{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:27:58Z","timestamp":1790922478356,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2011,12,1]],"date-time":"2011-12-01T00:00:00Z","timestamp":1322697600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1016\/j.joen.2011.09.009","type":"journal-article","created":{"date-parts":[[2011,11,18]],"date-time":"2011-11-18T11:58:33Z","timestamp":1321617513000},"page":"1603-1607","source":"Crossref","is-referenced-by-count":79,"title":["Anesthetic Efficacy of Four Percent Articaine for Pulpal Anesthesia by Using Inferior Alveolar Nerve Block and Buccal Infiltration Techniques in Patients with Irreversible Pulpitis: A Prospective Randomized Double-blind Clinical Trial"],"prefix":"10.1016","volume":"37","author":[{"given":"Saravanan","family":"Poorni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baskaran","family":"Veniashok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayyampudur Durairaj","family":"Senthilkumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajamani","family":"Indira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sundararaman","family":"Ramachandran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2011.09.009_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/sj.bdj.4811422","article-title":"Articaine and lignocaine efficiency in infiltration anaesthesia: a pilot study","volume":"197","author":"Oliveira","year":"2004","journal-title":"Br Dent J"},{"key":"10.1016\/j.joen.2011.09.009_bib2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.14219\/jada.archive.2001.0152","article-title":"Articaine hydrochloride: a study of the safety of a new amide local anesthetic","volume":"132","author":"Malamed","year":"2001","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2011.09.009_bib3","series-title":"Handbook of Local Anesthesia","author":"Malamed","year":"1997"},{"key":"10.1016\/j.joen.2011.09.009_bib4","first-page":"307","article-title":"A comparison between articaine HCl and lidocaine HCl in pediatric dental patients","volume":"22","author":"Malamed","year":"2000","journal-title":"Pediatr Dent"},{"key":"10.1016\/j.joen.2011.09.009_bib5","unstructured":"Lipp M, Daublander M. The German experience of articaine. In: Proceedings of the international symposium on local analgesia in dentistry. London: Faculty of General Dental Practitioners, 1999:21\u20132."},{"key":"10.1016\/j.joen.2011.09.009_bib6","unstructured":"Sloss DR. Articaine in dental practice. In: Proceedings of the international symposium on local analgesia in dentistry. London: Faculty of General Dental Practitioners, 1999:23\u20134."},{"key":"10.1016\/j.joen.2011.09.009_bib7","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/01.DON.0000125317.21892.8F","article-title":"Anesthetic efficacy of articaine for inferior alveolar nerve blocks in patients with irreversible pulpitis","volume":"30","author":"Claffey","year":"2004","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.14219\/jada.archive.1984.0470","article-title":"Difficulties in achieving local anesthesia","volume":"108","author":"Kaufman","year":"1984","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2011.09.009_bib9","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1046\/j.1365-2591.2002.00592.x","article-title":"Supplementary routes to local anaesthesia","volume":"35","author":"Meechan","year":"2002","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2011.09.009_bib10","first-page":"87","article-title":"A new anesthetic in dental prosthetics","volume":"8","author":"Ferger","year":"1973","journal-title":"Dtsch Zahn\u00e4rztl Z"},{"key":"10.1016\/j.joen.2011.09.009_bib11","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.14219\/jada.archive.2007.0324","article-title":"The anesthetic efficacy of articaine in buccal infiltration of mandibular posterior teeth","volume":"138","author":"Robertson","year":"2007","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2011.09.009_bib12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.joen.2005.09.016","article-title":"Articaine and lidocaine mandibular buccal infiltration anesthesia: a prospective randomized double-blind cross-over study","volume":"32","author":"Kanaa","year":"2006","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib13","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.joen.2007.09.006","article-title":"An evaluation of buccal infiltrations and inferior alveolar nerve blocks in pulpal anesthesia for mandibular first molars","volume":"34","author":"Jung","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib14","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.tripleo.2008.09.002","article-title":"Comparison of anesthetic efficacy of 4% articaine and 2% lidocaine for maxillary buccal infiltration in patients with irreversible pulpitis","volume":"107","author":"Srinivasan","year":"2009","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib15","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.joen.2009.04.012","article-title":"Anesthetic efficacy of supplemental buccal and lingual infiltrations of articaine and lidocaine after an inferior alveolar nerve block in patients with irreversible pulpitis","volume":"35","author":"Aggarwal","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0099-2399(87)80097-3","article-title":"An evaluation of electric pulp tester as a measure of analgesia in human vital teeth","volume":"13","author":"Dreven","year":"1987","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S0099-2399(98)80053-8","article-title":"Anesthetic efficacy of supplemental intraosseous injection of 2% lidocaine with 1:100,000 epinephrine in irreversible pulpitis","volume":"24","author":"Nusstein","year":"1998","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib18","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.joen.2011.01.016","article-title":"Comparative evaluation of local infiltration of articaine, articaine plus ketorolac, and dexamethasone on anesthetic efficacy of inferior alveolar nerve block with lidocaine in patients with irreversible pulpitis","volume":"37","author":"Aggarwal","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib19","doi-asserted-by":"crossref","first-page":"635","DOI":"10.14219\/jada.archive.2000.0237","article-title":"Efficacy of articaine: a new amide local anesthetic","volume":"131","author":"Malamed","year":"2000","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.joen.2011.09.009_bib20","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/S0022-3565(25)31457-6","article-title":"The rates of interaction of local anesthetics with sodium channels in nerve","volume":"207","author":"Courtney","year":"1978","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.joen.2011.09.009_bib21","first-page":"152","article-title":"Analytical investigations with the local anesthetic ultracain (HOE 045) (author\u2019s translation)","volume":"9","author":"Uihlein","year":"1974","journal-title":"Prakt Anaesth"},{"key":"10.1016\/j.joen.2011.09.009_bib22","first-page":"230","article-title":"Comparison of articaine and prilocaine anesthesia by infiltration in maxillary and mandibular arches","volume":"37","author":"Hass","year":"1990","journal-title":"Anesth Prog"},{"key":"10.1016\/j.joen.2011.09.009_bib23","first-page":"114","article-title":"Articaine and lidocaine for maxillary infiltration anaesthesia","volume":"40","author":"Vahatalo","year":"1993","journal-title":"Anesth Prog"},{"key":"10.1016\/j.joen.2011.09.009_bib24","first-page":"38","article-title":"Lack of differential effect by Ultracaine DS (articaine HCl) and Citanest forte (prilocaine HCl) in maxillary infiltration and mandibular nerve block","volume":"53","author":"Hass","year":"1987","journal-title":"J Can Dent Assoc"},{"key":"10.1016\/j.joen.2011.09.009_bib25","first-page":"278","article-title":"The effectiveness of infiltration anesthesia in the mandibular primary molar region","volume":"13","author":"Wright","year":"1991","journal-title":"Pediatr Dent"},{"key":"10.1016\/j.joen.2011.09.009_bib26","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.joen.2010.12.007","article-title":"Anesthetic efficacy of 4% articaine with 1:100,000 epinephrine versus 4% articaine with 1:200,000 epinephrine as a primary buccal infiltration in the mandibular first molar","volume":"37","author":"McEntire","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib27","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.joen.2011.01.001","article-title":"Anesthetic efficacy of 1.8 mL versus 3.6 mL of 4% articaine with 1:100,000 epinephrine as a primary buccal infiltration of the mandibular first molar","volume":"37","author":"Martin","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib28","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.joen.2010.03.004","article-title":"Anesthetic efficacy of articaine for combination labial plus lingual infiltrations versus labial infiltration in the mandibular lateral incisor","volume":"36","author":"Nuzum","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib29","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.joen.2009.12.014","article-title":"Anesthetic efficacy of articaine and lidocaine for incisive\/mental nerve block","volume":"36","author":"Batista da Silva","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib30","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.joen.2008.10.020","article-title":"A comparison of the anesthetic efficacy of articaine and lidocaine in patients with irreversible pulpitis","volume":"35","author":"Tortamano","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.joen.2008.11.025","article-title":"Articaine for supplemental buccal mandibular infiltration anesthesia in patients with irreversible pulpitis when the inferior alveolar nerve block fails","volume":"35","author":"Matthews","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib32","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.joen.2008.02.042","article-title":"Articaine infiltration for anesthesia of first molars","volume":"34","author":"Corbett","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib33","doi-asserted-by":"crossref","first-page":"128","DOI":"10.2344\/0003-3006-56.4.128","article-title":"Articaine for supplemental buccal infiltration of articaine in prolonging duration of pulpal anesthesia anesthesia in the mandibular first molar","volume":"56","author":"Pabst","year":"2009","journal-title":"Anesth Prog"},{"key":"10.1016\/j.joen.2011.09.009_bib34","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/S0099-2399(06)81366-X","article-title":"Endodontic anesthesia in mandibular molars: a clinical study","volume":"19","author":"Cohen","year":"1993","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib35","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/00004770-200310000-00004","article-title":"The significance of needle deflection in success of the inferior alveolar nerve block in patients with irreversible pulpitis","volume":"29","author":"Kennedy","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib36","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S1079-2104(99)70133-2","article-title":"Anesthetic efficacy of the mylohyoid nerve block and combination inferior alveolar nerve block\/mylohyoid nerve block","volume":"87","author":"Clark","year":"1999","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib37","first-page":"372","article-title":"Anesthetic efficacy of different volumes of lidocaine with epinephrine for inferior alveolar nerve blocks","volume":"50","author":"Nusstein","year":"2002","journal-title":"Gen Dent"},{"key":"10.1016\/j.joen.2011.09.009_bib38","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/01.don.0000140576.36513.cb","article-title":"A comparison of articaine and lidocaine for inferior alveolar nerve blocks","volume":"31","author":"Mikesell","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib39","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.joen.2008.02.017","article-title":"Evaluation of pretreatment analgesia and endodontic treatment for post operative endodontic pain","volume":"34","author":"Attar","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib40","first-page":"87","article-title":"Electrical excitation of teeth and its application to dentistry","volume":"39","author":"Bjorn","year":"1946","journal-title":"Swed Dent J"},{"key":"10.1016\/j.joen.2011.09.009_bib41","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0099-2399(87)80097-3","article-title":"An evaluation of an electric pulp tester as a measure of analgesia in human vital teeth","volume":"13","author":"Dreven","year":"1987","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib42","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0099-2399(97)80271-3","article-title":"The anesthetic efficacy of volumes of lidocaine in inferior alveolar nerve blocks","volume":"23","author":"Dagher","year":"1997","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib43","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0099-2399(89)80091-3","article-title":"An evaluation of volumes and concentrations of lidocaine in human inferior alveolar nerve block","volume":"15","author":"Vreeland","year":"1989","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/01.don.0000140576.36513.cb","article-title":"A comparison of articaine and lidocaine for inferior alveolar nerve blocks","volume":"31","author":"Mikesell","year":"2005","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2011.09.009_bib45","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1600-9657.1999.tb00782.x","article-title":"Failure of inferior alveolar nerve block in endodontics","volume":"15","author":"Potonik","year":"1999","journal-title":"Endod Dent Traumatol"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009923991101082X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009923991101082X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T06:19:58Z","timestamp":1741933198000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009923991101082X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["S009923991101082X"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2011.09.009","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}