{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:30:10Z","timestamp":1791891010111,"version":"4.3.4"},"reference-count":26,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.joen.2007.12.005","type":"journal-article","created":{"date-parts":[[2008,2,20]],"date-time":"2008-02-20T07:38:45Z","timestamp":1203493125000},"page":"280-283","source":"Crossref","is-referenced-by-count":32,"title":["The Efficacy of IntraFlow Intraosseous Injection as a Primary Anesthesia Technique"],"prefix":"10.1016","volume":"34","author":[{"given":"Todd","family":"Remmers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Glickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Spears","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2007.12.005_bib1","series-title":"Handbook of Local Anesthesia","author":"Malamed","year":"2004"},{"key":"10.1016\/j.joen.2007.12.005_bib2","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0099-2399(98)80053-8","article-title":"Anesthetic efficacy of the supplemental intraosseous injection of 2% lidocaine with 1:100,000 epinephrine in irreversible pulpitis","volume":"24","author":"Nusstein","year":"1998","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2007.12.005_bib3","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S1079-2104(97)90372-3","article-title":"Anesthetic efficacy of the supplemental intraosseous injection of 3% mepivacaine in irreversible pulpitis","volume":"84","author":"Reisman","year":"1997","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2007.12.005_bib4","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0099-2399(06)81366-X","article-title":"Endodontic anesthesia in mandibular molars: a clinical study","volume":"19","author":"Cohen","year":"1993","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2007.12.005_bib5","first-page":"372","article-title":"Anesthetic efficacy of different volumes of lidocaine with epinephrine for inferior alveolar nerve blocks","volume":"50","author":"Nusstein","year":"2002","journal-title":"Gen Dent"},{"key":"10.1016\/j.joen.2007.12.005_bib6","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/00004770-200310000-00004","article-title":"The significance of needle deflection in success of the inferior alveolar nerve block in patients with irreversible pulpitis","volume":"29","author":"Kennedy","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2007.12.005_bib7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.14219\/jada.archive.1992.0004","article-title":"Reasons for local anesthesia failures","volume":"123","author":"Wong","year":"1992","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2007.12.005_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/sj.bdj.4800006","article-title":"How to overcome failed local anaesthesia","volume":"186","author":"Meechan","year":"1999","journal-title":"Br Dent J"},{"key":"10.1016\/j.joen.2007.12.005_bib9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0030-4220(85)90095-7","article-title":"A pilot study of the clinical problem of regionally anesthetizing the pulp of an acutely inflamed mandibular molar","volume":"59","author":"Wallace","year":"1985","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2007.12.005_bib10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0099-2399(06)81568-2","article-title":"Effects of injury and inflammation on pulpal and periapical nerves","volume":"16","author":"Byers","year":"1990","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2007.12.005_bib11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S1079-2104(97)90087-1","article-title":"Anesthetic efficacy of the intraosseous injection of 2% lidocaine (1:100,000 epinephrine) and 3% mepivacaine in mandibular first molars","volume":"83","author":"Replogle","year":"1997","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2007.12.005_bib12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.2344\/0003-3006(2005)52[122:ASP]2.0.CO;2","article-title":"A survey of pain, pressure, and discomfort induced by commonly used oral local anesthesia injections","volume":"52","author":"Kaufman","year":"2005","journal-title":"Anesth Prog"},{"key":"10.1016\/j.joen.2007.12.005_bib13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.14219\/jada.archive.1981.0467","article-title":"An assessment of the Gow-Gates mandibular block for third molar surgery","volume":"103","author":"Levy","year":"1981","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2007.12.005_bib14","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0030-4220(81)90001-3","article-title":"The Gow-Gates mandibular block","volume":"51","author":"Malamed","year":"1981","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1016\/j.joen.2007.12.005_bib15","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0007-117X(77)90011-7","article-title":"A new approach to the mandibular nerve block","volume":"15","author":"Akinosi","year":"1977","journal-title":"Br J Oral Surg"},{"key":"10.1016\/j.joen.2007.12.005_bib16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0278-2391(86)90192-8","article-title":"Evaluation of the Akinosi mandibular block technique in oral surgery","volume":"44","author":"Sisk","year":"1986","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.joen.2007.12.005_bib17","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0300-9785(86)80115-6","article-title":"Mandibular versus inferior dental anaesthesia: clinical assessment of 3 different techniques","volume":"15","author":"Todorovic","year":"1986","journal-title":"Int J Oral Maxillofac Surg"},{"key":"10.1016\/j.joen.2007.12.005_bib18","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.joen.2006.06.006","article-title":"Articaine for supplemental intraosseous anesthesia in patients with irreversible pulpitis","volume":"32","author":"Bigby","year":"2006","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2007.12.005_bib19","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/00004770-200311000-00010","article-title":"Anesthetic efficacy of the supplemental X-tip intraosseous injection in patients with irreversible pulpitis","volume":"29","author":"Nusstein","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2007.12.005_bib20","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1016\/S0099-2399(98)80011-3","article-title":"Anesthetic efficacy of the supplemental intraosseous injection for teeth with irreversible pulpitis","volume":"24","author":"Parente","year":"1998","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2007.12.005_bib21","first-page":"25","article-title":"A clinical evaluation of the electric pulp tester as an indicator of local anesthesia","volume":"21","author":"Certosimo","year":"1996","journal-title":"Oper Dent"},{"key":"10.1016\/j.joen.2007.12.005_bib22","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.14219\/jada.archive.2003.0077","article-title":"A comparison of two intraosseous anesthetic techniques in mandibular posterior teeth","volume":"134","author":"Gallatin","year":"2003","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2007.12.005_bib23","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/01.don.0000167395.61075.38","article-title":"A prospective, randomized, double-blind comparison of bupivacaine and lidocaine for inferior alveolar nerve blocks","volume":"31","author":"Fernandez","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2007.12.005_bib24","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/S1079-2104(96)80067-9","article-title":"Anesthetic efficacy of the intraosseous injection in maxillary and mandibular teeth","volume":"81","author":"Coggins","year":"1996","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2007.12.005_bib25","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.joen.2007.01.023","article-title":"The incidence of mechanical allodynia in patients with irreversible pulpitis","volume":"33","author":"Owatz","year":"2007","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2007.12.005_bib26","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.joen.2007.01.021","article-title":"Measurement of mechanical allodynia and local anesthetic efficacy in patients with irreversible pulpitis and acute periradicular periodontitis","volume":"33","author":"Khan","year":"2007","journal-title":"J Endod"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239907011521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239907011521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:41:53Z","timestamp":1557276113000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239907011521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":26,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0099239907011521"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2007.12.005","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]}}}