{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:58:22Z","timestamp":1791665902006,"version":"4.3.4"},"reference-count":25,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,7,1]],"date-time":"2012-07-01T00:00:00Z","timestamp":1341100800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2012,7]]},"DOI":"10.1016\/j.joen.2012.03.004","type":"journal-article","created":{"date-parts":[[2012,4,21]],"date-time":"2012-04-21T14:57:08Z","timestamp":1335020228000},"page":"954-959","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["Bacterial Flora and Extraradicular Biofilm Associated with the Apical Segment of Teeth with Post-treatment Apical Periodontitis"],"prefix":"10.1016","volume":"38","author":[{"given":"Juan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntao","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cailian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingping","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2012.03.004_bib1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1177\/154411130401500604","article-title":"Pathogenesis of apical periodontitis and the causes of endodontic failures","volume":"15","author":"Nair","year":"2004","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.joen.2012.03.004_bib2","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1016\/j.joen.2010.07.001","article-title":"Apical root canal microbiota as determined by reverse-capture checkerboard analysis of cryogenically ground root samples from teeth with apical periodontitis","volume":"36","author":"Rocas","year":"2010","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.03.004_bib3","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1097\/00004770-200210000-00001","article-title":"Participation of bacterial biofilms in refractory and chronic periapical periodontitis","volume":"28","author":"Noiri","year":"2002","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.03.004_bib4","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.284.5418.1318","article-title":"Bacterial biofilms: a common cause of persistent infections","volume":"284","author":"Costerton","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.joen.2012.03.004_bib5","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1365-2591.2006.01099.x","article-title":"On the causes of persistent apical periodontitis: a review","volume":"39","author":"Nair","year":"2006","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2012.03.004_bib6","first-page":"7","article-title":"Update on endodontic microbiology: candidate pathogens and patterns of colonisation","volume":"2","author":"Siqueira","year":"2008","journal-title":"ENDO (Lond Engl)"},{"key":"10.1016\/j.joen.2012.03.004_bib7","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/j.1399-302X.2009.00534.x","article-title":"Characterization of bacterial flora in persistent apical periodontitis lesions","volume":"24","author":"Fujii","year":"2009","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2012.03.004_bib8","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1177\/154405910408301210","article-title":"Localization of Porphyromonas gingivalis-carrying fimbriae in situ in human periodontal pockets","volume":"83","author":"Noiri","year":"2004","journal-title":"J Dent Res"},{"key":"10.1016\/j.joen.2012.03.004_bib9","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/ni1102-1033","article-title":"Bacterial strategies for overcoming host innate and adaptive immune responses","volume":"3","author":"Hornef","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1016\/j.joen.2012.03.004_bib10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.joen.2008.10.024","article-title":"New bacterial compositions in root-filled teeth with periradicular lesions","volume":"35","author":"Schirrmeister","year":"2009","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.03.004_bib11","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S1991-7902(10)60015-3","article-title":"Refractory apical periodontitis associated with a calculus-like deposit at the root apex","volume":"5","author":"Yang","year":"2010","journal-title":"J Dent Sci"},{"key":"10.1016\/j.joen.2012.03.004_bib12","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1016\/j.tripleo.2009.12.051","article-title":"Surgical endodontic treatment of refractory periapical periodontitis with extraradicular biofilm","volume":"110","author":"Su","year":"2010","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2012.03.004_bib13","doi-asserted-by":"crossref","first-page":"8738","DOI":"10.1128\/AEM.71.12.8738-8743.2005","article-title":"Identification and localization of extraradicular biofilm-forming bacteria associated with refractory endodontic pathogens","volume":"71","author":"Noguchi","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.joen.2012.03.004_bib14","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1600-9657.1991.tb00441.x","article-title":"Scanning electron microscopy of bacteria in the apical part of root canals in permanent teeth with periapical lesions","volume":"7","author":"Molven","year":"1991","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2012.03.004_bib15","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/j.joen.2011.09.018","article-title":"Persistent extraradicular infection in root-filled asymptomatic human tooth: scanning electron microscopic analysis and microbial investigation after apical microsurgery","volume":"37","author":"Signoretti","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.03.004_bib16","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1097\/00004770-200212000-00006","article-title":"EM evaluation of bacterial biofilm and microorganisms on the apical external root surface of human teeth","volume":"28","author":"Leonardo","year":"2002","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.03.004_bib17","first-page":"115","article-title":"Identification of dominant pathogens in periapical lesions associated with persistent apical periodontitis","volume":"13","author":"Zhang","year":"2010","journal-title":"Chin J Dent Res"},{"key":"10.1016\/j.joen.2012.03.004_bib18","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.joen.2011.06.020","article-title":"Molecular characterization of the microbial flora residing at the apical portion of infected root canals of human teeth","volume":"37","author":"Chugal","year":"2011","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.03.004_bib19","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1600-0714.1985.tb00512.x","article-title":"Immunocytochemical demonstration of Actinomyces species and Arachnia propionica in periapical infections","volume":"14","author":"Happonen","year":"1985","journal-title":"J Oral Pathol"},{"key":"10.1016\/j.joen.2012.03.004_bib20","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0099-2399(88)80217-6","article-title":"Periapical actinomycosis involving Actinomyces israelii","volume":"14","author":"O\u2019Grady","year":"1988","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.03.004_bib21","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1365-2591.1988.tb01012.x","article-title":"Survival of Arachnia propionica in periapical tissue","volume":"21","author":"Sjogren","year":"1988","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2012.03.004_bib22","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/00004770-200204000-00011","article-title":"Microbiota of periapical lesions refractory to endodontic therapy","volume":"28","author":"Sunde","year":"2002","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.03.004_bib23","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1834-7819.1997.tb00109.x","article-title":"Cell surface structures of Actinomyces israelii","volume":"42","author":"Figdor","year":"1997","journal-title":"Aust Dent J"},{"key":"10.1016\/j.joen.2012.03.004_bib24","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1399-302X.1992.tb00525.x","article-title":"Pathogenicity of Actinomyces israelii and Arachnia propionica: experimental infection in guinea pigs and phagocytosis and intracellular killing by human polymorphonuclear leukocytes in\u00a0vitro","volume":"7","author":"Figdor","year":"1992","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2012.03.004_bib25","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1016\/j.joen.2011.08.012","article-title":"Pyrosequencing analysis of the apical root canal microbiota","volume":"37","author":"Siqueira","year":"2011","journal-title":"J Endod"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239912002853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239912002853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:44:54Z","timestamp":1758829494000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239912002853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["S0099239912002853"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2012.03.004","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2012,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bacterial Flora and Extraradicular Biofilm Associated with the Apical Segment of Teeth with Post-treatment Apical Periodontitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2012.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}