{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T13:45:27Z","timestamp":1792676727163,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T00:00:00Z","timestamp":1251763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2009,9]]},"DOI":"10.1016\/j.joen.2009.06.006","type":"journal-article","created":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T08:25:16Z","timestamp":1251793516000},"page":"1229-1233","source":"Crossref","is-referenced-by-count":39,"title":["Regulatory T Cells in Mouse Periapical Lesions"],"prefix":"10.1016","volume":"35","author":[{"given":"Emad","family":"AlShwaimi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihisa","family":"Kawai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Oukka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Campos-Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Stashenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2009.06.006_bib1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.4049\/jimmunol.155.3.1151","article-title":"Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases","volume":"155","author":"Sakaguchi","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.joen.2009.06.006_bib2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1084\/jem.184.2.387","article-title":"Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation","volume":"184","author":"Asano","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.joen.2009.06.006_bib3","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S1471-4906(02)02288-3","article-title":"Pathogen-specific regulatory T cells provoke a shift in the Th1\/Th2 paradigm in immunity to infectious diseases","volume":"23","author":"McGuirk","year":"2002","journal-title":"Trends Immunol"},{"key":"10.1016\/j.joen.2009.06.006_bib4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/ni1179","article-title":"A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3","volume":"6","author":"Fontenot","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.joen.2009.06.006_bib5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1074-7613(03)00207-3","article-title":"Foxp3 and natural regulatory T cells: key to a cell lineage?","volume":"19","author":"Ramsdell","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.joen.2009.06.006_bib6","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1084\/jem.188.2.287","article-title":"CD4 + CD25+ immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production","volume":"188","author":"Thornton","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.joen.2009.06.006_bib7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nri821","article-title":"CD4 + CD25+ suppressor T cells: more questions than answers","volume":"2","author":"Shevach","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.joen.2009.06.006_bib8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.immuni.2005.01.016","article-title":"Regulatory T cell lineage specification by the forkhead transcription factor foxp3","volume":"22","author":"Fontenot","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.joen.2009.06.006_bib9","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1177\/154405910508400711","article-title":"Regulatory T-cells infiltrate periodontal disease tissues","volume":"84","author":"Nakajima","year":"2005","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2009.06.006_bib10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.joen.2009.06.006_bib11","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni1263","article-title":"A function for interleukin 2 in Foxp3-expressing regulatory T cells","volume":"6","author":"Fontenot","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.joen.2009.06.006_bib12","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0099-2399(87)80033-X","article-title":"Identification of inflammatory cells in developing rat periapical lesions","volume":"13","author":"Yu","year":"1987","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2009.06.006_bib13","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0092-8674(03)00268-X","article-title":"A somitic compartment of tendon progenitors","volume":"113","author":"Brent","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.joen.2009.06.006_bib14","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.modgep.2007.07.002","article-title":"Expression analysis of nha-oc\/NHA2: a novel gene selectively expressed in osteoclasts","volume":"7","author":"Pham","year":"2007","journal-title":"Gene Expr Patterns"},{"key":"10.1016\/j.joen.2009.06.006_bib15","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1601-0825.2005.01191.x","article-title":"RANKL in human periapical granuloma: possible involvement in periapical bone destruction","volume":"12","author":"Vernal","year":"2006","journal-title":"Oral Dis"},{"key":"10.1016\/j.joen.2009.06.006_bib16","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1126\/science.1079490","article-title":"Control of regulatory T cell development by the transcription factor Foxp3","volume":"299","author":"Hori","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.joen.2009.06.006_bib17","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/path.1711580403","article-title":"In situ hybridization demonstration of poly-adenylated RNA sequences in formalin-fixed paraffin sections using a biotinylated oligonucleotide poly d(T) probe","volume":"158","author":"Pringle","year":"1989","journal-title":"J Pathol"},{"key":"10.1016\/j.joen.2009.06.006_bib18","first-page":"345","article-title":"Relationships between periapical lesion and IL-1, TNF-alpha gene expression in rat","volume":"38","author":"Mei","year":"2003","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"10.1016\/j.joen.2009.06.006_bib19","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1034\/j.1600-0447.2002.11227.x","article-title":"Sequential expressions of MMP-1, TIMP-1, IL-6, and COX-2 genes in induced periapical lesions in rats","volume":"110","author":"Lin","year":"2002","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2009.06.006_bib20","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0099-2399(98)80175-1","article-title":"Relative distribution of plasma cells expressing immunoglobulin G subclass mRNA in human dental periapical lesions using in situ hybridization","volume":"24","author":"Takahashi","year":"1998","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2009.06.006_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-4615-2492-2_3","article-title":"Production and selection of B lymphocytes in bone marrow: lymphostromal interactions and apoptosis in normal, mutant and transgenic mice","volume":"355","author":"Osmond","year":"1994","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.joen.2009.06.006_bib22","doi-asserted-by":"crossref","first-page":"8451","DOI":"10.1158\/0008-5472.CAN-04-1987","article-title":"Bone marrow is a reservoir for CD4 + CD25+ regulatory T cells that traffic through CXCL12\/CXCR4 signals","volume":"64","author":"Zou","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.joen.2009.06.006_bib23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0099-2399(06)80023-3","article-title":"Distribution of Ia antigen-expressing nonlymphoid cells in various stages of induced periapical lesions in rat molars","volume":"20","author":"Okiji","year":"1994","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2009.06.006_bib24","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1600-9657.1994.tb00536.x","article-title":"Immunohistochemical examination on the localization of macrophages and plasma cells in induced rat periapical lesions","volume":"10","author":"Akamine","year":"1994","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2009.06.006_bib25","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0099-2399(96)80266-4","article-title":"Kinetics of macrophages and lymphoid cells during the development of experimentally induced periapical lesions in rat molars: a quantitative immunohistochemical study","volume":"22","author":"Kawashima","year":"1996","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2009.06.006_bib26","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1067\/moe.2001.115025","article-title":"Effect of interleukin-6 deficiency on the formation of periapical lesions after pulp exposure in mice","volume":"92","author":"Huang","year":"2001","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2009.06.006_bib27","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ni1181","article-title":"Natural regulatory T cells in infectious disease","volume":"6","author":"Belkaid","year":"2005","journal-title":"Nat Immunol"},{"key":"10.1016\/j.joen.2009.06.006_bib28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nri1032","article-title":"Natural versus adaptive regulatory T cells","volume":"3","author":"Bluestone","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.joen.2009.06.006_bib29","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1056\/NEJM200010053431407","article-title":"T-cell function and migration. Two sides of the same coin","volume":"343","author":"von Andrian","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.joen.2009.06.006_bib30","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1126\/science.1155209","article-title":"Coordination of early protective immunity to viral infection by regulatory T cells","volume":"320","author":"Lund","year":"2008","journal-title":"Science"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239909005470?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239909005470?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T15:10:37Z","timestamp":1685113837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239909005470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":30,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2009,9]]}},"alternative-id":["S0099239909005470"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2009.06.006","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}