{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T21:34:38Z","timestamp":1790026478473,"version":"4.0.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004257","name":"Helse Vest","doi-asserted-by":"publisher","award":["911684"],"award-info":[{"award-number":["911684"]}],"id":[{"id":"10.13039\/501100004257","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.jp","jendodon.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Endodontics"],"published-print":{"date-parts":[[2013,5]]},"DOI":"10.1016\/j.joen.2012.12.017","type":"journal-article","created":{"date-parts":[[2013,1,30]],"date-time":"2013-01-30T05:16:09Z","timestamp":1359522969000},"page":"605-611","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Localization and Signaling Patterns of Vascular Endothelial Growth Factors and Receptors in Human Periapical Lesions"],"prefix":"10.1016","volume":"39","author":[{"given":"Anca","family":"Virtej","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigbj\u00f8rn S.","family":"L\u00f8es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Berggreen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasia","family":"Bletsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.joen.2012.12.017_bib1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1177\/10454411980090040701","article-title":"Periapical inflammatory responses and their modulation","volume":"9","author":"Stashenko","year":"1998","journal-title":"Crit Rev Oral Biol Med"},{"key":"10.1016\/j.joen.2012.12.017_bib2","doi-asserted-by":"crossref","first-page":"5304","DOI":"10.3402\/jom.v3i0.5304","article-title":"Review of osteoimmunology and the host response in endodontic and periodontal lesions","volume":"3","author":"Graves","year":"2011","journal-title":"J Oral Microbiol"},{"key":"10.1016\/j.joen.2012.12.017_bib3","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1046\/j.1365-2591.2003.00627.x","article-title":"Inflammatory infiltrate of chronic periradicular lesions: an immunohistochemical study","volume":"36","author":"Liapatas","year":"2003","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2012.12.017_bib4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0099-2399(06)81587-6","article-title":"Quantitative analysis of the immunocompetent cells in periapical granuloma: correlation with the histological characteristics of the lesions","volume":"16","author":"Lukic","year":"1990","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.12.017_bib5","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.tripleo.2006.11.036","article-title":"Kinetics of RANKL, RANK and OPG expressions in experimentally induced rat periapical lesions","volume":"103","author":"Kawashima","year":"2007","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2012.12.017_bib6","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.joen.2008.05.002","article-title":"Differential patterns of receptor activator of nuclear factor kappa B ligand\/osteoprotegerin expression in human periapical granulomas: possible association with progressive or stable nature of the lesions","volume":"34","author":"Menezes","year":"2008","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.12.017_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0076-6879(08)03001-2","article-title":"Chapter 1: inflammation, angiogenesis, and lymphangiogenesis","volume":"445","author":"Halin","year":"2008","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.joen.2012.12.017_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s10456-008-9099-z","article-title":"Vascular permeability, vascular hyperpermeability and angiogenesis","volume":"11","author":"Nagy","year":"2008","journal-title":"Angiogenesis"},{"key":"10.1016\/j.joen.2012.12.017_bib9","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.cell.2010.01.045","article-title":"Lymphangiogenesis: molecular mechanisms and future promise","volume":"140","author":"Tammela","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.joen.2012.12.017_bib10","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1182\/blood-2007-01-065714","article-title":"Distinct roles of VEGFR-1 and VEGFR-2 in the aberrant hematopoiesis associated with elevated levels of VEGF","volume":"110","author":"Huang","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.joen.2012.12.017_bib11","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1134\/S0006297907110041","article-title":"Gene expression for VEGF-A, VEGF-C, and their receptors in murine lymphocytes and macrophages","volume":"72","author":"Stepanova","year":"2007","journal-title":"Biochemistry (Mosc)"},{"key":"10.1016\/j.joen.2012.12.017_bib12","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/S0002-9440(10)64255-1","article-title":"Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis","volume":"161","author":"Schoppmann","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1016\/j.joen.2012.12.017_bib13","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1182\/blood.V92.11.4150","article-title":"Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in\u00a0vivo","volume":"92","author":"Gabrilovich","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.joen.2012.12.017_bib14","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.devcel.2010.01.009","article-title":"Regulation of developmental lymphangiogenesis by Syk(+) leukocytes","volume":"18","author":"Bohmer","year":"2010","journal-title":"Dev Cell"},{"key":"10.1016\/j.joen.2012.12.017_bib15","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.bbrc.2005.07.145","article-title":"Vascular endothelial growth factor receptors in osteoclast differentiation and function","volume":"335","author":"Aldridge","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.joen.2012.12.017_bib16","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1007\/s11033-010-0249-1","article-title":"Vascular endothelial growth factor stimulates osteoblastic differentiation of cultured human periosteal-derived cells expressing vascular endothelial growth factor receptors","volume":"38","author":"Hah","year":"2011","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.joen.2012.12.017_bib17","doi-asserted-by":"crossref","first-page":"160265","DOI":"10.1155\/2012\/160265","article-title":"Changes in cytokines of the bone microenvironment during breast cancer metastasis","volume":"2012","author":"Sosnoski","year":"2012","journal-title":"Int J Breast Cancer"},{"key":"10.1016\/j.joen.2012.12.017_bib18","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.joen.2012.01.005","article-title":"Vascular endothelial growth factors and receptors are up-regulated during development of apical periodontitis","volume":"38","author":"Bletsa","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.12.017_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1034\/j.1399-302x.2000.150301.x","article-title":"Protective and destructive immune reactions in apical periodontitis","volume":"15","author":"Marton","year":"2000","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.joen.2012.12.017_bib20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/00004770-200303000-00004","article-title":"Detection of vascular endothelial growth factor\/vascular permeability factor in periapical lesions","volume":"29","author":"Leonardi","year":"2003","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.12.017_bib21","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.tripleo.2008.06.028","article-title":"Immunoexpression of vascular endothelial growth factor in periapical granulomas, radicular cysts, and residual radicular cysts","volume":"106","author":"Nonaka","year":"2008","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.joen.2012.12.017_bib22","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.joen.2011.09.011","article-title":"Expression analysis of wound healing genes in human periapical granulomas of progressive and stable nature","volume":"38","author":"Garlet","year":"2012","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.12.017_bib23","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.joen.2012.12.017_bib24","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1111\/j.1365-2591.2009.01605.x","article-title":"Sensory pulpal nerve fibres and trigeminal ganglion neurons express IL-1RI: a potential mechanism for development of inflammatory hyperalgesia","volume":"42","author":"Bletsa","year":"2009","journal-title":"Int Endod J"},{"key":"10.1016\/j.joen.2012.12.017_bib25","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0099-2399(07)80157-9","article-title":"Immune cells in periapical granuloma: morphological and immunohistochemical characterization","volume":"17","author":"Piattelli","year":"1991","journal-title":"J Endod"},{"key":"10.1016\/j.joen.2012.12.017_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1034\/j.1600-9657.2000.016001001.x","article-title":"Macrophages in periapical lesions","volume":"16","author":"Metzger","year":"2000","journal-title":"Endod Dent Traumatol"},{"key":"10.1016\/j.joen.2012.12.017_bib27","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1042\/BJ20110301","article-title":"Signal transduction by vascular endothelial growth factor receptors","volume":"437","author":"Koch","year":"2011","journal-title":"Biochem J"},{"key":"10.1016\/j.joen.2012.12.017_bib28","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ceb.2012.02.002","article-title":"VEGF signaling inside vascular endothelial cells and beyond","volume":"24","author":"Eichmann","year":"2012","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.joen.2012.12.017_bib29","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1182\/blood-2010-02-271478","article-title":"PLD1-dependent PKCgamma activation downstream to Src is essential for the development of pathologic retinal neovascularization","volume":"116","author":"Zhang","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.joen.2012.12.017_bib30","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1093\/emboj\/20.11.2768","article-title":"A single autophosphorylation site on KDR\/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells","volume":"20","author":"Takahashi","year":"2001","journal-title":"Embo J"},{"key":"10.1016\/j.joen.2012.12.017_bib31","doi-asserted-by":"crossref","first-page":"22489","DOI":"10.1074\/jbc.M110.217786","article-title":"Activation of cytosolic phospholipase A2 downstream of the Src-phospholipase D1 (PLD1)-protein kinase C gamma (PKCgamma) signaling axis is required for hypoxia-induced pathological retinal angiogenesis","volume":"286","author":"Zhang","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.joen.2012.12.017_bib32","doi-asserted-by":"crossref","first-page":"4762","DOI":"10.1093\/emboj\/20.17.4762","article-title":"Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C\/D receptor VEGFR-3","volume":"20","author":"Makinen","year":"2001","journal-title":"Embo J"},{"key":"10.1016\/j.joen.2012.12.017_bib33","doi-asserted-by":"crossref","first-page":"3423","DOI":"10.1182\/blood-2005-04-1388","article-title":"Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways","volume":"106","author":"Salameh","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.joen.2012.12.017_bib34","doi-asserted-by":"crossref","first-page":"6307","DOI":"10.1038\/sj.onc.1205781","article-title":"Sck is expressed in endothelial cells and participates in vascular endothelial growth factor-induced signaling","volume":"21","author":"Ratcliffe","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.joen.2012.12.017_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1593\/neo.111600","article-title":"Merlin\/NF2 regulates angiogenesis in schwannomas through a Rac1\/semaphorin 3F-dependent mechanism","volume":"14","author":"Wong","year":"2012","journal-title":"Neoplasia"},{"key":"10.1016\/j.joen.2012.12.017_bib36","doi-asserted-by":"crossref","first-page":"L711","DOI":"10.1152\/ajplung.00116.2011","article-title":"Vascular endothelial growth factor enhances macrophage clearance of apoptotic cells","volume":"302","author":"Kearns","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.joen.2012.12.017_bib37","doi-asserted-by":"crossref","first-page":"5648","DOI":"10.4049\/jimmunol.1001713","article-title":"Distinct roles of vascular endothelial growth factor receptor-1- and receptor-2-mediated signaling in T cell priming and Th17 polarization to lipopolysaccharide-containing allergens in the lung","volume":"185","author":"Kim","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.joen.2012.12.017_bib38","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.2174\/092986709788803169","article-title":"Vascular endothelial growth factor receptor 1, a therapeutic target in cancer, inflammation and other disorders","volume":"16","author":"Wu","year":"2009","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.joen.2012.12.017_bib39","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbrc.2005.06.065","article-title":"Vascular endothelial growth factor impairs the functional ability of dendritic cells through Id pathways","volume":"334","author":"Laxmanan","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.joen.2012.12.017_bib40","doi-asserted-by":"crossref","first-page":"L1014","DOI":"10.1152\/ajplung.00357.2011","article-title":"Interplay of macrophages and T cells in the lung vasculature","volume":"302","author":"Gerasimovskaya","year":"2012","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.joen.2012.12.017_bib41","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1600-0722.2010.00717.x","article-title":"Absence of lymphatic vessels in human dental pulp: a morphological study","volume":"118","author":"Gerli","year":"2010","journal-title":"Eur J Oral Sci"},{"key":"10.1016\/j.joen.2012.12.017_bib42","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1172\/JCI23874","article-title":"Inflammation-induced lymphangiogenesis in the cornea arises from CD11b-positive macrophages","volume":"115","author":"Maruyama","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.joen.2012.12.017_bib43","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/path.1942","volume":"209","author":"Schledzewski","year":"2006","journal-title":"J Pathol"}],"container-title":["Journal of Endodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239912012216?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0099239912012216?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T19:45:41Z","timestamp":1758829541000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0099239912012216"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,5]]}},"alternative-id":["S0099239912012216"],"URL":"https:\/\/doi.org\/10.1016\/j.joen.2012.12.017","relation":{},"ISSN":["0099-2399"],"issn-type":[{"value":"0099-2399","type":"print"}],"subject":[],"published":{"date-parts":[[2013,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Localization and Signaling Patterns of Vascular Endothelial Growth Factors and Receptors in Human Periapical Lesions","name":"articletitle","label":"Article Title"},{"value":"Journal of Endodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.joen.2012.12.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}