{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T01:41:53Z","timestamp":1790905313478,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1016\/j.joen.2006.12.020","type":"journal-article","created":{"date-parts":[[2007,3,21]],"date-time":"2007-03-21T06:52:47Z","timestamp":1174459967000},"page":"447-450","source":"Crossref","is-referenced-by-count":43,"title":["Effect of Mineral Trioxide Aggregate Cements on Transforming Growth Factor \u03b21 and Bone Morphogenetic Protein Production by Human Fibroblasts In Vitro"],"prefix":"10.1016","volume":"33","author":[{"given":"Gunseli","family":"Guven","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zafer C.","family":"Cehreli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Ural","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhittin A.","family":"Serdar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feridun","family":"Basak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2006.12.020_bib1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/S0099-2399(06)80271-2","article-title":"Sealing ability of a mineral trioxide aggregate when used as a root end filling material","volume":"19","author":"Torabinejad","year":"1993","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2006.12.020_bib2","first-page":"85","article-title":"Clinical and histological evaluation of white ProRoot MTA in direct pulp capping","volume":"19","author":"Iwamoto","year":"2006","journal-title":"Am J Dent"},{"key":"10.1016\/j.joen.2006.12.020_bib3","first-page":"248","article-title":"Comparison of apexification with mineral trioxide aggregate and calcium hydroxide","volume":"28","author":"El-Meligy","year":"2006","journal-title":"Pediatr Dent"},{"key":"10.1016\/j.joen.2006.12.020_bib4","first-page":"15","article-title":"Mineral trioxide aggregate vs. formocresol in pulpotomized primary molars: a preliminary report","volume":"23","author":"Eidelman","year":"2001","journal-title":"Pediatr Dent"},{"key":"10.1016\/j.joen.2006.12.020_bib5","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/00004770-200402000-00004","article-title":"Repair of root perforations using mineral trioxide aggregate: a long-term study","volume":"30","author":"Main","year":"2004","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2006.12.020_bib6","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1002\/(SICI)1097-4636(19971205)37:3<432::AID-JBM14>3.0.CO;2-D","article-title":"Mineral trioxide aggregate stimulates a biological response in human osteoblasts","volume":"37","author":"Koh","year":"1997","journal-title":"J Biomed Mater Res"},{"key":"10.1016\/j.joen.2006.12.020_bib7","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0142-9612(98)00157-4","article-title":"Osteoblast biocompatibility of mineral trioxide aggregate","volume":"20","author":"Mitchell","year":"1999","journal-title":"Biomaterials"},{"key":"10.1016\/j.joen.2006.12.020_bib8","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/01.don.0000153842.06657.e2","article-title":"Biocompatibility in vitro tests of mineral trioxide aggregate and regular and white Portland cements","volume":"31","author":"Ribeiro","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2006.12.020_bib9","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.joen.2006.03.019","article-title":"Human alveolar bone cells interact with ProRoot and tooth-colored MTA","volume":"32","author":"Al-Rabeah","year":"2006","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2006.12.020_bib10","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.joen.2005.10.036","article-title":"Effects of gray and white mineral trioxide aggregate on the proliferation of oral keratinocytes and cementoblasts","volume":"32","author":"Oviir","year":"2006","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2006.12.020_bib11","doi-asserted-by":"crossref","first-page":"967","DOI":"10.14219\/jada.archive.1999.0337","article-title":"Mineral trioxide aggregate: a new material for endodontics","volume":"130","author":"Schwartz","year":"1999","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2006.12.020_bib12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/01.don.0000140584.65320.cc","article-title":"Preliminary evaluation of BMP-2 expression and histological characteristics during apexification with calcium hydroxide and mineral trioxide aggregate","volume":"31","author":"Ham","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2006.12.020_bib13","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1101\/gad.8.2.133","article-title":"The TGF-\u03b2 superfamily: new members, new receptors, and new genetic tests of function in different organisms","volume":"8","author":"Kingsley","year":"1994","journal-title":"Genes Dev"},{"key":"10.1016\/j.joen.2006.12.020_bib14","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/0955-0674(92)90110-X","article-title":"Regulation of cartilage and bone differentiation by bone morphogenetic proteins","volume":"4","author":"Reddi","year":"1992","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.joen.2006.12.020_bib15","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1359-6101(96)00049-4","article-title":"Bone morphogenetic proteins: an unconventional approach to isolation of first mammalian morphogens","volume":"8","author":"Reddi","year":"1997","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.joen.2006.12.020_bib16","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/10454411970080020401","article-title":"Tissue engineering, morphogenesis and regeneration of the periodontal tissues by morphogenetic proteins","volume":"8","author":"Ripamonti","year":"1997","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.joen.2006.12.020_bib17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1902\/jop.1995.66.2.131","article-title":"Periodontal repair in dogs: recombinant human bone morphogenetic protein-2 significantly enhances periodontal regeneration","volume":"66","author":"Sigurdsson","year":"1995","journal-title":"J Periodontol"},{"key":"10.1016\/j.joen.2006.12.020_bib18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1006\/dbio.1994.1063","article-title":"Regulatory role of transforming growth factor-beta, bone morphogenetic protein-2, and protein-4 on gene expression of extracellular matrix proteins and differentiation of dental pulp cells","volume":"162","author":"Nakashima","year":"1994","journal-title":"Dev Biol"},{"key":"10.1016\/j.joen.2006.12.020_bib19","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/jcb.1200","article-title":"Regulation of osteoclastogenesis and RANK expression by TGF-beta1","volume":"83","author":"Yan","year":"2001","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.joen.2006.12.020_bib20","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1172\/JCI117738","article-title":"Regulation of human bone marrow-derived osteoprogenitor cells by osteogenic growth factors","volume":"95","author":"Long","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.joen.2006.12.020_bib21","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/jcp.1041600214","article-title":"TGF-\u03b2 alters growth and differentiation related gene expression in proliferating osteoblasts in vitro, preventing development of the mature bone phenotype","volume":"160","author":"Breen","year":"1994","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.joen.2006.12.020_bib22","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S8756-3282(01)00580-4","article-title":"Opposite effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on osteoblast differentiation","volume":"29","author":"Spinella-Jaegle","year":"2001","journal-title":"Bone"},{"key":"10.1016\/j.joen.2006.12.020_bib23","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1365-2591.2005.01043.x","article-title":"Ex vivo biocompatibility tests of regular and white forms of mineral trioxide aggregate","volume":"39","author":"Ribeiro","year":"2006","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2006.12.020_bib24","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1046\/j.0143-2885.2003.00611.x","article-title":"Short-term periradicular tissue response to mineral trioxide aggregate (MTA) as root-end filling material","volume":"36","author":"Economides","year":"2003","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2006.12.020_bib25","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1177\/154405910408300511","article-title":"Root-end Filling materials alter fibroblast differentiation","volume":"83","author":"Bonson","year":"2004","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2006.12.020_bib26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1034\/j.1600-0757.2000.2240105.x","article-title":"Molecular and cell biology of cementum","volume":"24","author":"Saygin","year":"2000","journal-title":"Periodontology"},{"key":"10.1016\/j.joen.2006.12.020_bib27","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/j.1365-2591.2005.01028.x","article-title":"The chemical constitution and biocompatibility of accelerated Portland cement for endodontic use","volume":"38","author":"Camilleri","year":"2005","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2006.12.020_bib28","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/BF02983818","article-title":"The biphosphonate zoledronic acid induces cytotoxicity in human myeloma cell lines with enhancing effect of dexamethasone and thalidomide","volume":"78","author":"Ural","year":"2003","journal-title":"Int J Hematol"},{"key":"10.1016\/j.joen.2006.12.020_bib29","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1067\/moe.2003.231","article-title":"Effects of root-end filling materials on fibroblasts and macrophages in vitro","volume":"95","author":"Haglund","year":"2003","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2006.12.020_bib30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00441-006-0282-5","article-title":"Use of microarrays to find novel regulators of periodontal ligament fibroblast differentiation","volume":"327","author":"Lallier","year":"2007","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.joen.2006.12.020_bib31","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1177\/154405910508400605","article-title":"Enamel matrix derivative gel stimulates signal transduction of BMP and TGF-{beta}","volume":"84","author":"Suzuki","year":"2005","journal-title":"J Dent Res"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239906012349?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239906012349?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T13:22:23Z","timestamp":1546953743000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239906012349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0099239906012349"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2006.12.020","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]}}}