-title":"Ophthalmology"},{"key":"R11-5-20240910","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1177\/1060028015574593","article-title":"Comparing the efficacy of ophthalmic NSAIDs in common indications: A literature review to support costeffective prescribing","volume":"49","author":"Wilson","year":"2015","journal-title":"Ann Pharmacother"},{"key":"R12-5-20240910","first-page":"6072","article-title":"Cataract surgery and nonsteroidal antiinflammatory drugs","volume":"118","author":"Riaz","year":"2016","journal-title":"J Cataract Refract 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