{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T11:22:55Z","timestamp":1769167375346,"version":"3.49.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.joen.2007.06.017","type":"journal-article","created":{"date-parts":[[2007,8,18]],"date-time":"2007-08-18T11:16:34Z","timestamp":1187435794000},"page":"1208-1211","source":"Crossref","is-referenced-by-count":8,"title":["Iontophoresis Significantly Increases the Trans-dentinal Delivery of Osteoprotegerin, Alendronate, and Calcitonin"],"prefix":"10.1016","volume":"33","author":[{"given":"James A.","family":"Kitchens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott A.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William G.","family":"Schindler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth M.","family":"Hargreaves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2007.06.017_bib1","first-page":"27","article-title":"Clinical, radiologic, and histopathologic features of invasive cervical resorption","volume":"30","author":"Heithersay","year":"1999","journal-title":"Quintessence Int"},{"key":"10.1016\/j.joen.2007.06.017_bib2","first-page":"83","article-title":"Invasive cervical resorption: an analysis of potential predisposing factors","volume":"30","author":"Heithersay","year":"1999","journal-title":"Quintessence Int"},{"key":"10.1016\/j.joen.2007.06.017_bib3","first-page":"96","article-title":"Treatment of invasive cervical resorption: an analysis of results using topical application of trichloroacetic acid, curettage, and restoration","volume":"30","author":"Heithersay","year":"1999","journal-title":"Quintessence Int"},{"issue":"Suppl 4","key":"10.1016\/j.joen.2007.06.017_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1634\/theoncologist.9-90004-3","article-title":"Bisphosphonates: preclinical review","volume":"9","author":"Green","year":"2004","journal-title":"Oncologist"},{"key":"10.1016\/j.joen.2007.06.017_bib5","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1002\/jbmr.5650101008","article-title":"Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo","volume":"10;","author":"Hughes","year":"1995","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joen.2007.06.017_bib6","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.joen.2007.06.017_bib7","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0092-8674(00)80209-3","article-title":"Osteoprotegerin: a novel secreted protein involved in the regulation of bone density","volume":"89","author":"Simonet","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.joen.2007.06.017_bib8","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1359\/jbmr.1999.14.9.1478","article-title":"A chimeric form of osteoprotegerin inhibits hypercalcemia and bone resorption induced by IL-1\u03b2, TNF-\u03b1, PTH, PTHrP, and 1,25(OH)2D3","volume":"14","author":"Morony","year":"1999","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.joen.2007.06.017_bib9","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1056\/NEJMoa050893","article-title":"Recombinant osteoprotegerin for juvenile Paget\u2019s disease","volume":"353","author":"Cundy","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.joen.2007.06.017_bib10","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1210\/en.139.3.1329","article-title":"Identity of osteoclastogenesis inhibitory factor (OCIF) and osteoprotegerin (OPG): a mechanism by which OPG\/OCIF inhibits osteoclastogenesis in vitro","volume":"139","author":"Yasuda","year":"1998","journal-title":"Endocrinology"},{"key":"10.1016\/j.joen.2007.06.017_bib11","series-title":"Principles of bone biology","first-page":"1423","article-title":"Molecular and clinical pharmacology of calcitonin","author":"Zaidi","year":"2002"},{"key":"10.1016\/j.joen.2007.06.017_bib12","first-page":"17","article-title":"Iontophoresis in dental practice","author":"Gangarosa","year":"1983"},{"key":"10.1016\/j.joen.2007.06.017_bib13","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1600-9657.2005.00308.x","article-title":"Dentinal pH changes following electrophoretically activated calcium hydroxide ions in the root canal space of bovine teeth","volume":"21","author":"Tsesis","year":"2005","journal-title":"Dent Traumatol"},{"key":"10.1016\/j.joen.2007.06.017_bib14","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1177\/00220345740530064101","article-title":"A versatile split-chamber device for studying dentin permeability","volume":"53","author":"Outhwaite","year":"1974","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2007.06.017_bib15","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0003-9969(78)90098-5","article-title":"Effect of molecular size on permeability coefficients in human dentine","volume":"23","author":"Pashley","year":"1978","journal-title":"Arch Oral Biol"},{"key":"10.1016\/j.joen.2007.06.017_bib16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0021-9258(19)68322-5","article-title":"Direct linkage of [125I]-EGF to cell surface receptors","volume":"257","author":"Comens","year":"1982","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joen.2007.06.017_bib17","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1177\/00220345830620111601","article-title":"Plasma \u00df-endorphin-like immunoreactivity, pain and anxiety following administration of placebo in oral surgery patients","volume":"62","author":"Hargreaves","year":"1983","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2007.06.017_bib18","first-page":"275","article-title":"Design of experiments: statistical principles of research design and analysis","author":"Kuehl","year":"1999"},{"key":"10.1016\/j.joen.2007.06.017_bib19","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/BF02547227","article-title":"The binding of pyrophosphate and two diphosphonates by hydroxyapatite crystals","volume":"11","author":"Jung","year":"1973","journal-title":"Calcif Tissue Res"},{"key":"10.1016\/j.joen.2007.06.017_bib20","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1902\/jop.2005.76.7.1106","article-title":"A scanning electron microscopy study of idiopathic external tooth resorption in the cat","volume":"76","author":"DeLaurler","year":"2005","journal-title":"J Periodontol"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239907005936?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239907005936?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T13:12:48Z","timestamp":1708175568000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239907005936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":20,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0099239907005936"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2007.06.017","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}